TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 343.382 | Formula: C20H17N5O
H donors: 1 H acceptors: 4 LogP: 3.79 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(cc(c1C=Cc1cncc(c1)c1nn[nH]n1)C)c1ccco1
InChi: 1S/C20H17N5O/c1-13-8-16(19-4-3-7-26-19)9-14(2)18(13)6-5-15-10-17(12-21-11-15)20-22-24-25-23-20/h3-12H,1-2H3,(H,22,23,24,25)
InChiKey: XFBUODNVNPFENG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	YES proto-oncogene 1, Src family tyrosine kinase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	TK protein kinase	0.0041	0.8785	0.8785
Loa Loa (eye worm)	SRC-1	0.0045	1	1
Loa Loa (eye worm)	dehydrogenase	0.0021	0.3321	0.3321
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Possible oxidoreductase	0.0021	0.3321	0.5
Schistosoma mansoni	tyrosine kinase	0.0045	1	1
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	dehydrogenase	0.0021	0.3321	0.5
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0021	0.3321	0.5
Schistosoma mansoni	carbonyl reductase	0.0021	0.3321	0.3321
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	oxidoreductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Echinococcus multilocularis	retinol dehydrogenase 13	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Onchocerca volvulus	Sepiapterin reductase homolog	0.0021	0.3321	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	ketoacyl reductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Echinococcus granulosus	c src tyrosine kinase	0.001	0.035	0.035
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0021	0.3321	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Brugia malayi	Retinol dehydrogenase 12	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.8785	0.8785
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0021	0.3321	0.5
Entamoeba histolytica	protein kinase, putative	0.0036	0.7539	1
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0021	0.3321	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0021	0.3321	0.5
Schistosoma mansoni	carbonyl reductase	0.0021	0.3321	0.3321
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0021	0.3321	0.5
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	1	1
Schistosoma mansoni	tyrosine kinase	0.001	0.035	0.035
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	oxidoreductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.035	0.035
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0021	0.3321	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0021	0.3321	0.3321
Echinococcus granulosus	WW domain containing oxidoreductase	0.0021	0.3321	0.3321
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0021	0.3321	0.3321
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0021	0.3321	0.5
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0021	0.3321	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0021	0.3321	0.3321
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0021	0.3321	0.3321
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.7539	0.7539
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	hypothetical protein	0.0021	0.3321	0.3321
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Giardia lamblia	Short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0021	0.3321	0.3321
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.035	0.035
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	1	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0021	0.3321	0.3321
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Echinococcus granulosus	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	1	1
Brugia malayi	hypothetical protein	0.0021	0.3321	0.3321
Echinococcus granulosus	steroid dehydrogenase	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.8435	0.8435
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase	0.0021	0.3321	0.3321
Toxoplasma gondii	oxidoreductase, putative	0.0021	0.3321	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	1	1
Giardia lamblia	Hypothetical protein	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0021	0.3321	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Leishmania major	short chain dehydrogenase, putative	0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0045	1	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Toxoplasma gondii	carbonyl reductase 1, putative	0.0021	0.3321	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0021	0.3321	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.035	0.035
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.8785	0.8785
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Schistosoma mansoni	tyrosine kinase	0.001	0.035	0.035
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0021	0.3321	0.3321
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.035	0.035
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.7539	0.7539
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	1	1
Schistosoma mansoni	tyrosine kinase	0.0045	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0021	0.3321	0.3321
Onchocerca volvulus		0.0021	0.3321	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0021	0.3321	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	1	1
Onchocerca volvulus		0.0021	0.3321	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0021	0.3321	0.3321
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0021	0.3321	0.3321
Echinococcus multilocularis	carbonyl reductase 1	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0021	0.3321	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0021	0.3321	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Brugia malayi	dehydrogenases, short chain protein 2	0.0021	0.3321	0.3321
Brugia malayi	protein-tyrosine kinase	0.0041	0.8785	0.8785
Loa Loa (eye worm)	dehydrogenase	0.0021	0.3321	0.3321
Leishmania major	pteridine reductase 1	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0021	0.3321	0.3321
Echinococcus multilocularis	retinol dehydrogenase 11	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.8785	0.8785
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.8785	0.8785
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Giardia lamblia	Reductase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.035	0.035
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	1	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	short chain dehydrogenase-like protein	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0021	0.3321	0.5
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0021	0.3321	0.3321
Schistosoma mansoni	carbonyl reductase	0.0021	0.3321	0.3321
Onchocerca volvulus		0.0021	0.3321	0.5
Echinococcus granulosus	hypothetical protein	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.8785	0.8785
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	1	1
Onchocerca volvulus		0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Leishmania major	oxidoreductase-like protein	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	conserved hypothetical protein	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0021	0.3321	0.3321
Echinococcus multilocularis	carbonyl reductase 1	0.0021	0.3321	0.3321
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0021	0.3321	0.3321
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.8435	0.8435
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	1	1
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Leishmania major	dehydrogenase-like protein	0.0021	0.3321	0.5
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.3321
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.035	0.035
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0021	0.3321	0.5
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Brugia malayi	Dehydrogenases, short chain protein 2	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Echinococcus multilocularis	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Brugia malayi	hypothetical protein	0.0021	0.3321	0.3321
Brugia malayi	dehydrogenases, short chain protein 9	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	1	1
Onchocerca volvulus		0.0021	0.3321	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0021	0.3321	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0021	0.3321	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0021	0.3321	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine kinase	0.0041	0.8785	0.8785
Loa Loa (eye worm)	TK protein kinase	0.0036	0.7539	0.7539
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0021	0.3321	0.3321
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Echinococcus granulosus	carbonyl reductase 1	0.0021	0.3321	0.3321
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	ketoacyl reductase	0.0021	0.3321	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	1	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	ketoacyl reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0021	0.3321	0.3321
Leishmania major	short chain dehydrogenase, putative	0.0021	0.3321	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.0358 uM	PubChem BioAssay. qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3188999

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1874358