Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Niemann-Pick disease, type C1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0271 | 0.1124 | 0.1011 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.2025 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0138 | 0.0129 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.2025 | 1 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.0353 | 0.0344 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0138 | 0.0129 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.0316 | 0.0307 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.2025 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0067 | 0.0058 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.2025 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0138 | 0.0129 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.2025 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0138 | 0.0129 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.0611 | 0.0602 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0138 | 0.0129 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.2025 | 1 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.2025 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0058 | 0.0046 | 0.0037 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0138 | 0.0129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0138 | 0.0138 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.1754 | 0.8627 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0138 | 0.0138 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.2025 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.0611 | 0.0602 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.0316 | 0.0307 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0138 | 0.0129 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0074 | 0.0125 | 0.0116 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0353 | 0.0344 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0074 | 0.0125 | 0.0116 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.0362 | 0.0362 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.1754 | 0.8627 | 1 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.1754 | 0.8627 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0538 | 0.2474 | 0.2379 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.0353 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.0353 | 0.0344 |
Brugia malayi | ribonucleotide reductase 2 | 0.0074 | 0.0125 | 0.0116 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.0353 | 0.0344 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0138 | 0.0129 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.1754 | 0.8627 | 1 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.2025 | 1 | 1 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0074 | 0.0125 | 0.0125 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0138 | 0.0138 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.2025 | 1 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.1754 | 0.8627 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0271 | 0.1124 | 0.1175 |
Schistosoma mansoni | patched 1 | 0.0051 | 0.0009 | 0.0009 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0074 | 0.0125 | 0.0116 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.2025 | 1 | 1 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0631 | 0.2942 | 0.3313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.2025 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4654 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.