TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 317.335 | Formula: C16H12FNO3S
H donors: 1 H acceptors: 3 LogP: 3.51 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(c1nc(oc1c1cscc1)c1ccc(cc1)F)C
InChi: 1S/C16H12FNO3S/c1-9(16(19)20)13-14(11-6-7-22-8-11)21-15(18-13)10-2-4-12(17)5-3-10/h2-9H,1H3,(H,19,20)
InChiKey: INXZINLRRUFHKB-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0151	0.135	0.3919
Brugia malayi	Trypsin family protein	0.0045	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0812	0.0812
Brugia malayi	Cathepsin L-like precursor	0.0226	0.2251	0.2251
Brugia malayi	Trypsin family protein	0.0045	0.0053	0.0053
Brugia malayi	hypothetical protein	0.0233	0.2344	0.2344
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0151	0.135	0.135
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0063	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Brugia malayi	Cathepsin L-like precursor	0.0159	0.1444	0.1444
Echinococcus multilocularis	cysteine protease	0.0226	0.2251	0.2251
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0292	0.0292
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0128	0.1067	0.3261
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0411	0.4504	0.4504
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0292	0.0292
Echinococcus multilocularis	cathepsin L cysteine protease	0.0226	0.2251	0.2251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.1067	0.268
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0863	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0062	0.026	0.0273
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.0034	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0863	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0159	0.1444	0.1444
Plasmodium vivax	vivapain-1	0.0128	0.1067	0.4741
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0411	0.4504	0.4504
Entamoeba histolytica	cysteine proteinase 2	0.0128	0.1067	0.4054
Echinococcus granulosus	cathepsin l1	0.0226	0.2251	0.2251
Entamoeba histolytica	cysteine proteinase 1, putative	0.0128	0.1067	0.4054
Onchocerca volvulus		0.0226	0.2251	1
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0112	0.0871	0.0871
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0151	0.135	0.5473
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0292	0.0292
Plasmodium vivax	RNA helicase-1, putative	0.0151	0.135	0.5996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0151	0.135	0.135
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Onchocerca volvulus	Cathepsin L homolog	0.0226	0.2251	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.031	0.3272	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0226	0.2251	0.2251
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1024	0.4417
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.026	0.026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.2344	0.2344
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0159	0.1444	0.393
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0205	0.0205
Onchocerca volvulus		0.0057	0.0204	0.0687
Echinococcus multilocularis	calpain family protein 1, d	0.0079	0.0468	0.0468
Brugia malayi	cathepsin F-like cysteine proteinase	0.0066	0.0315	0.0315
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1126	0.1126
Echinococcus multilocularis	glycoprotein Antigen 5	0.0045	0.0053	0.0053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0623	0.0623
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0053	0.0053
Onchocerca volvulus		0.0088	0.0581	0.2404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Echinococcus multilocularis	Mastin	0.0045	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0053	0.0053
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0045	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0062	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2344	0.2344
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0151	0.135	0.3618
Plasmodium falciparum	serine repeat antigen 5	0.0062	0.026	0.0273
Leishmania major	eukaryotic initiation factor 4a, putative	0.0151	0.135	0.4125
Brugia malayi	Papain family cysteine protease containing protein	0.0128	0.1067	0.1067
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0205	0.0205
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0226	0.2251	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0063	0.0274	0.0274
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0863	1	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0055	0.0181	0.0581
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0181	0.0181
Trypanosoma cruzi	cysteine proteinase, putative	0.0128	0.1067	0.1067
Brugia malayi	Cathepsin L-like precursor	0.0066	0.0315	0.0315
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0151	0.135	0.135
Entamoeba histolytica	cysteine protease, putative	0.0226	0.2251	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0034	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0307	0.3245	0.3245
Plasmodium vivax	unspecified product	0.0128	0.1067	0.4741
Brugia malayi	cathepsin L precursor	0.0062	0.026	0.026
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.026	0.026
Loa Loa (eye worm)	TK/ROR protein kinase	0.0057	0.0204	0.0204
Echinococcus granulosus	polycomb protein SCMH1	0.0055	0.0181	0.0181
Onchocerca volvulus		0.0226	0.2251	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0062	0.026	0.1155
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0087	0.0087
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Leishmania major	cathepsin L-like protease	0.0226	0.2251	0.6879
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0112	0.0871	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1126	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1444	0.1444
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0045	0.0053	0.0053
Brugia malayi	Trypsin-like protease protein 5	0.0045	0.0053	0.0053
Onchocerca volvulus		0.0226	0.2251	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0226	0.2251	0.2251
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0034	0.0034
Trypanosoma cruzi	major cysteine proteinase, putative	0.0062	0.026	0.026
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.026	0.026
Leishmania major	cathepsin L-like protease	0.0226	0.2251	0.6879
Brugia malayi	RNA binding protein	0.0064	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0053	0.0053
Echinococcus granulosus	transmembrane protease serine 3	0.0045	0.0053	0.0053
Plasmodium falciparum	serine repeat antigen 4	0.0062	0.026	0.0273
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.0315	0.0315
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0623	0.0623
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0151	0.135	0.4125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Echinococcus granulosus	histone acetyltransferase MYST2	0.0063	0.0274	0.0274
Echinococcus granulosus	cathepsin l1	0.0159	0.1444	0.1444
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0128	0.1067	0.4217
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0128	0.1067	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0315	0.0315
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0062	0.026	0.026
Echinococcus granulosus	tumor protein p63	0.0392	0.4272	0.4272
Schistosoma mansoni	hypothetical protein	0.0045	0.0053	0.0053
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0204	0.0204
Leishmania major	cathepsin L-like protease	0.0226	0.2251	0.6879
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0063	0.0274	0.0274
Onchocerca volvulus		0.0062	0.026	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1444	0.1444
Brugia malayi	Trypsin family protein	0.0133	0.1126	0.1126
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0151	0.135	0.135
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0043	0.0034	0.0034
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Echinococcus multilocularis	cathepsin L	0.0128	0.1067	0.1067
Trypanosoma cruzi	cysteine peptidase, putative	0.0128	0.1067	0.1067
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0623	0.0623
Brugia malayi	cathepsin L-like cysteine proteinase	0.0062	0.026	0.026
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.2344	0.2344
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0112	0.0871	0.0871
Brugia malayi	mbt repeat family protein	0.0055	0.0181	0.0181
Echinococcus granulosus	tissue type plasminogen activator	0.0057	0.0204	0.0204
Echinococcus granulosus	cathepsin L	0.0062	0.026	0.026
Onchocerca volvulus		0.0067	0.032	0.1215
Echinococcus multilocularis	polycomb protein SCMH1	0.0055	0.0181	0.0181
Brugia malayi	Cathepsin L-like precursor	0.0226	0.2251	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1024	0.1024
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.1126	0.1126
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0053	0.0053
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0128	0.1067	0.1067
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0292	0.0292
Onchocerca volvulus		0.0055	0.0181	0.0581
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0292	0.0292
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0226	0.2251	0.661
Brugia malayi	Papain family cysteine protease containing protein	0.0128	0.1067	0.1067
Echinococcus granulosus	cathepsin b	0.0863	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0226	0.2251	1
Onchocerca volvulus		0.0133	0.1126	0.4882
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0226	0.2251	0.2251
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0315	0.0315
Loa Loa (eye worm)	calpain family protein 1	0.0107	0.0812	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0315	0.0315
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0292	0.0292
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0062	0.026	0.026
Echinococcus multilocularis	transmembrane protease serine 3	0.0045	0.0053	0.0053
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0053	0.0053
Schistosoma mansoni	cathepsin C	0.0062	0.026	0.026
Plasmodium falciparum	serine repeat antigen 9	0.0062	0.026	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0664	0.0664
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0062	0.026	0.026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.08	0.9233	0.9233
Toxoplasma gondii	cathepsin CPL	0.0226	0.2251	0.677
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0226	0.2251	0.2251
Schistosoma mansoni	cathepsin B (C01 family)	0.0062	0.026	0.026
Plasmodium vivax	serine-repeat antigen (SERA)	0.0062	0.026	0.1155
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0062	0.026	0.026
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0151	0.135	0.5597
Schistosoma mansoni	cathepsin F (C01 family)	0.0226	0.2251	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0062	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0062	0.026	0.026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0128	0.1067	0.3261
Echinococcus granulosus	cathepsin b	0.0863	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.026	0.026
Trypanosoma cruzi	hypothetical protein, conserved	0.0057	0.0204	0.0204
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0066	0.0315	0.0315
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0066	0.0315	0.0315
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.026	0.026
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0307	0.3245	0.9915
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0863	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0128	0.1067	0.1067
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0057	0.0204	0.0907
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0128	0.1067	0.1067
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0159	0.1444	0.1444
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0062	0.026	0.1155
Schistosoma mansoni	cathepsin F (C01 family)	0.0226	0.2251	0.2251
Giardia lamblia	Cathepsin B precursor	0.031	0.3272	1
Brugia malayi	calpain family protein 1	0.0107	0.0812	0.0812
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0062	0.026	0.1155
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.031	0.3272	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0062	0.026	0.026
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0181	0.0181
Loa Loa (eye worm)	cathepsin B	0.031	0.3272	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0226	0.2251	0.2251
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0292	0.0292
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0623	0.0623
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0055	0.0181	0.0181
Onchocerca volvulus	Cathepsin F homolog	0.0226	0.2251	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0863	1	1
Leishmania major	cathepsin L-like protease	0.0226	0.2251	0.6879
Trypanosoma cruzi	cysteine peptidase, putative	0.0226	0.2251	0.2251
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0062	0.026	0.0273
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0226	0.2251	0.2251
Schistosoma mansoni	cathepsin S (C01 family)	0.0062	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0062	0.026	0.026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Giardia lamblia	Cathepsin B precursor	0.031	0.3272	1
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.1067	0.4054
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.031	0.3272	0.3272
Brugia malayi	Cathepsin L-like precursor	0.0226	0.2251	0.2251
Plasmodium falciparum	serine repeat antigen 8	0.0062	0.026	0.0273
Loa Loa (eye worm)	ctsf protein	0.0226	0.2251	0.2251
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0112	0.0871	0.0871
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0151	0.135	0.59
Toxoplasma gondii	cathepsin CPC1	0.0062	0.026	0.0472
Plasmodium falciparum	serine repeat antigen 2	0.0062	0.026	0.0273
Echinococcus granulosus	cathepsin L	0.0128	0.1067	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1024	0.1024
Echinococcus granulosus	calpain A	0.0112	0.0871	0.0871
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Schistosoma mansoni	cathepsin s	0.0066	0.0315	0.0315
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0292	0.0292
Brugia malayi	Trypsin family protein	0.0045	0.0053	0.0053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0863	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0226	0.2251	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0053	0.0053
Trypanosoma cruzi	major cysteine proteinase, putative	0.0062	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0204	0.0204
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0623	0.0623
Mycobacterium ulcerans	hypothetical protein	0.0162	0.1476	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0062	0.026	0.1155
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Brugia malayi	Kringle domain containing protein	0.0057	0.0204	0.0204
Loa Loa (eye worm)	mbt repeat family protein	0.0055	0.0181	0.0181
Trypanosoma cruzi	cysteine peptidase, putative	0.0226	0.2251	0.2251
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1024	0.4417
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.026	0.026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0226	0.2251	0.661
Echinococcus granulosus	SAM and MBT domain containing protein	0.0055	0.0181	0.0181
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0145	0.1277	0.3901
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0087	0.0087
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0623	0.0623
Echinococcus multilocularis	cathepsin b	0.0863	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0062	0.026	0.026
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0623	0.0623
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0623	0.0623
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0151	0.135	0.135
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.026	0.026
Echinococcus multilocularis	tissue type plasminogen activator	0.0057	0.0204	0.0204
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0062	0.026	0.1155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0063	0.0274	0.0274
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0062	0.026	0.1155
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0062	0.026	0.1155
Brugia malayi	calpain family protein 1	0.0107	0.0812	0.0812
Onchocerca volvulus		0.0226	0.2251	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0468	0.0468
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.1126	0.1126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Toxoplasma gondii	kringle domain-containing protein	0.0057	0.0204	0.0295
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Loa Loa (eye worm)	calpain family protein 1	0.0079	0.0468	0.0468
Brugia malayi	Cathepsin L-like precursor	0.0159	0.1444	0.1444
Leishmania major	cysteine peptidase A (CPA)	0.0226	0.2251	0.6879
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0062	0.026	0.1155
Echinococcus multilocularis	cathepsin L cysteine protease	0.0226	0.2251	0.2251
Leishmania major	cathepsin L-like protease	0.0226	0.2251	0.6879
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Plasmodium falciparum	serine repeat antigen 1	0.0062	0.026	0.0273
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0226	0.2251	0.2251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0151	0.135	0.3618
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Onchocerca volvulus		0.0226	0.2251	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0307	0.3245	0.3245
Brugia malayi	eukaryotic initiation factor 4A	0.0151	0.135	0.135
Plasmodium vivax	serine-repeat antigen (SERA)	0.0062	0.026	0.1155
Schistosoma mansoni	hypothetical protein	0.0048	0.0087	0.0087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0623	0.0623
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.026	0.026
Plasmodium vivax	unspecified product	0.0066	0.0315	0.1401
Leishmania major	cathepsin L-like protease	0.0226	0.2251	0.6879
Loa Loa (eye worm)	fibroinase	0.0226	0.2251	0.2251
Onchocerca volvulus	Cathepsin L homolog	0.0226	0.2251	1
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.1067	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0226	0.2251	1
Brugia malayi	TAR-binding protein	0.0064	0.0292	0.0292
Echinococcus granulosus	cathepsin L cysteine protease	0.0128	0.1067	0.1067
Leishmania major	cathepsin L-like protease	0.0226	0.2251	0.6879
Loa Loa (eye worm)	hypothetical protein	0.0151	0.135	0.135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Trypanosoma brucei	cysteine peptidase C (CPC)	0.031	0.3272	1
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1444	0.1444
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.026	0.026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.1067	0.268
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0181	0.0181
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0107	0.0812	0.0812
Brugia malayi	hypothetical protein	0.0045	0.0053	0.0053
Plasmodium falciparum	serine repeat antigen 3	0.0062	0.026	0.0273
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0151	0.135	0.135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.026	0.026
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0162	0.1476	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0062	0.026	0.0273
Brugia malayi	Cathepsin L-like precursor	0.0226	0.2251	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0411	0.4504	0.4504
Onchocerca volvulus		0.0226	0.2251	1
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0045	0.0053	0.0053
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0226	0.2251	0.2251
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0151	0.135	0.135
Onchocerca volvulus		0.0048	0.0087	0.0153
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Giardia lamblia	Cathepsin B precursor	0.031	0.3272	1
Plasmodium falciparum	serine repeat antigen 6	0.0062	0.026	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0159	0.1444	0.393
Echinococcus multilocularis	tumor protein p63	0.0392	0.4272	0.4272
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0128	0.1067	0.1067
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0181	0.0223
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.1067	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Echinococcus granulosus	Mastin	0.0045	0.0053	0.0053
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0145	0.1277	0.1277
Echinococcus multilocularis	cathepsin L	0.0062	0.026	0.026
Echinococcus granulosus	cysteine protease	0.0128	0.1067	0.1067
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0062	0.026	0.0472
Schistosoma mansoni	hypothetical protein	0.0045	0.0053	0.0053
Onchocerca volvulus		0.0226	0.2251	1
Loa Loa (eye worm)	trypsin family protein	0.0045	0.0053	0.0053
Leishmania major	mitochondrial DNA polymerase beta	0.0307	0.3245	0.9915
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0222	0.2205	0.2205
Echinococcus multilocularis	calpain A	0.0112	0.0871	0.0871
Brugia malayi	Papain family cysteine protease containing protein	0.0226	0.2251	0.2251
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0062	0.026	0.1155
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0151	0.135	0.3618
Brugia malayi	fibroinase precursor	0.0062	0.026	0.026
Loa Loa (eye worm)	cysteine protease	0.0226	0.2251	0.2251
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0226	0.2251	0.2251
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0053	0.0053
Leishmania major	cathepsin L-like protease	0.0226	0.2251	0.6879
Plasmodium falciparum	serine repeat antigen 7	0.0062	0.026	0.0273
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.026	0.026
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0053	0.0053
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0055	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0067	0.032	0.032
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0151	0.135	0.135
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0262	0.0262
Onchocerca volvulus		0.0057	0.0205	0.0694
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.031	0.3272	1
Echinococcus multilocularis	cathepsin b	0.0863	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0128	0.1067	0.1067
Plasmodium vivax	vivapain-2	0.0226	0.2251	1
Plasmodium vivax	vivapain-3	0.0128	0.1067	0.4741
Brugia malayi	Cathepsin L-like precursor	0.0226	0.2251	0.2251
Entamoeba histolytica	cysteine proteinase, putative	0.0226	0.2251	1
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0151	0.135	0.3618
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0045	0.0053	0.0053
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.1067	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0159	0.1444	0.1444
Schistosoma mansoni	cercarial elastase (S01 family)	0.0045	0.0053	0.0053
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0222	0.2205	0.2205
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Treponema pallidum	ATP-dependent RNA helicase	0.0151	0.135	0.5
Plasmodium vivax	unspecified product	0.0062	0.026	0.1155
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.026	0.026
Toxoplasma gondii	cathepsin CPC2	0.0062	0.026	0.0472
Echinococcus multilocularis	enteropeptidase	0.0045	0.0053	0.0053
Leishmania major	eukaryotic initiation factor 4a, putative	0.0151	0.135	0.4125
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.026	0.026
Loa Loa (eye worm)	MBCTL1	0.0063	0.0274	0.0274
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0063	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0226	0.2251	0.661
Onchocerca volvulus	Cathepsin L homolog	0.0062	0.026	0.0942
Brugia malayi	Cathepsin L-like precursor	0.0226	0.2251	0.2251
Trypanosoma cruzi	cysteine peptidase, putative	0.0226	0.2251	0.2251
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0292	0.0292
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.026	0.026
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0226	0.2251	0.6879
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054
Onchocerca volvulus		0.0159	0.1444	0.6328
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0062	0.026	0.1155
Schistosoma mansoni	hypothetical protein	0.034	0.3643	0.3643
Toxoplasma gondii	cathepsin B	0.031	0.3272	1
Brugia malayi	hypothetical protein	0.0125	0.1024	0.1024
Brugia malayi	mbt repeat family protein	0.0055	0.0181	0.0181
Leishmania major	hypothetical protein, conserved	0.0057	0.0204	0.0624
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0053	0.0149	0.0149
Echinococcus granulosus	enteropeptidase	0.0045	0.0053	0.0053
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0045	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.2251	0.661
Plasmodium vivax	vivapain-2	0.0226	0.2251	1
Entamoeba histolytica	cysteine proteinase, putative	0.0159	0.1444	0.5946
Echinococcus granulosus	glycoprotein Antigen 5	0.0045	0.0053	0.0053
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0145	0.1277	0.3901
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0062	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.0057	0.0204	0.0204
Brugia malayi	cathepsin L-like precursor	0.0159	0.1444	0.1444
Echinococcus multilocularis	cysteine protease	0.0226	0.2251	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0315	0.0315
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1067	0.4054

Activities

Activity type	Activity value	Assay description	Source	Reference
Reduction (functional)	= 6 %	Percent decrease in serum cholesterol (Cho) after 7 days at 0.05 percent in the diet of SD male rats in comparison to control animals	ChEMBL.	3950914
Reduction (functional)	= 40 %	Percent decrease in triglyceride (TG) after 7 days at 0.05 percent in the diet of SD male rats in comparison to control animals	ChEMBL.	3950914

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL332723

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 189244