Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cysteine protease | 0.003 | 0.0321 | 0.0321 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0123 | 0.3066 | 0.2836 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0035 | 0.0488 | 0.0173 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin l1 | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Echinococcus granulosus | cathepsin l1 | 0.0035 | 0.0488 | 0.0488 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0123 | 0.3066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0048 | 0.0848 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0035 | 0.0488 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0123 | 0.3066 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | ctsf protein | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | fibroinase | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0035 | 0.0488 | 0.0488 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0359 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | cathepsin B | 0.0123 | 0.3066 | 0.3066 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0048 | 0.0848 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Onchocerca volvulus | Cathepsin F homolog | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Entamoeba histolytica | cysteine protease, putative | 0.0048 | 0.0848 | 1 |
Echinococcus granulosus | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0359 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0048 | 0.0848 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0123 | 0.3066 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Toxoplasma gondii | cathepsin B | 0.0123 | 0.3066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.003 | 0.0321 | 0.0321 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0035 | 0.0488 | 0.5762 | |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0123 | 0.3066 | 0.3066 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.