TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 259.343 | Formula: C16H21NO2
H donors: 0 H acceptors: 1 LogP: 2.62 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@H]1C[C@H]2CC[C@H]([C@H]1c1ccccc1)N2C
InChi: 1S/C16H21NO2/c1-17-12-8-9-14(17)15(11-6-4-3-5-7-11)13(10-12)16(18)19-2/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m1/s1
InChiKey: KCKMEVZULURHST-BARDWOONSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0031	0.007	0.007
Giardia lamblia	Cathepsin B precursor	0.1157	0.3729	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0014	0.0016	0.0016
Echinococcus granulosus	cysteine protease	0.0663	0.2123	0.2123
Schistosoma mansoni	smad1 5 8 and	0.0014	0.0016	0.0016
Echinococcus granulosus	cathepsin L	0.0663	0.2123	0.2123
Brugia malayi	Cathepsin L-like precursor	0.1205	0.3886	0.3886
Loa Loa (eye worm)	hypothetical protein	0.1205	0.3886	0.3886
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Brugia malayi	Cathepsin L-like precursor	0.1205	0.3886	0.3886
Leishmania major	cathepsin L-like protease	0.1205	0.3886	1
Leishmania major	cathepsin L-like protease	0.1205	0.3886	1
Schistosoma mansoni	coup transcription factor	0.0018	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0835	0.2684	0.2684
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0293	0.0921	0.0921
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Schistosoma mansoni	hypothetical protein	0.0027	0.0059	0.0059
Entamoeba histolytica	cysteine proteinase, putative	0.1205	0.3886	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1157	0.3729	0.3729
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0018	0.0027	0.0027
Brugia malayi	Cathepsin L-like precursor	0.037	0.1172	0.1172
Leishmania major	cathepsin L-like protease	0.1205	0.3886	1
Onchocerca volvulus		0.1205	0.3886	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0027	0.0027
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0293	0.0921	0.2288
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Onchocerca volvulus	Cathepsin L homolog	0.1205	0.3886	1
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Brugia malayi	nuclear hormone receptor	0.0018	0.0027	0.0027
Onchocerca volvulus	Cathepsin L homolog	0.0293	0.0921	0.2318
Brugia malayi	hypothetical protein	0.0014	0.0016	0.0016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Plasmodium falciparum	serine repeat antigen 7	0.0293	0.0921	0.2288
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1157	0.3729	0.9472
Schistosoma mansoni	hypothetical protein	0.0481	0.1532	0.1532
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0087	0.0252	0.0252
Trypanosoma cruzi	cruzipain precursor, putative	0.1205	0.3886	0.386
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Loa Loa (eye worm)	hypothetical protein	0.0835	0.2684	0.2684
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0293	0.0921	0.2288
Echinococcus multilocularis	G protein coupled receptor 139	0.0216	0.0673	0.0673
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1157	0.3729	0.9593
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Schistosoma mansoni	cathepsin C	0.0293	0.0921	0.0921
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0018	0.0027	0.0027
Echinococcus granulosus	cathepsin b	0.3087	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0087	0.0252	0.0252
Plasmodium vivax	serine-repeat antigen (SERA)	0.0293	0.0921	0.2288
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0293	0.0921	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0293	0.0921	0.0921
Loa Loa (eye worm)	hypothetical protein	0.037	0.1172	0.1172
Brugia malayi	Latrophilin receptor protein 2	0.0027	0.0059	0.0059
Plasmodium falciparum	serine repeat antigen 9	0.0293	0.0921	0.2288
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0018	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0663	0.2123	0.2123
Brugia malayi	Papain family cysteine protease containing protein	0.0293	0.0921	0.0921
Plasmodium vivax	vivapain-2	0.1205	0.3886	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1205	0.3886	0.3886
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0027	0.0027
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0293	0.0921	0.2231
Loa Loa (eye worm)	ctsf protein	0.1205	0.3886	0.3886
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0004	0.0004
Toxoplasma gondii	cathepsin B	0.1157	0.3729	0.9593
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0027	0.0059	0.0059
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0027	0.0059	0.0059
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0293	0.0921	0.2288
Loa Loa (eye worm)	fibroinase	0.1205	0.3886	0.3886
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0293	0.0921	0.0921
Echinococcus multilocularis	cpg binding protein	0.0036	0.0086	0.0086
Schistosoma mansoni	transcription factor LCR-F1	0.0031	0.007	0.007
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1205	0.3886	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Onchocerca volvulus		0.1205	0.3886	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0293	0.0921	0.2288
Brugia malayi	steroid hormone receptor	0.0018	0.0027	0.0027
Toxoplasma gondii	cathepsin CPC1	0.0293	0.0921	0.2288
Echinococcus multilocularis	dnaJ subfamily B	0.0481	0.1532	0.1532
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0018	0.0027	0.0027
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.0921	0.0921
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3087	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0014	0.0016	0.0016
Brugia malayi	Cathepsin L-like precursor	0.0835	0.2684	0.2684
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0018	0.0027	0.0027
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0293	0.0921	0.0921
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0018	0.0027	0.0027
Echinococcus granulosus	smad	0.0014	0.0016	0.0016
Leishmania major	cathepsin L-like protease	0.1205	0.3886	1
Brugia malayi	hypothetical protein	0.0022	0.0042	0.0042
Echinococcus granulosus	ecdysone induced protein 78C	0.0018	0.0027	0.0027
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0027	0.0059	0.0059
Schistosoma mansoni	cathepsin S (C01 family)	0.0293	0.0921	0.0921
Entamoeba histolytica	cysteine proteinase, putative	0.0663	0.2123	0.538
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0018	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Schistosoma mansoni	hypothetical protein	0.0146	0.0443	0.0443
Leishmania major	cathepsin L-like protease	0.1205	0.3886	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0018	0.0027	0.0027
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0018	0.0027	0.0027
Echinococcus granulosus	cpg binding protein	0.0036	0.0086	0.0086
Plasmodium vivax	vivapain-3	0.0663	0.2123	0.5414
Onchocerca volvulus	Cathepsin L homolog	0.1205	0.3886	1
Brugia malayi	CXXC zinc finger family protein	0.0034	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Echinococcus multilocularis	GPCR, family 2	0.0027	0.0059	0.0059
Brugia malayi	MH2 domain containing protein	0.0014	0.0016	0.0016
Plasmodium falciparum	serine repeat antigen 5	0.0293	0.0921	0.2288
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0018	0.0027	0.0027
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0663	0.2123	0.5414
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0293	0.0921	0.2288
Entamoeba histolytica	cysteine proteinase, putative	0.0663	0.2123	0.538
Plasmodium vivax	unspecified product	0.0663	0.2123	0.5414
Trypanosoma cruzi	cysteine protease, putative	0.0663	0.2123	0.209
Brugia malayi	cathepsin L-like cysteine proteinase	0.0293	0.0921	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Brugia malayi	Cathepsin L-like precursor	0.0835	0.2684	0.2684
Echinococcus multilocularis	cysteine protease	0.1205	0.3886	0.3886
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0293	0.0921	0.2288
Entamoeba histolytica	hypothetical protein	0.0293	0.0921	0.2231
Toxoplasma gondii	cathepsin CPL	0.1205	0.3886	1
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Brugia malayi	photoreceptor-specific nuclear receptor	0.0018	0.0027	0.0027
Brugia malayi	Steroid receptor seven-up type 2	0.0018	0.0027	0.0027
Schistosoma mansoni	cpg binding protein	0.0036	0.0086	0.0086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0014	0.0016	0.0016
Echinococcus granulosus	dnaJ subfamily B	0.0481	0.1532	0.1532
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0663	0.2123	0.4054
Brugia malayi	Cathepsin L-like precursor	0.1205	0.3886	0.3886
Brugia malayi	Smad1	0.0014	0.0016	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0027	0.0027
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0018	0.0027	0.0027
Schistosoma mansoni	smad	0.0014	0.0016	0.0016
Trypanosoma cruzi	cysteine peptidase, putative	0.037	0.1172	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0293	0.0921	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0663	0.2123	0.2123
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0027	0.0059	0.0059
Trypanosoma cruzi	cysteine peptidase, putative	0.1205	0.3886	0.386
Plasmodium falciparum	serine repeat antigen 6	0.0293	0.0921	0.2288
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0293	0.0921	0.2231
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0027	0.0027
Echinococcus multilocularis	Smad4	0.0014	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.037	0.1172	0.1172
Onchocerca volvulus		0.1205	0.3886	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0293	0.0921	0.0883
Schistosoma mansoni	smad1 5 8 and	0.0014	0.0016	0.0016
Brugia malayi	cathepsin F-like cysteine proteinase	0.0293	0.0921	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0293	0.0921	0.0921
Plasmodium falciparum	serine repeat antigen 2	0.0293	0.0921	0.2288
Echinococcus multilocularis	cathepsin L	0.0293	0.0921	0.0921
Schistosoma mansoni	smad1 5 8 and	0.0014	0.0016	0.0016
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0027	0.0027
Trypanosoma cruzi	cysteine peptidase, putative	0.1205	0.3886	0.386
Schistosoma mansoni	cathepsin F (C01 family)	0.1205	0.3886	0.3886
Leishmania major	cathepsin L-like protease	0.1205	0.3886	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Brugia malayi	MH1 domain containing protein	0.0014	0.0016	0.0016
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0835	0.2684	0.2653
Entamoeba histolytica	cysteine proteinase, putative	0.0663	0.2123	0.538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Echinococcus granulosus	FTZ F1 alpha	0.0018	0.0027	0.0027
Echinococcus multilocularis	cathepsin L cysteine protease	0.1205	0.3886	0.3886
Plasmodium falciparum	serine repeat antigen 1	0.0293	0.0921	0.2288
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0293	0.0921	0.2288
Brugia malayi	nuclear receptor NHR-88	0.0018	0.0027	0.0027
Echinococcus granulosus	cathepsin b	0.3087	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0293	0.0921	0.2288
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0018	0.0027	0.0027
Echinococcus granulosus	cathepsin l1	0.1205	0.3886	0.3886
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Echinococcus multilocularis	FTZ F1 alpha	0.0018	0.0027	0.0027
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0018	0.0027	0.0027
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0014	0.0016	0.0016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0835	0.2684	0.5946
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0027	0.0027
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0031	0.007	0.007
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0027	0.0027
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Loa Loa (eye worm)	hypothetical protein	0.0293	0.0921	0.0921
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0018	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1205	0.3886	0.386
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.001	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0018	0.0027	0.0027
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.0027	0.0027
Schistosoma mansoni	retinoic acid receptor RXR	0.0018	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Entamoeba histolytica	cysteine protease, putative	0.0293	0.0921	0.2231
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0293	0.0921	0.2288
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0293	0.0921	0.0921
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Entamoeba histolytica	cysteine proteinase 2	0.0663	0.2123	0.538
Brugia malayi	latrophilin 2 splice variant baaae	0.0059	0.0163	0.0163
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3087	1	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0014	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0293	0.0921	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Echinococcus granulosus	cathepsin L cysteine protease	0.0663	0.2123	0.2123
Entamoeba histolytica	cysteine proteinase, putative	0.0835	0.2684	0.685
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0018	0.0027	0.0027
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1205	0.3886	0.3886
Brugia malayi	MH1 domain containing protein	0.0014	0.0016	0.0016
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0293	0.0921	0.2288
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0293	0.0921	0.2288
Onchocerca volvulus		0.1205	0.3886	1
Schistosoma mansoni	cathepsin s	0.037	0.1172	0.1172
Brugia malayi	MH2 domain containing protein	0.0014	0.0016	0.0016
Leishmania major	cysteine peptidase A (CPA)	0.1205	0.3886	1
Loa Loa (eye worm)	cathepsin B	0.1157	0.3729	0.3729
Echinococcus multilocularis	cathepsin L	0.0663	0.2123	0.2123
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0663	0.2123	0.5414
Schistosoma mansoni	cpg binding protein	0.0036	0.0086	0.0086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.0921	0.0921
Echinococcus multilocularis	ecdysone induced protein 78C	0.0018	0.0027	0.0027
Toxoplasma gondii	cathepsin CPC2	0.0293	0.0921	0.2288
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0252	0.0252
Echinococcus granulosus	cathepsin l1	0.0835	0.2684	0.2684
Schistosoma mansoni	Smad4	0.0014	0.0016	0.0016
Echinococcus multilocularis	smad	0.0014	0.0016	0.0016
Trypanosoma cruzi	cysteine peptidase, putative	0.1205	0.3886	0.386
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0003	0.0003
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0027	0.0027
Echinococcus granulosus	GPCR family 2	0.0027	0.0059	0.0059
Brugia malayi	cathepsin L-like precursor	0.0835	0.2684	0.2684
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0663	0.2123	0.2123
Loa Loa (eye worm)	hypothetical protein	0.037	0.1172	0.1172
Plasmodium vivax	unspecified product	0.037	0.1172	0.2939
Giardia lamblia	Cathepsin B precursor	0.1157	0.3729	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.0921	0.0921
Schistosoma mansoni	cathepsin F (C01 family)	0.0835	0.2684	0.2684
Echinococcus multilocularis	cathepsin L cysteine protease	0.1205	0.3886	0.3886
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0014	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0027	0.0059	0.0059
Echinococcus granulosus	Smad4	0.0014	0.0016	0.0016
Echinococcus multilocularis	cathepsin b	0.3087	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1205	0.3886	0.3886
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0018	0.0027	0.0027
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0293	0.0921	0.0921
Schistosoma mansoni	hypothetical protein	0.0059	0.0163	0.0163
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0835	0.2684	0.2684
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1157	0.3729	0.9593
Entamoeba histolytica	cysteine proteinase, putative	0.1205	0.3886	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1205	0.3886	1
Entamoeba histolytica	cysteine protease, putative	0.0293	0.0921	0.2231
Schistosoma mansoni	hypothetical protein	0.0146	0.0443	0.0443
Trypanosoma cruzi	cysteine peptidase, putative	0.0663	0.2123	0.209
Schistosoma mansoni	cpg binding protein	0.0034	0.008	0.008
Plasmodium vivax	vivapain-2	0.1205	0.3886	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1205	0.3886	0.3886
Loa Loa (eye worm)	Smad1	0.0014	0.0016	0.0016
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Plasmodium vivax	unspecified product	0.0293	0.0921	0.2288
Entamoeba histolytica	cysteine protease, putative	0.0663	0.2123	0.538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Brugia malayi	ecdysteroid receptor	0.0018	0.0027	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0018	0.0027	0.0027
Plasmodium vivax	serine-repeat antigen (SERA)	0.0293	0.0921	0.2288
Echinococcus granulosus	cathepsin L	0.0293	0.0921	0.0921
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1157	0.3729	0.3703
Brugia malayi	Cathepsin L-like precursor	0.1205	0.3886	0.3886
Loa Loa (eye worm)	hypothetical protein	0.0835	0.2684	0.2684
Loa Loa (eye worm)	hypothetical protein	0.0293	0.0921	0.0921
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0018	0.0027	0.0027
Brugia malayi	Papain family cysteine protease containing protein	0.0663	0.2123	0.2123
Brugia malayi	Papain family cysteine protease containing protein	0.0663	0.2123	0.2123
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1205	0.3886	0.3886
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Onchocerca volvulus		0.1205	0.3886	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0293	0.0921	0.2288
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0663	0.2123	0.209
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0087	0.0252	0.0252
Plasmodium vivax	vivapain-1	0.0663	0.2123	0.5414
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1205	0.3886	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Plasmodium falciparum	serine repeat antigen 3	0.0293	0.0921	0.2288
Trypanosoma cruzi	major cysteine proteinase, putative	0.0293	0.0921	0.0883
Leishmania major	cathepsin L-like protease	0.1205	0.3886	1
Brugia malayi	Papain family cysteine protease containing protein	0.0293	0.0921	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1205	0.3886	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0663	0.2123	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3087	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0027	0.0027
Plasmodium falciparum	serine repeat antigen 4	0.0293	0.0921	0.2288
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3087	1	1
Entamoeba histolytica	cysteine protease, putative	0.0293	0.0921	0.2231
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.0202	0.0202
Echinococcus granulosus	neuropeptide receptor	0.0216	0.0673	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0042	0.0042
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0018	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0018	0.0027	0.0027
Echinococcus multilocularis	neuropeptide receptor	0.0216	0.0673	0.0673
Entamoeba histolytica	cysteine protease, putative	0.0293	0.0921	0.2231
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3087	1	1
Schistosoma mansoni	hypothetical protein	0.001	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0031	0.007	0.007
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0064	0.0178	0.0353
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0031	0.007	0.007
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0027	0.0059	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0663	0.2123	0.209
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0004	0.0004
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.001	0.0002	0.0002
Brugia malayi	Cathepsin L-like precursor	0.1205	0.3886	0.3886
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0027	0.0027
Brugia malayi	Papain family cysteine protease containing protein	0.1205	0.3886	0.3886
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.008	0.008
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0293	0.0921	0.0921
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0018	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1205	0.3886	1
Entamoeba histolytica	cysteine protease, putative	0.1205	0.3886	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0027	0.0059	0.0059
Giardia lamblia	Cathepsin B precursor	0.1157	0.3729	1
Echinococcus multilocularis	cathepsin b	0.3087	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0027	0.0027
Leishmania major	cathepsin L-like protease	0.1205	0.3886	1
Brugia malayi	Cathepsin L-like precursor	0.1205	0.3886	0.3886
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0027	0.0027
Brugia malayi	cathepsin L precursor	0.0293	0.0921	0.0921
Echinococcus multilocularis	geminin	0.0146	0.0443	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0027	0.0027
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1205	0.3886	0.3886
Schistosoma mansoni	cathepsin F (C01 family)	0.1205	0.3886	0.3886
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0027	0.0059	0.0059
Loa Loa (eye worm)	cysteine protease	0.1205	0.3886	0.3886
Schistosoma mansoni	hypothetical protein	0.0027	0.0059	0.0059
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.0921	0.0921
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1205	0.3886	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Entamoeba histolytica	cysteine proteinase, putative	0.0663	0.2123	0.538
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0059	0.0059
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0018	0.0027	0.0027
Schistosoma mansoni	RAR-like nuclear receptor	0.0018	0.0027	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0018	0.0027	0.0027
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.0921	0.0921
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0293	0.0921	0.2288
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0018	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1205	0.3886	1
Onchocerca volvulus		0.0293	0.0921	0.2318
Plasmodium falciparum	serine repeat antigen 8	0.0293	0.0921	0.2288
Entamoeba histolytica	cysteine protease, putative	0.0293	0.0921	0.2231
Loa Loa (eye worm)	steroid hormone receptor	0.0018	0.0027	0.0027
Onchocerca volvulus		0.0835	0.2684	0.6886
Trypanosoma cruzi	cysteine proteinase, putative	0.0663	0.2123	0.209
Trypanosoma cruzi	cruzipain precursor, putative	0.037	0.1172	0.1134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0663	0.2123	0.5414
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0018	0.0027	0.0027
Onchocerca volvulus		0.0034	0.008	0.0136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1205	0.3886	1
Entamoeba histolytica	cysteine protease, putative	0.0293	0.0921	0.2231
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0018	0.0027	0.0027
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0293	0.0921	0.0921
Brugia malayi	fibroinase precursor	0.0293	0.0921	0.0921
Loa Loa (eye worm)	transcription factor SMAD2	0.0208	0.0645	0.0645
Onchocerca volvulus	Cathepsin F homolog	0.1205	0.3886	1
Onchocerca volvulus		0.1205	0.3886	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0018	0.0027	0.0027
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0018	0.0027	0.0027
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0004	0.0004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0018	0.0027	0.0027
Brugia malayi	MH2 domain containing protein	0.0208	0.0645	0.0645
Echinococcus multilocularis	cysteine protease	0.1205	0.3886	0.3886
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0293	0.0921	0.0921
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.037	0.1172	0.1172
Schistosoma mansoni	neuropeptide receptor	0.0216	0.0673	0.0673
Loa Loa (eye worm)	MH2 domain-containing protein	0.0208	0.0645	0.0645
Loa Loa (eye worm)	hypothetical protein	0.3087	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0293	0.0921	0.0921
Onchocerca volvulus		0.1205	0.3886	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0835	0.2684	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0163	0.0163
Echinococcus granulosus	geminin	0.0146	0.0443	0.0443
Echinococcus granulosus	mothers against decapentaplegic 5	0.0014	0.0016	0.0016
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.037	0.1172	0.1172
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0293	0.0921	0.0921
Brugia malayi	cathepsin F-like cysteine proteinase	0.037	0.1172	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0293	0.0921	0.0921
Entamoeba histolytica	cysteine proteinase 1, putative	0.0663	0.2123	0.538
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0293	0.0921	0.2288
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 18 mg kg-1	Analgesic activity in sc dosed Swiss-Webster mouse assessed as reduction of acetylcholine-induced writhing	ChEMBL.	31482

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3277627

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1905875