Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cysteine protease | 0.003 | 0.0321 | 0.0321 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0035 | 0.0488 | 0.0173 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0123 | 0.3066 | 0.2836 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0035 | 0.0488 | 0.0488 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Echinococcus granulosus | cathepsin l1 | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0048 | 0.0848 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0123 | 0.3066 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0035 | 0.0488 | 0.3182 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0048 | 0.0848 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | ctsf protein | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0123 | 0.3066 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | fibroinase | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0359 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0035 | 0.0488 | 0.0488 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | cathepsin B | 0.0123 | 0.3066 | 0.3066 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Onchocerca volvulus | Cathepsin F homolog | 0.0048 | 0.0848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0048 | 0.0848 | 0.0544 |
Entamoeba histolytica | cysteine protease, putative | 0.0048 | 0.0848 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0048 | 0.0848 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0359 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0123 | 0.3066 | 1 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Echinococcus multilocularis | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Toxoplasma gondii | cathepsin B | 0.0123 | 0.3066 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Echinococcus granulosus | cathepsin L cysteine protease | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0035 | 0.0488 | 0.5762 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0123 | 0.3066 | 0.3066 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 20 % | Analgesic activity in Swiss-Webster mouse assessed as reduction of acetylcholine-induced writhing at 25 mg/kg, sc relative to control | ChEMBL. | 31482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.