Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0359 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0035 | 0.0488 | 0.0488 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0848 | 0.0848 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0035 | 0.0488 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | fibroinase | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | ctsf protein | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0123 | 0.3066 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin l1 | 0.0035 | 0.0488 | 0.0488 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0035 | 0.0488 | 0.0488 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0048 | 0.0848 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0123 | 0.3066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0048 | 0.0848 | 0.0848 |
Echinococcus granulosus | cysteine protease | 0.003 | 0.0321 | 0.0321 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0035 | 0.0488 | 0.0173 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0123 | 0.3066 | 0.2836 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0123 | 0.3066 | 0.3066 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.003 | 0.0321 | 0.0321 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Toxoplasma gondii | cathepsin B | 0.0123 | 0.3066 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Echinococcus multilocularis | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0035 | 0.0488 | 0.5762 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Entamoeba histolytica | cysteine protease, putative | 0.0048 | 0.0848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Onchocerca volvulus | Cathepsin F homolog | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0048 | 0.0848 | 0.0544 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0123 | 0.3066 | 1 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0359 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0048 | 0.0848 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Echinococcus granulosus | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | cathepsin B | 0.0123 | 0.3066 | 0.3066 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 7 % | Analgesic activity in Swiss-Webster mouse assessed as reduction of acetylcholine-induced writhing at 75 mg/kg, sc relative to control | ChEMBL. | 31482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.