Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0248 | 0.3469 | 0.4857 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0644 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0048 | 0.0254 |
Loa Loa (eye worm) | glutaminase | 0.0276 | 0.3928 | 0.8862 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.3067 |
Loa Loa (eye worm) | glutaminase 2 | 0.0276 | 0.3928 | 0.8862 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Echinococcus granulosus | slit 2 protein | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.036 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.5612 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.0911 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0129 | 0.1487 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Schistosoma mansoni | egf-like domain protein | 0.0112 | 0.1211 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1487 | 0.3258 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Brugia malayi | Fibulin-1 precursor | 0.0112 | 0.1211 | 0.2473 |
Echinococcus granulosus | notch | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | neural cadherin | 0.0043 | 0.0068 | 0.036 |
Brugia malayi | glutaminase DH11.1 | 0.0276 | 0.3928 | 0.8345 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0295 | 0.4243 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.5388 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0641 | 0.9962 | 0.9933 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.1513 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0048 | 0.0195 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.409 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0084 | 0.075 | 0.1476 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1875 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0372 | 0.5503 | 0.2188 |
Trichomonas vaginalis | glutaminase, putative | 0.0276 | 0.3928 | 0.7113 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.2422 |
Echinococcus granulosus | fibropellin Ia | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | fibropellin Ia | 0.0043 | 0.0068 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0084 | 0.075 | 0.1769 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1308 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.0464 | 0.0858 |
Onchocerca volvulus | Arrow homolog | 0.0112 | 0.1211 | 0.3519 |
Mycobacterium ulcerans | glutaminase | 0.0276 | 0.3928 | 0.3914 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus multilocularis | fibrillin 1 | 0.0112 | 0.1211 | 0.4951 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.7104 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.2838 | 0.636 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.2814 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0112 | 0.1211 | 0.2626 |
Toxoplasma gondii | kringle domain-containing protein | 0.0129 | 0.1487 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.0739 | 0.1739 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0068 | 0.000000045149 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0112 | 0.1211 | 0.2626 |
Echinococcus granulosus | laminin | 0.0112 | 0.1211 | 0.6463 |
Schistosoma mansoni | glutaminase | 0.0276 | 0.3928 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.0502 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1898 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.032 | 0.0546 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0112 | 0.1211 | 0.4951 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.3318 | 0.5995 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0248 | 0.3469 | 0.6211 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0123 | 0.1396 | 0.2122 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0372 | 0.5503 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0043 | 0.0068 | 0.000000045149 |
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.1332 | 0.3275 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0187 | 0.2447 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.4003 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0372 | 0.5503 | 0.5502 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.7932 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0248 | 0.3469 | 0.3451 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0323 | 0.4693 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.5443 |
Echinococcus multilocularis | neural cadherin | 0.0043 | 0.0068 | 0.0276 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Echinococcus granulosus | delta-like protein 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1875 | 0.7661 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.000000047947 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.9714 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2473 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1237 |
Echinococcus multilocularis | laminin | 0.0112 | 0.1211 | 0.4951 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0112 | 0.1211 | 0.2473 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0058 | 0.032 | 0.0654 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.1028 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0112 | 0.1211 | 0.6463 |
Echinococcus multilocularis | slit 2 protein | 0.0043 | 0.0068 | 0.0276 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.1487 | 0.3677 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0644 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.075 | 0.1568 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0641 | 0.9962 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0043 | 0.0068 | 0.000000064246 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.1746 | 0.1714 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0372 | 0.5503 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0112 | 0.1211 | 0.2964 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1707 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.6077 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0043 | 0.0068 | 0.0276 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Onchocerca volvulus | 0.0129 | 0.1487 | 0.4366 | |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0043 | 0.0068 | 0.000000064246 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0129 | 0.1487 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0129 | 0.1487 | 0.3258 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Brugia malayi | Protein kinase domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Onchocerca volvulus | 0.0084 | 0.075 | 0.2101 | |
Onchocerca volvulus | 0.0239 | 0.3318 | 1 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus multilocularis | notch | 0.0043 | 0.0068 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.4391 | 0.9926 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1875 | 0.4681 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.2477 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.0255 | 0.0431 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.2838 | 0.5989 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.