Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | glutaminase DH11.1 | 0.0276 | 0.3928 | 0.8345 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0129 | 0.1487 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Schistosoma mansoni | egf-like domain protein | 0.0112 | 0.1211 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1487 | 0.3258 |
Echinococcus granulosus | notch | 0.0043 | 0.0068 | 0.036 |
Brugia malayi | Fibulin-1 precursor | 0.0112 | 0.1211 | 0.2473 |
Echinococcus granulosus | neural cadherin | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.0276 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0048 | 0.0195 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.409 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0084 | 0.075 | 0.1476 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1875 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0295 | 0.4243 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.5388 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0641 | 0.9962 | 0.9933 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.1513 |
Loa Loa (eye worm) | glutaminase | 0.0276 | 0.3928 | 0.8862 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.3067 |
Loa Loa (eye worm) | glutaminase 2 | 0.0276 | 0.3928 | 0.8862 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Echinococcus granulosus | slit 2 protein | 0.0043 | 0.0068 | 0.036 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0248 | 0.3469 | 0.4857 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0644 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0048 | 0.0254 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.5612 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.0911 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.036 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0068 | 0.000000045149 |
Echinococcus granulosus | laminin | 0.0112 | 0.1211 | 0.6463 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | glutaminase | 0.0276 | 0.3928 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.0502 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1898 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.032 | 0.0546 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.3318 | 0.5995 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0112 | 0.1211 | 0.4951 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0248 | 0.3469 | 0.6211 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0112 | 0.1211 | 0.2626 |
Toxoplasma gondii | kringle domain-containing protein | 0.0129 | 0.1487 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.0739 | 0.1739 |
Echinococcus multilocularis | protein jagged 2 | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0123 | 0.1396 | 0.2122 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0372 | 0.5503 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0043 | 0.0068 | 0.000000045149 |
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.1332 | 0.3275 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.0464 | 0.0858 |
Onchocerca volvulus | Arrow homolog | 0.0112 | 0.1211 | 0.3519 |
Mycobacterium ulcerans | glutaminase | 0.0276 | 0.3928 | 0.3914 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus multilocularis | fibrillin 1 | 0.0112 | 0.1211 | 0.4951 |
Trichomonas vaginalis | glutaminase, putative | 0.0276 | 0.3928 | 0.7113 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0372 | 0.5503 | 0.2188 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.2422 |
Echinococcus granulosus | fibropellin Ia | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | fibropellin Ia | 0.0043 | 0.0068 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0084 | 0.075 | 0.1769 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1308 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.2838 | 0.636 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.2814 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.7104 |
Echinococcus granulosus | delta-like protein 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1875 | 0.7661 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.5443 |
Echinococcus multilocularis | neural cadherin | 0.0043 | 0.0068 | 0.0276 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.1028 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.000000047947 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.9714 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2473 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1237 |
Echinococcus multilocularis | laminin | 0.0112 | 0.1211 | 0.4951 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0058 | 0.032 | 0.0654 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0112 | 0.1211 | 0.2473 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0187 | 0.2447 | 1 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0248 | 0.3469 | 0.3451 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0323 | 0.4693 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.4003 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0372 | 0.5503 | 0.5502 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.7932 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0129 | 0.1487 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0129 | 0.1487 | 0.3258 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | notch | 0.0043 | 0.0068 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.4391 | 0.9926 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1875 | 0.4681 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.2477 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.0255 | 0.0431 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.2838 | 0.5989 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Brugia malayi | Protein kinase domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Onchocerca volvulus | 0.0084 | 0.075 | 0.2101 | |
Onchocerca volvulus | 0.0239 | 0.3318 | 1 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.075 | 0.1568 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0641 | 0.9962 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0043 | 0.0068 | 0.000000064246 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.1746 | 0.1714 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0372 | 0.5503 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0112 | 0.1211 | 0.2964 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0112 | 0.1211 | 0.6463 |
Echinococcus multilocularis | slit 2 protein | 0.0043 | 0.0068 | 0.0276 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.1487 | 0.3677 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0644 | 1 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Onchocerca volvulus | 0.0129 | 0.1487 | 0.4366 | |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0043 | 0.0068 | 0.000000064246 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1707 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.6077 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0043 | 0.0068 | 0.0276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.