Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0405 | 0.2991 | 0.297 |
Loa Loa (eye worm) | hypothetical protein | 0.1135 | 1 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.0405 | 0.2991 | 0.297 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0405 | 0.2991 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0405 | 0.2991 | 1 |
Echinococcus granulosus | neutral sphingomyelinase | 0.0096 | 0.0029 | 0.0098 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0183 | 0.0868 | 0.5 |
Mycobacterium ulcerans | hydrolase/amidase | 0.0595 | 0.4813 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.3065 | 0.3045 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0405 | 0.2991 | 0.9754 |
Brugia malayi | cancer related gene-liver 1 | 0.0412 | 0.3065 | 0.3045 |
Echinococcus multilocularis | neutral sphingomyelinase | 0.0096 | 0.0029 | 0.0098 |
Onchocerca volvulus | Alkaline ceramidase homolog | 0.0412 | 0.3065 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0405 | 0.2991 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0405 | 0.2991 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.