Detailed information for compound 1924474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 549.06 | Formula: C30H33ClN4O4
  • H donors: 2 H acceptors: 3 LogP: 4.23 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)c1ccc(cc1)N1CCN(CC1)C(=O)CN1CC[C@H](C1)C(=O)Nc1ccc(c(c1)Cl)O
  • InChi: 1S/C30H33ClN4O4/c1-39-26-9-4-22(5-10-26)21-2-7-25(8-3-21)34-14-16-35(17-15-34)29(37)20-33-13-12-23(19-33)30(38)32-24-6-11-28(36)27(31)18-24/h2-11,18,23,36H,12-17,19-20H2,1H3,(H,32,38)/t23-/m1/s1
  • InChiKey: IENGFJPUQKIIMW-HSZRJFAPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.0162 1 1
Leishmania major pteridine reductase 1 0.0162 1 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0162 1 1
Schistosoma mansoni carbonyl reductase 0.0162 1 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0162 1 1
Leishmania major oxidoreductase-like protein 0.0162 1 1
Leishmania major hypothetical protein, conserved 0.0162 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0162 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Toxoplasma gondii oxidoreductase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.0162 1 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Echinococcus granulosus carbonyl reductase 1 0.0162 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0162 1 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0162 1 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0162 1 1
Toxoplasma gondii carbonyl reductase 1, putative 0.0162 1 1
Loa Loa (eye worm) dehydrogenase 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Brugia malayi Retinol dehydrogenase 12 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Schistosoma mansoni carbonyl reductase 0.0162 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0162 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0162 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0162 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0162 1 1
Trypanosoma brucei oxidoreductase-like protein 0.0162 1 1
Onchocerca volvulus Sepiapterin reductase homolog 0.0162 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Echinococcus granulosus WW domain containing oxidoreductase 0.0162 1 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0162 1 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Echinococcus granulosus hypothetical protein 0.0162 1 1
Echinococcus granulosus carbonyl reductase 1 0.0162 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Schistosoma mansoni carbonyl reductase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans oxidoreductase 0.0162 1 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0162 1 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0162 1 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0162 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0162 1 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0162 1 1
Mycobacterium ulcerans oxidoreductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0162 1 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0162 1 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0162 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0162 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0162 1 1
Leishmania major hypothetical protein, conserved 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Echinococcus granulosus hypothetical protein 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Leishmania major hypothetical protein, conserved 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0162 1 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0162 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0162 1 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0162 1 0.5
Schistosoma mansoni retinal dehydrogenase 0.0162 1 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0162 1 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0162 1 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0162 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0162 1 0.5
Plasmodium vivax hypothetical protein, conserved 0.0162 1 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0162 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Mycobacterium leprae Probable oxidoreductase 0.0162 1 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0162 1 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Leishmania major short chain dehydrogenase, putative 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0162 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0162 1 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0162 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0162 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0162 1 0.5
Leishmania major hypothetical protein, conserved 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0162 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Entamoeba histolytica hypothetical protein 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Leishmania major hypothetical protein, conserved 0.0162 1 1
Leishmania major short chain dehydrogenase-like protein 0.0162 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0162 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0162 1 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Giardia lamblia Short-chain dehydrogenase, putative 0.0162 1 1
Brugia malayi dehydrogenases, short chain protein 2 0.0162 1 1
Echinococcus granulosus steroid dehydrogenase 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0162 1 0.5
Giardia lamblia Reductase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0162 1 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0162 1 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Leishmania major short chain dehydrogenase, putative 0.0162 1 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0162 1 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.0162 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0162 1 1
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0162 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Brugia malayi oxidoreductase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0162 1 0.5
Echinococcus granulosus oxidoreductase 0.0162 1 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Echinococcus multilocularis oxidoreductase 0.0162 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0162 1 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0162 1 0.5
Leishmania major dehydrogenase-like protein 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0162 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0162 1 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0162 1 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0162 1 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0162 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0162 1 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0162 1 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0162 1 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0162 1 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0162 1 1
Mycobacterium ulcerans dehydrogenase 0.0162 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0162 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0162 1 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0162 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Brugia malayi hypothetical protein 0.0162 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0162 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0162 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0162 1 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Brugia malayi hypothetical protein 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Loa Loa (eye worm) dehydrogenase 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Giardia lamblia Hypothetical protein 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0162 1 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0162 1 1
Echinococcus granulosus carbonyl reductase 1 0.0162 1 1
Toxoplasma gondii oxidoreductase, putative 0.0162 1 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0162 1 1
Echinococcus multilocularis steroid dehydrogenase 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.3 uM Inhibition of non-activated Erk2 (unknown origin) using activating Mek1 and peptide substrate by coupled Erk2 assay ChEMBL. 25716905
IC50 (binding) = 50 uM Inhibition of activated Erk2 (unknown origin) by biochemical assay ChEMBL. 25716905

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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