Detailed information for compound 1927633

Basic information

Technical information
  • TDR Targets ID: 1927633
  • Name: N-[2,4-dimethoxy-5-[(2S)-2-methylpiperidin-1- yl]sulfonylphenyl]acetamide
  • MW: 356.437 | Formula: C16H24N2O5S
  • H donors: 1 H acceptors: 3 LogP: 1.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c(cc1S(=O)(=O)N1CCCC[C@@H]1C)NC(=O)C
  • InChi: 1S/C16H24N2O5S/c1-11-7-5-6-8-18(11)24(20,21)16-9-13(17-12(2)19)14(22-3)10-15(16)23-4/h9-11H,5-8H2,1-4H3,(H,17,19)/t11-/m0/s1
  • InChiKey: HMBGZUOVQQJXEN-NSHDSACASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2,4-dimethoxy-5-[[(2S)-2-methyl-1-piperidyl]sulfonyl]phenyl]acetamide
  • N-[2,4-dimethoxy-5-[[(2S)-2-methyl-1-piperidinyl]sulfonyl]phenyl]acetamide
  • N-[2,4-dimethoxy-5-[(2S)-2-methylpiperidin-1-yl]sulfonyl-phenyl]ethanamide
  • ZINC04241525

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chromatin regulatory protein sir2 0.012 0.0639 0.0639
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0048 0.0212 0.0205
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0016 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0501 0.0501
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0296 0.1679 0.1674
Loa Loa (eye worm) hypothetical protein 0.0439 0.2524 0.2519
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1705 1 1
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0203 0.113 0.113
Schistosoma mansoni hypothetical protein 0.0023 0.0064 0.0064
Echinococcus multilocularis GA binding protein alpha chain 0.0056 0.0263 0.0256
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0379 0.1303
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0296 0.1679 0.1674
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.1705 1 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.097 0.0964
Leishmania major cathepsin L-like protease 0.005 0.0223 0.0223
Brugia malayi hypothetical protein 0.0028 0.0095 0.0088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0016 0.0009
Giardia lamblia Hypothetical protein 0.0203 0.113 0.2921
Leishmania major sir2-family protein-like protein 0.012 0.0639 0.0639
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.066 0.383 0.3826
Loa Loa (eye worm) sirtuin 4 0.012 0.0639 0.0633
Echinococcus multilocularis geminin 0.018 0.0993 0.0987
Brugia malayi hypothetical protein 0.0184 0.1017 0.1011
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0191 0.1057 0.1051
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0007 0.0007
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0045 0.0198 0.0198
Echinococcus multilocularis RUN 0.0021 0.0052 0.0045
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0191 0.1057 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0379 0.3488
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0162 0.0162
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.0659 0.0652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0229 0.128 0.128
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0075 0.037 0.0364
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0108 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0501 0.0501
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0379 0.1303
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0052 0.0045
Loa Loa (eye worm) hypothetical protein 0.0296 0.1679 0.1674
Loa Loa (eye worm) hypothetical protein 0.0184 0.1017 0.1011
Schistosoma mansoni dihydroorotate dehydrogenase 0.0191 0.1057 0.1057
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0016 0.0009
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0296 0.1679 0.1674
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0203 0.113 0.1124
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0075 0.037 0.0364
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0075 0.037 0.0364
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0016 0.0016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0162 0.0155
Entamoeba histolytica hypothetical protein 0.0203 0.113 0.1124
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0162 0.0155
Echinococcus multilocularis muscleblind protein 0.0439 0.2524 0.2519
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0075 0.037 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.113 0.1124
Echinococcus multilocularis jumonji domain containing protein 0.0032 0.0116 0.011
Schistosoma mansoni ap endonuclease 0.0015 0.0016 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0379 0.0379
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0064 0.0508
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.0041 0.0034
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.012 0.0639 0.0633
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0162 0.0162
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0074 0.0369 0.0362
Loa Loa (eye worm) hypothetical protein 0.0439 0.2524 0.2519
Echinococcus granulosus lysine specific demethylase 5A 0.003 0.0108 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0501 0.0495
Brugia malayi beta-lactamase family protein 0.0076 0.0379 0.0373
Loa Loa (eye worm) hypothetical protein 0.0034 0.0133 0.0127
Mycobacterium ulcerans beta-lactamase 0.0076 0.0379 0.3488
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0296 0.1679 0.4361
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0379 0.0373
Toxoplasma gondii histone deacetylase SIR2-like 0.012 0.0639 0.0633
Toxoplasma gondii histone deacetylase SIR2 0.012 0.0639 0.0633
Loa Loa (eye worm) hypothetical protein 0.0039 0.0159 0.0153
Loa Loa (eye worm) hypothetical protein 0.0037 0.0148 0.0142
Plasmodium falciparum phd finger protein, putative 0.0023 0.0064 0.0508
Echinococcus granulosus tumor protein p63 0.0359 0.2049 0.2044
Onchocerca volvulus 0.0021 0.0052 0.04
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Schistosoma mansoni lipoxygenase 0.0123 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0173
Toxoplasma gondii exonuclease III APE 0.0015 0.0016 0.0009
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.1705 1 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0162 0.0155
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.012 0.0639 0.0633
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0379 0.0373
Brugia malayi transcriptional regulator, Sir2 family protein 0.066 0.383 0.3826
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0075 0.037 0.0364
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0095 0.0088
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0013 0.0008 0.0001
Giardia lamblia Hypothetical protein 0.066 0.383 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0379 0.0379
Giardia lamblia Hypothetical protein 0.0203 0.113 0.2921
Brugia malayi jmjC domain containing protein 0.0074 0.0369 0.0362
Schistosoma mansoni loxhd1 0.0021 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0056 0.0263 0.0256
Trichomonas vaginalis set domain proteins, putative 0.0185 0.1022 0.1016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0379 0.1303
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.1705 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0501 0.0495
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0162 0.0155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0149 0.0142
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.012 0.0639 0.0633
Brugia malayi CXXC zinc finger family protein 0.0022 0.0062 0.0055
Giardia lamblia Transcriptional regulator, Sir2 family 0.012 0.0639 0.1634
Brugia malayi Doublecortin family protein 0.0021 0.0052 0.0045
Schistosoma mansoni sex comb on midleg homolog 0.0037 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0076 0.0379 0.0373
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0223 0.0223
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0075 0.037 0.0364
Schistosoma mansoni bromodomain containing protein 0.0051 0.0228 0.0228
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.012 0.0639 0.563
Echinococcus granulosus cpg binding protein 0.0025 0.0078 0.0071
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0045
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0162 0.0162
Mycobacterium ulcerans hypothetical protein 0.0076 0.0379 0.3488
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0007 0.0007
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0203 0.113 0.113
Echinococcus granulosus RUN 0.0021 0.0052 0.0045
Onchocerca volvulus 0.0037 0.0149 0.1267
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0162 0.0155
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0203 0.113 0.113
Giardia lamblia Sirtuin type 2 0.012 0.0639 0.1634
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0075 0.037 0.037
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0191 0.1057 1
Brugia malayi Bromodomain containing protein 0.0025 0.0075 0.0068
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0203 0.113 0.1124
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.012 0.0639 0.0633
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0075 0.037 0.0364
Echinococcus granulosus SAM and MBT domain containing protein 0.0037 0.0149 0.0142
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0074 0.0369 0.0362
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Toxoplasma gondii hypothetical protein 0.013 0.0698 0.0692
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0016 0.0084
Loa Loa (eye worm) transcriptional regulator 0.012 0.0639 0.0633
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0162 0.0162
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0203 0.113 0.113
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Loa Loa (eye worm) transcriptional regulator 0.012 0.0639 0.0633
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.016 0.016
Leishmania major hypothetical protein, conserved 0.0203 0.113 0.113
Echinococcus multilocularis survival motor neuron protein 1 0.0184 0.1017 0.1011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0296 0.1679 0.1674
Mycobacterium ulcerans NAD-dependent deacetylase 0.012 0.0639 0.5985
Brugia malayi transcriptional regulator, Sir2 family protein 0.012 0.0639 0.0633
Leishmania major silent information regulator 2, putative 0.066 0.383 0.383
Mycobacterium tuberculosis Conserved protein 0.0076 0.0379 0.1303
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0095 0.0095
Schistosoma mansoni rab6-interacting 0.0021 0.0052 0.0052
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0052 0.04
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0379 0.3317
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0095 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Leishmania major dihydroorotate dehydrogenase 0.0191 0.1057 0.1057
Brugia malayi Muscleblind-like protein 0.0439 0.2524 0.2519
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.1705 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0501 0.0495
Echinococcus multilocularis cpg binding protein 0.0025 0.0078 0.0071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0117 0.011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0379 0.0373
Brugia malayi mbt repeat family protein 0.0037 0.0149 0.0142
Toxoplasma gondii hypothetical protein 0.0203 0.113 0.1124
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0379 0.1303
Loa Loa (eye worm) hypothetical protein 0.0076 0.0379 0.0373
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0062 0.0055
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.066 0.383 0.3826
Leishmania major cathepsin L-like protease 0.0013 0.0007 0.0007
Brugia malayi hypothetical protein 0.0021 0.0052 0.0045
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0016 0.0016
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0075 0.037 0.0364
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0162 0.0155
Echinococcus multilocularis polycomb protein SCMH1 0.0037 0.0149 0.0142
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0203 0.113 0.1124
Echinococcus multilocularis chromatin regulatory protein sir2 0.066 0.383 0.3826
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0075 0.037 0.0364
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0203 0.113 0.1124
Loa Loa (eye worm) hypothetical protein 0.0076 0.0379 0.0373
Leishmania major hypothetical protein, conserved 0.0203 0.113 0.113
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0162 0.0162
Leishmania major cathepsin L-like protease 0.0013 0.0007 0.0007
Echinococcus granulosus jumonji domain containing protein 0.0032 0.0116 0.011
Leishmania major eukaryotic translation initiation factor-like protein 0.1705 1 1
Onchocerca volvulus 0.0076 0.0379 0.3317
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0379 0.0373
Brugia malayi Ets-domain containing protein 0.0056 0.0263 0.0256
Brugia malayi PHD-finger family protein 0.0023 0.0064 0.0057
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0203 0.113 0.1124
Brugia malayi transcriptional regulator, Sir2 family protein 0.012 0.0639 0.0633
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0203 0.113 0.1124
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.007 0.0063
Mycobacterium ulcerans lipase LipD 0.0076 0.0379 0.3488
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0203 0.113 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0108 0.0108
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0052 0.04
Loa Loa (eye worm) hypothetical protein 0.0076 0.0379 0.0373
Echinococcus granulosus peregrin 0.0025 0.0075 0.0068
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0379 0.3488
Schistosoma mansoni gabp alpha 0.0056 0.0263 0.0263
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0223 0.0223
Leishmania major cathepsin L-like protease 0.0013 0.0007 0.0007
Schistosoma mansoni myelin transcription factor 1 myt1 0.0042 0.0179 0.0179
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.1705 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0162 0.0155
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0203 0.113 0.113
Brugia malayi Fli-1 protein 0.0171 0.0941 0.0935
Brugia malayi hypothetical protein 0.0021 0.0052 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Onchocerca volvulus 0.0021 0.0052 0.04
Plasmodium falciparum transcriptional regulatory protein sir2b 0.012 0.0639 0.563
Brugia malayi Pre-SET motif family protein 0.0162 0.0889 0.0883
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.0659 0.0652
Echinococcus multilocularis tumor protein p63 0.0359 0.2049 0.2044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.007 0.007
Schistosoma mansoni methyl-cpg binding protein mbd 0.0013 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0501 0.0495
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.012 0.0639 0.0633
Schistosoma mansoni hypothetical protein 0.018 0.0993 0.0993
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0052 0.0045
Onchocerca volvulus 0.0053 0.024 0.2076
Entamoeba histolytica hypothetical protein 0.0028 0.0095 0.0088
Entamoeba histolytica hypothetical protein 0.0028 0.0095 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0016 0.0009
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0162 0.0155
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0278 0.0278
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0379 0.0379
Leishmania major cathepsin L-like protease 0.0013 0.0007 0.0007
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0149 0.0811 0.0805
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.012 0.0639 0.0633
Leishmania major eukaryotic translation initiation factor-like 0.1705 1 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.066 0.383 0.383
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0016 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.013 0.0698 0.0692
Echinococcus multilocularis muscleblind protein 1 0.0439 0.2524 0.2519
Echinococcus multilocularis peregrin 0.0025 0.0075 0.0068
Mycobacterium tuberculosis Conserved protein 0.0076 0.0379 0.1303
Schistosoma mansoni cpg binding protein 0.0022 0.0062 0.0062
Schistosoma mansoni polycystin 1-related 0.0021 0.0052 0.0052
Brugia malayi jmjC domain containing protein 0.003 0.0108 0.0102
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0023 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.013 0.0698 0.0692
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.012 0.0639 0.0639
Mycobacterium tuberculosis Conserved protein 0.0076 0.0379 0.1303
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0037 0.0149 0.0149
Trichomonas vaginalis esterase, putative 0.0076 0.0379 0.0373
Entamoeba histolytica hypothetical protein 0.0028 0.0095 0.0088
Schistosoma mansoni chromatin regulatory protein sir2 0.066 0.383 0.383
Onchocerca volvulus 0.0022 0.0062 0.049
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.0041 0.0041
Echinococcus granulosus PHD finger protein rhinoceros 0.0023 0.0064 0.0057
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0191 0.1057 0.1057
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.013 0.0698 0.0692
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0203 0.113 0.1124
Echinococcus multilocularis PHD finger protein rhinoceros 0.0023 0.0064 0.0057
Trichomonas vaginalis hypothetical protein 0.0203 0.113 0.1124
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.066 0.383 0.383
Schistosoma mansoni chromatin regulatory protein sir2 0.066 0.383 0.383
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.012 0.0639 0.0639
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0203 0.113 0.1124
Echinococcus granulosus polycomb protein SCMH1 0.0037 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0076 0.0379 0.0373
Echinococcus granulosus dnaJ subfamily B 0.0318 0.181 0.1805
Schistosoma mansoni chromatin regulatory protein sir2 0.012 0.0639 0.0639
Giardia lamblia hypothetical protein 0.0203 0.113 0.2921
Schistosoma mansoni hypothetical protein 0.0038 0.0151 0.0151
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0162 0.0155
Brugia malayi NAD-dependent deacetylase SIRT1 0.0296 0.1679 0.1674
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0149 0.0811 0.0805
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1705 1 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.012 0.0639 0.0633
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.1705 1 1
Brugia malayi PHD-finger family protein 0.0021 0.0052 0.0045
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0203 0.113 0.1124
Trypanosoma cruzi cruzipain precursor, putative 0.005 0.0223 0.0223
Entamoeba histolytica hypothetical protein 0.0203 0.113 0.1124
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.1705 1 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0191 0.1057 0.1057
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0052 0.0045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0016 0.0016
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0075 0.037 0.0364
Toxoplasma gondii PHD-finger domain-containing protein 0.0023 0.0064 0.0057
Brugia malayi Zinc finger, C2H2 type family protein 0.0075 0.037 0.0364
Loa Loa (eye worm) hypothetical protein 0.0055 0.0255 0.0248
Trypanosoma brucei SIR2-like protein 4, putative 0.012 0.0639 0.0639
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0379 0.1303
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.007 0.007
Entamoeba histolytica hypothetical protein, conserved 0.012 0.0639 0.0633
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0203 0.113 0.1124
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0191 0.1057 0.1051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0379 0.1303
Onchocerca volvulus 0.0185 0.1022 0.9033
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Onchocerca volvulus 0.0076 0.0379 0.3317
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0379 0.0373
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0206 0.02
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0379 0.0379
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0016 0.0009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0028 0.0095 0.0088
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0196 0.0189
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.007 0.0063
Echinococcus granulosus methyl CpG binding domain protein 2 0.0013 0.0008 0.0001
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.0041 0.0034
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0191 0.1057 0.1057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0379 0.0373
Schistosoma mansoni ets-related 0.0171 0.0941 0.0941
Schistosoma mansoni survival motor neuron protein 0.0038 0.0151 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0162 0.0155
Echinococcus multilocularis lysine specific demethylase 5A 0.0027 0.0092 0.0085
Loa Loa (eye worm) transcriptional regulator 0.066 0.383 0.3826
Echinococcus granulosus chromatin regulatory protein sir2 0.066 0.383 0.3826
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0223 0.0223
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0203 0.113 0.113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0501 0.0495
Schistosoma mansoni hypothetical protein 0.0318 0.181 0.181
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0203 0.113 1
Loa Loa (eye worm) translation initiation factor 4E 0.1705 1 1
Loa Loa (eye worm) fli-1 protein 0.0171 0.0941 0.0935
Schistosoma mansoni ap endonuclease 0.0015 0.0016 0.0016
Onchocerca volvulus 0.0076 0.0379 0.3317
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.066 0.383 0.3826
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0064 0.0057
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0203 0.113 0.1124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0039 0.0162 0.0155
Entamoeba histolytica translation initiation factor 4e, putative 0.0203 0.113 0.1124
Entamoeba histolytica hypothetical protein 0.0028 0.0095 0.0088
Leishmania major cysteine peptidase A (CPA) 0.0013 0.0007 0.0007
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.1705 1 1
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0203 0.113 0.113
Toxoplasma gondii PHD-finger domain-containing protein 0.0023 0.0064 0.0057
Echinococcus granulosus zinc finger protein 0.0017 0.0027 0.0021
Schistosoma mansoni chromatin regulatory protein sir2 0.0296 0.1679 0.1679
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.113 0.1124
Giardia lamblia Translation elongation factor 0.0203 0.113 0.2921
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0025 0.0078 0.0078
Onchocerca volvulus 0.0024 0.007 0.0562
Plasmodium vivax NAD-dependent deacetylase, putative 0.012 0.0639 0.563
Loa Loa (eye worm) hypothetical protein 0.0076 0.0379 0.0373
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Loa Loa (eye worm) mbt repeat family protein 0.0037 0.0149 0.0142
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1705 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.012 0.0639 0.0639
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0148 0.0148
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0191 0.1057 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0045
Echinococcus multilocularis dnaJ subfamily B 0.0318 0.181 0.1805
Loa Loa (eye worm) bromodomain containing protein 0.0014 0.0011 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0075 0.037 0.0364
Leishmania major cathepsin L-like protease 0.0013 0.0007 0.0007
Echinococcus multilocularis histone acetyltransferase MYST2 0.0042 0.0179 0.0173
Toxoplasma gondii ABC1 family protein 0.0076 0.0379 0.0373
Schistosoma mansoni chromatin regulatory protein sir2 0.066 0.383 0.383
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0191 0.1057 0.1057
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0203 0.113 0.113
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0048 0.0212 0.0205
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0379 0.1303
Brugia malayi Pre-SET motif family protein 0.0024 0.007 0.0063
Echinococcus granulosus survival motor neuron protein 1 0.0184 0.1017 0.1011
Schistosoma mansoni hypothetical protein 0.0021 0.0052 0.0052
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0016 0.0009
Plasmodium vivax SET domain protein, putative 0.0024 0.007 0.0562
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0203 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0023 0.0064 0.0057
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0203 0.113 0.113
Leishmania major eukaryotic translation initiation factor, putative 0.0203 0.113 0.113
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Mycobacterium tuberculosis Transcriptional regulatory protein 0.012 0.0639 0.2236
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.012 0.0639 0.0633
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1705 1 1
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0191 0.1057 0.3737
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0162 0.0155
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.066 0.383 0.383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.066 0.383 0.3826
Plasmodium vivax hypothetical protein, conserved 0.0203 0.113 1
Brugia malayi beta-lactamase 0.0076 0.0379 0.0373
Schistosoma mansoni methyl-cpg binding protein mbd 0.0013 0.0008 0.0008
Leishmania major cathepsin L-like protease 0.005 0.0223 0.0223
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0203 0.113 0.113
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0028 0.0021
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0042 0.0179 0.0173
Trypanosoma brucei Silent information regulator 2 related protein 3 0.012 0.0639 0.0639
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.1705 1 1
Schistosoma mansoni hypothetical protein 0.0028 0.0095 0.0095
Schistosoma mansoni zinc finger protein 0.0017 0.0027 0.0027
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0052 0.0045
Brugia malayi mbt repeat family protein 0.0037 0.0149 0.0142
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0501 0.0495
Onchocerca volvulus Alhambra homolog 0.0023 0.0064 0.0508
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.024 0.024
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0296 0.1679 0.1674
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0148 0.0142
Schistosoma mansoni lipoxygenase 0.0086 0.0439 0.0439
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0025 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0099
Loa Loa (eye worm) hypothetical protein 0.0048 0.0214 0.0208
Plasmodium falciparum transcriptional regulatory protein sir2a 0.012 0.0639 0.563
Brugia malayi Bromodomain containing protein 0.003 0.0106 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0501 0.0501
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0486 0.2803 1
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.113 0.1124
Plasmodium vivax translation initiation factor 4E, putative 0.0203 0.113 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0296 0.1679 0.1674
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0203 0.113 0.113
Plasmodium falciparum dihydroorotate dehydrogenase 0.0191 0.1057 0.9351
Echinococcus granulosus GA binding protein alpha chain 0.0056 0.0263 0.0256
Trypanosoma cruzi cysteine peptidase, putative 0.0013 0.0007 0.0007
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0203 0.113 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0042 0.0179 0.0173
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Echinococcus granulosus histone acetyltransferase MYST2 0.0042 0.0179 0.0173
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.012 0.0639 0.0633
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0062 0.0055
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0162 0.0382
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0191 0.1057 0.1051
Echinococcus multilocularis SAM and MBT domain containing protein 0.0037 0.0149 0.0142
Echinococcus multilocularis zinc finger protein 0.0017 0.0027 0.0021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0028 0.0095 0.0088
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0037 0.0149 0.1267
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.1705 1 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0042 0.0179 0.0173
Giardia lamblia PHD finger protein 15 0.0023 0.0064 0.0125
Loa Loa (eye worm) MBCTL1 0.0042 0.0179 0.0173
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0203 0.113 0.1124
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0052 0.0045
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.066 0.383 0.3826
Onchocerca volvulus 0.0038 0.0151 0.1289
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0016 0.5
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0203 0.113 0.1124
Brugia malayi Ets-domain containing protein 0.0056 0.0263 0.0256
Schistosoma mansoni cpg binding protein 0.0025 0.0078 0.0078
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.066 0.383 0.3826
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0379 0.0379
Brugia malayi beta-lactamase family protein 0.0076 0.0379 0.0373
Schistosoma mansoni sex comb on midleg homolog 0.0037 0.0149 0.0149
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0162 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0379 0.0373
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0052 0.0045
Echinococcus granulosus geminin 0.018 0.0993 0.0987
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0215 0.0215
Loa Loa (eye worm) beta-lactamase 0.0076 0.0379 0.0373
Leishmania major hypothetical protein, conserved 0.0076 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.013 0.0698 0.0692
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0379 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0223 0.0223
Brugia malayi Bromodomain containing protein 0.006 0.0282 0.0276
Loa Loa (eye worm) hypothetical protein 0.0053 0.024 0.0233
Schistosoma mansoni hypothetical protein 0.018 0.0993 0.0993
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0148 0.0142
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0108 0.0102
Leishmania major cathepsin L-like protease 0.005 0.0223 0.0223
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0052 0.0045
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.012 0.0639 0.0633
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.012 0.0639 0.0633
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0379 0.0373
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0203 0.113 0.1124
Mycobacterium ulcerans Sir2-like regulatory protein 0.012 0.0639 0.5985
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.012 0.0639 0.0639
Echinococcus granulosus muscleblind protein 0.0439 0.2524 0.2519
Schistosoma mansoni rab6-interacting 0.0021 0.0052 0.0052
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0191 0.1057 0.9351
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0162 0.0889 0.0883
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0038 0.0151 0.0145
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0853 0.4971 0.4968

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.886 Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate ChEMBL. 25544688
IC50 (binding) = 130 uM Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate ChEMBL. 25544688

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.