Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin b | 0.0329 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.0871 | 0.0871 |
Plasmodium vivax | vivapain-2 | 0.0062 | 0.0871 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0871 | 0.0611 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0238 | 0.6887 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0085 | 0.1643 | 0.1643 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0045 | 0.0277 | 0.0277 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.1643 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0062 | 0.0871 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0329 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0085 | 0.1643 | 0.1643 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Leishmania major | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.4258 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Leishmania major | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.4258 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0238 | 0.6887 | 0.6887 |
Onchocerca volvulus | Cathepsin F homolog | 0.0062 | 0.0871 | 0.0899 |
Onchocerca volvulus | 0.0062 | 0.0871 | 0.0899 | |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0238 | 0.6887 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0085 | 0.1643 | 0.1643 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0062 | 0.0871 | 0.1265 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.1643 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.6123 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0045 | 0.0277 | 0.0403 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0238 | 0.6887 | 0.6887 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1643 | 0.1404 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0238 | 0.6887 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0238 | 0.6887 | 0.6887 |
Giardia lamblia | Cathepsin B precursor | 0.0115 | 0.2682 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1643 | 0.1404 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.0871 | 0.0871 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0115 | 0.2682 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0085 | 0.1643 | 0.1643 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0238 | 0.6887 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0062 | 0.0871 | 0.0611 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0045 | 0.0277 | 0.0277 |
Echinococcus granulosus | cathepsin b | 0.0329 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0329 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0085 | 0.1643 | 0.1643 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0085 | 0.1643 | 0.1643 |
Schistosoma mansoni | fusion | 0.0085 | 0.1643 | 0.1643 |
Onchocerca volvulus | 0.0062 | 0.0871 | 0.0899 | |
Onchocerca volvulus | 0.0062 | 0.0871 | 0.0899 | |
Echinococcus multilocularis | cysteine protease | 0.0062 | 0.0871 | 0.0871 |
Brugia malayi | Cathepsin L-like precursor | 0.0045 | 0.0277 | 0.0277 |
Toxoplasma gondii | ran binding protein | 0.0085 | 0.1643 | 0.1282 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.1643 |
Brugia malayi | cathepsin L-like precursor | 0.0045 | 0.0277 | 0.0277 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.0871 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0062 | 0.0871 | 0.0871 |
Onchocerca volvulus | Cathepsin L homolog | 0.0062 | 0.0871 | 0.0899 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0871 | 0.0871 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0062 | 0.0871 | 0.1265 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0085 | 0.1643 | 0.1643 |
Onchocerca volvulus | 0.0085 | 0.1643 | 0.2065 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0062 | 0.0871 | 0.0871 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0238 | 0.6887 | 0.6887 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.0871 | 0.0871 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0062 | 0.0871 | 0.0871 |
Onchocerca volvulus | 0.0085 | 0.1643 | 0.2065 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0085 | 0.1643 | 0.1643 |
Onchocerca volvulus | Cathepsin L homolog | 0.0062 | 0.0871 | 0.0899 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0871 | 0.0871 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.0871 | 0.0871 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0062 | 0.0871 | 0.0871 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0085 | 0.1643 | 0.2385 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0085 | 0.1643 | 0.1643 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0062 | 0.0871 | 0.0871 |
Echinococcus multilocularis | cysteine protease | 0.0062 | 0.0871 | 0.0871 |
Leishmania major | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.4258 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0062 | 0.0871 | 0.0871 |
Loa Loa (eye worm) | cathepsin B | 0.0115 | 0.2682 | 0.2474 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Chlamydia trachomatis | SWIB complex protein | 0.0238 | 0.6887 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.4258 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0085 | 0.1643 | 0.1643 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0085 | 0.1643 | 0.1643 |
Onchocerca volvulus | 0.0062 | 0.0871 | 0.0899 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Echinococcus multilocularis | cathepsin b | 0.0329 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0085 | 0.1643 | 0.1643 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0238 | 0.6887 | 0.6887 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0085 | 0.1643 | 0.1282 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0085 | 0.1643 | 0.1643 |
Onchocerca volvulus | 0.0238 | 0.6887 | 1 | |
Onchocerca volvulus | 0.0062 | 0.0871 | 0.0899 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0085 | 0.1643 | 0.6123 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0238 | 0.6887 | 0.6799 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0871 | 0.0871 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0062 | 0.0871 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0085 | 0.1643 | 0.1643 |
Echinococcus granulosus | cathepsin l1 | 0.0045 | 0.0277 | 0.0277 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0115 | 0.2682 | 0.2682 |
Onchocerca volvulus | 0.0085 | 0.1643 | 0.2065 | |
Loa Loa (eye worm) | ctsf protein | 0.0062 | 0.0871 | 0.0611 |
Onchocerca volvulus | 0.0085 | 0.1643 | 0.2065 | |
Echinococcus granulosus | cathepsin b | 0.0329 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Loa Loa (eye worm) | fibroinase | 0.0062 | 0.0871 | 0.0611 |
Echinococcus granulosus | cathepsin l1 | 0.0062 | 0.0871 | 0.0871 |
Brugia malayi | YY1-associated factor 2 | 0.0085 | 0.1643 | 0.1643 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0238 | 0.6887 | 0.6887 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0329 | 1 | 1 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0085 | 0.1643 | 0.1643 |
Leishmania major | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.4258 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0085 | 0.1643 | 0.6123 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1643 | 0.1404 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0045 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0062 | 0.0871 | 0.0611 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0238 | 0.6887 | 0.6887 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0238 | 0.6887 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0115 | 0.2682 | 0.3895 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Onchocerca volvulus | 0.0062 | 0.0871 | 0.0899 | |
Brugia malayi | brahma associated protein 60 kDa | 0.0238 | 0.6887 | 0.6887 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0062 | 0.0871 | 0.0871 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Schistosoma mansoni | hypothetical protein | 0.0238 | 0.6887 | 0.6887 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.0871 | 0.0871 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0085 | 0.1643 | 0.2065 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0238 | 0.6887 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0062 | 0.0871 | 0.0871 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0085 | 0.1643 | 0.1643 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0871 | 0.0871 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0045 | 0.0277 | 0.0403 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0085 | 0.1643 | 0.1643 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0238 | 0.6887 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0062 | 0.0871 | 0.0871 |
Plasmodium vivax | hypothetical protein, conserved | 0.0238 | 0.6887 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0238 | 0.6887 | 0.6887 |
Schistosoma mansoni | brg-1 associated factor | 0.0238 | 0.6887 | 0.6887 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.1643 | 0.1643 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.0871 | 0.0871 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0115 | 0.2682 | 0.2682 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0238 | 0.6887 | 0.6887 |
Toxoplasma gondii | cathepsin B | 0.0115 | 0.2682 | 0.3011 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0871 | 0.3248 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0115 | 0.2682 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0115 | 0.2682 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0045 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | cysteine protease | 0.0062 | 0.0871 | 0.0611 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0085 | 0.1643 | 0.1643 |
Schistosoma mansoni | hypothetical protein | 0.0238 | 0.6887 | 0.6887 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0085 | 0.1643 | 0.1643 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0085 | 0.1643 | 0.1643 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0085 | 0.1643 | 0.1643 |
Giardia lamblia | Cathepsin B precursor | 0.0115 | 0.2682 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0045 | 0.0277 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1643 | 0.1404 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.0871 | 0.0871 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0062 | 0.0871 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1643 | 0.1404 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Plasmodium vivax | vivapain-2 | 0.0062 | 0.0871 | 0.1265 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0329 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.0871 | 0.1265 |
Loa Loa (eye worm) | brahma associated protein | 0.0238 | 0.6887 | 0.6799 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0085 | 0.1643 | 0.6123 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0329 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.0871 | 0.0899 | |
Schistosoma mansoni | RNA binding protein | 0.0085 | 0.1643 | 0.1643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.