Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peptidylprolyl isomerase G (cyclophilin G) | Starlite/ChEMBL | No references |
Homo sapiens | peptidylprolyl isomerase D | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | peptidylprolyl isomerase D | 370 aa | 345 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | neuropeptide F receptor | 0.0007 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Brugia malayi | G protein-coupled receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Trichomonas vaginalis | peptidyl-prolyl cis-trans isomerase A, ppia, putative | 0.0126 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | peptidyl-prolyl cis-trans isomerase G ppig | 0.0126 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative | 0.0063 | 0.4706 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0007 | 0 | 0.5 |
Trypanosoma cruzi | rotamase, putative | 0.0063 | 0.4706 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Brugia malayi | larval opioid receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl isomerase G | 0.0126 | 1 | 1 |
Brugia malayi | ORL1-like opioid receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0063 | 0.4706 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0007 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0007 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0007 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0007 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Leishmania major | cyclophilin 40 | 0.0063 | 0.4706 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0007 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Trypanosoma cruzi | 40 kDa cyclophilin, putative | 0.0063 | 0.4706 | 0.5 |
Brugia malayi | AKH receptor | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | peptidyl-prolyl cis-trans isomerase G ppig | 0.0126 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0007 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6200 nM | BindingDB_Patents: Enzymatic Assay. Cyclophilin PPlase activity was measured at 20 C. by using the standard chymotrypsin coupled assay (Kofron J L, Kuzmic P, Kishore V, Colon-Bonilla E, Rich D H. Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay. Biochemistry. 1991 Jun. 25; 30(25):6127-34). The assay buffer (25 mM Hepes, 100 mM NaCl, pH 7.8) and CypA, B or D (1900 nM stock solution) were pre-cooled to 4 C., to which then was added 5 uL of 50 mg/ml chymotrypsin in 1 mM HCl. The reaction was initiated by adding 20 uL of 3.2 mM peptide substrate (Suc-Ala-Ala-cis-Pro-Phe-pNA) in LiCl/TFE solution with rapid inversion. After a delay from the onset of mixing, the absorbance of p-nitroaniline was followed at 390 nM until the reaction was complete (1 min). The final concentration of LiCl in the assay was 20 mM; TFE was present at a concentration of 4% (v/v). Absorbance readings were collected every 1 s by spectrophotometer. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.