Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | methionine tRNA synthetase | 0.0062 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.7556 | 0.7546 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.7556 | 0.7556 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0062 | 1 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0062 | 1 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0062 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.7556 | 0.7546 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0062 | 1 | 0.5 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.7556 | 0.7556 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0062 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0062 | 1 | 0.5 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.004 | 0.004 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0062 | 1 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0062 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0062 | 1 | 0.5 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0062 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.