Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | meningioma expressed antigen 5 (hyaluronidase) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Smad4 | 0.0018 | 0.0002 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0356 | 0.3697 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0002 | 0.0005 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0037 | 0.0204 | 0.0604 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0 | 0.0001 |
Brugia malayi | Hyaluronidase family protein | 0.0327 | 0.338 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0429 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.023 | 0.0623 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0 | 0.0001 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0 | 0.0001 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0002 | 0.0005 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0235 | 0.0636 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0002 | 0.0005 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0002 | 0.0006 |
Echinococcus granulosus | snurportin 1 | 0.0356 | 0.3697 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.023 | 0.0623 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0036 | 0.0195 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0204 | 1 |
Brugia malayi | Smad1 | 0.0018 | 0.0002 | 0.0006 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0269 | 0.2742 | 0.7417 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0.0097 | 0.5 |
Brugia malayi | RNA, U transporter 1 | 0.0095 | 0.0839 | 0.2483 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0269 | 0.2742 | 0.7417 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0002 | 0.0006 |
Echinococcus granulosus | smad | 0.0018 | 0.0002 | 0.0005 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0002 | 0.0006 |
Trichomonas vaginalis | rotamase, putative | 0.0037 | 0.0204 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0235 | 0.0636 |
Schistosoma mansoni | importin beta-1 | 0.0033 | 0.0166 | 0.045 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0033 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0429 | 0.1159 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.0195 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0002 | 0.0002 |
Brugia malayi | MH2 domain containing protein | 0.0269 | 0.2742 | 0.8113 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0037 | 0.0204 | 0.0552 |
Schistosoma mansoni | smad | 0.0018 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | hyaluronidase | 0.0327 | 0.338 | 0.9142 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0235 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.1758 | 0.4755 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0235 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0033 | 0.0166 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0235 | 0.0636 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0356 | 0.3697 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0002 | 0.0005 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0033 | 0.0166 | 0.8551 |
Echinococcus multilocularis | snurportin 1 | 0.0356 | 0.3697 | 0.3697 |
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.0166 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.0036 | 0.0195 | 0.9111 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0002 | 0.0005 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0166 | 0.8551 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0235 | 0.0235 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.023 | 0.0681 |
Brugia malayi | hypothetical protein | 0.004 | 0.0235 | 0.0696 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0002 | 0.0006 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0429 | 0.1268 |
Schistosoma mansoni | Hyaluronidase | 0.0327 | 0.338 | 0.9142 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0002 | 0.0005 |
Echinococcus multilocularis | expressed protein | 0.0037 | 0.0204 | 0.0204 |
Echinococcus granulosus | geminin | 0.0179 | 0.1758 | 0.4755 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0429 | 0.1268 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0 | 0.0001 |
Echinococcus multilocularis | geminin | 0.0179 | 0.1758 | 0.1758 |
Echinococcus granulosus | expressed protein | 0.0037 | 0.0204 | 0.0552 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0 | 0.0001 |
Schistosoma mansoni | rotamase | 0.0037 | 0.0204 | 0.0552 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0166 | 0.8551 |
Leishmania major | importin beta-1 subunit, putative | 0.0027 | 0.0097 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0235 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0036 | 0.0195 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.1758 | 0.4755 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0327 | 0.338 | 0.9142 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.0166 | 0.0493 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1322 | 0.3575 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0002 | 0.0002 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0327 | 0.338 | 0.9142 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.0166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0166 | 0.045 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0327 | 0.338 | 0.338 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0036 | 0.0195 | 0.7057 |
Echinococcus multilocularis | smad | 0.0018 | 0.0002 | 0.0002 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0036 | 0.0195 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.0195 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0002 | 0.0005 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 16.28 nM | BindingDB_Patents: Inhibition Assay. Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acetyl-ß-D-glucosaminide dihydrate (Sigma M2133) dissolved in ddH2O, as a substrate. The amount of purified human O-GlcNAcase enzyme used in the reaction is 0.7 nM. Test compound of varying concentrations is added to the enzyme prior to initiation of the reaction. The reaction is performed at room temperature in a 96-well plate and is initiated with the addition of substrate. The production of fluorescent product is measured every 60 sec for 45 min with a Tecan Infinite M200 plate-reader with excitation at 355 nM and emission detected at 460 nM, with 4-Methylumbelliferone (Sigma M1381) used to produce a standard curve. The slope of product production is determined for each concentration of compound tested and plotted, using standard curve fitting algorithms for sigmoidal dose response curves. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.