Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | meningioma expressed antigen 5 (hyaluronidase) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.1605 | 0.1605 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.317 | 0.317 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3624 | 0.3624 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.199 | 0.199 |
Echinococcus multilocularis | geminin | 0.0196 | 0.555 | 0.555 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.1156 | 0.1156 |
Brugia malayi | hypothetical protein | 0.0079 | 0.1605 | 0.1605 |
Giardia lamblia | PHD finger protein 15 | 0.0032 | 0 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0105 | 0.2471 | 0.2471 |
Schistosoma mansoni | Hyaluronidase | 0.0327 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0105 | 0.2471 | 0.2471 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0091 | 0.199 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.1605 | 0.1605 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0091 | 0.199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0776 | 0.0776 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0039 | 0.0228 | 0.0228 |
Echinococcus granulosus | jumonji domain containing protein | 0.0045 | 0.0425 | 0.0425 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.1605 | 0.1605 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.555 | 0.555 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.317 | 0.317 |
Plasmodium falciparum | phd finger protein, putative | 0.0032 | 0 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0039 | 0.0228 | 0.0228 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0105 | 0.2471 | 0.2471 |
Onchocerca volvulus | Alhambra homolog | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.0327 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.1605 | 0.1605 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.555 | 0.555 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0039 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.317 | 0.317 |
Schistosoma mansoni | jumonji domain containing protein | 0.0083 | 0.174 | 0.174 |
Echinococcus granulosus | geminin | 0.0196 | 0.555 | 0.555 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0228 | 0.0228 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0039 | 0.0228 | 0.0228 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0045 | 0.0425 | 0.0425 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0327 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.17 nM | BindingDB_Patents: Inhibition Assay. Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acetyl-ß-D-glucosaminide dihydrate (Sigma M2133) dissolved in ddH2O, as a substrate. The amount of purified human O-GlcNAcase enzyme used in the reaction is 0.7 nM. Test compound of varying concentrations is added to the enzyme prior to initiation of the reaction. The reaction is performed at room temperature in a 96-well plate and is initiated with the addition of substrate. The production of fluorescent product is measured every 60 sec for 45 min with a Tecan Infinite M200 plate-reader with excitation at 355 nM and emission detected at 460 nM, with 4-Methylumbelliferone (Sigma M1381) used to produce a standard curve. The slope of product production is determined for each concentration of compound tested and plotted, using standard curve fitting algorithms for sigmoidal dose response curves. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.