Detailed information for compound 1995087

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 470.584 | Formula: C25H36N5O4+
  • H donors: 1 H acceptors: 3 LogP: 5.27 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCOc1cc(cc(c1)C(C)(C)C)C(=O)C[n+]1nc(n2c1ccc(n2)OC(CC)CC)N
  • InChi: 1S/C25H36N5O4/c1-7-19(8-2)34-22-9-10-23-29(28-24(26)30(23)27-22)16-21(31)17-13-18(25(3,4)5)15-20(14-17)33-12-11-32-6/h9-10,13-15,19H,7-8,11-12,16H2,1-6H3,(H2,26,28)/q+1
  • InChiKey: VNGQUWHQKYVJDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) heterochromatin protein 1 0.0046 0.0126 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Echinococcus granulosus dnaJ subfamily B 0.1127 0.4848 0.4846
Onchocerca volvulus Cathepsin F homolog 0.0688 0.2929 0.8473
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0073 0.0244 0.024
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0004 0.0001
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0023 0.0024 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0412 0.1725 0.9415
Echinococcus granulosus expressed conserved protein 0.0077 0.0261 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0118 0.0441 0.0438
Giardia lamblia Cysteine protease 0.0171 0.0674 0.1709
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0381 0.1588 0.1585
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0332 0.0868
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0381 0.1588 0.1585
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Plasmodium vivax unspecified product 0.0209 0.0839 0.2856
Loa Loa (eye worm) glutathione reductase 0.0105 0.0382 0.0451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0688 0.2929 1
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0023 0.0024 0.0024
Echinococcus multilocularis muscleblind protein 0.02 0.08 0.0797
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0171 0.0674 0.1761
Schistosoma mansoni single-minded 0.0035 0.0078 0.0075
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0083 0.0271
Echinococcus multilocularis chromobox protein 1 0.0046 0.0126 0.0123
Plasmodium falciparum thioredoxin reductase 0.0105 0.0382 0.1291
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0004 0.0001
Echinococcus granulosus single minded 2 0.0026 0.0038 0.0035
Toxoplasma gondii HEAT repeat-containing protein 0.0037 0.0085 0.0265
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0118 0.0441 0.0438
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0023 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0339 0.0335
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0082 0.0282 0.0679
Echinococcus granulosus cathepsin L cysteine proteinase 0.0688 0.2929 0.2927
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.0099
Trypanosoma cruzi metacaspase 5, putative 0.0115 0.0427 0.0504
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0083 0.0095
Schistosoma mansoni aldehyde dehydrogenase 0.0412 0.1725 0.1722
Giardia lamblia Cathepsin B precursor 0.0717 0.3058 0.7981
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0171 0.0674 0.1761
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0098 0.0321
Echinococcus multilocularis cysteine protease 0.0688 0.2929 0.2927
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0024 0.0069
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Schistosoma mansoni hypothetical protein 0.0391 0.1633 0.163
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0171 0.0674 0.1761
Loa Loa (eye worm) thioredoxin reductase 0.0105 0.0382 0.0451
Echinococcus multilocularis importin subunit beta 1 0.0037 0.0085 0.0082
Toxoplasma gondii ABC1 family protein 0.0093 0.0332 0.1074
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0065
Entamoeba histolytica cysteine protease, putative 0.0688 0.2929 0.764
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0024 0.0021
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0027 0.0043 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.0099
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Mycobacterium ulcerans aldehyde dehydrogenase 0.0412 0.1725 0.9415
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0171 0.0674 0.1761
Onchocerca volvulus 0.0688 0.2929 0.8473
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Echinococcus multilocularis caspase 8 0.0115 0.0427 0.0423
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0171 0.0674 0.229
Trichomonas vaginalis glucosylceramidase, putative 0.0103 0.0377 0.0985
Schistosoma mansoni hypothetical protein 0.0023 0.0024 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Plasmodium falciparum glutathione reductase 0.0105 0.0382 0.1291
Trypanosoma cruzi cysteine peptidase, putative 0.0688 0.2929 0.349
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0269 0.0316
Plasmodium vivax vivapain-2 0.0688 0.2929 1
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0427 0.1445
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0083 0.2186
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0023 0.0024 0.0063
Leishmania major cysteine peptidase A (CPA) 0.0688 0.2929 0.9576
Schistosoma mansoni zinc finger protein 0.0022 0.002 0.0017
Schistosoma mansoni chromobox protein 0.0046 0.0126 0.0123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0171 0.0674 0.1761
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0098 0.0194
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0023 0.0024 0.0065
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0086 0.03 0.0296
Onchocerca volvulus 0.0688 0.2929 0.8473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0032 0.0064 0.006
Echinococcus granulosus cathepsin L 0.0171 0.0674 0.0671
Echinococcus multilocularis cathepsin L cysteine protease 0.0688 0.2929 0.2927
Entamoeba histolytica Ran family GTPase 0.0027 0.0043 0.0049
Plasmodium vivax SET domain protein, putative 0.0103 0.0376 0.1273
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Brugia malayi cathepsin B-like cysteine proteinase 0.1937 0.8384 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0442 0.0439
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0412 0.1725 0.1722
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Chlamydia trachomatis recombinase RecA 0.0085 0.0295 1
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Schistosoma mansoni rab6-interacting 0.0023 0.0024 0.0021
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0427 0.1383
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0262 0.1071 0.1067
Schistosoma mansoni patched 1 0.0035 0.0078 0.0075
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Schistosoma mansoni cpg binding protein 0.0079 0.0271 0.0267
Echinococcus granulosus cathepsin L 0.0381 0.1588 0.1585
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0269 0.0316
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.0319 0.1318 0.1567
Brugia malayi Papain family cysteine protease containing protein 0.0381 0.1588 0.189
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.023 0.0227
Onchocerca volvulus 0.0026 0.0038 0.0072
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0083 0.0259
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0076 0.0086
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0024 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Trypanosoma cruzi metacaspase, putative 0.0115 0.0427 0.0504
Giardia lamblia Encystation-specific protease 0.0171 0.0674 0.1709
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0118 0.0441 0.0438
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0332 0.0868
Loa Loa (eye worm) hypothetical protein 0.1937 0.8384 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0717 0.3058 0.3645
Toxoplasma gondii preprocathepsin c precursor, putative 0.0171 0.0674 0.2193
Brugia malayi bHLH-PAS transcription factor 0.0026 0.0038 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Echinococcus granulosus chromobox protein 1 0.0046 0.0126 0.0123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0436 0.1831 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Echinococcus granulosus cathepsin b 0.1937 0.8384 0.8383
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0033 0.0071 0.0068
Brugia malayi RNA, U transporter 1 0.0104 0.038 0.0449
Echinococcus multilocularis RUN 0.0023 0.0024 0.0021
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0427 0.1383
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Leishmania major GTP-binding protein, putative 0.0027 0.0043 0.0127
Brugia malayi Glycosyl hydrolases family 31 protein 0.0354 0.1473 0.1753
Echinococcus multilocularis cathepsin L cysteine protease 0.0688 0.2929 0.2927
Schistosoma mansoni hypothetical protein 0.0073 0.0244 0.024
Leishmania major aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Echinococcus granulosus snurportin 1 0.0391 0.1633 0.163
Mycobacterium tuberculosis Conserved protein 0.0093 0.0332 0.0546
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0028 0.0046 0.0096
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0269 0.0702
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Plasmodium vivax thioredoxin reductase, putative 0.0105 0.0382 0.1291
Brugia malayi CXXC zinc finger family protein 0.0079 0.0271 0.0318
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0085 0.0295 0.1308
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Echinococcus granulosus GPCR family 2 0.0073 0.0244 0.024
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0069
Mycobacterium tuberculosis Probable dehydrogenase 0.0239 0.0967 0.1601
Plasmodium vivax vivapain-3 0.0381 0.1588 0.5416
Onchocerca volvulus Glucosylceramidase homolog 0.0098 0.0354 0.0989
Entamoeba histolytica cysteine proteinase 1, putative 0.0381 0.1588 0.4114
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0023 0.0024 0.0021
Echinococcus granulosus cysteine protease 0.0381 0.1588 0.1585
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0209 0.0839 0.0997
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0083 0.0259
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0004 0.0001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0098 0.2725
Schistosoma mansoni caspase-7 (C14 family) 0.0262 0.1071 0.1067
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0053 0.016
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0086 0.03 0.0968
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0032 0.0064 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0332 0.0392
Giardia lamblia Cysteine protease 0.0171 0.0674 0.1709
Brugia malayi Ets-domain containing protein 0.007 0.023 0.027
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0083 0.0095
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0032 0.0028
Schistosoma mansoni hypothetical protein 0.0023 0.0024 0.0021
Trypanosoma cruzi cysteine protease, putative 0.0381 0.1588 0.189
Brugia malayi Cathepsin L-like precursor 0.0478 0.2015 0.2399
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0071 0.0186
Entamoeba histolytica cysteine proteinase, putative 0.0688 0.2929 0.764
Echinococcus multilocularis Niemann Pick C1 protein 0.0117 0.0436 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0078 0.0205
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0103 0.0376 0.1219
Onchocerca volvulus 0.0093 0.0332 0.0927
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0073 0.0244 0.024
Brugia malayi cathepsin L precursor 0.0171 0.0674 0.0799
Trypanosoma cruzi PAB1-binding protein , putative 0.004 0.01 0.0114
Trypanosoma cruzi importin beta-1 subunit, putative 0.003 0.0055 0.006
Giardia lamblia Kinase, CMGC MAPK 0.0033 0.0071 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.0688 0.2929 0.2927
Schistosoma mansoni hypothetical protein 0.0158 0.0614 0.0611
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0339 0.0335
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0033 0.0071 0.008
Brugia malayi aldehyde dehydrogenase 0.0023 0.0024 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0717 0.3058 1
Loa Loa (eye worm) ctsf protein 0.0688 0.2929 0.349
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Trypanosoma brucei metacaspase MCA3 0.0115 0.0427 0.1383
Loa Loa (eye worm) hypothetical protein 0.006 0.0186 0.0217
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0436 0.1831 0.8719
Echinococcus granulosus cathepsin b 0.1937 0.8384 0.8383
Echinococcus granulosus caspase 3 0.0147 0.0569 0.0566
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0054 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Mycobacterium leprae Conserved hypothetical protein 0.0497 0.2096 1
Onchocerca volvulus 0.0093 0.0332 0.0927
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0073 0.0244 0.0286
Mycobacterium ulcerans hypothetical protein 0.0093 0.0332 0.1706
Brugia malayi Cathepsin L-like cysteine proteinase 0.0478 0.2015 0.2399
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0126 0.033
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.015 0.0579 0.0686
Brugia malayi hypothetical protein 0.004 0.01 0.0114
Mycobacterium tuberculosis Probable esterase LipL 0.0093 0.0332 0.0546
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0086 0.03 0.0353
Leishmania major hypothetical protein, conserved 0.0093 0.0332 0.1074
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0412 0.1725 0.1722
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0027 0.0024
Echinococcus multilocularis transcription factor Dp 1 0.005 0.0142 0.0138
Brugia malayi Latrophilin receptor protein 2 0.0073 0.0244 0.0286
Onchocerca volvulus Cathepsin L homolog 0.0688 0.2929 0.8473
Trichomonas vaginalis esterase, putative 0.0093 0.0332 0.0868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0023 0.0024 0.0024
Trypanosoma brucei cysteine peptidase C (CPC) 0.0717 0.3058 1
Echinococcus multilocularis cathepsin b 0.1937 0.8384 0.8383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0381 0.1588 0.4151
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0053 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Trypanosoma cruzi metacaspase, putative 0.0115 0.0427 0.0504
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0023 0.0024 0.0033
Echinococcus multilocularis caspase 3 0.0147 0.0569 0.0566
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0023 0.0024 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.004 0.01 0.0328
Onchocerca volvulus 0.0079 0.0271 0.0748
Brugia malayi Glycosyl hydrolases family 31 protein 0.0079 0.0269 0.0316
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0024 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Echinococcus multilocularis protein patched 0.0035 0.0078 0.0075
Toxoplasma gondii histone lysine methyltransferase SET1 0.0156 0.0605 0.1969
Schistosoma mansoni ap endonuclease 0.004 0.0098 0.0095
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0478 0.2015 0.2399
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0033 0.0071 0.0219
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0027 0.0024
Echinococcus granulosus apoptotic protease activating factor 1 0.0142 0.0546 0.0542
Trypanosoma brucei protein kinase, putative 0.0033 0.0071 0.0219
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0023 0.0024 0.0024
Mycobacterium tuberculosis Probable hydrolase 0.0093 0.0332 0.0546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Loa Loa (eye worm) transcription factor SMAD2 0.0103 0.0374 0.0442
Trichomonas vaginalis Importin beta-1 subunit, putative 0.003 0.0055 0.0143
Echinococcus granulosus zinc finger protein 0.0022 0.002 0.0017
Onchocerca volvulus 0.0688 0.2929 0.8473
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0339 0.0335
Schistosoma mansoni hypothetical protein 0.0436 0.1829 0.1827
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0053 0.016
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0436 0.1831 0.3038
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0032 0.0028
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0171 0.0674 0.229
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0098 0.0307
Loa Loa (eye worm) RNA binding protein 0.0042 0.0108 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Schistosoma mansoni hypothetical protein 0.0436 0.1829 0.1827
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0098 0.0321
Leishmania major aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0053 0.0058
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0023 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Echinococcus multilocularis lysosomal alpha glucosidase 0.0354 0.1473 0.147
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0171 0.0674 0.0671
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Toxoplasma gondii cathepsin CPC1 0.0171 0.0674 0.2193
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1937 0.8384 0.8383
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0086 0.03 0.0353
Trichomonas vaginalis ran, putative 0.0027 0.0043 0.0112
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0086 0.03 0.0968
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0071 0.0186
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0083 0.008
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0023 0.0024 0.0021
Echinococcus granulosus cathepsin L cysteine protease 0.0381 0.1588 0.1585
Schistosoma mansoni hypothetical protein 0.0073 0.0244 0.024
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Echinococcus granulosus mitogen activated protein kinase 0.0033 0.0071 0.0068
Brugia malayi Ets-domain containing protein 0.007 0.023 0.027
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0086 0.03 0.0353
Schistosoma mansoni cathepsin S (C01 family) 0.0171 0.0674 0.0671
Plasmodium vivax ataxin-2 like protein, putative 0.004 0.01 0.0328
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Echinococcus granulosus Protein patched homolog 1 0.0035 0.0078 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Brugia malayi cathepsin Z-like cysteine proteinase 0.0171 0.0674 0.0799
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0674 0.1761
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Onchocerca volvulus 0.0688 0.2929 0.8473
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0083 0.0095
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Brugia malayi hypothetical protein 0.0023 0.0024 0.0024
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0171 0.0674 0.229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0111 0.0409 0.0406
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0033 0.0071 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Schistosoma mansoni ets-related 0.0212 0.0851 0.0848
Loa Loa (eye worm) TAR-binding protein 0.0042 0.0108 0.0124
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0093 0.0332 0.1706
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0098 0.0095
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0053 0.0139
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Entamoeba histolytica hypothetical protein 0.0138 0.0529 0.1328
Echinococcus granulosus neuropeptide s receptor 0.0316 0.1307 0.1303
Onchocerca volvulus 0.0688 0.2929 0.8473
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0024
Echinococcus multilocularis snurportin 1 0.0391 0.1633 0.163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Mycobacterium ulcerans esterase/lipase LipP 0.0093 0.0332 0.1706
Plasmodium falciparum serine repeat antigen 2 0.0171 0.0674 0.229
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0441 0.143
Trypanosoma brucei PAB1-binding protein , putative 0.004 0.01 0.0314
Echinococcus multilocularis geminin 0.0436 0.1829 0.1827
Brugia malayi beta-lactamase family protein 0.0093 0.0332 0.0392
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0171 0.0674 0.1761
Plasmodium vivax vivapain-2 0.0688 0.2929 1
Echinococcus granulosus X box binding protein 1 0.0165 0.0644 0.064
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0103 0.0376 0.0373
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0069
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0171 0.0674 0.1709
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0126 0.033
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0083 0.0132
Trichomonas vaginalis importin beta-1, putative 0.003 0.0055 0.0143
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0053 0.0076
Brugia malayi Niemann-Pick C1 protein precursor 0.0082 0.0282 0.0332
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0027 0.0043 0.0046
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0171 0.0674 0.1709
Giardia lamblia Hypothetical protein 0.0171 0.0674 0.1709
Brugia malayi cathepsin F-like cysteine proteinase 0.0209 0.0839 0.0997
Echinococcus granulosus muscleblind protein 0.02 0.08 0.0797
Onchocerca volvulus 0.0319 0.1318 0.379
Onchocerca volvulus 0.0093 0.0332 0.0927
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0083 0.0259
Plasmodium falciparum thioredoxin reductase 0.0036 0.0083 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0546 0.0646
Onchocerca volvulus 0.0023 0.0024 0.0032
Loa Loa (eye worm) runx1 0.004 0.01 0.0114
Plasmodium falciparum cysteine proteinase falcipain 3 0.0688 0.2929 1
Echinococcus multilocularis Protein lozenge 0.004 0.01 0.0096
Brugia malayi cathepsin L-like cysteine proteinase 0.0171 0.0674 0.0799
Loa Loa (eye worm) hypothetical protein 0.0035 0.0078 0.0089
Loa Loa (eye worm) glutaminase 2 0.0359 0.1492 0.1775
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Loa Loa (eye worm) hypothetical protein 0.0156 0.0608 0.072
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1937 0.8384 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.0257 0.1047 0.1245
Plasmodium falciparum serine repeat antigen 3 0.0171 0.0674 0.229
Brugia malayi cathepsin L-like precursor 0.0478 0.2015 0.2399
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0027 0.0043 0.0046
Echinococcus multilocularis protein dispatched 1 0.004 0.01 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Echinococcus multilocularis neuropeptide s receptor 0.0316 0.1307 0.1303
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0893 0.3826 1
Plasmodium falciparum serine repeat antigen 1 0.0171 0.0674 0.229
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Plasmodium falciparum serine repeat antigen 6 0.0171 0.0674 0.229
Onchocerca volvulus 0.0171 0.0674 0.1919
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0071 0.0186
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Plasmodium falciparum metacaspase-like protein 0.0115 0.0427 0.1445
Plasmodium falciparum glutathione reductase 0.0036 0.0083 0.0271
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0004 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Loa Loa (eye worm) hypothetical protein 0.0043 0.0113 0.013
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1937 0.8384 0.8383
Brugia malayi Pre-SET motif family protein 0.071 0.3027 0.3607
Trypanosoma cruzi metacaspase 5, putative 0.0115 0.0427 0.0504
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0259
Echinococcus granulosus tm gpcr rhodopsin 0.0315 0.1301 0.1298
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0083 0.0218
Trypanosoma brucei glucosidase, putative 0.0079 0.0269 0.0866
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0172 0.0675 0.0671
Loa Loa (eye worm) hypothetical protein 0.02 0.08 0.095
Trichomonas vaginalis glucosylceramidase, putative 0.0103 0.0377 0.0985
Trypanosoma cruzi DNA repair protein, putative 0.0026 0.0039 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0093 0.0332 0.0329
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0239 0.0967 0.1601
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0098 0.0307
Schistosoma mansoni cpg binding protein 0.0085 0.0298 0.0294
Schistosoma mansoni lipoxygenase 0.0095 0.0341 0.0337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0339 0.0335
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0071 0.0068
Brugia malayi hypothetical protein 0.0138 0.0529 0.0626
Trypanosoma cruzi cysteine peptidase, putative 0.0381 0.1588 0.189
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0027 0.0043 0.0132
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Brugia malayi MAP kinase sur-1 0.0033 0.0071 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0442 0.0439
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0688 0.2929 0.349
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0239 0.0967 0.4551
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0023 0.0024 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Loa Loa (eye worm) hypothetical protein 0.004 0.01 0.0114
Entamoeba histolytica hypothetical protein 0.0171 0.0674 0.1709
Leishmania major aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Brugia malayi hypoxia-induced factor 1 0.0108 0.0398 0.0471
Trypanosoma brucei importin beta-1 subunit, putative 0.0037 0.0085 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Brugia malayi Papain family cysteine protease containing protein 0.0688 0.2929 0.349
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0048 0.0053
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0023 0.0024 0.0024
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0171 0.0674 0.229
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0073 0.0244 0.024
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.131 0.5647 0.9384
Echinococcus granulosus cathepsin l1 0.0478 0.2015 0.2012
Echinococcus granulosus thioredoxin glutathione reductase 0.0105 0.0383 0.038
Toxoplasma gondii thioredoxin reductase 0.0105 0.0382 0.1237
Brugia malayi glutaminase DH11.1 0.0359 0.1492 0.1775
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0024 0.0021
Trichomonas vaginalis set domain proteins, putative 0.0808 0.3454 0.9028
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0033 0.0071 0.0219
Echinococcus multilocularis zinc finger protein 0.0022 0.002 0.0017
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.004 0.01 0.0314
Trichomonas vaginalis penicillin-binding protein, putative 0.0093 0.0332 0.0868
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0339 0.0335
Echinococcus multilocularis chromobox protein 1 0.0046 0.0126 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0171 0.0674 0.1761
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0171 0.0674 0.229
Plasmodium vivax importin-beta 2, putative 0.0037 0.0085 0.0277
Loa Loa (eye worm) hypothetical protein 0.0319 0.1318 0.1567
Trypanosoma cruzi trypanothione reductase, putative 0.0105 0.0382 0.0451
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0023 0.0024 0.0065
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0171 0.0674 0.229
Trypanosoma brucei trypanothione reductase 0.0105 0.0382 0.1237
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0023 0.0024 0.0021
Brugia malayi hypothetical protein 0.0117 0.0438 0.0518
Schistosoma mansoni aryl hydrocarbon receptor 0.0035 0.0078 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0171 0.0674 0.1761
Trypanosoma brucei hypothetical protein, conserved 0.0093 0.0332 0.1074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0032 0.0064 0.0072
Echinococcus granulosus histone lysine methyltransferase setb 0.0118 0.0442 0.0439
Onchocerca volvulus Cell death protein 3 homolog 0.0257 0.1047 0.3005
Onchocerca volvulus 0.0688 0.2929 0.8473
Onchocerca volvulus 0.0111 0.0409 0.1151
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0083 0.2186
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0412 0.1725 0.2862
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0332 0.0868
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0171 0.0674 0.1761
Trypanosoma cruzi cysteine proteinase, putative 0.0381 0.1588 0.189
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0262 0.1071 0.1067
Schistosoma mansoni hypothetical protein 0.0165 0.0644 0.064
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0478 0.2015 0.5266
Schistosoma mansoni ran 0.0027 0.0043 0.0039
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Giardia lamblia Cathepsin L-like protease 0.0171 0.0674 0.1709
Brugia malayi Cathepsin L-like precursor 0.0209 0.0839 0.0997
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Brugia malayi TAR-binding protein 0.0042 0.0108 0.0124
Echinococcus granulosus GTP binding nuclear protein Ran 0.0027 0.0043 0.0039
Brugia malayi Aldehyde dehydrogenase protein 4 0.0023 0.0024 0.0024
Echinococcus multilocularis caspase 2 0.0257 0.1047 0.1044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0011
Trichomonas vaginalis sucrase-isomaltase, putative 0.0079 0.0269 0.0702
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0023 0.0024 0.0033
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0024 0.0021
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Loa Loa (eye worm) hypothetical protein 0.0082 0.0282 0.0332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0478 0.2015 0.5266
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0098 0.0095
Mycobacterium tuberculosis Probable lipase LipE 0.0093 0.0332 0.0546
Brugia malayi RNA recognition motif domain containing protein 0.0042 0.0108 0.0124
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0098 0.0409
Treponema pallidum fructose-bisphosphate aldolase 0.0893 0.3826 1
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Echinococcus granulosus geminin 0.0436 0.1829 0.1827
Brugia malayi hypothetical protein 0.0026 0.0038 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Loa Loa (eye worm) fibroinase 0.0688 0.2929 0.349
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0098 0.0112
Mycobacterium tuberculosis Probable lipase LipD 0.0093 0.0332 0.0546
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Echinococcus granulosus caspase 8 0.0115 0.0427 0.0423
Loa Loa (eye worm) MH2 domain-containing protein 0.0103 0.0374 0.0442
Loa Loa (eye worm) hypothetical protein 0.0158 0.0614 0.0728
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.0175 0.0171
Entamoeba histolytica hypothetical protein 0.0138 0.0529 0.1328
Loa Loa (eye worm) hypothetical protein 0.0209 0.0839 0.0997
Brugia malayi hypothetical protein 0.0229 0.0925 0.1099
Loa Loa (eye worm) hypothetical protein 0.0062 0.0198 0.0231
Trichomonas vaginalis Importin beta-1 subunit, putative 0.003 0.0055 0.0143
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0083 0.0259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0339 0.0335
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0839 0.0997
Mycobacterium ulcerans beta-lactamase 0.0093 0.0332 0.1706
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0083 0.0156
Echinococcus granulosus cathepsin l cysteine peptidase 0.0688 0.2929 0.2927
Loa Loa (eye worm) hypothetical protein 0.0073 0.0244 0.0286
Plasmodium falciparum importin beta, putative 0.0037 0.0085 0.0277
Schistosoma mansoni hypothetical protein 0.0142 0.0546 0.0542
Echinococcus multilocularis dnaJ subfamily B 0.1127 0.4848 0.4846
Echinococcus granulosus Niemann Pick C1 protein 0.0117 0.0436 0.0432
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0069
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Giardia lamblia Cysteine protease 0.0171 0.0674 0.1709
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0023 0.0024 0.0021
Echinococcus multilocularis mitogen activated protein kinase 0.0033 0.0071 0.0068
Schistosoma mansoni cathepsin s 0.0209 0.0839 0.0836
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0171 0.0674 0.1709
Brugia malayi Cathepsin L-like precursor 0.0478 0.2015 0.2399
Echinococcus granulosus caspase 2 0.0257 0.1047 0.1044
Schistosoma mansoni cathepsin F (C01 family) 0.0688 0.2929 0.2927
Entamoeba histolytica hypothetical protein 0.003 0.0055 0.0081
Loa Loa (eye worm) hypothetical protein 0.0118 0.0442 0.0523
Echinococcus multilocularis GPCR, family 2 0.0073 0.0244 0.024
Entamoeba histolytica hypothetical protein 0.0138 0.0529 0.1328
Echinococcus multilocularis muscleblind protein 1 0.02 0.08 0.0797
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0171 0.0674 0.1761
Schistosoma mansoni loxhd1 0.0023 0.0024 0.0021
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0171 0.0674 0.229
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0026 0.0038 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Loa Loa (eye worm) hypothetical protein 0.0231 0.0933 0.1108
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0005 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Plasmodium falciparum ataxin-2 like protein, putative 0.004 0.01 0.0328
Onchocerca volvulus 0.0688 0.2929 0.8473
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0171 0.0674 0.229
Onchocerca volvulus 0.0478 0.2015 0.5816
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0115 0.0427 0.0423
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Trichomonas vaginalis maltase-glucoamylase, putative 0.0079 0.0269 0.0702
Schistosoma mansoni importin beta-1 0.0037 0.0085 0.0082
Brugia malayi Cell death protein 3 precursor 0.0257 0.1047 0.1245
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Schistosoma mansoni chromobox protein 0.0046 0.0126 0.0123
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0023 0.0024 0.0033
Echinococcus granulosus tar DNA binding protein 0.0042 0.0108 0.0104
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0118 0.0441 0.0521
Trypanosoma cruzi metacaspase, putative 0.0115 0.0427 0.0504
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0332 0.0392
Echinococcus multilocularis cathepsin b 0.1937 0.8384 0.8383
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0118 0.0441 0.0438
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0118 0.0442 0.0439
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0005 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0381 0.1588 0.4114
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0098 0.0256
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0027 0.0024
Schistosoma mansoni gabp alpha 0.007 0.023 0.0227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0265 0.1083 0.5112
Schistosoma mansoni rab6-interacting 0.0023 0.0024 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0239 0.0967 0.1601
Schistosoma mansoni hypothetical protein 0.0138 0.0529 0.0526
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0086 0.03 0.0353
Loa Loa (eye worm) hypothetical protein 0.0688 0.2929 0.349
Plasmodium vivax vivapain-1 0.0381 0.1588 0.5416
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0093 0.0332 0.0329
Trypanosoma cruzi cysteine peptidase, putative 0.0688 0.2929 0.349
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0032 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0381 0.1588 0.5186
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0339 0.0399
Brugia malayi chromobox protein homolog 3 0.0026 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0098 0.0156
Trypanosoma cruzi PAB1-binding protein , putative 0.004 0.01 0.0114
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0269 0.0643
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0033 0.0071 0.008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.071 0.3027 0.3607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0083 0.0328
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0093 0.0332 0.0392
Echinococcus multilocularis caspase 0.0262 0.1071 0.1067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0083 0.0095
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0171 0.0674 0.0799
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0688 0.2929 0.7655
Entamoeba histolytica hypothetical protein 0.0138 0.0529 0.1328
Loa Loa (eye worm) hypothetical protein 0.0478 0.2015 0.2399
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0083 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0688 0.2929 0.7655
Brugia malayi Muscleblind-like protein 0.02 0.08 0.095
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0023 0.0024 0.0021
Giardia lamblia Hypothetical protein 0.0171 0.0674 0.1709
Trypanosoma brucei metacaspase 0.0115 0.0427 0.1383
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.0441 0.1152
Loa Loa (eye worm) glutaminase 0.0359 0.1492 0.1775
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0171 0.0674 0.229
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0098 0.0112
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0118 0.0441 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Mycobacterium tuberculosis Probable oxidoreductase 0.0265 0.1083 0.1795
Schistosoma mansoni caspase-3 (C14 family) 0.0262 0.1071 0.1067
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0083 0.0271
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0023 0.0024 0.0024
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0023 0.0024 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0688 0.2929 0.349
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Plasmodium falciparum serine repeat antigen 7 0.0171 0.0674 0.229
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0093 0.0332 0.0546
Treponema pallidum NADH oxidase 0.0036 0.0083 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0023 0.0024 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0412 0.1725 0.9415
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0027 0.0043 0.0046
Trypanosoma cruzi major cysteine proteinase, putative 0.0171 0.0674 0.0799
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0093 0.0332 0.0392
Brugia malayi latrophilin 2 splice variant baaae 0.0158 0.0614 0.0728
Trypanosoma brucei metacaspase 5, putative 0.0115 0.0427 0.1383
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0086 0.03 0.0725
Echinococcus granulosus chromobox protein 1 0.0046 0.0126 0.0123
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0036 0.0095
Schistosoma mansoni transcription factor LCR-F1 0.0138 0.0529 0.0526
Schistosoma mansoni alpha-glucosidase 0.0305 0.1257 0.1254
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0086 0.03 0.0296
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0893 0.3826 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.0175 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Trypanosoma cruzi cruzipain precursor, putative 0.0209 0.0839 0.0997
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0118 0.0441 0.1096
Entamoeba histolytica cysteine proteinase, putative 0.0381 0.1588 0.4114
Schistosoma mansoni cathepsin B (C01 family) 0.0171 0.0674 0.0671
Mycobacterium tuberculosis Probable reductase 0.0239 0.0967 0.1601
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0171 0.0674 0.1709
Brugia malayi PHD-finger family protein 0.0026 0.0041 0.0044
Loa Loa (eye worm) fli-1 protein 0.0212 0.0851 0.1011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1937 0.8384 0.8383
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0053 0.0058
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0004 0.0001
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0098 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0381 0.1588 0.5186
Trichomonas vaginalis helicase, putative 0.0018 0.0003 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0231 0.0933 0.1108
Giardia lamblia Cathepsin L-like protease 0.0171 0.0674 0.1709
Echinococcus multilocularis thioredoxin glutathione reductase 0.0105 0.0383 0.038
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0209 0.0839 0.0997
Schistosoma mansoni microtubule-associated protein tau 0.2307 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0105 0.0382 0.0628
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Toxoplasma gondii exonuclease III APE 0.004 0.0098 0.0307
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0231 0.0933 0.1108
Echinococcus multilocularis apoptotic protease activating factor 1 0.0142 0.0546 0.0542
Echinococcus multilocularis neuropeptide receptor A26 0.0316 0.1307 0.1303
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0053 0.0139
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0441 0.0521
Onchocerca volvulus 0.0023 0.0024 0.0032
Echinococcus granulosus GA binding protein alpha chain 0.007 0.023 0.0227
Echinococcus multilocularis beta LACTamase domain containing family member 0.0093 0.0332 0.0329
Schistosoma mansoni cathepsin C 0.0171 0.0674 0.0671
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0083 0.0328
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0098 0.0353 0.0349
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0027 0.0043 0.0127
Trypanosoma cruzi cysteine proteinase, putative 0.0381 0.1588 0.189
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0596 0.2527 0.4195
Loa Loa (eye worm) latrophilin receptor protein 2 0.0073 0.0244 0.0286
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0083 0.0259
Brugia malayi hypothetical protein 0.0142 0.0546 0.0646
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0332 0.1122
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0024 0.0021
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0053 0.0115
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0023 0.0024 0.0065
Onchocerca volvulus 0.0142 0.0546 0.1547
Plasmodium falciparum serine repeat antigen 8 0.0171 0.0674 0.229
Onchocerca volvulus Cathepsin L homolog 0.0171 0.0674 0.1919
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0058
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0023 0.0024 0.0033
Trypanosoma cruzi major cysteine proteinase, putative 0.0171 0.0674 0.0799
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0688 0.2929 0.2927
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.015 0.0579 0.0686
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0098 0.0194
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Onchocerca volvulus 0.0229 0.0925 0.265
Brugia malayi Bromodomain containing protein 0.0071 0.0234 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Loa Loa (eye worm) hypothetical protein 0.0209 0.0839 0.0997
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0033 0.0071 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Schistosoma mansoni lozenge 0.004 0.01 0.0096
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0136 0.0519 0.0516
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0004 0.0001
Leishmania major metacaspase, putative 0.0115 0.0427 0.1383
Giardia lamblia Cysteine protease 0.0171 0.0674 0.1709
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0339 0.0399
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0023 0.0024 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0381 0.1588 0.4151
Mycobacterium tuberculosis Conserved protein 0.0093 0.0332 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0441 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Brugia malayi PAS domain containing protein 0.0035 0.0078 0.0088
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1937 0.8384 0.8383
Schistosoma mansoni bromodomain containing protein 0.006 0.0189 0.0185
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Loa Loa (eye worm) aldehyde dehydrogenase 0.0023 0.0024 0.0024
Trypanosoma cruzi cruzipain precursor, putative 0.0688 0.2929 0.349
Loa Loa (eye worm) hypothetical protein 0.0229 0.0925 0.1099
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0354 0.1473 0.1753
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0023 0.0024 0.0021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0027 0.0043 0.0046
Trypanosoma cruzi DNA repair protein, putative 0.0026 0.0039 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Echinococcus multilocularis Niemann Pick C1 protein 0.0082 0.0282 0.0279
Onchocerca volvulus 0.0808 0.3454 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0354 0.1473 0.147
Echinococcus granulosus caspase 0.0262 0.1071 0.1067
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0239 0.0967 0.1601
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0023 0.0024 0.0021
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Echinococcus multilocularis cathepsin L 0.0171 0.0674 0.0671
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0023 0.0024 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0412 0.1725 0.5634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0004 0.0001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0269 0.0643
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0023 0.0024 0.0033
Echinococcus granulosus cpg binding protein 0.0085 0.0298 0.0294
Brugia malayi Thioredoxin reductase 0.0105 0.0382 0.0451
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0071 0.0186
Echinococcus granulosus ubiquitin specific protease 41 0.0118 0.0441 0.0438
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0036 0.0095
Mycobacterium ulcerans glutaminase 0.0359 0.1492 0.8123
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0023 0.0024 0.0065
Plasmodium falciparum serine repeat antigen 5 0.0171 0.0674 0.229
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0381 0.1588 0.189
Schistosoma mansoni hypothetical protein 0.0032 0.0064 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0674 0.1761
Echinococcus multilocularis tar DNA binding protein 0.0042 0.0108 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Giardia lamblia Cathepsin B precursor 0.0717 0.3058 0.7981
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0027 0.0024
Brugia malayi Pre-SET motif family protein 0.0103 0.0376 0.0444
Echinococcus multilocularis sterol regulatory element binding protein 0.0035 0.0078 0.0075
Giardia lamblia Cathepsin B precursor 0.0717 0.3058 0.7981
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0041 0.0044
Schistosoma mansoni cpg binding protein 0.0085 0.0298 0.0294
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Echinococcus multilocularis cysteine protease 0.0688 0.2929 0.2927
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0048 0.0045
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Onchocerca volvulus Cathepsin L homolog 0.0688 0.2929 0.8473
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0118 0.0441 0.0438
Echinococcus granulosus survival motor neuron protein 1 0.0156 0.0608 0.0604
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0171 0.0674 0.0671
Entamoeba histolytica cysteine proteinase 2 0.0381 0.1588 0.4114
Brugia malayi Importin beta-1 subunit 0.0037 0.0085 0.0097
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0136 0.0519 0.0516
Loa Loa (eye worm) hypothetical protein 0.0209 0.0839 0.0997
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0023 0.0024 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0171 0.0674 0.0671
Trypanosoma brucei metacaspase MCA2 0.0115 0.0427 0.1383
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0138 0.0529 0.0526
Entamoeba histolytica cysteine proteinase, putative 0.0688 0.2929 0.764
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0171 0.0674 0.0799
Echinococcus multilocularis X box binding protein 1 0.0165 0.0644 0.064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Schistosoma mansoni hypothetical protein 0.0073 0.0244 0.024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0042 0.0108 0.0124
Echinococcus granulosus neutral alpha glucosidase AB 0.0079 0.0269 0.0265
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0023 0.0024 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Toxoplasma gondii cathepsin B 0.0717 0.3058 1
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0115 0.0427 0.0504
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Toxoplasma gondii aldehyde dehydrogenase 0.0412 0.1725 0.5634
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Schistosoma mansoni lipoxygenase 0.0136 0.0519 0.0516
Plasmodium vivax metacaspase 1, putative 0.0115 0.0427 0.1445
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Schistosoma mansoni hypothetical protein 0.1127 0.4848 0.4846
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Plasmodium vivax unspecified product 0.0381 0.1588 0.5416
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0083 0.0259
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0023 0.0024 0.0031
Echinococcus multilocularis expressed conserved protein 0.0077 0.0261 0.0257
Echinococcus granulosus Niemann Pick C1 protein 0.0082 0.0282 0.0279
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0041 0.0044
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0027 0.0043 0.0132
Brugia malayi beta-lactamase family protein 0.0093 0.0332 0.0392
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0065
Plasmodium vivax glutathione reductase, putative 0.0105 0.0382 0.1291
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0083 0.0288 0.0284
Schistosoma mansoni survival motor neuron protein 0.0032 0.0064 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1006 0.4318 0.4316
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0098 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0033 0.0071 0.008
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0412 0.1725 0.1722
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Brugia malayi cathepsin Z-like cysteine proteinase 0.0171 0.0674 0.0799
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0024 0.0021
Trypanosoma cruzi metacaspase, putative 0.0115 0.0427 0.0504
Schistosoma mansoni cathepsin F (C01 family) 0.0478 0.2015 0.2012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0048 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0138 0.0529 0.0526
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0083 0.0328
Brugia malayi CHE-14 protein 0.0035 0.0078 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0005 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Brugia malayi beta-lactamase 0.0093 0.0332 0.0392
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0171 0.0674 0.229
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0315 0.1301 0.1298
Brugia malayi fibroinase precursor 0.0171 0.0674 0.0799
Schistosoma mansoni alpha-glucosidase 0.0305 0.1257 0.1254
Loa Loa (eye worm) hypothetical protein 0.0117 0.0438 0.0518
Plasmodium vivax serine-repeat antigen (SERA) 0.0171 0.0674 0.229
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Toxoplasma gondii cathepsin CPL 0.0688 0.2929 0.9576
Loa Loa (eye worm) hypothetical protein 0.0478 0.2015 0.2399
Trichomonas vaginalis chromobox protein, putative 0.0028 0.0046 0.0121
Plasmodium falciparum serine repeat antigen 9 0.0171 0.0674 0.229
Mycobacterium ulcerans recombinase A 0.0085 0.0295 0.1501
Brugia malayi Papain family cysteine protease containing protein 0.0381 0.1588 0.189
Echinococcus granulosus beta LACTamase domain containing family member 0.0093 0.0332 0.0329
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0171 0.0674 0.0671
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0717 0.3058 0.7993
Giardia lamblia Fructose-bisphosphate aldolase 0.0893 0.3826 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0354 0.1473 0.147
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0259
Onchocerca volvulus 0.0032 0.0064 0.0148
Schistosoma mansoni ran 0.0027 0.0043 0.0039
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0079 0.0269 0.0316
Brugia malayi Fli-1 protein 0.0212 0.0851 0.1011
Trichomonas vaginalis chromobox protein, putative 0.0028 0.0046 0.0121
Schistosoma mansoni polycystin 1-related 0.0023 0.0024 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Loa Loa (eye worm) hypothetical protein 0.0034 0.0073 0.0082
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0231 0.0933 0.1108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0717 0.3058 0.3056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0339 0.0335
Toxoplasma gondii cathepsin CPC2 0.0171 0.0674 0.2193
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.0441 0.1152
Loa Loa (eye worm) beta-lactamase 0.0093 0.0332 0.0392
Plasmodium falciparum serine repeat antigen 4 0.0171 0.0674 0.229
Plasmodium vivax unspecified product 0.0171 0.0674 0.229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0093 0.0332 0.0546
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0035 0.0078 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Echinococcus multilocularis neutral alpha glucosidase AB 0.0079 0.0269 0.0265
Onchocerca volvulus 0.0205 0.082 0.2345
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0026 0.0039 0.0114
Loa Loa (eye worm) hypothetical protein 0.02 0.08 0.095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0053 0.0058
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.023 0.027
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Schistosoma mansoni glutaminase 0.0359 0.1492 0.1489
Loa Loa (eye worm) CXXC zinc finger family protein 0.0079 0.0271 0.0318
Schistosoma mansoni ap endonuclease 0.004 0.0098 0.0095
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0086 0.03 0.0296
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Schistosoma mansoni caspase-7 (C14 family) 0.0257 0.1047 0.1044
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0171 0.0674 0.1709
Trypanosoma brucei importin beta-1 subunit, putative 0.0037 0.0085 0.0265
Schistosoma mansoni alpha glucosidase 0.0079 0.0269 0.0265
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0083 0.0259
Treponema pallidum recombinase A 0.0085 0.0295 0.0713
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0103 0.0376 0.0373
Entamoeba histolytica cysteine proteinase, putative 0.0381 0.1588 0.4114
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Trichomonas vaginalis penicillin-binding protein, putative 0.0093 0.0332 0.0868
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0073 0.0244 0.024
Echinococcus granulosus cathepsin l1 0.0688 0.2929 0.2927
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0391 0.1633 0.1944
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0239 0.0967 0.1601
Mycobacterium leprae Probable lipase LipE 0.0093 0.0332 0.1487
Echinococcus granulosus transcription factor Dp 1 0.005 0.0142 0.0138
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0085 0.0295 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0033 0.0071 0.0219
Brugia malayi hypothetical protein 0.0023 0.0024 0.0024
Echinococcus granulosus mitogen activated protein kinase 3 0.0033 0.0071 0.0068
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0171 0.0674 0.229
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Loa Loa (eye worm) cysteine protease 0.0688 0.2929 0.349
Leishmania major importin beta-1 subunit, putative 0.003 0.0055 0.0166
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0118 0.0441 0.0438
Echinococcus multilocularis cathepsin L 0.0381 0.1588 0.1585
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0083 0.0218
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0171 0.0674 0.229
Mycobacterium ulcerans lipase LipD 0.0093 0.0332 0.1706
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0079 0.0269 0.0866
Brugia malayi MH2 domain containing protein 0.0103 0.0374 0.0442
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0098 0.0112
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0083 0.0271
Loa Loa (eye worm) hypothetical protein 0.0115 0.0427 0.0504
Brugia malayi hypothetical protein 0.0319 0.1318 0.1567
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0033 0.0071 0.008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0688 0.2929 0.349
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Plasmodium falciparum cysteine proteinase falcipain 1 0.0381 0.1588 0.5416
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0269 0.0702
Echinococcus multilocularis ubiquitin specific protease 41 0.0118 0.0441 0.0438
Echinococcus granulosus importin subunit beta 1 0.0037 0.0085 0.0082
Mycobacterium ulcerans putative regulatory protein 0.0026 0.0038 0.0078
Echinococcus multilocularis transfer RNA-Lys 0.0026 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0171 0.0674 0.1761
Echinococcus multilocularis survival motor neuron protein 1 0.0156 0.0608 0.0604
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0265 0.1083 0.1795
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0027 0.0043 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0688 0.2929 0.349
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0441 0.0521
Echinococcus granulosus RUN 0.0023 0.0024 0.0021
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0265 0.1083 0.1795
Brugia malayi hypothetical protein 0.0156 0.0608 0.072
Plasmodium falciparum metacaspase 1 0.0115 0.0427 0.1445
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Leishmania major trypanothione reductase 0.0105 0.0382 0.1237
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Brugia malayi Cytochrome P450 family protein 0.0035 0.0076 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Schistosoma mansoni hypothetical protein 0.0073 0.0244 0.024
Mycobacterium tuberculosis Conserved protein 0.0093 0.0332 0.0546
Leishmania major hypothetical protein, conserved 0.004 0.01 0.0314
Brugia malayi Bromodomain containing protein 0.0034 0.0073 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0098 0.0194
Loa Loa (eye worm) hypothetical protein 0.0478 0.2015 0.2399
Plasmodium vivax serine-repeat antigen (SERA) 0.0171 0.0674 0.229
Entamoeba histolytica cysteine proteinase, putative 0.0381 0.1588 0.4114
Mycobacterium leprae conserved hypothetical protein 0.0093 0.0332 0.1487
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0069
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.0125
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.0093
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1395 0.6017 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0381 0.1588 0.1585
Echinococcus granulosus sterol regulatory element binding protein 0.0035 0.0078 0.0075
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0427 0.1383
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0023 0.0024 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.2015 0.5236
Trypanosoma brucei Metacaspase-4 0.0115 0.0427 0.1383
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0118 0.0441 0.1096
Brugia malayi Doublecortin family protein 0.0023 0.0024 0.0024
Brugia malayi glutathione reductase 0.0105 0.0382 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0083 0.0271
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0171 0.0674 0.229
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0171 0.0674 0.1709
Echinococcus multilocularis cpg binding protein 0.0085 0.0298 0.0294
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0688 0.2929 1
Echinococcus granulosus neuropeptide receptor A26 0.0316 0.1307 0.1303
Leishmania major alpha glucosidase II subunit, putative 0.0079 0.0269 0.0866
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0118 0.0441 0.143
Loa Loa (eye worm) cathepsin B 0.0717 0.3058 0.3645
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Loa Loa (eye worm) hypoxia-induced factor 1 0.0108 0.0398 0.0471
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0688 0.2929 0.2927
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0093 0.0332 0.0546
Brugia malayi Heterochromatin protein 1 0.0046 0.0126 0.0146
Brugia malayi RNA binding protein 0.0042 0.0108 0.0124
Trichomonas vaginalis glutaminase, putative 0.0359 0.1492 0.3899
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0027 0.0043 0.0127
Brugia malayi cathepsin F-like cysteine proteinase 0.0171 0.0674 0.0799
Echinococcus multilocularis microtubule associated protein 2 0.2307 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 85 nM BindingDB_Patents: Binding Assay. The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labeled PAR1 agonist known from the literature at the PAR1 receptor (Ho-Sam Ahn, Mol Pharm, 51:350-356, 1997).The human PAR1 receptor was expressed transiently in High Five insect cells. From these cells, after 48 hours, a membrane preparation was produced by standard methods, aliquoted into 10 mM Tris-HCl; 0.3 mM EDTA; 1 mM EGTA; 250 mM sucrose pH 7.5, and stored at -80 C.The substances were preincubated with the membrane at RT for 15 minutes, then the radioligand (ALA-(para-F-Phe)-Arg-ChA-homoArg-(3,4-3H-Tyr)-NH2; approx. 40 Ci/mMol) was added. The end concentration of the radioligand in the test buffer (50 mM Tris-HCl; 10 mM MgCl2; 1 mM EGTA; 0.1% BSA; 2% DMSO) was 20 nM, that of the membrane 1 mg/ml. After an incubation time of 60 minutes, 25 uL of the mixture were transferred to a 96-well MultiScreenHTS FB microtiter filtration. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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