Detailed information for compound 1996714

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.415 | Formula: C19H17F4N3O4S
  • H donors: 1 H acceptors: 3 LogP: 3.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N2C[C@H](C[C@H]2CN1c1ccc(cc1)OC(F)(F)F)NS(=O)(=O)c1ccccc1F
  • InChi: 1S/C19H17F4N3O4S/c20-16-3-1-2-4-17(16)31(28,29)24-12-9-14-11-26(18(27)25(14)10-12)13-5-7-15(8-6-13)30-19(21,22)23/h1-8,12,14,24H,9-11H2/t12-,14-/m0/s1
  • InChiKey: OWTIXMFGKYOTLR-JSGCOSHPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lipase, hormone-sensitive Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus hormone sensitive lipase Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132840 All targets in OG5_132840
Echinococcus multilocularis hormone sensitive lipase Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum ko:K07188 hormone-sensitive lipase [EC3.1.1.79], putative Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum Hormone-sensitive lipase, putative Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum Hormone-sensitive lipase, putative Get druggable targets OG5_132840 All targets in OG5_132840
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0392 0.1629
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0232 0.0949
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0232 0.0949
Echinococcus multilocularis caspase 0.0138 0.3601 0.3595
Echinococcus multilocularis bloom syndrome protein 0.0054 0.12 0.1191
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0019 0.0035
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0169 0.4467 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.1459 0.1459
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0392 0.1505
Giardia lamblia DNA damage repair protein 0.0019 0.0232 0.0235
Leishmania major DNA polymerase eta, putative 0.005 0.1086 0.4104
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0019 0.0035
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.1163 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0553 0.232
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0035
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0464 0.0479
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0392 0.3308
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1124 0.4758
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0392 0.1629
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0035
Trypanosoma brucei unspecified product 0.0043 0.0907 0.3832
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.6865 0.6865
Echinococcus multilocularis caspase 2 0.0101 0.2544 0.2537
Trypanosoma brucei metacaspase 5, putative 0.0052 0.1163 0.4926
Brugia malayi hypothetical protein 0.0049 0.1061 0.4148
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0052 0.1163 0.1163
Entamoeba histolytica recQ family helicase, putative 0.0029 0.0492 0.0519
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0647 0.5561
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0345 0.9479 1
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0647 0.0637
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1163 0.1218
Schistosoma mansoni caspase-3 (C14 family) 0.0138 0.3601 0.3601
Trypanosoma cruzi DNA polymerase eta, putative 0.0093 0.2313 0.984
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0308 0.0298
Echinococcus multilocularis hormone sensitive lipase 0.0253 0.6865 0.6862
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0035
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0492 0.206
Trichomonas vaginalis DNA helicase recq1, putative 0.0054 0.12 0.1257
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0392 0.0382
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0019 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0009
Echinococcus multilocularis dna polymerase kappa 0.0094 0.2351 0.2343
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0464 0.0479
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0019 0.0035
Echinococcus multilocularis dna polymerase eta 0.0093 0.2313 0.2306
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0019 0.0009
Echinococcus granulosus caspase 8 0.0052 0.1163 0.1154
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Brugia malayi Bloom's syndrome protein homolog 0.0054 0.12 0.4696
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.1163 1
Schistosoma mansoni ran 0.0025 0.0392 0.0392
Echinococcus granulosus caspase 2 0.0101 0.2544 0.2537
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.007 0.1681 0.0735
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0019 0.0019
Brugia malayi ecdysteroid receptor 0.0012 0.0019 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0345 0.9479 1
Plasmodium falciparum metacaspase 1 0.0052 0.1163 1
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.001 0.5
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0492 0.1249
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.2313 0.2306
Echinococcus multilocularis caspase 8 0.0052 0.1163 0.1154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0345 0.9479 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0345 0.9479 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0042 0.088 0.088
Trypanosoma brucei metacaspase 0.0052 0.1163 0.4926
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0232 0.0949
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0553 0.0573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0094 0.2351 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1163 0.1218
Plasmodium falciparum metacaspase-like protein 0.0052 0.1163 1
Trypanosoma brucei DNA polymerase eta, putative 0.0093 0.2313 0.984
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.001 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0035
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0308 0.0298
Schistosoma mansoni hypothetical protein 0.02 0.5361 0.5361
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0009
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0553 0.0584
Treponema pallidum fructose-bisphosphate aldolase 0.0345 0.9479 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.1163 0.4926
Loa Loa (eye worm) RecQ helicase 0.0054 0.12 0.1191
Trypanosoma brucei unspecified product 0.0086 0.213 0.9055
Brugia malayi Importin beta-1 subunit 0.0034 0.0647 0.2512
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1128 0.4777
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0232 0.0949
Brugia malayi Flap endonuclease-1 0.0031 0.0553 0.2143
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0019 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0009
Plasmodium falciparum importin beta, putative 0.0034 0.0647 0.5522
Entamoeba histolytica hypothetical protein 0.0012 0.001 0.0011
Giardia lamblia Fructose-bisphosphate aldolase 0.0345 0.9479 1
Trypanosoma brucei Metacaspase-4 0.0052 0.1163 0.4926
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0019 0.0019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.1459 0.1451
Chlamydia trachomatis DNA ligase 0.0012 0.001 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1163 0.1218
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Trypanosoma brucei metacaspase MCA3 0.0052 0.1163 0.4926
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0308 0.0298
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0232 0.1927
Trypanosoma cruzi DNA polymerase kappa, putative 0.0094 0.2351 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0052 0.1163 0.455
Leishmania major metacaspase, putative 0.0052 0.1163 0.4473
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0308 0.0298
Schistosoma mansoni hypothetical protein 0.0049 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0009
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.001 0.0088
Mycobacterium ulcerans hypothetical protein 0.0019 0.0232 0.0498
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0232 0.0949
Brugia malayi steroid hormone receptor 0.0012 0.0019 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0019 0.0035
Trichomonas vaginalis DNA helicase recq, putative 0.0054 0.12 0.1257
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0019 0.0019
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.1459 0.1459
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.6865 0.6865
Leishmania major importin beta-1 subunit, putative 0.0028 0.0464 0.1113
Mycobacterium ulcerans DNA polymerase IV 0.0094 0.2351 0.5252
Leishmania major DNA polymerase kappa, putative 0.007 0.1681 0.6959
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.6865 0.6865
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.1086 0.4598
Echinococcus granulosus geminin 0.02 0.5361 0.5356
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0169 0.4467 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.0019 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0052 0.1163 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.2544 0.2537
Echinococcus multilocularis apoptotic protease activating factor 1 0.0049 0.1061 0.1052
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0553 0.0573
Schistosoma mansoni hypothetical protein 0.0364 1 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0019 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0308 0.2645
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1128 0.4777
Schistosoma mansoni coup transcription factor 0.0012 0.0019 0.0019
Schistosoma mansoni caspase-7 (C14 family) 0.0101 0.2544 0.2544
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0308 0.1174
Entamoeba histolytica hypothetical protein 0.0042 0.0886 0.0935
Brugia malayi ImpB/MucB/SamB family protein 0.0093 0.2313 0.9089
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.1459 0.1451
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.1459 0.154
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0464 0.1939
Echinococcus granulosus hormone sensitive lipase 0.0253 0.6865 0.6862
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0169 0.4467 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.1459 0.5719
Entamoeba histolytica hypothetical protein 0.0042 0.0886 0.0935
Trypanosoma brucei unspecified product 0.0043 0.0907 0.3832
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0492 0.206
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0232 0.0949
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0138 0.3601 0.3595
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0392 0.1629
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0345 0.9479 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Onchocerca volvulus 0.0049 0.1061 0.4148
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0364 1 1
Schistosoma mansoni importin beta-1 0.0034 0.0647 0.0647
Brugia malayi nuclear hormone receptor 0.0012 0.0019 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0094 0.2351 1
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0232 0.0949
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0036 0.0696 0.5982
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1163 0.1218
Trypanosoma cruzi metacaspase, putative 0.0052 0.1163 0.4926
Brugia malayi polk-prov protein 0.0051 0.1124 0.4394
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0553 0.0544
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0036 0.0708 0.6052
Schistosoma mansoni caspase-7 (C14 family) 0.0138 0.3601 0.3601
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0308 0.2645
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Trypanosoma brucei DNA polymerase IV, putative 0.0086 0.213 0.9055
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0647 0.0637
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0019 0.0019
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.1016 0.8721
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0647 0.272
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.007 0.1681 0.6959
Echinococcus granulosus importin subunit beta 1 0.0034 0.0647 0.0637
Schistosoma mansoni DNA polymerase eta 0.0093 0.2313 0.2313
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0232 0.1927
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.001 0.001
Schistosoma mansoni DNA helicase recq5 0.0022 0.0308 0.0308
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0392 0.0382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0009
Trypanosoma cruzi metacaspase, putative 0.0052 0.1163 0.4926
Brugia malayi Cell death protein 3 precursor 0.0101 0.2544 1
Schistosoma mansoni ran 0.0025 0.0392 0.0392
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0345 0.9479 1
Echinococcus granulosus dna polymerase kappa 0.0094 0.2351 0.2343
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.1681 0.7136
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0553 0.4756
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0232 0.1998
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Echinococcus multilocularis caspase 3 0.0086 0.2118 0.211
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0345 0.9479 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0035
Entamoeba histolytica Ran family GTPase 0.0025 0.0392 0.0413
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0019 0.0009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0009
Plasmodium vivax metacaspase 1, putative 0.0052 0.1163 1
Schistosoma mansoni topbp1 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0009
Echinococcus granulosus caspase 3 0.0086 0.2118 0.211
Loa Loa (eye worm) hypothetical protein 0.0163 0.4302 0.4296
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0019 0.0009
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0138 0.3601 0.3595
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0886 0.0877
Mycobacterium ulcerans DNA polymerase IV 0.0094 0.2351 0.5252
Echinococcus granulosus flap endonuclease 1 0.0031 0.0553 0.0544
Entamoeba histolytica hypothetical protein 0.0028 0.0464 0.049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0647 0.272
Echinococcus granulosus apoptotic protease activating factor 1 0.0049 0.1061 0.1052
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0392 0.0382
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0019 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0009
Echinococcus granulosus dna polymerase eta 0.0093 0.2313 0.2306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0345 0.9479 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0049 0.1061 0.1052
Leishmania major GTP-binding protein, putative 0.0025 0.0392 0.0765
Leishmania major DNA polymerase eta, putative 0.0093 0.2313 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.001 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0886 0.0877
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0094 0.2351 0.2472
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0035
Trichomonas vaginalis ran, putative 0.0025 0.0392 0.0403
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0019 0.0019
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0553 0.232
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0553 0.1542
Schistosoma mansoni hypothetical protein 0.02 0.5361 0.5361
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1163 0.1218
Schistosoma mansoni DNA helicase recq1 0.0022 0.0308 0.0308
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0009
Plasmodium falciparum flap endonuclease 1 0.0031 0.0553 0.471
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0392 0.3367
Echinococcus granulosus caspase 0.0138 0.3601 0.3595
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0345 0.9479 1
Plasmodium vivax importin-beta 2, putative 0.0034 0.0647 0.5522
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0886 0.0886
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0232 0.0949
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0232 0.0232
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0464 0.0479
Loa Loa (eye worm) hypothetical protein 0.0253 0.6865 0.6862
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0035
Trypanosoma cruzi metacaspase, putative 0.0052 0.1163 0.4926
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0019 0.0009
Onchocerca volvulus 0.0012 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0009
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.1163 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1163 0.1218
Entamoeba histolytica hypothetical protein 0.0042 0.0886 0.0935
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.1459 0.1451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0009
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0553 0.0544
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0232 0.0949
Schistosoma mansoni DNA ligase IV 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0009
Echinococcus multilocularis snurportin 1 0.0364 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0019 0.0035
Toxoplasma gondii ImpB/MucB/SamB family protein 0.005 0.1086 0.934
Brugia malayi hypothetical protein 0.0042 0.0886 0.3457
Echinococcus granulosus bloom syndrome protein 0.0054 0.12 0.1191
Echinococcus multilocularis geminin 0.02 0.5361 0.5356
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0009
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0308 0.0298
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0027 0.0454 0.3899
Trichomonas vaginalis DNA polymerase eta, putative 0.0094 0.2351 0.2472
Trypanosoma cruzi DNA polymerase kappa, putative 0.0094 0.2351 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0345 0.9479 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0492 0.0509
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0019 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0019 0.0019
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0308 0.1174
Trypanosoma brucei metacaspase MCA2 0.0052 0.1163 0.4926
Entamoeba histolytica hypothetical protein 0.0042 0.0886 0.0935
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0035
Trypanosoma cruzi metacaspase, putative 0.0052 0.1163 0.4926
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0035
Schistosoma mansoni hypothetical protein 0.0042 0.0886 0.0886
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1128 0.4777
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1124 0.4758
Loa Loa (eye worm) hypothetical protein 0.0051 0.1124 0.1115
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.1163 0.4926
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.2351 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.1163 0.1218
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0009
Schistosoma mansoni flap endonuclease-1 0.0028 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0022 0.0308 0.0298
Trypanosoma brucei DNA polymerase IV, putative 0.0094 0.2351 1
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0553 0.471
Onchocerca volvulus Cell death protein 3 homolog 0.0101 0.2544 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0019 0.0019
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0392 0.0403
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0308 0.258
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0392 0.3308
Trypanosoma brucei DNA polymerase IV, putative 0.0094 0.2351 1
Schistosoma mansoni topbp1 0.0012 0.001 0.001
Giardia lamblia DINP protein human, muc B family 0.007 0.1681 0.1764
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0308 0.0314
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0009
Brugia malayi RNA, U transporter 1 0.0097 0.2429 0.9545
Loa Loa (eye worm) hypothetical protein 0.0052 0.1163 0.1154

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 222 nM BindingDB_Patents: Colorimetric Assay. Human hormone-sensitive lipase (HSL) enzyme assay: HSL enzyme activity was measured by a colorimetic assay. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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