Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0036 | 0.0101 | 0.0055 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.019 | 0.0338 |
Brugia malayi | hypoxia-induced factor 1 | 0.0152 | 0.0677 | 0.2837 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.0049 | 0.0207 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.0286 | 0.051 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.0089 | 0.0372 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0209 | 0.0876 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0672 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0918 | 0.4484 | 0.7988 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.2027 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0.0101 | 0.0101 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.1197 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0011 | 0.002 |
Brugia malayi | MH2 domain containing protein | 0.0269 | 0.1257 | 0.5266 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0101 | 0.0425 |
Echinococcus multilocularis | peregrin | 0.0034 | 0.0089 | 0.0158 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.1025 |
Echinococcus granulosus | smad | 0.0018 | 0.0011 | 0.002 |
Mycobacterium ulcerans | hypothetical protein | 0.0298 | 0.1401 | 0.1401 |
Schistosoma mansoni | apoferritin-2 | 0.002 | 0.0018 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.2388 | 1 |
Schistosoma mansoni | ferritin light chain | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | CXXC zinc finger family protein | 0.008 | 0.032 | 0.1341 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.002 | 0.002 | 0.0035 |
Schistosoma mansoni | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0089 | 0.0158 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0155 | 0.0276 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0152 | 0.0677 | 0.2837 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0268 | 0.1124 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0089 | 0.1311 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0011 | 0.002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.013 | 0.0231 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0298 | 0.1401 | 0.1401 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.0286 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0772 | 0.3232 |
Schistosoma mansoni | cpg binding protein | 0.008 | 0.032 | 0.057 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.013 | 0.0231 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0011 | 0.002 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.0772 | 0.3232 |
Loa Loa (eye worm) | histone methyltransferase | 0.0025 | 0.0044 | 0.0184 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.2027 | 1 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0101 | 0.0181 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.0124 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0502 | 0.2104 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.2027 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0052 | 0.0179 | 0.1551 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.0472 | 0.1978 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.002 | 0.0035 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.002 | 0.002 | 0.0035 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.002 | 0.0018 | 0.0018 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0151 | 0.0672 | 0.9913 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0089 | 0.1311 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0101 | 0.0181 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0049 | 0.0857 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.1575 | 0.775 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.0179 | 0.2645 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0099 | 0.0413 | 0.0413 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0269 | 0.1257 | 0.5266 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Echinococcus multilocularis | Protein lozenge | 0.0062 | 0.023 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0741 | 0.3103 |
Schistosoma mansoni | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0171 | 0.0768 | 0.1369 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0011 | 0.002 |
Echinococcus multilocularis | ferritin | 0.002 | 0.0018 | 0.0032 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0099 | 0.0413 | 0.0413 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0132 | 0.0576 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0011 | 0.002 |
Echinococcus multilocularis | dnaJ subfamily B | 0.1145 | 0.5614 | 1 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.0286 | 0.12 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0099 | 0.0413 | 0.0736 |
Brugia malayi | Smad1 | 0.0018 | 0.0011 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.1145 | 0.5614 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.1197 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0046 | 0.0147 | 0.0262 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0152 | 0.0678 | 1 |
Echinococcus multilocularis | smad | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0286 | 0.12 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.0502 | 0.2104 |
Schistosoma mansoni | apoferritin-2 | 0.002 | 0.0018 | 0.0032 |
Echinococcus granulosus | Smad4 | 0.0018 | 0.0011 | 0.002 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.0049 | 0.0049 |
Schistosoma mansoni | lozenge | 0.0062 | 0.023 | 0.0409 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0036 | 0.0098 | 0.0408 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.0472 | 0.0841 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0269 | 0.1257 | 0.5266 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Brugia malayi | hypothetical protein | 0.0496 | 0.2388 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Schistosoma mansoni | smad | 0.0018 | 0.0011 | 0.002 |
Brugia malayi | Probable ClpP-like protease | 0.0151 | 0.0672 | 0.2814 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.0772 | 0.3232 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | 0.1583 | 0.7789 | 0.7789 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0089 | 0.0372 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0046 | 0.0147 | 0.0262 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0099 | 0.0413 | 0.0413 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.019 | 0.0794 |
Brugia malayi | RNA binding protein | 0.0074 | 0.0286 | 0.12 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0215 | 0.09 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0025 | 0.0044 | 0.0078 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0042 | 0.013 | 0.0544 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0049 | 0.0165 | 0.0294 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 0.775 |
Echinococcus multilocularis | expressed protein | 0.002 | 0.0018 | 0.0032 |
Schistosoma mansoni | single-minded | 0.0049 | 0.0165 | 0.0294 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0031 | 0.0075 | 0.0133 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0286 | 0.12 |
Echinococcus granulosus | peregrin | 0.0034 | 0.0089 | 0.0158 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0099 | 0.0413 | 0.0736 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0215 | 0.09 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.019 | 0.0338 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.0286 | 0.12 |
Brugia malayi | jmjC domain containing protein | 0.0046 | 0.0147 | 0.0616 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0151 | 0.0672 | 0.9913 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0089 | 0.0158 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.0472 | 0.0841 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Brugia malayi | PAS domain containing protein | 0.0049 | 0.0165 | 0.0691 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Mycobacterium leprae | Isocitrate lyase | 0.095 | 0.4645 | 0.4645 |
Echinococcus multilocularis | geminin | 0.039 | 0.186 | 0.3314 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.0772 | 0.3232 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0011 | 0.0048 |
Schistosoma mansoni | ferritin light chain | 0.002 | 0.0018 | 0.0032 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.019 | 0.0338 |
Chlamydia trachomatis | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Giardia lamblia | PHD finger protein 15 | 0.0034 | 0.0089 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0286 | 0.12 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | 0.1583 | 0.7789 | 0.7789 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.2388 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.8492 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0025 | 0.0044 | 0.0078 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.019 | 0.0794 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.002 | 0.0018 | 0.0018 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.002 | 0.0035 |
Mycobacterium ulcerans | error-prone DNA polymerase | 0.1575 | 0.775 | 0.775 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.0502 | 0.0895 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0089 | 0.0158 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0151 | 0.0672 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.013 | 0.0231 |
Echinococcus granulosus | dnaJ subfamily B | 0.1145 | 0.5614 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.0359 | 0.0639 |
Echinococcus multilocularis | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0672 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.002 | 0.0018 | 0.0018 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.019 | 0.0794 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0672 | 0.2814 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.019 | 0.0338 |
Echinococcus granulosus | geminin | 0.039 | 0.186 | 0.3314 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.186 | 0.3314 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0846 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0011 | 0.002 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.002 | 0.0018 | 0.0018 |
Brugia malayi | hypothetical protein | 0.0165 | 0.0741 | 0.3103 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.008 | 0.032 | 0.1341 |
Onchocerca volvulus | 0.0496 | 0.2388 | 1 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.019 | 0.0338 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0846 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0052 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0046 | 0.0147 | 0.0616 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0132 | 0.0576 | 0.1025 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0042 | 0.013 | 0.0544 |
Echinococcus granulosus | ferritin | 0.002 | 0.0018 | 0.0032 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0155 | 0.0276 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0011 | 0.0048 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0052 | 0.0179 | 0.0209 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.019 | 0.0338 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.013 | 0.0231 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0089 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0046 | 0.0147 | 0.0262 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0132 | 0.0576 | 0.1025 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0089 | 0.0158 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0011 | 0.002 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0052 | 0.0179 | 0.1551 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.2027 | 1 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0151 | 0.0672 | 0.1197 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.019 | 0.0794 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0151 | 0.0672 | 0.0672 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) | 0.1583 | 0.7789 | 0.7789 |
Trichomonas vaginalis | ferritin, putative | 0.002 | 0.0018 | 1 |
Loa Loa (eye worm) | runx1 | 0.0062 | 0.023 | 0.0963 |
Onchocerca volvulus | 0.008 | 0.032 | 0.1006 | |
Echinococcus granulosus | expressed protein | 0.002 | 0.0018 | 0.0032 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.002 | 0.0018 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.186 | 0.3314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0089 | 0.0372 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.2027 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0011 | 0.0048 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 100000 nM | BindingDB_Patents: Enzyme Assay. The aim of this study was to evaluate TK-112690 in vivo as an inhibitor of uridine phosphorylase (UPase) enzyme activity. The range of TK-112690 doses studied for ability to prevent metabolic breakdown of uridine, through the in vitro inhibition of mouse and human small intestinal UPase enzyme, was 0, 0.1, 0.5, 1, 5, 10, 50, 100, 500, 1000, 5000 and 10000 uM). Detection of UPase activity was determined by HPLC analysis using UV detection of uracil concentration (UPase catabolizes uridine into uracil and ribose-1-phosphate).The UPase enzyme material was prepared from homogenized mouse and human being small intestinal tissue. TK-112690 was dissolved in water (50 mg/ml) and analyzed for UPase inhibition in aqueous solution containing 5 mM uridine, 0.01 M Tris, 0.01 M phosphate, 1 mM EDTA, and 1 mM DTT. Reactions were performed at 37 C. at pH of 7.3.TK-11260 inhibition of mouse and human UPase was analyzed by reverse phase HPLC using UV detection. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.