Detailed information for compound 200386

Basic information

Technical information
  • TDR Targets ID: 200386
  • Name: (2S)-4-methyl-N-[2-oxo-3-[(4-phenoxyphenyl)su lfonylamino]propyl]-2-(3-phenylphenyl)pentana mide
  • MW: 570.698 | Formula: C33H34N2O5S
  • H donors: 2 H acceptors: 4 LogP: 6.46 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(CNS(=O)(=O)c1ccc(cc1)Oc1ccccc1)CNC(=O)[C@H](c1cccc(c1)c1ccccc1)CC(C)C
  • InChi: 1S/C33H34N2O5S/c1-24(2)20-32(27-13-9-12-26(21-27)25-10-5-3-6-11-25)33(37)34-22-28(36)23-35-41(38,39)31-18-16-30(17-19-31)40-29-14-7-4-8-15-29/h3-19,21,24,32,35H,20,22-23H2,1-2H3,(H,34,37)/t32-/m0/s1
  • InChiKey: CNLHZZCRCBTRHI-YTTGMZPUSA-N  


Substructure search Similarity search

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Synonyms

  • (2S)-N-[2-keto-3-[(4-phenoxyphenyl)sulfonylamino]propyl]-4-methyl-2-(3-phenylphenyl)valeramide
  • (2S)-4-methyl-N-[2-oxo-3-[[4-(phenoxy)phenyl]sulfonylamino]propyl]-2-(3-phenylphenyl)pentanamide
  • (2S)-N-[2-keto-3-[[4-(phenoxy)phenyl]sulfonylamino]propyl]-4-methyl-2-(3-phenylphenyl)valeramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus orexin receptor type 2 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.3311 0.7543
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.4286 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Schistosoma mansoni biogenic amine receptor 0.0055 0.2442 0.2442
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0728 0.0425
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0316 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Leishmania major cathepsin L-like protease 0.0086 0.4286 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin C 0.002 0.0316 0.0316
Schistosoma mansoni adenoreceptor 0.0055 0.2442 0.2442
Giardia lamblia Cathepsin B precursor 0.007 0.3311 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.2442 0.2442
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Echinococcus granulosus sex peptide receptor 0.0055 0.2442 0.2442
Brugia malayi Cathepsin L-like precursor 0.0086 0.4286 0.41
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Echinococcus multilocularis g protein coupled receptor 0.0055 0.2442 0.2442
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.2677 0.2438
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.1926 0.4054
Onchocerca volvulus 0.0086 0.4286 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0316 0.0316
Brugia malayi follicle stimulating hormone receptor 0.0055 0.2442 0.2195
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Toxoplasma gondii cathepsin B 0.007 0.3311 0.7543
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Brugia malayi Dopamine receptor protein 2 0.0055 0.2442 0.2195
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.3311 0.3311
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.2442 0.2442
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4286 0.41
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0316 0.0316
Onchocerca volvulus Cathepsin L homolog 0.0086 0.4286 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0316 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.2442 0.2442
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4286 0.41
Onchocerca volvulus 0.0055 0.2442 0.5353
Echinococcus multilocularis fmrfamide receptor 0.0055 0.2442 0.2442
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.3311 0.3093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Loa Loa (eye worm) cysteine protease 0.0086 0.4286 0.4286
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.2442 0.2195
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.2442 0.2442
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4286 0.41
Plasmodium vivax unspecified product 0.0027 0.0728 0.1037
Schistosoma mansoni neuropeptide receptor 0.0055 0.2442 0.2442
Schistosoma mansoni hypothetical protein 0.0055 0.2442 0.2442
Echinococcus multilocularis somatostatin receptor 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.2442 0.2442
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Leishmania major cysteine peptidase A (CPA) 0.0086 0.4286 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Brugia malayi neuropeptide F receptor 0.0055 0.2442 0.2195
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.2442 0.5353
Loa Loa (eye worm) hypothetical protein 0.0059 0.2677 0.2677
Brugia malayi G-protein coupled receptor 0.0055 0.2442 0.2195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.2442 0.2442
Schistosoma mansoni amine GPCR 0.0055 0.2442 0.2442
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.2442 0.2442
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.2442 0.2442
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Echinococcus multilocularis allatostatin A receptor 0.0055 0.2442 0.2442
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.2442 0.2442
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Echinococcus multilocularis sex peptide receptor 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.0052 0.2264 0.2264
Loa Loa (eye worm) hypothetical protein 0.002 0.0316 0.0316
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Schistosoma mansoni opsin-like receptor 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Echinococcus multilocularis cysteine protease 0.0086 0.4286 0.4286
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.2442 0.2442
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.2442 0.2442
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.2442 0.2442
Plasmodium vivax unspecified product 0.0047 0.1926 0.4054
Echinococcus multilocularis cathepsin b 0.0181 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4286 0.41
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.4286 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0728 0.0728
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine proteinase 2 0.0047 0.1926 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0728 0.0425
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.3311 0.5868
Brugia malayi Cathepsin L-like precursor 0.0027 0.0728 0.0425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.4286 0.4286
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.2442 0.2442
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0728 0.0425
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Brugia malayi GnHR receptor homolog 0.0055 0.2442 0.2195
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.4286 0.4286
Loa Loa (eye worm) ctsf protein 0.0086 0.4286 0.4286
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.2442 0.2442
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1926 0.1662
Loa Loa (eye worm) fibroinase 0.0086 0.4286 0.4286
Schistosoma mansoni opsin-like receptor 0.0055 0.2442 0.2442
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.2442 0.2442
Brugia malayi larval opioid receptor 0.0055 0.2442 0.2195
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.2442 0.2442
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.2442 0.2442
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Onchocerca volvulus 0.0055 0.2442 0.5353
Onchocerca volvulus 0.0086 0.4286 1
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1926 0.1662
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Echinococcus granulosus fmrfamide receptor 0.0055 0.2442 0.2442
Echinococcus granulosus neuropeptide receptor 0.0055 0.2442 0.2442
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.2442 0.2442
Leishmania major cathepsin L-like protease 0.0086 0.4286 1
Brugia malayi G protein-coupled receptor 0.0055 0.2442 0.2195
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.0055 0.2442 0.2442
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1926 0.1926
Schistosoma mansoni myosin xvIII 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0316 0.0316
Brugia malayi Serotonin receptor 0.0055 0.2442 0.2195
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.4286 0.4286
Brugia malayi Cathepsin L-like precursor 0.0086 0.4286 0.41
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.2442 0.2442
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.2677 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Onchocerca volvulus 0.0055 0.2442 0.5353
Echinococcus granulosus neuropeptide receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus cysteine protease 0.0047 0.1926 0.1926
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus multilocularis cathepsin L 0.002 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Echinococcus multilocularis cysteine protease 0.0086 0.4286 0.4286
Echinococcus granulosus cathepsin b 0.0181 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Brugia malayi G-protein coupled receptor 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Loa Loa (eye worm) hypothetical protein 0.002 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1926 0.4054
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.4286 0.4286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.4286 0.4286
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.1926 0.1926
Schistosoma mansoni neuropeptide receptor 0.0055 0.2442 0.2442
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.2442 0.2442
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.2442 0.2442
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.2677 0.2438
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.1926 0.4054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus g protein coupled receptor 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Leishmania major cathepsin L-like protease 0.0086 0.4286 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.4286 0.41
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.002 0.0316 0.0316
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Trypanosoma cruzi cysteine protease, putative 0.0047 0.1926 0.1662
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.2442 0.2442
Leishmania major cathepsin L-like protease 0.0086 0.4286 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.2442 0.2442
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.4286 1
Echinococcus multilocularis neuropeptide receptor 0.0055 0.2442 0.2442
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Onchocerca volvulus 0.0055 0.2442 0.5353
Onchocerca volvulus 0.0086 0.4286 1
Schistosoma mansoni biogenic amine receptor 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.2677 0.5946
Brugia malayi Cathepsin L-like precursor 0.0086 0.4286 0.41
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.4286 1
Plasmodium vivax vivapain-3 0.0047 0.1926 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.4286 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Brugia malayi AKH receptor 0.0055 0.2442 0.2195
Brugia malayi Cathepsin L-like precursor 0.0059 0.2677 0.2438
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1926 0.1662
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.1926 0.1662
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1926 0.1926
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.4286 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2677 0.5946
Schistosoma mansoni cathepsin s 0.0027 0.0728 0.0728
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.2442 0.2442
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Giardia lamblia Cathepsin B precursor 0.007 0.3311 1
Brugia malayi Dopamine receptor protein 1 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.2442 0.2442
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.2442 0.2195
Echinococcus multilocularis fmrfamide receptor 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Loa Loa (eye worm) hypothetical protein 0.0059 0.2677 0.2677
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.2442 0.2442
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0316 0.0316
Leishmania major cathepsin L-like protease 0.0086 0.4286 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.2442 0.2442
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.2442 0.2442
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Giardia lamblia Cathepsin B precursor 0.007 0.3311 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Brugia malayi Dopamine receptor 0.0055 0.2442 0.2195
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.2442 0.2442
Echinococcus granulosus allatostatin A receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2677 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.2442 0.2442
Brugia malayi Cathepsin L-like precursor 0.0086 0.4286 0.41
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.2442 0.2195
Echinococcus granulosus g protein coupled receptor 0.0055 0.2442 0.2442
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.0728 0.0425
Toxoplasma gondii cathepsin CPL 0.0086 0.4286 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Echinococcus granulosus cathepsin L 0.002 0.0316 0.0316
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Leishmania major cathepsin L-like protease 0.0086 0.4286 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0086 0.4286 1
Echinococcus multilocularis serotonin receptor 0.0055 0.2442 0.2442
Echinococcus multilocularis cathepsin L 0.0047 0.1926 0.1926
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.1926 0.1662
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0316 0.0316
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Onchocerca volvulus Cathepsin F homolog 0.0086 0.4286 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.4286 0.41
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.4286 0.4286
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1926 0.1926
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.2442 0.2442
Echinococcus multilocularis serotonin receptor 0.0055 0.2442 0.2442
Brugia malayi cathepsin L-like precursor 0.0059 0.2677 0.2438
Echinococcus granulosus hypothetical protein 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.3598 0.3598
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.2442 0.2442
Echinococcus multilocularis g protein coupled receptor 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Echinococcus granulosus cathepsin b 0.0181 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0086 0.4286 1
Brugia malayi Melatonin receptor type 1A 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Onchocerca volvulus 0.0055 0.2442 0.5353
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.2442 0.5353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.2442 0.2442
Echinococcus granulosus cathepsin l1 0.0059 0.2677 0.2677
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.4286 0.4286
Loa Loa (eye worm) cathepsin B 0.007 0.3311 0.3311
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0316 0.0316
Schistosoma mansoni amine GPCR 0.0055 0.2442 0.2442
Brugia malayi Cathepsin L-like precursor 0.0086 0.4286 0.41
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0027 0.0728 0.0728
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 1 1
Schistosoma mansoni amine GPCR 0.0055 0.2442 0.2442
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0728 0.0728
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.4286 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.4286 1
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1926 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Schistosoma mansoni hypothetical protein 0.0055 0.2442 0.2442
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.002 0.0316 0.0316
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.2442 0.2442
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.4286 0.4286
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine protease, putative 0.0086 0.4286 1
Echinococcus granulosus cathepsin l1 0.0086 0.4286 0.4286
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.2442 0.2442
Onchocerca volvulus Cathepsin L homolog 0.0086 0.4286 1
Schistosoma mansoni hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0316 0.0316
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1926 0.4054
Schistosoma mansoni amine GPCR 0.0055 0.2442 0.2442
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.2442 0.2195
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.4286 0.4286
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.3598 0.3598
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0316 0.0316
Schistosoma mansoni neuropeptide receptor 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0086 0.4286 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.2442 0.2442
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.4286 0.4286
Echinococcus multilocularis neuropeptide receptor 0.0055 0.2442 0.2442
Echinococcus granulosus somatostatin receptor 0.0055 0.2442 0.2442
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.2442 0.2442
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.2442 0.2442
Brugia malayi Serotonin receptor 0.0055 0.2442 0.2195
Brugia malayi neuropeptide F receptor 0.0055 0.2442 0.2195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Echinococcus granulosus cathepsin L 0.0047 0.1926 0.1926
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 1 1
Onchocerca volvulus 0.0055 0.2442 0.5353
Echinococcus multilocularis cathepsin b 0.0181 1 1
Brugia malayi RE15519p 0.0055 0.2442 0.2195
Onchocerca volvulus 0.0055 0.2442 0.5353
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.2442 0.2442
Plasmodium vivax vivapain-2 0.0086 0.4286 1
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Brugia malayi ORL1-like opioid receptor 0.0055 0.2442 0.2195
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.4286 0.4286
Echinococcus multilocularis g protein coupled receptor 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4286 1
Brugia malayi putative neuropeptide receptor 0.0055 0.2442 0.2195
Echinococcus granulosus g-protein coupled receptor 0.0055 0.2442 0.2442
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Plasmodium vivax vivapain-2 0.0086 0.4286 1
Schistosoma mansoni biogenic amine receptor 0.0055 0.2442 0.2442
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine protease, putative 0.0047 0.1926 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1926 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Echinococcus multilocularis orexin receptor type 2 0.0055 0.2442 0.2442
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.2442 0.2442
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.2442 0.2442
Schistosoma mansoni amine GPCR 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0316 0.0316
Schistosoma mansoni opsin-like receptor 0.0055 0.2442 0.2442
Leishmania major cathepsin L-like protease 0.0086 0.4286 1
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0181 1 1
Onchocerca volvulus 0.0059 0.2677 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1926 0.4054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.2442 0.2442
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.002 0.0316 0.0316
Brugia malayi hypothetical protein 0.0055 0.2442 0.2195
Plasmodium vivax vivapain-1 0.0047 0.1926 0.4054
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.2442 0.2442
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.2677 0.2677
Echinococcus granulosus g protein coupled receptor 0.0055 0.2442 0.2442
Echinococcus granulosus neuropeptide s receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.2442 0.2195
Loa Loa (eye worm) hypothetical protein 0.002 0.0316 0.0316
Brugia malayi sulfakinin receptor protein 0.0055 0.2442 0.2195
Schistosoma mansoni neuropeptide receptor 0.0055 0.2442 0.2442
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1926 0.4054
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0316 0.0316
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.2442 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4286 1
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Loa Loa (eye worm) hypothetical protein 0.0027 0.0728 0.0728
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Echinococcus granulosus serotonin receptor 0.0055 0.2442 0.2442
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.2442 0.2442
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.2442 0.2442
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.2442 0.2442
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0055 0.2442 0.5353
Leishmania major cathepsin L-like protease 0.0086 0.4286 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4286 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0059 0.2677 0.2677
Schistosoma mansoni histamine h1 receptor 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.2442 0.2442
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.2442 0.2442
Loa Loa (eye worm) hypothetical protein 0.0055 0.2442 0.2442
Onchocerca volvulus 0.0086 0.4286 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1926 0.4054

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.4 nM The apparent binding affinity against cathepsin K. ChEMBL. 10669559
Ki (binding) = 0.91 uM The apparent binding affinity against cathepsin S. ChEMBL. 10669559
Ki (binding) > 1 uM The apparent binding affinity against cathepsin L. ChEMBL. 10669559
Ki (binding) > 10 uM The apparent binding affinity against cathepsin B. ChEMBL. 10669559
Ki app (binding) = 1.4 nM The apparent binding affinity against cathepsin K. ChEMBL. 10669559
Ki app (binding) = 0.91 uM The apparent binding affinity against cathepsin S. ChEMBL. 10669559
Ki app (binding) > 1 uM The apparent binding affinity against cathepsin L. ChEMBL. 10669559
Ki app (binding) > 10 uM The apparent binding affinity against cathepsin B. ChEMBL. 10669559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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