Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0178 | 0.5983 | 0.5983 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.5983 | 0.5983 |
Schistosoma mansoni | titin | 0.0178 | 0.5983 | 0.5983 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0178 | 0.5983 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0178 | 0.5983 | 0.5983 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | myotactin form B | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0178 | 0.5983 | 0.5983 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0178 | 0.5983 | 0.5983 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0178 | 0.5983 | 0.5983 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0178 | 0.5983 | 0.5983 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0178 | 0.5983 | 0.5983 |
Brugia malayi | protein unc-22 | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.5983 | 0.5983 |
Schistosoma mansoni | ephrin receptor | 0.023 | 1 | 1 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Brugia malayi | myotactin form A | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0178 | 0.5983 | 0.5983 |
Schistosoma mansoni | hemicentin | 0.0178 | 0.5983 | 0.5983 |
Brugia malayi | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Brugia malayi | SPRY domain containing protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0178 | 0.5983 | 0.5983 |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0178 | 0.5983 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Brugia malayi | Lethal protein 805 | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Lethal protein 805 | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | UNCoordinated family member | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | titin | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | lethal protein 805 | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | myosin-binding protein-related | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | tripartite motif protein trim9 | 0.0178 | 0.5983 | 0.5983 |
Schistosoma mansoni | nephrin | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | neuroglian | 0.0178 | 0.5983 | 0.5983 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0178 | 0.5983 | 0.5983 |
Schistosoma mansoni | cell adhesion molecule | 0.0178 | 0.5983 | 0.5983 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Loa Loa (eye worm) | projectin | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | nephrin | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | myotactin form A | 0.0178 | 0.5983 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.023 | 1 | 1 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.5983 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5983 | 0.5 | |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0178 | 0.5983 | 0.5983 |
Schistosoma mansoni | titin | 0.0178 | 0.5983 | 0.5983 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5983 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0178 | 0.5983 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.0178 | 0.5983 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 111 uM | Cytostatic concentration of the compound required to reduce MT-4 cell viability in mock-infected cell cultures | ChEMBL. | 15189038 |
CC50 (functional) | = 178 uM | Cytostatic concentration of the compound required to inhibit proliferation of CEM cells | ChEMBL. | 15189038 |
EC50 (functional) | = 0.16 uM | Anti-HIV activity of the compound against PFA-resistant mutant HIV-1W88G strain in P4/R5 cells | ChEMBL. | 15189038 |
EC50 (functional) | = 0.3 uM | Anti-HIV activity of the compound against PFA-resistant mutant HIV-1(LAI) strain in P4/R5 cells | ChEMBL. | 15189038 |
EC50 (functional) | = 0.47 uM | Effective concentration of the compound required to inhibit HIV-1 induced cytopathicity in human CEM cell lines | ChEMBL. | 15189038 |
EC50 (functional) | = 0.82 uM | Effective concentration of the compound required to inhibit HIV-1 induced cytopathicity in human MT-4 cell lines | ChEMBL. | 15189038 |
EC50 (functional) | > 50 uM | Effective concentration of the compound required to inhibit HIV-2 induced cytopathicity in human MT-4 cell lines | ChEMBL. | 15189038 |
EC50 (functional) | > 50 uM | Effective concentration of the compound required to inhibit HIV-2 induced cytopathicity in human CEM cell lines | ChEMBL. | 15189038 |
EC50 (functional) | >= 50 uM | Effective concentration of the compound required to inhibit HIV-1E138K induced cytopathicity in human MT-4 cell lines | ChEMBL. | 15189038 |
IC50 (binding) | = 3.7 uM | Inhibitory concentration against wild type HIV-1 reverse transcriptase (RT) using poly rC.dG as the template or primer | ChEMBL. | 15189038 |
IC50 (binding) | = 437 uM | Inhibitory concentration against wild type HIV-1/138Lys reverse transcriptase (RT) using [3H]-dGTP as a radioligand | ChEMBL. | 15189038 |
logP (ADMET) | = 0.63 | Partition coefficient (logP) | ChEMBL. | 15189038 |
Ratio (functional) | = 0.53 | Fold-R is the ratio of EC50 of mutant HIV-1W88G to the average EC50 of HIV-1(LAI) | ChEMBL. | 15189038 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.