Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | 6-phosphogluconate dehydrogenase, decarboxylating | Starlite/ChEMBL | References |
Homo sapiens | phosphogluconate dehydrogenase | Starlite/ChEMBL | References |
Trypanosoma brucei | 6-phosphogluconate dehydrogenase, decarboxylating | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | 6-phosphogluconate dehydrogenase, decarboxylating | 483 aa | 469 aa | 69.5 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 330 uM | Antitrypanosomal activity against Trypanosoma brucei BS427 after 48 hrs by Alamar blue assay | ChEMBL. | 20666371 |
IC50 (functional) | > 111 uM | In vitro antiparasitic activity was determined against Leishmania donovani | ChEMBL. | 15189039 |
IC50 (functional) | > 111 uM | In vitro antiparasitic activity was determined against Leishmania donovani | ChEMBL. | 15189039 |
IC50 (functional) | > 184 uM | In vitro antiparasitic activity was determined against Plasmodium falciparum | ChEMBL. | 15189039 |
IC50 (functional) | > 184 uM | In vitro antiparasitic activity was determined against Plasmodium falciparum | ChEMBL. | 15189039 |
IC50 (functional) | > 332 uM | In vitro antiparasitic activity was determined against Trypanosoma brucei | ChEMBL. | 15189039 |
IC50 (functional) | > 332 uM | In vitro antiparasitic activity was determined against Trypanosoma cruzi | ChEMBL. | 15189039 |
IC50 (functional) | > 332 uM | In vitro cytotoxic activity of the compound was determined against L6 cells | ChEMBL. | 15189039 |
IC50 (functional) | > 332 uM | In vitro antiparasitic activity was determined against Trypanosoma brucei | ChEMBL. | 15189039 |
IC50 (functional) | > 332 uM | In vitro antiparasitic activity was determined against Trypanosoma cruzi | ChEMBL. | 15189039 |
IC50 (binding) | = 3000 uM | Inhibition of Francisella tularensis N-terminal hexahistidine-tagged arabinose phosphate isomerase expressed in Escherichia coli BL21(DE3) after 3 hrs | ChEMBL. | 21236668 |
Ki (binding) | = 0.035 uM | Inhibition constant against 6-phosphogluconate dehydrogenase of Trypanosoma brucei expressed in Escherichia coli | ChEMBL. | 15189039 |
Ki (binding) | = 0.035 uM | Inhibition constant against 6-phosphogluconate dehydrogenase of Trypanosoma brucei expressed in Escherichia coli | ChEMBL. | 15189039 |
Ki (binding) | = 0.035 uM | Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase | ChEMBL. | 21236668 |
Ki (binding) | = 1.1 uM | Inhibition constant against 6-phosphogluconate dehydrogenase of sheep liver | ChEMBL. | 15189039 |
Ki (binding) | = 1.1 uM | Inhibition constant against 6-phosphogluconate dehydrogenase of sheep liver | ChEMBL. | 15189039 |
Ki (binding) | = 1.1 uM | Inhibition of sheep 6PGDH expressed in Escherichia coli by spectroscopy | ChEMBL. | 20598892 |
Ki (binding) | = 1.1 uM | Inhibition of sheep 6PGDH | ChEMBL. | 20666371 |
Ratio (binding) | = 31.4 | Selectivity ratio of inhibition constant of compound against 6-phosphogluconate dehydrogenase of sheep to 6-phosphogluconate dehydrogenase of trypanosoma brucei | ChEMBL. | 15189039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.