Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0312 | 0.2106 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0176 | 0.0656 | 0.0656 |
Echinococcus multilocularis | cysteine protease | 0.0312 | 0.2106 | 0.2062 |
Onchocerca volvulus | 0.0219 | 0.1117 | 0.4276 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Brugia malayi | Cathepsin L-like precursor | 0.0312 | 0.2106 | 0.2106 |
Brugia malayi | cathepsin L-like precursor | 0.0219 | 0.1117 | 0.1117 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1057 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0312 | 0.2106 | 0.1552 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0219 | 0.1117 | 0.1117 |
Brugia malayi | Trypsin family protein | 0.0149 | 0.0379 | 0.0379 |
Echinococcus multilocularis | cathepsin b | 0.1057 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0312 | 0.2106 | 0.592 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0209 | 0.1007 | 0.0376 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0209 | 0.1007 | 0.2421 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.1117 | 0.1117 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0119 | 0.0055 | 0.0055 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0468 | 0.3754 | 0.3754 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0312 | 0.2106 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Loa Loa (eye worm) | cathepsin B | 0.0384 | 0.2863 | 0.2863 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.1117 | 0.1117 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.2106 | 0.2106 |
Leishmania major | cathepsin L-like protease | 0.0312 | 0.2106 | 0.592 |
Brugia malayi | Cathepsin L-like precursor | 0.0312 | 0.2106 | 0.2106 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0312 | 0.2106 | 0.2106 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Onchocerca volvulus | 0.0312 | 0.2106 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0384 | 0.2863 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0209 | 0.1007 | 0.0958 |
Giardia lamblia | Cathepsin B precursor | 0.0384 | 0.2863 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0384 | 0.2863 | 1 |
Toxoplasma gondii | cathepsin B | 0.0384 | 0.2863 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0209 | 0.1007 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0209 | 0.1007 | 0.0958 |
Leishmania major | cathepsin L-like protease | 0.0312 | 0.2106 | 0.592 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Plasmodium vivax | RNA helicase-1, putative | 0.0209 | 0.1007 | 0.2421 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1057 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Entamoeba histolytica | cysteine protease, putative | 0.0312 | 0.2106 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0384 | 0.2863 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0209 | 0.1007 | 0.1591 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0312 | 0.2106 | 0.2062 |
Onchocerca volvulus | Cathepsin F homolog | 0.0312 | 0.2106 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0176 | 0.0656 | 0.0656 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.0379 | 0.0379 |
Onchocerca volvulus | 0.0312 | 0.2106 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.1117 | 0.1117 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0209 | 0.1007 | 0.0958 |
Loa Loa (eye worm) | fibroinase | 0.0312 | 0.2106 | 0.2106 |
Echinococcus multilocularis | cathepsin L | 0.0176 | 0.0656 | 0.0605 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Onchocerca volvulus | 0.0312 | 0.2106 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0312 | 0.2106 | 0.1552 |
Onchocerca volvulus | 0.0312 | 0.2106 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.3754 | 0.3754 |
Onchocerca volvulus | 0.0312 | 0.2106 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.1117 | 0.209 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0312 | 0.2106 | 0.2062 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1057 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Leishmania major | cathepsin L-like protease | 0.0312 | 0.2106 | 0.592 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0176 | 0.0656 | 0.0656 |
Echinococcus granulosus | cathepsin b | 0.1057 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0209 | 0.1007 | 0.1591 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0209 | 0.1007 | 0.1007 |
Echinococcus multilocularis | cathepsin b | 0.1057 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0312 | 0.2106 | 0.1552 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0384 | 0.2863 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0219 | 0.1117 | 0.3182 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0209 | 0.1007 | 0.1007 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0209 | 0.1007 | 0.3638 |
Loa Loa (eye worm) | hypothetical protein | 0.1057 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0312 | 0.2106 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0209 | 0.1007 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0312 | 0.2106 | 0.2106 |
Leishmania major | cathepsin L-like protease | 0.0312 | 0.2106 | 0.592 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0219 | 0.1117 | 0.0494 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0384 | 0.2863 | 0.2863 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Leishmania major | cathepsin L-like protease | 0.0312 | 0.2106 | 0.592 |
Echinococcus granulosus | cysteine protease | 0.0176 | 0.0656 | 0.0605 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0176 | 0.0656 | 0.0656 |
Leishmania major | cathepsin L-like protease | 0.0312 | 0.2106 | 0.592 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0209 | 0.1007 | 0.1591 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.0379 | 0.0379 |
Onchocerca volvulus | Cathepsin L homolog | 0.0312 | 0.2106 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0312 | 0.2106 | 0.2062 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0384 | 0.2863 | 0.2362 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0312 | 0.2106 | 0.2062 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0312 | 0.2106 | 0.2062 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Onchocerca volvulus | 0.0312 | 0.2106 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0312 | 0.2106 | 0.2106 |
Brugia malayi | Cathepsin L-like precursor | 0.0312 | 0.2106 | 0.2106 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1057 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1057 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0219 | 0.1117 | 0.1117 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0468 | 0.3754 | 0.3754 |
Leishmania major | cathepsin L-like protease | 0.0312 | 0.2106 | 0.592 |
Echinococcus multilocularis | cysteine protease | 0.0312 | 0.2106 | 0.2062 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0209 | 0.1007 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.1117 | 0.1117 |
Plasmodium vivax | vivapain-2 | 0.0312 | 0.2106 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0312 | 0.2106 | 0.2106 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0312 | 0.2106 | 0.2062 |
Plasmodium vivax | vivapain-2 | 0.0312 | 0.2106 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.1117 | 0.1117 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0209 | 0.1007 | 0.1007 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0209 | 0.1007 | 0.0958 |
Toxoplasma gondii | cathepsin CPL | 0.0312 | 0.2106 | 0.592 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0379 | 0.0379 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0119 | 0.0055 | 0.0055 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0312 | 0.2106 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0312 | 0.2106 | 0.2106 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0209 | 0.1007 | 0.2421 |
Giardia lamblia | Cathepsin B precursor | 0.0384 | 0.2863 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.1117 | 0.209 |
Leishmania major | cysteine peptidase A (CPA) | 0.0312 | 0.2106 | 0.592 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0312 | 0.2106 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0312 | 0.2106 | 0.2062 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0209 | 0.1007 | 0.1591 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Loa Loa (eye worm) | ctsf protein | 0.0312 | 0.2106 | 0.2106 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0312 | 0.2106 | 0.2106 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1007 | 0.1007 |
Loa Loa (eye worm) | cysteine protease | 0.0312 | 0.2106 | 0.2106 |
Brugia malayi | Cathepsin L-like precursor | 0.0312 | 0.2106 | 0.2106 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0312 | 0.2106 | 0.1552 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0312 | 0.2106 | 0.1552 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0312 | 0.2106 | 0.2106 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Onchocerca volvulus | Cathepsin L homolog | 0.0312 | 0.2106 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0379 | 0.0379 |
Onchocerca volvulus | 0.0312 | 0.2106 | 1 | |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0176 | 0.0656 | 0.0605 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0312 | 0.2106 | 0.6569 |
Echinococcus granulosus | cathepsin b | 0.1057 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0176 | 0.0656 | 0.0605 |
Echinococcus granulosus | cathepsin l1 | 0.0219 | 0.1117 | 0.1068 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0312 | 0.2106 | 0.6569 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0176 | 0.0656 | 0.0656 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta mean survival time (functional) | = 0.4 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 20 mg/kg dose | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 1 | Antimalarial activity of the compound was measured in mice infected with Plasmodium berghei by subcutaneous administraton at 40 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 3 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 8.6 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 11.6 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 11.8 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg dose | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 0.4 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 20 mg/kg dose | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 1 | Antimalarial activity of the compound was measured in mice infected with Plasmodium berghei by subcutaneous administraton at 40 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 3 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 8.6 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 11.6 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 11.8 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 1 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 1 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg | ChEMBL. | 1404226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.