Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0281 | 0.2163 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0419 | 0.0419 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0157 | 0.0599 | 0.054 |
Onchocerca volvulus | Cathepsin L homolog | 0.0281 | 0.2163 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0281 | 0.2163 | 0.2163 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0157 | 0.0599 | 0.0599 |
Echinococcus granulosus | cathepsin l1 | 0.0197 | 0.1097 | 0.1041 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Echinococcus granulosus | cathepsin b | 0.0903 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0157 | 0.0599 | 0.054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0281 | 0.2163 | 0.2163 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | ctsf protein | 0.0281 | 0.2163 | 0.2163 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0281 | 0.2163 | 0.2114 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0176 | 0.0837 | 0.1096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0281 | 0.2163 | 0.1663 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0281 | 0.2163 | 0.1663 |
Brugia malayi | Cathepsin L-like precursor | 0.0281 | 0.2163 | 0.2163 |
Loa Loa (eye worm) | cysteine protease | 0.0281 | 0.2163 | 0.2163 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0115 | 0.0063 | 0.0063 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0281 | 0.2163 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0281 | 0.2163 | 0.6858 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0419 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0176 | 0.0837 | 0.078 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0176 | 0.0837 | 0.0837 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Leishmania major | cysteine peptidase A (CPA) | 0.0281 | 0.2163 | 0.6858 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0281 | 0.2163 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.033 | 0.277 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1097 | 0.2292 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0281 | 0.2163 | 0.2163 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0176 | 0.0837 | 0.1522 |
Brugia malayi | Cathepsin L-like precursor | 0.0281 | 0.2163 | 0.2163 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0281 | 0.2163 | 0.2114 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1097 | 0.1097 |
Plasmodium vivax | vivapain-2 | 0.0281 | 0.2163 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0176 | 0.0837 | 0.0253 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1097 | 0.1097 |
Plasmodium vivax | vivapain-2 | 0.0281 | 0.2163 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0903 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0903 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0281 | 0.2163 | 0.2163 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Echinococcus multilocularis | cysteine protease | 0.0281 | 0.2163 | 0.2114 |
Leishmania major | cathepsin L-like protease | 0.0281 | 0.2163 | 0.6858 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.033 | 0.277 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0197 | 0.1097 | 0.1097 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0281 | 0.2163 | 0.2114 |
Onchocerca volvulus | Cathepsin L homolog | 0.0281 | 0.2163 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0281 | 0.2163 | 0.2114 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0143 | 0.0419 | 0.0419 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0281 | 0.2163 | 0.2114 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0297 | 0.2363 | 0.2363 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0176 | 0.0837 | 0.1096 |
Brugia malayi | Cathepsin L-like precursor | 0.0281 | 0.2163 | 0.2163 |
Onchocerca volvulus | 0.0281 | 0.2163 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Leishmania major | cathepsin L-like protease | 0.0281 | 0.2163 | 0.6858 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0197 | 0.1097 | 0.0529 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0176 | 0.0837 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0281 | 0.2163 | 0.2163 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0281 | 0.2163 | 1 |
Leishmania major | cathepsin L-like protease | 0.0281 | 0.2163 | 0.6858 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0157 | 0.0599 | 0.0599 |
Echinococcus granulosus | cysteine protease | 0.0157 | 0.0599 | 0.054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.033 | 0.277 | 0.2309 |
Leishmania major | cathepsin L-like protease | 0.0281 | 0.2163 | 0.6858 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Echinococcus multilocularis | cathepsin b | 0.0903 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0176 | 0.0837 | 0.0837 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0176 | 0.0837 | 0.1096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0176 | 0.0837 | 0.0837 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0176 | 0.0837 | 0.2398 |
Loa Loa (eye worm) | hypothetical protein | 0.0903 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0197 | 0.1097 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0281 | 0.2163 | 0.1663 |
Giardia lamblia | Cathepsin B precursor | 0.033 | 0.277 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0903 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0281 | 0.2163 | 0.2114 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Echinococcus granulosus | cathepsin b | 0.0903 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0157 | 0.0599 | 0.0599 |
Leishmania major | cathepsin L-like protease | 0.0281 | 0.2163 | 0.6858 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Loa Loa (eye worm) | fibroinase | 0.0281 | 0.2163 | 0.2163 |
Echinococcus multilocularis | cathepsin L | 0.0157 | 0.0599 | 0.054 |
Brugia malayi | Cathepsin L-like precursor | 0.0197 | 0.1097 | 0.1097 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0176 | 0.0837 | 0.078 |
Onchocerca volvulus | 0.0281 | 0.2163 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0157 | 0.0599 | 0.0599 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0143 | 0.0419 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1097 | 0.2292 |
Onchocerca volvulus | 0.0281 | 0.2163 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0281 | 0.2163 | 0.1663 |
Onchocerca volvulus | 0.0281 | 0.2163 | 1 | |
Loa Loa (eye worm) | cathepsin B | 0.033 | 0.277 | 0.277 |
Onchocerca volvulus | 0.0281 | 0.2163 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Plasmodium vivax | RNA helicase-1, putative | 0.0176 | 0.0837 | 0.1522 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0903 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Onchocerca volvulus | Cathepsin F homolog | 0.0281 | 0.2163 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0176 | 0.0837 | 0.1096 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0281 | 0.2163 | 0.2114 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.2363 | 0.2363 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Entamoeba histolytica | cysteine protease, putative | 0.0281 | 0.2163 | 1 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0297 | 0.2363 | 0.2363 |
Leishmania major | cathepsin L-like protease | 0.0281 | 0.2163 | 0.6858 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0176 | 0.0837 | 0.078 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.033 | 0.277 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.033 | 0.277 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0176 | 0.0837 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.033 | 0.277 | 0.277 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0176 | 0.0837 | 0.078 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Onchocerca volvulus | 0.0281 | 0.2163 | 1 | |
Toxoplasma gondii | cathepsin B | 0.033 | 0.277 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0281 | 0.2163 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.033 | 0.277 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0281 | 0.2163 | 0.7202 |
Brugia malayi | Cathepsin L-like precursor | 0.0197 | 0.1097 | 0.1097 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0115 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1097 | 0.1097 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0176 | 0.0837 | 0.1522 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0176 | 0.0837 | 0.0253 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0281 | 0.2163 | 0.2163 |
Brugia malayi | Cathepsin L-like precursor | 0.0281 | 0.2163 | 0.2163 |
Leishmania major | cathepsin L-like protease | 0.0281 | 0.2163 | 0.6858 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.2163 | 0.2163 |
Echinococcus multilocularis | cathepsin b | 0.0903 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0281 | 0.2163 | 0.6858 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0197 | 0.1097 | 0.1097 |
Brugia malayi | Trypsin family protein | 0.0143 | 0.0419 | 0.0419 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0281 | 0.2163 | 0.1663 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0903 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0157 | 0.0599 | 0.0599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0281 | 0.2163 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Brugia malayi | cathepsin L-like precursor | 0.0197 | 0.1097 | 0.1097 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0281 | 0.2163 | 0.7202 |
Brugia malayi | Cathepsin L-like precursor | 0.0281 | 0.2163 | 0.2163 |
Onchocerca volvulus | 0.0197 | 0.1097 | 0.3887 | |
Echinococcus multilocularis | cysteine protease | 0.0281 | 0.2163 | 0.2114 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Insulin-sensitizing activity (functional) | = 27 % | Percentage of rosiglitazone response for insulin-sensitizing activity at 1 microM concentration in 3T3-L1 cells | ChEMBL. | 14505644 |
Insulin-sensitizing activity (functional) | = 27 % | Percentage of rosiglitazone response for insulin-sensitizing activity at 1 microM concentration in 3T3-L1 cells | ChEMBL. | 14505644 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.