Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ribonucleoside-diphosphate reductase large chain, putative | 0.0190345 | 1 | 1 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0152935 | 0.723187 | 0.5 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0190345 | 1 | 1 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0190345 | 1 | 0.5 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0190345 | 1 | 1 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0190345 | 1 | 0.5 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0190345 | 1 | 0.5 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0190345 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0069969 | 0.109279 | 0.5 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0190345 | 1 | 0.5 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0190345 | 1 | 0.5 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0190345 | 1 | 0.5 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0152935 | 0.723187 | 1 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0190345 | 1 | 1 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0190345 | 1 | 0.5 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0152935 | 0.723187 | 0.5 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0190345 | 1 | 0.5 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0152935 | 0.723187 | 0.5 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0152935 | 0.723187 | 0.5 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0069969 | 0.109279 | 0.5 |
Onchocerca volvulus | 0.0069969 | 0.109279 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 0.4 % | Protein binding in human plasma | ChEMBL. | 25599834 |
IC50 (functional) | < 0.004 uM | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR Green-based method | ChEMBL. | 25599834 |
IC50 (functional) | = 0.005 uM | Antiplasmodial activity against Plasmodium falciparum NF54 by SYBR Green-based method | ChEMBL. | 25599834 |
Inhibition (binding) | = 26.8 % | Inhibition of human ERG at at 11.1 uM | ChEMBL. | 25599834 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 25599834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.