Detailed information for compound 202227

Basic information

Technical information
  • TDR Targets ID: 202227
  • Name: but-1-ene
  • MW: 56.1063 | Formula: C4H8
  • H donors: 0 H acceptors: 0 LogP: 1.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC=C
  • InChi: 1S/C4H8/c1-3-4-2/h3H,1,4H2,2H3
  • InChiKey: VXNZUUAINFGPBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-butene
  • poly(1-butene)
  • polybutene
  • 61788-35-0
  • 106-98-9
  • 1735-75-7
  • 33004-02-3
  • 54366-07-3
  • 172345-47-0
  • 25038-50-0
  • 9003-28-5
  • 25167-67-3
  • Poly(1-butene), isotactic
  • Actipol E6
  • .alpha.-Butene
  • 1-Butylene
  • Butene, 1-
  • CCRIS 8970
  • EINECS 203-449-2
  • Ethylethylene
  • HSDB 179
  • alpha-Butene
  • alpha-Butylene
  • BUTENE
  • Butylene
  • Butylene [UN1012] [Flammable gas]
  • EINECS 246-689-3
  • HSDB 5127
  • UN1012
  • n-Butene
  • n-Butylene
  • 19061_FLUKA
  • 189391_ALDRICH
  • Butene, homopolymer, phosphosulfurized
  • Butene, homopolymer, phosphosulfurized, steam treated
  • 1-n-Butene
  • 649775_ALDRICH
  • Butene, polymer-bound
  • InChI=1/C4H8/c1-3-4-2/h3H,1,4H2,2H
  • 1-Butene, homopolymer
  • Poly-alpha-butylene
  • 295051_ALDRICH

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi tailless protein 0.0021 0.0153 0.0153
Schistosoma mansoni jumonji domain containing protein 0.0058 0.1413 0.1279
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.4269 1
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0984 0.1134
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0984 0.0888
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.4269 0.4699
Echinococcus granulosus carbonic anhydrase 0.0028 0.0378 0.0241
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0043 0.089 0.1034
Schistosoma mansoni carbonic anhydrase 0.0028 0.0378 0.0229
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0242 0.0242
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.2542 0.2542
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0203 0.6453 0.9043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1221 0.1221
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.4269 0.4123
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0378 0.0241
Plasmodium vivax SET domain protein, putative 0.0029 0.0427 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0427 0.0278
Brugia malayi nuclear receptor NHR-67 0.0021 0.0153 0.0153
Schistosoma mansoni aldehyde dehydrogenase 0.0203 0.6453 0.6398
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0043 0.089 0.075
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.1968 0.1941
Schistosoma mansoni glutaminase 0.0305 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0203 0.6453 1
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0148 0.4555 0.4416
Loa Loa (eye worm) hypothetical protein 0.0036 0.0648 0.0503
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0043 0.089 0.0788
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Loa Loa (eye worm) hypothetical protein 0.009 0.2542 0.2426
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0984 0.0984
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0984 0.0888
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.398 0.4093
Brugia malayi glutaminase DH11.1 0.0305 1 1
Toxoplasma gondii hypothetical protein 0.0028 0.0378 0.0209
Brugia malayi nuclear receptor NHR-88 0.0021 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0984 0.0888
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0984 0.0844
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0984 0.0984
Echinococcus multilocularis Aminotransferase class III 0.0024 0.0249 0.0102
Schistosoma mansoni hypothetical protein 0.0131 0.398 0.3887
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0984 0.0984
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0378 0.0229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0984 0.0844
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0984 0.0844
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0153 0.0153
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0024 0.0249 0.5
Brugia malayi steroid hormone receptor 0.0045 0.0984 0.0984
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0984 0.0888
Schistosoma mansoni hypothetical protein 0.0036 0.0648 0.0503
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0242 0.009
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0378 0.0229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0984 0.0888
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0153 0.0153
Brugia malayi nuclear receptor RXR 0.0024 0.0242 0.0242
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0984 0.0888
Onchocerca volvulus 0.009 0.2542 0.3262
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0984 0.0844
Brugia malayi jmjC domain containing protein 0.0058 0.1413 0.1413
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0984 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0984 0.0984
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0427 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0984 0.0984
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0203 0.6453 0.6737
Brugia malayi Pre-SET motif family protein 0.0204 0.6492 0.6492
Brugia malayi hypothetical protein 0.0024 0.0242 0.0242
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0427 0.0293
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0043 0.089 0.089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0153 0.0153
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0028 0.0378 0.0229
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1968 0.1753
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Brugia malayi hypothetical protein 0.0021 0.0153 0.0153
Schistosoma mansoni tyrosinase precursor 0.009 0.2542 0.2426
Trichomonas vaginalis set domain proteins, putative 0.0232 0.7471 0.7406
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0153 0.0153
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.1968 0.1843
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.6492 0.6438
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0043 0.089 0.0658
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.2542 0.2426
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0122 0.3653 0.3653
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0153 0.0153
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.9356 0.9802
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.1968 0.1968
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0242 0.0095
Loa Loa (eye worm) tyrosinase 1 0.009 0.2542 0.2426
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0984 0.0888
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0122 0.3653 0.4491
Trichomonas vaginalis glutaminase, putative 0.0305 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0378 0.0229
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0122 0.3653 0.3554
Schistosoma mansoni hypothetical protein 0.0028 0.0378 0.0229
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0043 0.089 0.0788
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0043 0.089 0.0658
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0203 0.6453 0.6737
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0984 0.0984
Brugia malayi ecdysteroid receptor 0.0045 0.0984 0.0984
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0984 0.0984
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0984 0.0888
Brugia malayi ecdysone receptor 0.0021 0.0153 0.0153
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0984 0.0844
Brugia malayi jmjC domain containing protein 0.0058 0.1413 0.1413
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0242 0.009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0984 0.0888
Onchocerca volvulus 0.009 0.2542 0.3262
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0378 0.0229
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0984 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0984 0.0984
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.7042 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0143 0.4368 0.4508
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0984 0.0844
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0984 0.0888
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1413 0.1279
Schistosoma mansoni tyrosinase precursor 0.009 0.2542 0.2426
Loa Loa (eye worm) hypothetical protein 0.0029 0.0427 0.0278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Mycobacterium ulcerans aldehyde dehydrogenase 0.0203 0.6453 0.6363
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Echinococcus granulosus carbonic anhydrase 0.0028 0.0378 0.0241
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Echinococcus granulosus carbonic anhydrase II 0.0122 0.3653 0.3743
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0249 0.0102
Plasmodium falciparum carbonic anhydrase 0.0028 0.0378 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0427 0.0278
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.022 0.7042 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0242 0.0095
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0892 0.079
Brugia malayi nuclear receptor NHR-88 0.0045 0.0984 0.0984
Loa Loa (eye worm) carbonic anhydrase 3 0.0122 0.3653 0.3554
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.8401 0.8377
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0892 0.079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Brugia malayi ShTK domain containing protein 0.009 0.2542 0.2542
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.2542 0.2542
Echinococcus multilocularis carbonic anhydrase II 0.0122 0.3653 0.3743
Brugia malayi nuclear hormone receptor 0.0045 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.2542 0.2426
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.1968 0.1941
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0984 0.0844
Schistosoma mansoni thyroid hormone receptor 0.0177 0.5553 0.5483
Echinococcus granulosus ornithine aminotransferase 0.0024 0.0249 0.0102
Entamoeba histolytica protein kinase, putative 0.029 0.9505 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0984 0.0984
Loa Loa (eye worm) glutaminase 0.0305 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0984 0.0844
Schistosoma mansoni retinoic acid receptor RXR 0.0143 0.4368 0.4281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0378 0.0229
Brugia malayi nuclear receptor RXR 0.0021 0.0153 0.0153
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0984 0.0888
Mycobacterium ulcerans aldehyde dehydrogenase 0.0203 0.6453 0.6363
Mycobacterium ulcerans glutaminase 0.0305 1 1
Schistosoma mansoni coup transcription factor 0.0045 0.0984 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0984 0.0984
Echinococcus granulosus carbonic anhydrase 0.0028 0.0378 0.0241
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0203 0.6453 0.7252
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0984 0.0984
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0378 0.0378
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0378 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0984 0.0844
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0984 0.0888
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.9356 0.5
Loa Loa (eye worm) hypothetical protein 0.009 0.2542 0.2426
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0648 0.0648
Schistosoma mansoni thyroid hormone receptor 0.0177 0.5553 0.5483
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.1413 0.1347
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.027 0.8804 1
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.027 0.8804 0.8804
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.1968 0.1753
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.2542 0.2542
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0024 0.0249 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0984 0.0844
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.029 0.9505 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.1413 0.1347
Onchocerca volvulus 0.009 0.2542 0.3262
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0043 0.089 0.075
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0024 0.0249 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0984 0.0844
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0242 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0984 0.0844
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0122 0.3653 0.3554
Loa Loa (eye worm) hypothetical protein 0.0028 0.0378 0.0229
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1221 0.1221
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0984 0.0888
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.0378 0.0378
Brugia malayi hypothetical protein 0.0021 0.0153 0.0153
Echinococcus multilocularis thyroid hormone receptor alpha 0.0177 0.5553 0.5774
Leishmania major carbonic anhydrase-like protein 0.0122 0.3653 0.4491
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Mycobacterium ulcerans L-lysine aminotransferase 0.027 0.8804 0.8774
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0378 0.0241
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1413 0.1279
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0984 0.0888
Brugia malayi hypothetical protein 0.0024 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Entamoeba histolytica protein kinase, putative 0.029 0.9505 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0984 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0984 0.0984
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0119 0.3538 0.3619
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.2264 0.2257
Loa Loa (eye worm) hypothetical protein 0.0052 0.1221 0.1084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1221 0.1084
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.029 0.9505 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0122 0.3653 0.4491
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.398 0.4093
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.1413 0.1347
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0984 0.1134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0984 0.0984
Loa Loa (eye worm) IRE protein kinase 0.029 0.9505 0.9497
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0122 0.3653 0.3653
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0984 0.0888
Echinococcus granulosus Aminotransferase class III 0.0024 0.0249 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0984 0.0888
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.2542 0.2542
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.4586 0.4502
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1413 0.1279
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.2542 0.2542
Mycobacterium ulcerans aldehyde dehydrogenase 0.0203 0.6453 0.6363
Brugia malayi Pre-SET motif family protein 0.0029 0.0427 0.0427
Trypanosoma brucei carbonic anhydrase-like protein 0.0122 0.3653 0.4491
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0153 0.0153
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0984 0.1134
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0043 0.089 0.0788
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.9356 0.5
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0378 0.0378
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0122 0.3653 0.3554
Onchocerca volvulus 0.0232 0.7475 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0984 0.0984
Brugia malayi Ribonuclease 2-5A family protein 0.029 0.9505 0.9505
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1968 0.1753
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.4555 0.4416
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0043 0.089 0.0748
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.2264 0.2257
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0043 0.089 0.0658
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0427 0.0293
Brugia malayi conserved hypotetical protein 0.0021 0.0153 0.0153
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0427 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0984 0.0984
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0427 0.0278
Loa Loa (eye worm) hypothetical protein 0.0043 0.089 0.0748
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0043 0.089 0.1596
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0984 0.0844
Onchocerca volvulus 0.0045 0.0984 0.1134
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0984 0.0984
Schistosoma mansoni aldehyde dehydrogenase 0.0203 0.6453 0.6398
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0984 0.0844
Loa Loa (eye worm) hypothetical protein 0.0043 0.089 0.0748
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.1413 0.1347
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.9356 0.9802
Brugia malayi follicle stimulating hormone receptor 0.0259 0.8401 0.8401
Brugia malayi nuclear hormone receptor 0.0021 0.0153 0.0153
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1968 0.1753
Leishmania major hypothetical protein, conserved 0.022 0.7042 1
Onchocerca volvulus 0.009 0.2542 0.3262
Onchocerca volvulus 0.0029 0.0427 0.0374
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.039 0.0253
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0242 0.0242
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.1968 0.1843
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0249 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0427 0.0278
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844

Activities

Activity type Activity value Assay description Source Reference
logP (ADMET) = 2.4 Partition coefficient (logP) ChEMBL. 3882967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.