Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cell death protein 3 precursor | 0.044 | 0.1437 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0891 | 0.4126 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0891 | 0.4126 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0308 | 0.0649 | 0.0649 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0891 | 0.4126 | 1 |
Echinococcus granulosus | hormone sensitive lipase | 0.0891 | 0.4126 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.044 | 0.1437 | 0.3482 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.1437 | 0.2265 |
Echinococcus granulosus | caspase 2 | 0.044 | 0.1437 | 0.3482 |
Echinococcus multilocularis | caspase 2 | 0.044 | 0.1437 | 0.1437 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0308 | 0.0649 | 0.1573 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0891 | 0.4126 | 0.4126 |
Schistosoma mansoni | hypothetical protein | 0.0308 | 0.0649 | 0.1573 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0262 | 0.0379 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0891 | 0.4126 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.044 | 0.1437 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 nM | Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand | ChEMBL. | 15177445 |
IC90 (functional) | = 100 nM | Anti viral activity of the compound was determined in anti HIV-1 infectivity assay in HeLa Magi cells | ChEMBL. | 15177445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.