Detailed information for compound 202421

Basic information

Technical information
  • TDR Targets ID: 202421
  • Name: ethyl 2,2-diphenyl-2-piperidin-1-ylacetate
  • MW: 323.429 | Formula: C21H25NO2
  • H donors: 0 H acceptors: 1 LogP: 4.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(c1ccccc1)(c1ccccc1)N1CCCCC1
  • InChi: 1S/C21H25NO2/c1-2-24-20(23)21(18-12-6-3-7-13-18,19-14-8-4-9-15-19)22-16-10-5-11-17-22/h3-4,6-9,12-15H,2,5,10-11,16-17H2,1H3
  • InChiKey: OUYQXPSBMLHCAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2,2-diphenyl-2-(1-piperidyl)acetate
  • 2,2-diphenyl-2-(1-piperidyl)acetic acid ethyl ester
  • ethyl 2,2-diphenyl-2-piperidin-1-yl-ethanoate
  • 2,2-diphenyl-2-piperidino-acetic acid ethyl ester
  • ethyl 2,2-di(phenyl)-2-piperidin-1-ylacetate
  • ethyl 2,2-di(phenyl)-2-(1-piperidyl)acetate
  • 2,2-di(phenyl)-2-(1-piperidyl)acetic acid ethyl ester
  • 2,2-di(phenyl)-2-piperidino-acetic acid ethyl ester
  • ethyl 2,2-di(phenyl)-2-piperidin-1-yl-ethanoate
  • NSC16981

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0828 0.0828
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0064 0.0346 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.026 0.2163 0.249
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.021 0.02
Echinococcus multilocularis ubiquitin specific protease 41 0.026 0.2163 0.2155
Loa Loa (eye worm) hypothetical protein 0.0038 0.0109 0.0109
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0094 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0642 0.2647
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0311 0.1048
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0064 0.0346 1
Schistosoma mansoni lamin 0.0057 0.028 0.0188
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0064 0.0346 0.3436
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0109 0.01
Echinococcus multilocularis lamin dm0 0.0057 0.028 0.0271
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0064 0.0346 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0311 0.8774
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0311 0.2956
Trypanosoma brucei metacaspase 0.0096 0.0642 0.2647
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0064 0.0346 0.3436
Leishmania major cytochrome p450-like protein 0.0064 0.0346 0.1219
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0096 0.0642 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0064 0.0346 1
Trichomonas vaginalis conserved hypothetical protein 0.026 0.2163 1
Echinococcus multilocularis musashi 0.0057 0.028 0.0271
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0064 0.0346 1
Echinococcus granulosus lamin dm0 0.0057 0.028 0.0271
Brugia malayi intermediate filament protein 0.0057 0.028 0.0284
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.021 0.0559
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.026 0.2163 0.2088
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0064 0.0346 1
Schistosoma mansoni lipoxygenase 0.0159 0.1228 0.1145
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0096 0.0642 1
Mycobacterium leprae Conserved hypothetical protein 0.0064 0.0346 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.026 0.2163 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0227 0.1861 0.1853
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.021 0.0559
Echinococcus granulosus intermediate filament protein 0.0057 0.028 0.0271
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0064 0.0346 0.3436
Loa Loa (eye worm) hypothetical protein 0.0096 0.0642 0.0642
Brugia malayi Inositol-1 0.0036 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.028 0.028
Echinococcus multilocularis 0.0064 0.0346 0.0337
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0064 0.0346 0.1219
Trypanosoma cruzi metacaspase, putative 0.0096 0.0642 0.2647
Schistosoma mansoni polycystin 1-related 0.0038 0.0109 0.0015
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.026 0.2163 0.2155
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.026 0.2163 1
Echinococcus granulosus RUN 0.0038 0.0109 0.01
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0109 0.01
Brugia malayi Cytochrome P450 family protein 0.0116 0.0828 0.0926
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0109 0.01
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0064 0.0346 0.3436
Loa Loa (eye worm) hypothetical protein 0.0052 0.0239 0.0239
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0064 0.0346 1
Echinococcus multilocularis RUN 0.0038 0.0109 0.01
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0064 0.0346 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0116 0.0828 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0064 0.0346 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0064 0.0346 0.3436
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0064 0.0346 0.3436
Echinococcus multilocularis caspase 3 0.016 0.1241 0.1232
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0064 0.0346 0.1219
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.026 0.2163 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.026 0.2163 0.2155
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0064 0.0346 0.3436
Schistosoma mansoni rab6-interacting 0.0038 0.0109 0.0015
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.026 0.2163 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Trypanosoma cruzi metacaspase 5, putative 0.0096 0.0642 0.2647
Loa Loa (eye worm) cytochrome P450 family protein 0.0139 0.1042 0.1042
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.021 0.0117
Trypanosoma cruzi metacaspase, putative 0.0096 0.0642 0.2647
Loa Loa (eye worm) hypothetical protein 0.026 0.2163 0.2163
Loa Loa (eye worm) CYP4Cod1 0.0116 0.0828 0.0828
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.021 0.0559
Leishmania major metacaspase, putative 0.0096 0.0642 0.2647
Loa Loa (eye worm) hypothetical protein 0.0038 0.0109 0.0109
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.021 0.0559
Schistosoma mansoni lamin 0.0057 0.028 0.0188
Brugia malayi Cell death protein 3 precursor 0.0182 0.144 0.1644
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0064 0.0346 0.3436
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.0267 0.0835
Trypanosoma cruzi metacaspase 5, putative 0.0096 0.0642 0.2647
Loa Loa (eye worm) hypothetical protein 0.0086 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus granulosus caspase 3 0.016 0.1241 0.1232
Leishmania major cytochrome p450-like protein 0.0116 0.0828 0.3546
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0953 0.8572 0.8572
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0064 0.0346 0.3436
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.021 0.02
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0109 0.0109
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0311 0.0302
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0267 0.0269
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.026 0.2163 0.2155
Leishmania major cytochrome p450-like protein 0.0064 0.0346 0.1219
Trypanosoma cruzi metacaspase, putative 0.0096 0.0642 0.2647
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0064 0.0346 0.3436
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.1107 1 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0096 0.0642 0.0553
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0064 0.0346 0.3436
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0064 0.0346 0.3436
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0311 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0064 0.0346 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0064 0.0346 0.3436
Toxoplasma gondii cytochrome p450 superfamily protein 0.0064 0.0346 0.4604
Brugia malayi hypothetical protein 0.0038 0.0109 0.0084
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0109 0.01
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0064 0.0346 1
Schistosoma mansoni loxhd1 0.0038 0.0109 0.0015
Loa Loa (eye worm) cytochrome P450 0.0064 0.0346 0.0346
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0064 0.0346 0.3436
Plasmodium vivax hypothetical protein, conserved 0.0096 0.0642 1
Trypanosoma brucei protein kinase, putative 0.0049 0.021 0.0559
Schistosoma mansoni caspase-3 (C14 family) 0.0256 0.2125 0.205
Loa Loa (eye worm) inositol-1 0.0036 0.0094 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0064 0.0346 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.0267 0.0174
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0064 0.0346 0.1219
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.021 0.021
Mycobacterium leprae putative cytochrome p450 0.0064 0.0346 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0064 0.0346 1
Trypanosoma brucei metacaspase 5, putative 0.0096 0.0642 0.2647
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0064 0.0346 0.3436
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.021 0.02
Plasmodium vivax metacaspase 1, putative 0.0096 0.0642 1
Echinococcus granulosus caspase 0.0256 0.2125 0.2117
Loa Loa (eye worm) hypothetical protein 0.0055 0.027 0.027
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.0267 0.7236
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.026 0.2163 0.2155
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.028 0.028
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0096 0.0642 0.0708
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Trypanosoma cruzi metacaspase, putative 0.0096 0.0642 0.2647
Loa Loa (eye worm) intermediate filament protein 0.0057 0.028 0.028
Echinococcus granulosus apoptotic protease activating factor 1 0.0086 0.0556 0.0547
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0267 0.0257
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0311 0.0219
Trypanosoma cruzi cytochrome P450, putative 0.0116 0.0828 0.3546
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0094 0.5
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0064 0.0346 0.3436
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0064 0.0346 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0064 0.0346 0.1219
Schistosoma mansoni caspase-7 (C14 family) 0.0182 0.144 0.1359
Onchocerca volvulus 0.0057 0.028 0.1285
Echinococcus multilocularis hormone sensitive lipase 0.1107 1 1
Echinococcus granulosus cytochrome P450 2K1 0.0064 0.0346 0.0337
Trypanosoma brucei cytochrome P450, putative 0.0116 0.0828 0.3546
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.026 0.2163 0.2088
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.026 0.2163 1
Trypanosoma brucei Metacaspase-4 0.0096 0.0642 0.2647
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0064 0.0346 0.3436
Brugia malayi hypothetical protein 0.0038 0.0109 0.0084
Echinococcus multilocularis caspase 0.0256 0.2125 0.2117
Plasmodium falciparum metacaspase 1 0.0096 0.0642 1
Schistosoma mansoni caspase-7 (C14 family) 0.0256 0.2125 0.205
Echinococcus multilocularis lamin 0.0057 0.028 0.0271
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.1107 1 1
Brugia malayi Cytochrome P450 family protein 0.0064 0.0346 0.0362
Schistosoma mansoni hypothetical protein 0.0038 0.0109 0.0015
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0094 0.0085
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.021 0.0559
Echinococcus multilocularis caspase 2 0.0182 0.144 0.1432
Echinococcus multilocularis apoptotic protease activating factor 1 0.0086 0.0556 0.0547
Schistosoma mansoni cytochrome P450 0.0064 0.0346 0.0254
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0109 0.01
Onchocerca volvulus Cell death protein 3 homolog 0.0182 0.144 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0064 0.0346 0.3436
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0037 0.0037
Brugia malayi MAP kinase sur-1 0.0049 0.021 0.0202
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0096 0.0642 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.144 0.144
Schistosoma mansoni lipoxygenase 0.0227 0.1861 0.1784
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.021 0.0559
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0064 0.0346 1
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0642 0.2647
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0256 0.2125 0.2117
Trypanosoma brucei metacaspase MCA2 0.0096 0.0642 0.2647
Brugia malayi Cytochrome P450 family protein 0.0116 0.0828 0.0926
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0064 0.0346 1
Onchocerca volvulus 0.0086 0.0556 0.3357
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.021 0.0559
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.026 0.2163 1
Schistosoma mansoni hypothetical protein 0.0086 0.0556 0.0466
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0642 0.2647
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Schistosoma mansoni intermediate filament proteins 0.0057 0.028 0.0188
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Echinococcus granulosus caspase 8 0.0096 0.0642 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0642 0.2647
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0267 0.2353
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.021 0.02
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0064 0.0346 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.1107 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0064 0.0346 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.021 0.0559
Brugia malayi cytochrome P450 0.0064 0.0346 0.0362
Onchocerca volvulus 0.0057 0.028 0.1285
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.026 0.2163 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0267 0.0257
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.021 0.0559
Brugia malayi Cytochrome P450 family protein 0.0139 0.1042 0.1177
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0064 0.0346 0.1219
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0311 0.3961
Echinococcus granulosus ubiquitin specific protease 41 0.026 0.2163 0.2155
Echinococcus multilocularis caspase 8 0.0096 0.0642 0.0633
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0311 0.2956
Schistosoma mansoni hypothetical protein 0.0064 0.0346 0.0254
Brugia malayi hypothetical protein 0.0086 0.0556 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0642 0.2647
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0109 0.01
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0256 0.2125 0.2117
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0311 0.2956
Trypanosoma brucei metacaspase MCA3 0.0096 0.0642 0.2647
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0642 0.2647
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0064 0.0346 1
Schistosoma mansoni rab6-interacting 0.0038 0.0109 0.0015
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0227 0.1861 0.1853
Brugia malayi follicle stimulating hormone receptor 0.0953 0.8572 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0311 0.0302
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0828 0.0828
Echinococcus granulosus lamin 0.0057 0.028 0.0271
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.028 0.0284
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0064 0.0346 0.3436
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0064 0.0346 0.3436
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0051 0.0232 0.0232
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.026 0.2163 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.021 0.2113
Echinococcus granulosus caspase 2 0.0182 0.144 0.1432
Trypanosoma cruzi cytochrome P450, putative 0.0116 0.0828 0.3546
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0064 0.0346 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.021 0.0559
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.021 0.0559
Brugia malayi Doublecortin family protein 0.0038 0.0109 0.0084
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0267 0.2353
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0642 0.2647
Plasmodium falciparum metacaspase-like protein 0.0096 0.0642 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.2 uM Mitogen-induced cell proliferation assay to evaluate the antiproliferative effect in NIH 3T3 cells ChEMBL. 14698156
IC50 (functional) = 2.2 uM Mitogen-induced cell proliferation assay to evaluate the antiproliferative effect in NIH 3T3 cells ChEMBL. 14698156
Inhibition (functional) = 96 % Percent inhibition at 10 microM determined against mouse NIH 3T3 cells ChEMBL. 14698156
Inhibition (functional) = 96 % Percent inhibition at 10 microM determined against mouse NIH 3T3 cells ChEMBL. 14698156

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 14698156

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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