TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 434.526 | Formula: C23H34N2O6
H donors: 2 H acceptors: 4 LogP: 4.49 Rotable bonds: 17
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOC(=O)C(=O)C(NC(=O)C(NC(=O)OCc1ccccc1)CC(C)C)CC
InChi: 1S/C23H34N2O6/c1-5-7-13-30-22(28)20(26)18(6-2)24-21(27)19(14-16(3)4)25-23(29)31-15-17-11-9-8-10-12-17/h8-12,16,18-19H,5-7,13-15H2,1-4H3,(H,24,27)(H,25,29)
InChiKey: YBCYKWLFCIPEMH-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calpain 1, (mu/I) large subunit		References
Homo sapiens	calpain, small subunit 1	Starlite/ChEMBL	References
Bos taurus	Cathepsin B	Starlite/ChEMBL	References
Homo sapiens	calpain 2, (m/II) large subunit	Starlite/ChEMBL	References
Carica papaya	Papain	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Papain	345 aa	328 aa	33.5 %
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Cathepsin B	335 aa	288 aa	26.4 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.6 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin B	335 aa	296 aa	28.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	25.2 %
Plasmodium knowlesi	knowpain-4	Cathepsin B	335 aa	304 aa	25.3 %
Trypanosoma cruzi	cysteine protease, putative	Papain	345 aa	344 aa	30.8 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	343 aa	25.4 %
Plasmodium berghei	berghepain-1	Papain	345 aa	345 aa	29.9 %
Schistosoma japonicum	Cathepsin C precursor, putative	Cathepsin B	335 aa	289 aa	28.4 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	361 aa	24.9 %
Plasmodium vivax	vivapain-1	Papain	345 aa	360 aa	30.0 %
Onchocerca volvulus		Papain	345 aa	344 aa	23.3 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Papain	345 aa	281 aa	26.0 %
Plasmodium yoelii	cysteine proteinase precursor	Papain	345 aa	346 aa	30.6 %
Plasmodium vivax	vivapain-3	Papain	345 aa	340 aa	33.2 %
Babesia bovis	papain family cysteine protease containing protein	Papain	345 aa	342 aa	31.0 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin B	335 aa	313 aa	25.2 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	272 aa	24.6 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Papain	345 aa	355 aa	30.4 %
Echinococcus multilocularis	cathepsin L	Papain	345 aa	355 aa	27.3 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Papain	345 aa	323 aa	26.3 %
Echinococcus multilocularis	cathepsin L	Papain	345 aa	352 aa	36.4 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	25.1 %
Echinococcus granulosus	cathepsin L	Papain	345 aa	356 aa	36.0 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	373 aa	27.3 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	392 aa	23.0 %
Echinococcus granulosus	cathepsin L	Papain	345 aa	316 aa	29.1 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	297 aa	24.6 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Brugia malayi	Papain family cysteine protease containing protein	Papain	345 aa	308 aa	27.6 %
Plasmodium berghei	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	311 aa	22.5 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	286 aa	26.6 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	335 aa	280 aa	25.0 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	272 aa	25.0 %
Dictyostelium discoideum	cysteine proteinase 5 precursor	Cathepsin B	335 aa	271 aa	24.4 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	318 aa	22.3 %
Onchocerca volvulus		Papain	345 aa	307 aa	35.5 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Cathepsin B	335 aa	287 aa	25.1 %
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	313 aa	25.6 %
Echinococcus granulosus	cathepsin b	Papain	345 aa	321 aa	25.9 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Papain	345 aa	320 aa	28.4 %
Trypanosoma cruzi	cysteine proteinase, putative	Papain	345 aa	299 aa	30.1 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	302 aa	24.8 %
Echinococcus granulosus	calpain A	calpain 1, (mu/I) large subunit	714 aa	753 aa	31.7 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	291 aa	24.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	312 aa	23.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Papain	345 aa	376 aa	30.6 %
Onchocerca volvulus	Cathepsin L homolog	Papain	345 aa	317 aa	33.8 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	350 aa	29.4 %
Brugia malayi	Cathepsin L-like precursor	Cathepsin B	335 aa	312 aa	25.0 %
Dictyostelium discoideum	cysteine proteinase 3	Cathepsin B	335 aa	275 aa	28.7 %
Dictyostelium discoideum	cathepsin L-like proteinase	Papain	345 aa	330 aa	37.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.6 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Papain	345 aa	313 aa	29.7 %
Babesia bovis	cathepsin C precursor, putative	Cathepsin B	335 aa	305 aa	25.9 %
Schistosoma japonicum	Disco-interacting protein 2 homolog B, putative	Papain	345 aa	342 aa	30.7 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Papain	345 aa	328 aa	33.5 %
Neospora caninum	hypothetical protein	Papain	345 aa	297 aa	23.2 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Onchocerca volvulus	Protein MCM10 homolog	Papain	345 aa	294 aa	34.7 %
Echinococcus granulosus	calpain A	calpain 2, (m/II) large subunit	622 aa	663 aa	31.2 %
Onchocerca volvulus	Cathepsin B-like cysteine proteinase 6 homolog	Cathepsin B	335 aa	315 aa	49.2 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	24.4 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	357 aa	26.9 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Papain	345 aa	280 aa	29.6 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	324 aa	32.1 %
Onchocerca volvulus		Papain	345 aa	326 aa	31.9 %
Trypanosoma cruzi	cysteine proteinase, putative	Papain	345 aa	298 aa	29.2 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	289 aa	22.8 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Papain	345 aa	324 aa	35.2 %
Onchocerca volvulus		Papain	345 aa	312 aa	35.6 %
Cryptosporidium hominis	preprocathepsin c precursor	Cathepsin B	335 aa	280 aa	25.7 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	321 aa	29.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	25.1 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	307 aa	29.0 %
Plasmodium knowlesi	knowpain-1	Papain	345 aa	396 aa	29.8 %
Onchocerca volvulus		Papain	345 aa	324 aa	32.1 %
Plasmodium knowlesi	knowpain-2	Cathepsin B	335 aa	308 aa	23.1 %
Plasmodium knowlesi	knowpain-3	Cathepsin B	335 aa	301 aa	22.6 %
Brugia malayi	cathepsin B-like cysteine proteinase	Papain	345 aa	306 aa	26.1 %
Plasmodium vivax	unspecified product	Papain	345 aa	358 aa	30.2 %
Toxoplasma gondii	preprocathepsin c precursor, putative	Cathepsin B	335 aa	272 aa	24.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0171	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.2872	1
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.1091	0.1512
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.0253	0.0253
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Trypanosoma brucei	calpain-like protein, putative	0.005	0.2227	0.7755
Echinococcus multilocularis	hypothetical protein	0.005	0.2227	0.2026
Echinococcus multilocularis	cysteine protease	0.0032	0.1091	0.086
Loa Loa (eye worm)	cathepsin B	0.006	0.2872	0.2872
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0.0253	0.2315
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0253	0.0253
Leishmania major	cathepsin L-like protease	0.0032	0.1091	0.3799
Brugia malayi	calpain 7	0.005	0.2227	0.2227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Echinococcus multilocularis	cysteine protease	0.0032	0.1091	0.086
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.2227	0.2227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0519	0.1808
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0519	0.0519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.2872	1
Onchocerca volvulus		0.0032	0.1091	0.1512
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.1091	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.005	0.2227	0.2227
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Leishmania major	cathepsin L-like protease	0.0032	0.1091	0.3799
Schistosoma mansoni	calpain-7 (C02 family)	0.005	0.2227	0.2227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.1091	0.1091
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0253	0.0253
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Trypanosoma brucei	calpain-like protein, putative	0.005	0.2227	0.7755
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.1091	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Brugia malayi	calpain family protein 1	0.0132	0.7486	0.7486
Loa Loa (eye worm)	ctsf protein	0.0032	0.1091	0.1091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.1091	0.3799
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.005	0.2227	0.7755
Leishmania major	cathepsin L-like protease	0.0032	0.1091	0.3799
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1091	0.1091
Leishmania major	cathepsin L-like protease	0.0032	0.1091	0.3799
Plasmodium vivax	vivapain-2	0.0032	0.1091	0.4246
Trypanosoma brucei	kinesin, putative	0.0035	0.127	0.4421
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.1091	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Loa Loa (eye worm)	cysteine protease	0.0032	0.1091	0.1091
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.005	0.2227	0.7755
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1091	0.1091
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.1091	0.8592
Echinococcus granulosus	calpain 7 C02 family	0.005	0.2227	0.2026
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0519	0.0519
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.1091	0.086
Onchocerca volvulus		0.0032	0.1091	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0519	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0519	0.0519
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.1091	0.1091
Plasmodium vivax	calpain, putative	0.005	0.2227	1
Onchocerca volvulus		0.0032	0.1091	0.1512
Schistosoma mansoni	calpain (C02 family)	0.005	0.2227	0.2227
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.1091	0.086
Echinococcus multilocularis	calpain A	0.0142	0.8141	0.8093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0253	0.0879
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.1091	0.1512
Trypanosoma brucei	calpain-like protein, putative	0.005	0.2227	0.7755
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0519	0.0519
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Entamoeba histolytica	cysteine proteinase 2	0.0019	0.0253	0.1989
Echinococcus multilocularis	calpain family protein 1, d	0.0097	0.5258	0.5135
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0519	0.0519
Echinococcus granulosus	cathepsin l1	0.0032	0.1091	0.086
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.1091	0.086
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.005	0.2227	0.2227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.005	0.2227	0.7755
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.1091	0.3799
Echinococcus granulosus	calpain	0.005	0.2227	0.2026
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.2872	0.2872
Loa Loa (eye worm)	calpain family protein 1	0.0097	0.5258	0.5258
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.1091	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.005	0.2227	0.2227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Loa Loa (eye worm)	hypothetical protein	0.0132	0.7486	0.7486
Brugia malayi	calpain 5	0.0035	0.127	0.127
Trypanosoma cruzi	kinesin, putative	0.0035	0.127	0.127
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1091	0.1091
Giardia lamblia	Cathepsin B precursor	0.006	0.2872	0.5
Onchocerca volvulus		0.0032	0.1091	0.1512
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Echinococcus multilocularis	calpain 7 (C02 family)	0.005	0.2227	0.2026
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.1091	0.1091
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0253	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0142	0.8123	0.8074
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1091	0.1091
Leishmania major	cathepsin L-like protease	0.0032	0.1091	0.3799
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Leishmania major	cathepsin L-like protease	0.0032	0.1091	0.3799
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.2227	0.2227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.1091	0.1091
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.005	0.2227	0.2227
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0253	0.1989
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Loa Loa (eye worm)	calpain 5	0.0035	0.127	0.127
Giardia lamblia	Cathepsin B precursor	0.006	0.2872	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0253	0.1989
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0019	0.0253	0.1989
Echinococcus granulosus	cathepsin b	0.0171	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0253	0.0879
Trypanosoma brucei	antigen, putative	0.005	0.2227	0.7755
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Echinococcus granulosus	calpain A	0.005	0.2227	0.2026
Giardia lamblia	Cathepsin B precursor	0.006	0.2872	0.5
Schistosoma mansoni	calpain-7 (C02 family)	0.005	0.2227	0.2227
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0253	0.0253
Loa Loa (eye worm)	fibroinase	0.0032	0.1091	0.1091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Echinococcus multilocularis	calpain	0.005	0.2227	0.2026
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0142	0.8123	0.8074
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Leishmania major	cathepsin L-like protease	0.0032	0.1091	0.3799
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.2227	0.2227
Echinococcus multilocularis	calpain 5	0.005	0.2227	0.2026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0519	0.1808
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Onchocerca volvulus		0.0032	0.1091	0.1512
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1091	0.1091
Brugia malayi	calpain family protein 1	0.0132	0.7486	0.7486
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.1091	0.1091
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.005	0.2227	0.7755
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.2227	0.2227
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.1091	0.8592
Echinococcus granulosus	calpain 5	0.005	0.2227	0.2026
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1091	0.1091
Schistosoma mansoni	calpain C (C02 family)	0.005	0.2227	0.2227
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0519	0.0519
Loa Loa (eye worm)	calpain	0.005	0.2227	0.2227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1091	0.1091
Echinococcus granulosus	cathepsin b	0.0171	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.005	0.2227	0.7755
Echinococcus granulosus	cathepsin l1	0.0023	0.0519	0.0274
Loa Loa (eye worm)	calpain family protein 1	0.0132	0.7486	0.7486
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0132	0.7486	0.7486
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1091	0.1091
Onchocerca volvulus		0.0082	0.4301	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1091	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0117	0.6528	0.6528
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.2872	1
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0035	0.127	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0253	0.0253
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1091	0.1091
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0142	0.8123	0.8123
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0253	0.0879
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0253	0.0879
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0253	0.1989
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0253	0.0253
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Entamoeba histolytica	cysteine protease, putative	0.0032	0.1091	0.8592
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.005	0.2227	0.2227
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Brugia malayi	cathepsin L-like precursor	0.0023	0.0519	0.0519
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0253	0.0253
Onchocerca volvulus		0.0032	0.1091	0.1512
Entamoeba histolytica	protein kinase, putative	0.0035	0.127	1
Trypanosoma cruzi	kinesin, putative	0.0035	0.127	0.127
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0253	0.1989
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1091	0.1091
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0519	0.409
Leishmania major	cathepsin L-like protease	0.0032	0.1091	0.3799
Loa Loa (eye worm)	hypothetical protein	0.0097	0.5258	0.5258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Echinococcus granulosus	calpain A	0.0142	0.8141	0.8093
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.005	0.2227	0.2227
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0142	0.8123	0.8123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1091	0.3799
Plasmodium vivax	vivapain-2	0.0032	0.1091	0.4246
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.1091	0.1091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.1091	0.3799
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.4301	0.4301
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0253	0.0253
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Leishmania major	kinesin, putative	0.0035	0.127	0.4421
Onchocerca volvulus		0.0032	0.1091	0.1512
Toxoplasma gondii	cathepsin CPL	0.0032	0.1091	0.3799
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0253	0.1989
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.1091	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Trypanosoma brucei	calpain-like protein, putative	0.005	0.2227	0.7755
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1091	0.3799
Toxoplasma gondii	cathepsin B	0.006	0.2872	1
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.1091	0.1512
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.005	0.2227	0.2227
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.2872	0.2872
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.1091	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1091	0.3799
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0519	0.0519
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.0253	0.0253

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 28 uM	Inhibitory potency against rat platelet membrane permeability at pH 7.35	ChEMBL.	8230139
Ki (binding)	= 0.4 uM	Inhibitory activity of alpha-keto esters towards calpain 2 at pH 8.0	ChEMBL.	8230139
Ki (binding)	= 0.4 uM	Inhibitory activity of alpha-keto esters towards calpain 2 at pH 8.0	ChEMBL.	8230139
Ki (binding)	= 1.8 uM	Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.	ChEMBL.	8230139
Ki (binding)	= 1.8 uM	Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.	ChEMBL.	8230139
Ki (binding)	= 4 uM	Inhibition of alpha-keto esters towards cathepsin B at pH 5.2	ChEMBL.	8230139
Ki (binding)	= 4 uM	Inhibition of alpha-keto esters towards cathepsin B at pH 5.2	ChEMBL.	8230139
Ki (binding)	= 10 uM	Inhibitory activity of alpha-ketoesters towards papain at pH 6.0	ChEMBL.	8230139
Ki (binding)	= 10 uM	Inhibitory activity of alpha-ketoesters towards papain at pH 6.0	ChEMBL.	8230139

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL333388

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 203050