Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.0332 | 0.6796 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0027 | 0.0222 | 0.0196 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0272 | 0.5639 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0211 | 0.0564 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0059 | 0.092 | 0.2464 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.009 | 0.1601 | 0.239 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0272 | 0.5639 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0222 | 0.0196 |
Schistosoma mansoni | microtubule-associated protein tau | 0.047 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0489 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0032 | 0.0332 | 0.089 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0161 | 0.3178 | 0.3159 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0019 | 0.0051 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0027 | 0.0222 | 0.0196 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.0489 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0024 | 0.0162 | 0.0136 |
Echinococcus multilocularis | GPCR, family 2 | 0.0027 | 0.0222 | 0.0196 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.0489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.0071 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0027 | 0.0222 | 0.0595 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0162 | 0.0434 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0489 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0018 | 0.0026 | 0.0071 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0026 | 0.0189 | 0.0163 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0222 | 0.0196 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.0489 | 0.1309 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.2738 | 0.2718 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.2738 | 0.2718 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.009 | 0.1601 | 0.239 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0027 | 0.0211 | 0.0185 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0027 | 0.0211 | 0.0185 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0032 | 0.0332 | 0.089 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0086 | 0.1521 | 0.4074 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0332 | 0.089 |
Onchocerca volvulus | 0.0212 | 0.43 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0032 | 0.0332 | 0.089 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0161 | 0.3178 | 0.3159 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.009 | 0.1601 | 0.239 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0332 | 0.089 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0489 | 1 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0272 | 0.5639 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0222 | 0.0196 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0086 | 0.1521 | 0.4074 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.0489 | 0.1309 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0033 | 0.0346 | 0.0928 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0272 | 0.5639 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0222 | 0.0595 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.01 | 0.1821 | 0.2806 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.0489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.3178 | 0.8514 |
Mycobacterium ulcerans | putative regulatory protein | 0.0272 | 0.5639 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0027 | 0.0211 | 0.0185 |
Brugia malayi | Pre-SET motif family protein | 0.0027 | 0.0211 | 0.0564 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.092 | 0.0895 |
Loa Loa (eye worm) | intermediate filament protein | 0.0018 | 0.0026 | 0.0071 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0206 | 0.4165 | 0.7222 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0141 | 0.2738 | 0.7335 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0162 | 0.0136 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0032 | 0.0332 | 0.089 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0018 | 0.0026 | 0.0071 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0027 | 0.0211 | 0.0185 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0032 | 0.0332 | 0.0306 |
Onchocerca volvulus | 0.0027 | 0.0211 | 0.0431 | |
Brugia malayi | beta-lactamase | 0.0032 | 0.0332 | 0.089 |
Plasmodium vivax | SET domain protein, putative | 0.0027 | 0.0211 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0332 | 0.089 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0162 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0272 | 0.5639 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0162 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0332 | 0.089 |
Brugia malayi | hypothetical protein | 0.0161 | 0.3178 | 0.8514 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0141 | 0.2738 | 0.7335 |
Brugia malayi | beta-lactamase family protein | 0.0032 | 0.0332 | 0.089 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0027 | 0.0222 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0332 | 0.089 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0032 | 0.0332 | 0.0306 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0027 | 0.0211 | 0.0185 |
Echinococcus granulosus | GPCR family 2 | 0.0027 | 0.0222 | 0.0196 |
Brugia malayi | intermediate filament protein | 0.0018 | 0.0026 | 0.0071 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.01 | 0.1821 | 0.2806 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.0489 | 0.1309 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0272 | 0.5639 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.009 | 0.1601 | 0.239 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0024 | 0.0162 | 0.0136 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.0489 | 0.0463 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.0272 | 0.5639 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0346 | 0.0321 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0.0332 | 0.6796 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.01 | 0.1821 | 0.2806 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.009 | 0.1601 | 0.239 |
Onchocerca volvulus | 0.0032 | 0.0332 | 0.0715 | |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0027 | 0.0211 | 0.4309 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0222 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.092 | 0.2464 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.2738 | 0.2718 |
Toxoplasma gondii | ABC1 family protein | 0.0032 | 0.0332 | 0.6796 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0332 | 0.089 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0162 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0032 | 0.0332 | 0.6796 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0027 | 0.0222 | 0.0196 |
Trichomonas vaginalis | set domain proteins, putative | 0.0212 | 0.43 | 1 |
Brugia malayi | glutathione reductase | 0.0039 | 0.0489 | 0.1309 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.0489 | 0.0295 |
Onchocerca volvulus | 0.0032 | 0.0332 | 0.0715 | |
Onchocerca volvulus | 0.0033 | 0.0346 | 0.0748 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0024 | 0.0162 | 0.0136 |
Schistosoma mansoni | survival motor neuron protein | 0.0033 | 0.0346 | 0.0321 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0272 | 0.5639 | 1 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0272 | 0.5639 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1521 | 0.4074 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.0332 | 0.6796 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.2738 | 0.2718 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0032 | 0.0332 | 0.0306 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.2738 | 0.2718 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.047 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.01 | 0.1821 | 0.2806 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0027 | 0.0222 | 0.0595 |
Mycobacterium tuberculosis | Probable reductase | 0.009 | 0.1601 | 0.239 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.2738 | 0.2718 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0162 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0032 | 0.0332 | 0.6796 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.0489 | 1 |
Onchocerca volvulus | 0.0032 | 0.0332 | 0.0715 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0032 | 0.0332 | 0.0306 |
Brugia malayi | Pre-SET motif family protein | 0.0186 | 0.3732 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.2738 | 0.2718 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0489 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0086 | 0.1521 | 0.4074 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0027 | 0.0211 | 0.0185 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0027 | 0.0222 | 0.0595 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.009 | 0.1601 | 0.239 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0027 | 0.0211 | 0.0185 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.0489 | 0.0463 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0272 | 0.5639 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0272 | 0.5639 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0186 | 0.3732 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.9 uM | Antiviral activity against human cytomegalovirus (HCMV) in plaque reduction assay | ChEMBL. | 8784444 |
IC50 (functional) | = 40 uM | Antiviral activity activity against herpes simplex virus type 1 using ELISA | ChEMBL. | 8784444 |
IC50 (ADMET) | = 100 uM | Cytotoxicity produced in human foreskin fibroblasts (HFF) cells estimated by visual scoring of cells unaffected by virus infection. | ChEMBL. | 8784444 |
IC50 (functional) | > 100 uM | Cytotoxocity (growth inhibition) against human epidermoid oral carcinoma KB cell line. | ChEMBL. | 8784444 |
IC50 (ADMET) | = 100 uM | Cytotoxicity produced in human foreskin fibroblasts (HFF) cells estimated by visual scoring of cells unaffected by virus infection. | ChEMBL. | 8784444 |
IC50 (functional) | > 100 uM | Cytotoxocity (growth inhibition) against human epidermoid oral carcinoma KB cell line. | ChEMBL. | 8784444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.