Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5224 | 0.4326 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0166 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0166 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0166 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0062 | 0.3288 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0035 | 0.1582 | 0.1582 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Echinococcus multilocularis | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Mycobacterium ulcerans | hypothetical protein | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3288 | 0.2026 |
Leishmania major | delta-5 fatty acid desaturase | 0.0102 | 0.588 | 0.588 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0062 | 0.3288 | 0.2026 |
Leishmania major | cyclin | 0.0035 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3288 | 0.2026 |
Leishmania major | carbonic anhydrase-like protein | 0.0166 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0.3288 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0062 | 0.3288 | 0.2026 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0102 | 0.588 | 0.5105 |
Trichomonas vaginalis | cyclin A, putative | 0.0035 | 0.1582 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0035 | 0.1582 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0062 | 0.3288 | 0.2026 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0035 | 0.1582 | 0.1582 |
Echinococcus granulosus | carbonic anhydrase II | 0.0166 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0062 | 0.3288 | 0.2026 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0166 | 1 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0035 | 0.1582 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.0035 | 0.1582 | 0.1582 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0062 | 0.3288 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3288 | 0.2026 |
Onchocerca volvulus | 0.0102 | 0.59 | 1 | |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0102 | 0.588 | 0.5105 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0166 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0035 | 0.1582 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Echinococcus multilocularis | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Trichomonas vaginalis | cyclin D, putative | 0.0035 | 0.1582 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0035 | 0.1582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.588 | 0.5105 |
Schistosoma mansoni | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0035 | 0.1582 | 0.1582 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.3288 | 0.2026 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0062 | 0.3288 | 0.2026 |
Trichomonas vaginalis | cyclin B3, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.1582 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0102 | 0.59 | 0.513 |
Trichomonas vaginalis | cyclin D, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0166 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0062 | 0.3288 | 0.2026 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0166 | 1 | 1 |
Giardia lamblia | Cyclin A | 0.0035 | 0.1582 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0166 | 1 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0035 | 0.1582 | 0.1582 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0035 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0166 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0062 | 0.3288 | 0.2026 |
Echinococcus granulosus | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 27 nM | Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes. | ChEMBL. | 10669561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.