Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0083 | 0.0779 | 0.0779 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1734 | 0.1734 |
Trypanosoma brucei | Fatty acid elongase | 0.0083 | 0.0779 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.0183 | 0.2349 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0032 | 0.0183 | 0.2349 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0866 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0213 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0213 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0068 | 0.0068 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0083 | 0.0779 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0371 | 0.0371 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.0183 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0083 | 0.0779 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0083 | 0.0779 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0213 | 0.0213 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0324 | 0.0324 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0083 | 0.0779 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1734 | 0.1734 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0032 | 0.0183 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0324 | 0.0324 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0324 | 0.0324 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0083 | 0.0779 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0324 | 0.0324 |
Leishmania major | pyruvate kinase | 0.0032 | 0.0183 | 0.2349 |
Leishmania major | pyruvate kinase | 0.0032 | 0.0183 | 0.2349 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0213 | 0.0213 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0866 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0324 | 0.0324 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0371 | 0.4763 |
Echinococcus multilocularis | pyruvate kinase | 0.0025 | 0.0103 | 0.0103 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0083 | 0.0779 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0324 | 0.0324 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0083 | 0.0779 | 0.0779 |
Leishmania major | fatty acid elongase, putative | 0.0083 | 0.0779 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0032 | 0.0183 | 0.2349 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0213 | 0.2733 |
Chlamydia trachomatis | pyruvate kinase | 0.0032 | 0.0183 | 0.5 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0083 | 0.0779 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0866 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0083 | 0.0779 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0083 | 0.0779 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0213 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.0183 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0032 | 0.0183 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0032 | 0.0183 | 0.2349 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0032 | 0.0183 | 0.2349 |
Giardia lamblia | Pyruvate kinase | 0.0032 | 0.0183 | 0.5 |
Brugia malayi | Fatty acid elongation protein 3 | 0.0083 | 0.0779 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0032 | 0.0183 | 0.2349 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0191 | 0.0191 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0371 | 0.4763 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.0183 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0324 | 0.0324 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0324 | 0.4161 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0032 | 0.0183 | 0.2349 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.0183 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0032 | 0.0183 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0213 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0191 | 0.2455 |
Brugia malayi | GNS1/SUR4 family protein | 0.0083 | 0.0779 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.1734 | 0.1734 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0324 | 0.0324 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.0183 | 0.2349 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0083 | 0.0779 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.0183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0371 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0191 | 0.0191 |
Echinococcus multilocularis | geminin | 0.0164 | 0.1734 | 0.1734 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.0183 | 0.0183 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0213 | 0.0213 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0866 | 1 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0032 | 0.0183 | 0.2349 |
Leishmania major | fatty acid elongase, putative | 0.0083 | 0.0779 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.0068 | 0.0068 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3509 uM | Ability to inhibit [3H]-mazindol binding to cloned human dopamine (DA) transporter | ChEMBL. | 15177457 |
Ki (binding) | > 10000 uM | Ability to inhibit [3H]-paroxetine binding to cloned human serotonin (5-HT) transporter | ChEMBL. | 15177457 |
Ki (binding) | > 10000 uM | Ability to inhibit [3H]-nisoxatine binding to cloned human norepinephrine (NE) transporter | ChEMBL. | 15177457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.