Detailed information for compound 206169

Basic information

Technical information
  • TDR Targets ID: 206169
  • Name: trimethyl-[12-(trimethylazaniumyl)dodecyl]aza nium dibromide
  • MW: 446.347 | Formula: C18H42Br2N2
  • H donors: 0 H acceptors: 0 LogP: 6.95 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[N+](CCCCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]
  • InChi: 1S/C18H42N2.2BrH/c1-19(2,3)17-15-13-11-9-7-8-10-12-14-16-18-20(4,5)6;;/h7-18H2,1-6H3;2*1H/q+2;;/p-2
  • InChiKey: KTOBGLRRVLDLEI-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • trimethyl-[12-(trimethylammonio)dodecyl]ammonium dibromide
  • trimethyl-(12-trimethylazaniumyldodecyl)azanium dibromide
  • trimethyl-(12-trimethylammoniododecyl)ammonium dibromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0231588 0.0591325 0.0591325
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Trypanosoma cruzi target of rapamycin kinase 3 0.019267 0.0482552 0.0482552
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Echinococcus granulosus serine protein kinase ATM 0.00699957 0.0139695 0.00984847
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.00395794 0.0054685 0.001312
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00818585 0.0172849 0.0131778
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.023176 0.0591805 0.0540073
Brugia malayi Histone deacetylase family protein 0.272019 0.754663 0.754663
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0129293 0.0305422 0.0252116
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.119089 0.327244 0.327244
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.031132 0.0814165 0.0814165
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.00939988 0.020678 0.0152931
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Echinococcus granulosus voltage dependent calcium channel 0.00800569 0.0167814 0.0126722
Brugia malayi histone deacetylase 11 0.157184 0.433715 0.433715
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Echinococcus multilocularis BRCA1 associated protein 0.00939988 0.020678 0.0165851
Mycobacterium ulcerans alpha-L-fucosidase 0.0504952 0.135534 0.275144
Loa Loa (eye worm) hypothetical protein 0.157184 0.433715 0.433715
Loa Loa (eye worm) hypothetical protein 0.114835 0.315355 0.315355
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0411781 0.109494 0.109494
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.051848 0.139315 0.139315
Schistosoma mansoni histone deacetylase hda2 0.281419 0.780935 0.780019
Echinococcus granulosus histone deacetylase 6 0.272019 0.754663 0.753638
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.023176 0.0591805 0.0591805
Echinococcus multilocularis acetylcholinesterase 0.00818585 0.0172849 0.0131778
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0504952 0.135534 0.131921
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.00939988 0.020678 0.0152931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0722398 0.196307 0.191888
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Leishmania major phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.0054685
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.051848 0.139315 0.139315
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0129293 0.0305422 0.0252116
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.044329 0.1183 0.113452
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00699957 0.0139695 0.0139695
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0904426 0.247182 0.244987
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0591617 0.159756 0.157306
Loa Loa (eye worm) histone deacetylase 0.272019 0.754663 0.754663
Schistosoma mansoni protein kinase 0.00797042 0.0166828 0.0125732
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0382352 0.101269 0.0975129
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0814165
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.023176 0.0591805 0.0591805
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Leishmania major phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Toxoplasma gondii target of rapamycin (TOR), putative 0.0182839 0.0455076 0.0402593
Echinococcus granulosus acetylcholinesterase 0.00818585 0.0172849 0.0131778
Brugia malayi FAT domain containing protein 0.00349047 0.00416196 0.00416196
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0129293 0.0305422 0.0252116
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0129293 0.0305422 0.0252116
Loa Loa (eye worm) phosphatidylinositol 3 0.01049 0.0237248 0.0237248
Brugia malayi BRCA1-associated protein 2 containing protein 0.00939988 0.020678 0.020678
Toxoplasma gondii histone deacetylase HDAC3 0.3598 1 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0904426 0.247182 0.243042
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Leishmania major histone deacetylase, putative 0.3598 1 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.00939988 0.020678 0.0152931
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.00939988 0.020678 0.0152931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.023176 0.0591805 0.0552484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.00797042 0.0166828 0.0166828
Echinococcus multilocularis histone deacetylase 6 0.272019 0.754663 0.753638
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0382352 0.101269 0.0975129
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Echinococcus multilocularis histone deacetylase 6 0.281419 0.780935 0.780019
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.00395794 0.0054685 0.00256846
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.00395794 0.0054685 0.0054685
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.00939988 0.020678 0.0165851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0158007 0.0385675 0.035764
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.00939988 0.020678 0.0152931
Loa Loa (eye worm) hypothetical protein 0.3598 1 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0162191 0.0397368 0.0357235
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.00939988 0.020678 0.0165851
Loa Loa (eye worm) hypothetical protein 0.00744841 0.0152239 0.0152239
Schistosoma mansoni brca1-associated protein (brap2) 0.00939988 0.020678 0.0165851
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0625317 0.169175 0.166752
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Toxoplasma gondii transporter, cation channel family protein 0.00800569 0.0167814 0.0113751
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.023176 0.0591805 0.0552484
Loa Loa (eye worm) hypothetical protein 0.00349047 0.00416196 0.00416196
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0864846 0.23612 0.231919
Plasmodium vivax histone deacetylase 1, putative 0.3598 1 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Loa Loa (eye worm) hypothetical protein 0.00395794 0.0054685 0.0054685
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.11101 0.304664 0.300841
Loa Loa (eye worm) acetylcholinesterase 1 0.00818585 0.0172849 0.0172849
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.00395794 0.0054685 0.001312
Echinococcus multilocularis Zinc finger, PHD finger 0.0129293 0.0305422 0.0264905
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Schistosoma mansoni phosphatidylinositol 4-kinase 0.00395794 0.0054685 0.001312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Leishmania major hypothetical protein, conserved 0.00939988 0.020678 0.020678
Loa Loa (eye worm) phosphatidylinositol 3 0.023176 0.0591805 0.0591805
Echinococcus granulosus histone deacetylase 7 0.272019 0.754663 0.753638
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0784993 0.213802 0.213802
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0504952 0.135534 0.131921
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Schistosoma mansoni histone deacetylase 4 5 0.272019 0.754663 0.753638
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.051848 0.139315 0.139315
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Echinococcus multilocularis 0.00395794 0.0054685 0.001312
Loa Loa (eye worm) hypothetical protein 0.00704005 0.0140826 0.0140826
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.17825 0.492593 0.492593
Loa Loa (eye worm) hypothetical protein 0.119089 0.327244 0.327244
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0672407 0.182335 1
Echinococcus granulosus integrin beta 2 0.192028 0.5311 0.52914
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Loa Loa (eye worm) hypothetical protein 0.0313997 0.0821646 0.0821646
Brugia malayi histone deacetylase 3 (HD3) 0.3598 1 1
Schistosoma mansoni histone deacetylase 0.3598 1 1
Echinococcus multilocularis histone deacetylase 7 0.272019 0.754663 0.753638
Echinococcus granulosus BRCA1 associated protein 0.00939988 0.020678 0.0165851
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0672407 0.182335 1
Schistosoma mansoni voltage-gated cation channel 0.0382352 0.101269 0.0975129
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.00939988 0.020678 0.0152931
Trypanosoma brucei Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Giardia lamblia Histone deacetylase 0.3598 1 1
Loa Loa (eye worm) hypothetical protein 0.00818585 0.0172849 0.0172849
Giardia lamblia GTOR 0.023176 0.0591805 0.0540073
Echinococcus multilocularis serine protein kinase ATM 0.00699957 0.0139695 0.00984847
Onchocerca volvulus Histone deacetylase 10 homolog 0.157184 0.433715 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.023176 0.0591805 0.0591805
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0591617 0.159756 0.159756
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0117518 0.0272513 0.0272513
Toxoplasma gondii histone deacetylase HDAC1 0.272019 0.754663 0.753314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Loa Loa (eye worm) hypothetical protein 0.0590429 0.159424 0.159424
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.11101 0.304664 0.304664
Loa Loa (eye worm) histone deacetylase 11 0.157184 0.433715 0.433715
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00304162 0.00290751 0.00290751
Entamoeba histolytica protein kinase rad3, putative 0.00699957 0.0139695 0.00854769
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Toxoplasma gondii hypothetical protein 0.00704005 0.0140826 0.00866145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.023176 0.0591805 0.0591805
Trypanosoma brucei histone deacetylase 4 0.272019 0.754663 0.754663
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Leishmania major phosphatidylinositol kinase related protein, putative 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis carboxylesterase 5A 0.00818585 0.0172849 0.0131778
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0904426 0.247182 0.247182
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.17825 0.492593 0.492593
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0590429 0.159424 0.155911
Echinococcus multilocularis histone deacetylase 3 0.3598 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0382352 0.101269 0.0975129
Leishmania major phosphatidylinositol 3-kinase, putative 0.01049 0.0237248 0.0237248
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.031132 0.0814165 0.0814165
Echinococcus granulosus histone deacetylase 0.272019 0.754663 0.753638
Loa Loa (eye worm) histone deacetylase 7A 0.272019 0.754663 0.754663
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.17825 0.492593 0.489803
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.00797042 0.0166828 0.0166828
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Echinococcus multilocularis histone deacetylase 6 0.272019 0.754663 0.753638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0382352 0.101269 0.0975129
Giardia lamblia Hypothetical protein 0.00939988 0.020678 0.0152931
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.00939988 0.020678 0.0165851
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.031132 0.0814165 0.0787379
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.023176 0.0591805 0.0591805
Plasmodium falciparum histone deacetylase, putative 0.272019 0.754663 0.753314
Trichomonas vaginalis alpha-L-fucosidase, putative 0.00971519 0.0215593 0.0187061
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.0152931
Toxoplasma gondii histone deacetylase HDAC5 0.157184 0.433715 0.430601
Trypanosoma brucei histone deacetylase, putative 0.272019 0.754663 0.754663
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.00939988 0.020678 0.0355158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162496 0.0398219 0.0370221
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.17825 0.492593 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.0054685
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.023176 0.0591805 0.0552484
Trichomonas vaginalis BRCA1-associated protein, putative 0.00939988 0.020678 0.0178223
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0763656
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.023176 0.0591805 0.0591805
Loa Loa (eye worm) hypothetical protein 0.00699957 0.0139695 0.0139695
Plasmodium vivax histone deacetylase, putative 0.272019 0.754663 0.753314
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.119089 0.327244 0.325282
Trypanosoma cruzi histone deacetylase, putative 0.157184 0.433715 0.433715
Leishmania major hypothetical protein, conserved 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Schistosoma mansoni histone deacetylase hda2 0.157184 0.433715 0.431348
Plasmodium falciparum histone deacetylase 2 0.272019 0.754663 0.753314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0153822 0.0373977 0.0345907
Schistosoma mansoni hypothetical protein 0.00395794 0.0054685 0.001312
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Loa Loa (eye worm) hypothetical protein 0.00304162 0.00290751 0.00290751
Trypanosoma cruzi histone deacetylase 1, putative 0.3598 1 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0231588 0.0591325 0.0552003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Leishmania major histone deacetylase, putative 0.3598 1 1
Schistosoma mansoni brca1-associated protein (brap2) 0.00939988 0.020678 0.0165851
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0382352 0.101269 0.0975129
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0232591 0.0594128 0.0594128
Echinococcus granulosus histone deacetylase 6 0.281419 0.780935 0.780019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Toxoplasma gondii non-specific serine/threonine protein kinase 0.00744841 0.0152239 0.00980904
Trypanosoma brucei histone deacetylase 3 0.272019 0.754663 0.754663
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.00699957 0.0139695 0.00854769
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0113332 0.0260815 0.0260815
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0625317 0.169175 0.166752
Brugia malayi Alpha-L-fucosidase family protein 0.0241763 0.0619761 0.0619761
Loa Loa (eye worm) calcium channel 0.0382352 0.101269 0.101269
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Echinococcus multilocularis voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.00939988 0.020678 0.0165851
Trichomonas vaginalis conserved hypothetical protein 0.00349047 0.00416196 0.00125811
Schistosoma mansoni fkbp-rapamycin associated protein 0.00699957 0.0139695 0.00984847
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Trichomonas vaginalis brca1-associated protein, putative 0.00939988 0.020678 0.0178223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0590429 0.159424 0.159424
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.00939988 0.020678 0.020678
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Loa Loa (eye worm) hypothetical protein 0.124235 0.341627 0.341627
Loa Loa (eye worm) hypothetical protein 0.00818585 0.0172849 0.0172849
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0129293 0.0305422 0.0264905
Echinococcus multilocularis sodium channel protein 0.0162191 0.0397368 0.0357235
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0129293 0.0305422 0.0277153
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0408401 0.108549 0.103648
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.00256846
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.00395794 0.0054685 0.001312
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Loa Loa (eye worm) hypothetical protein 0.00800569 0.0167814 0.0167814
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.031132 0.0814165 0.0787379
Leishmania major hypothetical protein, conserved 0.00939988 0.020678 0.020678
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Brugia malayi hypothetical protein 0.0411781 0.109494 0.109494
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.00699957 0.0139695 0.0139695
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.051848 0.139315 0.139315
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.00939988 0.020678 0.0165851
Echinococcus granulosus serine:threonine protein kinase SMG1 0.00699957 0.0139695 0.00984847
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0221607 0.0563427 0.051154
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.00699957 0.0139695 0.0139695
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0129293 0.0305422 0.0264905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.119089 0.327244 0.325282
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Loa Loa (eye worm) phosphatidylinositol 3 0.0271741 0.0703545 0.0703545
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0129293 0.0305422 0.0264905
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.17825 0.492593 0.489803
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.01049 0.0237248 0.0237248
Loa Loa (eye worm) hypothetical protein 0.0382352 0.101269 0.101269
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.00939988 0.020678 0.0152931
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00699957 0.0139695 0.0139695
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.00939988 0.020678 0.020678
Echinococcus granulosus dual specificity mitogen activated protein 0.00797042 0.0166828 0.0125732
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.031132 0.0814165 0.0787379
Echinococcus granulosus histone deacetylase 6 0.272019 0.754663 0.753638
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0129293 0.0305422 0.0277153
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0129293 0.0305422 0.0264905
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Loa Loa (eye worm) hypothetical protein 0.0411781 0.109494 0.109494
Toxoplasma gondii histone deacetylase HDAC2 0.3598 1 1
Echinococcus multilocularis acetylcholinesterase 0.00818585 0.0172849 0.0131778
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0129293 0.0305422 0.0305422
Trypanosoma cruzi histone deacetylase 1, putative 0.3598 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0231588 0.0591325 0.0552003
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Plasmodium vivax hypothetical protein, conserved 0.00939988 0.020678 0.0152931
Brugia malayi histone deacetylase 1 (HD1) 0.3598 1 1
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.00939988 0.020678 0.0152931
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Trichomonas vaginalis PIKK family atypical protein kinase 0.00786697 0.0163937 0.0135255
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0382352 0.101269 0.101269
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.00939988 0.020678 0.020678
Loa Loa (eye worm) phosphatidylinositol 3 0.150739 0.415703 0.415703
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.00939988 0.020678 0.0165851
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.00395794 0.0054685 0.001312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Loa Loa (eye worm) integrin beta-2 0.262273 0.727426 0.727426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.01049 0.0237248 0.0237248
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0271741 0.0703545 0.0703545
Leishmania major histone deacetylase, putative 0.272019 0.754663 0.754663
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Toxoplasma gondii histone deacetylase HDAC4 0.157184 0.433715 0.430601
Echinococcus multilocularis histone deacetylase 0.272019 0.754663 0.753638
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.126402 0.347685 0.347685
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0904426 0.247182 0.244987
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Schistosoma mansoni alpha-l-fucosidase 0.0241763 0.0619761 0.0580557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196855 0.0494251 0.0466532
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.17825 0.492593 0.5
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Echinococcus granulosus c-Jun N-terminal kinases 0.0231588 0.0591325 0.0552003
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.00939988 0.020678 0.0152931
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.00939988 0.020678 0.0165851
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0232591 0.0594128 0.0594128
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.17825 0.492593 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.00699957 0.0139695 0.00984847
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Loa Loa (eye worm) histone deacetylase 3 0.3598 1 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.17825 0.492593 0.489803
Loa Loa (eye worm) carboxylesterase 0.00818585 0.0172849 0.0172849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Schistosoma mansoni histone deacetylase 0.3598 1 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Echinococcus multilocularis histone deacetylase 1 0.3598 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.168942 0.466577 0.464347
Echinococcus multilocularis voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Brugia malayi Kelch motif family protein 0.0411781 0.109494 0.109494
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00699957 0.0139695 0.0139695
Schistosoma mansoni histone deacetylase 1 2 3 0.157184 0.433715 0.431348
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0904426 0.247182 0.247182
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Toxoplasma gondii UBA/TS-N domain-containing protein 0.00939988 0.020678 0.0152931
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0129293 0.0305422 0.0277153
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0382352 0.101269 0.0975129
Toxoplasma gondii FATC domain-containing protein 0.00699957 0.0139695 0.00854769
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.031132 0.0814165 0.0775774
Loa Loa (eye worm) alpha-L-fucosidase 0.0241763 0.0619761 0.0619761
Entamoeba histolytica hypothetical protein 0.0722398 0.196307 0.191888
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0129293 0.0305422 0.0305422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Leishmania major phosphatidylinositol 3-kinase, putative 0.0129293 0.0305422 0.0305422
Trypanosoma cruzi Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.119089 0.327244 0.324432
Trypanosoma brucei histone deacetylase 2 0.157184 0.433715 0.433715
Brugia malayi Stress-activated protein kinase jnk-1 0.0231588 0.0591325 0.0591325
Brugia malayi Integrin beta pat-3 precursor 0.262273 0.727426 0.727426
Schistosoma mansoni integrin beta subunit 0.15085 0.416013 0.413572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.051848 0.139315 0.139315
Trypanosoma brucei target of rapamycin kinase 3, putative 0.019267 0.0482552 0.0482552
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.00797042 0.0166828 0.0166828
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0382352 0.101269 0.0975129
Trichomonas vaginalis PIKK family atypical protein kinase 0.00395794 0.0054685 0.00256846
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0129293 0.0305422 0.0252116
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Echinococcus granulosus histone deacetylase 8 0.157184 0.433715 0.431348
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.00699957 0.0139695 0.00984847
Trypanosoma brucei histone deacetylase 1 0.3598 1 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.00395794 0.0054685 0.001312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.019267 0.0482552 0.0482552
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.17825 0.492593 0.5
Plasmodium falciparum histone deacetylase 1 0.3598 1 1
Trichomonas vaginalis conserved hypothetical protein 0.00744841 0.0152239 0.0123523
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.00939988 0.020678 0.0165851
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0129293 0.0305422 0.0264905
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Echinococcus granulosus acetylcholinesterase 0.00818585 0.0172849 0.0131778
Echinococcus granulosus histone deacetylase 3 0.3598 1 1
Echinococcus granulosus histone deacetylase 1 0.3598 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.168942 0.466577 0.464347
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0763656
Brugia malayi Histone deacetylase family protein 0.272019 0.754663 0.754663
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Brugia malayi Histone deacetylase 1 0.3598 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0904426 0.247182 0.247182
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.119089 0.327244 0.324432
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.023176 0.0591805 0.0591805
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0904426 0.247182 0.244987
Trichomonas vaginalis alpha-L-fucosidase, putative 0.00971519 0.0215593 0.0187061
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Echinococcus granulosus carboxylesterase 5A 0.00818585 0.0172849 0.0131778
Leishmania major phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Trypanosoma cruzi Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Onchocerca volvulus 0.0224432 0.0571323 0.12064
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.00395794 0.0054685 0.0054685
Brugia malayi Carboxylesterase family protein 0.00818585 0.0172849 0.0172849
Giardia lamblia Kinase, STE STE20 0.00797042 0.0166828 0.011276
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.01049 0.0237248 0.0196446
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Leishmania major hypothetical protein, conserved 0.0224432 0.0571323 0.0571323
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0382352 0.101269 0.0975129
Leishmania major histone deacetylase, putative 0.272019 0.754663 0.754663
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0590429 0.159424 0.155911
Leishmania major hypothetical protein, unknown function 0.00395794 0.0054685 0.0054685
Trypanosoma cruzi histone deacetylase, putative 0.157184 0.433715 0.433715
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.168942 0.466577 0.464347
Loa Loa (eye worm) hypothetical protein 0.00390902 0.00533178 0.00533178
Brugia malayi Carboxylesterase family protein 0.00818585 0.0172849 0.0172849
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.00797042 0.0166828 0.0166828
Loa Loa (eye worm) phosphatidylinositol kinase 0.00395794 0.0054685 0.0054685
Plasmodium vivax histone deacetylase 2, putative 0.272019 0.754663 0.753314
Echinococcus multilocularis integrin beta 2 0.192028 0.5311 0.52914
Loa Loa (eye worm) histone deacetylase 1 0.3598 1 1
Echinococcus multilocularis histone deacetylase 8 0.157184 0.433715 0.431348
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.00797042 0.0166828 0.0166828
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.17825 0.492593 0.489803
Plasmodium vivax histone deacetylase, putative 0.157184 0.433715 0.430601
Loa Loa (eye worm) hypothetical protein 0.00704005 0.0140826 0.0140826
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.051848 0.139315 0.139315
Echinococcus granulosus voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.119089 0.327244 0.327244
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.00939988 0.020678 0.0152931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Echinococcus multilocularis dual specificity mitogen activated protein 0.00797042 0.0166828 0.0125732
Entamoeba histolytica hypothetical protein 0.00699957 0.0139695 0.00854769
Trichomonas vaginalis PIKK family atypical protein kinase 0.00395794 0.0054685 0.00256846
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Loa Loa (eye worm) voltage-dependent calcium channel 0.00800569 0.0167814 0.0167814
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.023176 0.0591805 0.0540073
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.01049 0.0237248 0.0196446
Entamoeba histolytica histone deacetylase, putative 0.3598 1 1
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.126402 0.347685 0.347685
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.01049 0.0237248 0.0196446
Schistosoma mansoni histone deacetylase 4 5 0.272019 0.754663 0.753638
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0129293 0.0305422 0.0252116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0153822 0.0373977 0.0345907

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 350 uM ChEMBL. 16420066
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 175 uM ChEMBL. 16420066
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 87.5 uM ChEMBL. 16420066
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 35 uM ChEMBL. 16420066
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 3.5 uM ChEMBL. 16420066
IC50 (functional) = 0 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
IC50 (functional) = 0.09 uM In vitro antimalarial activity against Plasmodium falciparum ChEMBL. 10669577
IC50 (functional) = 0.09 uM Inhibitory activity against Plasmodium falciparum ChEMBL. 9357523
IC50 (functional) = 0.09 uM In vitro antimalarial activity against Plasmodium falciparum ChEMBL. 10669577
IC50 (functional) = 0.09 uM Inhibitory activity against Plasmodium falciparum ChEMBL. 9357523
IC50 (functional) = 0.09 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by micro dilution assay ChEMBL. 20382538
IC50 (functional) = 0.395 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite-specific LDH release after 72 hrs by Malstat assay ChEMBL. 20382538
IC50 (binding) > 250 uM Inhibition of Cryptococccus neoformans H99 PLB1activity ChEMBL. 16420066
IC50 (binding) > 250 uM Inhibition of Cryptococccus neoformans H99 PLB1activity ChEMBL. 16420066
Inhibition (binding) Inhibition of porcine pancreatic PLA2 activity at 25 uM and below ChEMBL. 16420066
Inhibition (binding) Inhibition of porcine pancreatic PLA2 activity at 250 uM ChEMBL. 16420066
Inhibition (binding) 0 Inhibition of porcine pancreatic PLA2 activity at 250 uM ChEMBL. 16420066
Inhibition (binding) 0 Inhibition of porcine pancreatic PLA2 activity at 25 uM and below ChEMBL. 16420066
MIC (functional) = 175 uM Antifungal activity against Cryptococccus neoformans ATCC 90112 ChEMBL. 16420066
MIC (functional) = 175 uM Antifungal activity against Candida albicans ATCC 10231 ChEMBL. 16420066
MIC (functional) = 175 uM Antifungal activity against Cryptococccus neoformans ATCC 90112 ChEMBL. 16420066
MIC (functional) = 175 uM Antifungal activity against Candida albicans ATCC 10231 ChEMBL. 16420066

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 10669577

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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