Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0101 | 0.3365 | 0.4233 |
Loa Loa (eye worm) | beta-lactamase | 0.003 | 0.0257 | 0.0192 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.3365 | 0.4233 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0034 | 0.0438 | 0.5476 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0172 | 0.6509 | 0.8514 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.1932 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.005 | 0.1134 | 0.1364 |
Onchocerca volvulus | 0.004 | 0.0705 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0252 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0061 | 0.1613 | 0.1846 |
Trichomonas vaginalis | chromobox protein, putative | 0.0061 | 0.1613 | 0.8346 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.3365 | 0.4233 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0172 | 0.6509 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0257 | 0.1332 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.4765 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0192 | 0.7363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Brugia malayi | TAR-binding protein | 0.005 | 0.1134 | 0.1195 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.1385 | 0.1536 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.3365 | 0.4971 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.004 | 0.0679 | 0.0574 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0438 | 0.2265 |
Mycobacterium leprae | conserved hypothetical protein | 0.003 | 0.0257 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.004 | 0.0705 | 0.0716 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0101 | 0.3365 | 0.4343 |
Loa Loa (eye worm) | IRE protein kinase | 0.0134 | 0.4814 | 0.6278 |
Brugia malayi | RNA binding protein | 0.005 | 0.1134 | 0.1195 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0134 | 0.4814 | 0.6206 |
Mycobacterium leprae | Probable lipase LipE | 0.003 | 0.0257 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0119 | 0.4174 | 0.402 |
Echinococcus granulosus | chromobox protein 1 | 0.0061 | 0.1613 | 0.1846 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Schistosoma mansoni | chromobox protein | 0.0061 | 0.1613 | 0.2168 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0257 | 0.1332 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0172 | 0.6509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6509 | 0.8543 |
Entamoeba histolytica | protein kinase, putative | 0.0134 | 0.4814 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.003 | 0.0257 | 0.1332 |
Loa Loa (eye worm) | TAR-binding protein | 0.005 | 0.1134 | 0.1364 |
Trichomonas vaginalis | chromobox protein, putative | 0.0037 | 0.0551 | 0.2854 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0252 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.0257 | 0.2427 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.3365 | 0.4971 |
Brugia malayi | hypothetical protein | 0.0197 | 0.7599 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.005 | 0.1134 | 0.1195 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.004 | 0.0705 | 0.061 |
Echinococcus granulosus | chromobox protein 1 | 0.0061 | 0.1613 | 0.1846 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0197 | 0.7599 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.003 | 0.0257 | 0.1332 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0035 | 0.0494 | 0.0243 |
Onchocerca volvulus | 0.003 | 0.0257 | 0.2427 | |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0134 | 0.4814 | 0.6206 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Brugia malayi | RNA recognition motif domain containing protein | 0.005 | 0.1134 | 0.1195 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0252 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.005 | 0.1134 | 0.1364 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.3365 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.7599 | 1 |
Onchocerca volvulus | 0.003 | 0.0257 | 0.2427 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0119 | 0.4174 | 0.402 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0037 | 0.0551 | 0.7401 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.0834 | 0.0592 |
Echinococcus multilocularis | chromobox protein 1 | 0.0061 | 0.1613 | 0.1846 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Echinococcus granulosus | hormone sensitive lipase | 0.0172 | 0.6509 | 0.8514 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.003 | 0.0257 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0705 | 0.0716 |
Echinococcus multilocularis | tar DNA binding protein | 0.005 | 0.1134 | 0.1195 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.003 | 0.0257 | 0.1332 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.1385 | 0.1698 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0257 | 0.5 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0035 | 0.0494 | 0.0243 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.3365 | 0.4971 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.1951 | 0.2709 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0438 | 0.0433 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0068 | 0.1932 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Toxoplasma gondii | hypothetical protein | 0.0041 | 0.0723 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0035 | 0.0494 | 0.0243 |
Trichomonas vaginalis | chromobox protein, putative | 0.0037 | 0.0551 | 0.2854 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0257 | 0.1332 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0134 | 0.4814 | 0.6206 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0438 | 0.2265 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0061 | 0.1613 | 0.2002 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0035 | 0.0494 | 0.0243 |
Entamoeba histolytica | protein kinase, putative | 0.0134 | 0.4814 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0197 | 0.7599 | 1 |
Schistosoma mansoni | lipoxygenase | 0.004 | 0.0679 | 0.0674 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0119 | 0.4174 | 0.402 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.3365 | 0.4233 |
Brugia malayi | Heterochromatin protein 1 | 0.0061 | 0.1613 | 0.1846 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.004 | 0.0679 | 0.0574 |
Trichomonas vaginalis | chromobox protein, putative | 0.0061 | 0.1613 | 0.8346 |
Schistosoma mansoni | chromobox protein | 0.0061 | 0.1613 | 0.2168 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Brugia malayi | chromobox protein homolog 3 | 0.0034 | 0.0438 | 0.0246 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0133 | 0.4765 | 0.6343 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0172 | 0.6509 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.