Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | 0.0024 | 0 | 0.5 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0024 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.273 | 0.864 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0024 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.273 | 0.2233 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0091 | 0.273 | 0.8783 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0068 | 0.1802 | 0.5799 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.01 | 0.3108 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.273 | 0.2233 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.004 | 0.0639 | 0.2287 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0068 | 0.1802 | 0.6446 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.273 | 0.864 |
Echinococcus multilocularis | acetylcholinesterase | 0.0091 | 0.273 | 0.8783 |
Echinococcus granulosus | acetylcholinesterase | 0.0091 | 0.273 | 0.8783 |
Echinococcus granulosus | acetylcholinesterase | 0.0091 | 0.273 | 0.8783 |
Loa Loa (eye worm) | glutamate receptor | 0.0081 | 0.2341 | 0.7241 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.01 | 0.3108 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0092 | 0.2796 | 1 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0024 | 0 | 0.5 |
Mycobacterium leprae | Probable Acetylornithine aminotransferase ArgD | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3108 | 1 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0091 | 0.273 | 0.8783 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0081 | 0.2341 | 0.1818 |
Plasmodium falciparum | ornithine aminotransferase | 0.0024 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0269 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0068 | 0.1802 | 0.5799 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0091 | 0.273 | 0.864 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0024 | 0 | 0.5 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0269 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0091 | 0.273 | 0.8783 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.273 | 0.9764 |
Loa Loa (eye worm) | carboxylesterase | 0.0091 | 0.273 | 0.864 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0074 | 0.2029 | 0.1484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.