Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1186 | 0.912 | 1 |
Loa Loa (eye worm) | Gln-2 protein | 0.0534 | 0.327 | 0.327 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0945 | 0.6958 | 0.8878 |
Plasmodium vivax | glutamine synthetase, putative | 0.1008 | 0.7525 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0167 | 0.0167 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0713 | 0.4875 | 0.4467 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.088 | 0.088 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.1008 | 0.7525 | 0.5 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0534 | 0.327 | 0.5 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0534 | 0.327 | 0.5 |
Trichomonas vaginalis | glutamine synthetase, putative | 0.0238 | 0.062 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0874 | 0.6319 | 0.6319 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1043 | 0.7838 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0181 | 0.0106 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0796 | 0.0796 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0713 | 0.4875 | 0.5345 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0534 | 0.327 | 0.3586 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0874 | 0.6319 | 0.6929 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0713 | 0.4875 | 0.5 |
Leishmania major | glutamine synthetase, putative | 0.0534 | 0.327 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0508 | 0.3042 | 0.3335 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0276 | 0.0961 | 0.0961 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0267 | 0.088 | 0.088 |
Echinococcus granulosus | glutamine synthetase | 0.0534 | 0.327 | 0.327 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0534 | 0.327 | 1 |
Mycobacterium ulcerans | glutamine synthetase | 0.1008 | 0.7525 | 1 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.1008 | 0.7525 | 1 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0238 | 0.062 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0874 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.1021 | 0.1021 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0267 | 0.088 | 0.1122 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1284 | 1 | 1 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0238 | 0.062 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.041 | 0.2162 | 0.2162 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.1008 | 0.7525 | 1 |
Echinococcus multilocularis | glutamine synthetase | 0.0534 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.1284 | 1 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0267 | 0.088 | 0.088 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0713 | 0.4875 | 0.5345 |
Mycobacterium leprae | PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) | 0.1008 | 0.7525 | 1 |
Trichomonas vaginalis | glutamine synthetase-bacteria, putative | 0.0238 | 0.062 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.1043 | 0.7838 | 0.7838 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0534 | 0.327 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0474 | 0.2736 | 0.3064 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0508 | 0.3042 | 0.3881 |
Plasmodium falciparum | glutamine synthetase, putative | 0.1008 | 0.7525 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.