Detailed information for compound 2076874

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 476.533 | Formula: C22H35F3N4O4
  • H donors: 1 H acceptors: 4 LogP: -0.69 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.CCN1CCC2(C1=O)CN(CC12CCN(CC1)CC1CC1)C(=O)N(C)C
  • InChi: 1S/C20H34N4O2.C2HF3O2/c1-4-23-12-9-20(17(23)25)15-24(18(26)21(2)3)14-19(20)7-10-22(11-8-19)13-16-5-6-16;3-2(4,5)1(6)7/h16H,4-15H2,1-3H3;(H,6,7)
  • InChiKey: BPCJBQAFGIKLBY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0113 0.005 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Schistosoma mansoni cathepsin D (A01 family) 0.1386 0.6053 0.6053
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1914
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Brugia malayi Cathepsin L-like cysteine proteinase 0.1016 0.4308 0.4308
Schistosoma mansoni cathepsin B (C01 family) 0.0335 0.1098 0.1098
Onchocerca volvulus 0.0343 0.1134 0.1706
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.3767
Loa Loa (eye worm) hypothetical protein 0.0117 0.0068 0.0068
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Echinococcus granulosus apoptotic protease activating factor 1 0.0212 0.0518 0.0494
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0457 0.1672 0.1651
Echinococcus granulosus Tolloid protein 1 0.018 0.0365 0.0341
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0335 0.1098 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1016 0.4308 0.6191
Onchocerca volvulus 0.0343 0.1134 0.1706
Schistosoma mansoni memapsin-2 (A01 family) 0.0113 0.005 0.005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Loa Loa (eye worm) hypothetical protein 0.0303 0.0946 0.0946
Brugia malayi cathepsin L-like cysteine proteinase 0.0335 0.1098 0.1098
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Loa Loa (eye worm) hypothetical protein 0.0113 0.005 0.005
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.3365 0.3348
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Brugia malayi hypothetical protein 0.031 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.048 0.1781 0.1781
Leishmania major metacaspase, putative 0.0236 0.0631 0.0787
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Trypanosoma cruzi cysteine peptidase, putative 0.0815 0.3361 0.3278
Echinococcus granulosus transmembrane protease serine 3 0.0343 0.1134 0.1111
Plasmodium falciparum serine repeat antigen 4 0.0335 0.1098 0.1607
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Brugia malayi thymidylate synthase 0.0652 0.2591 0.2591
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Echinococcus granulosus cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0815 0.3361 0.5021
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0457 0.1672 0.1651
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0335 0.1098 0.1607
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0443 0.1607 0.2387
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Plasmodium vivax vivapain-1 0.0815 0.3361 0.5077
Echinococcus granulosus growth factor receptor bound protein 2 0.0856 0.3555 0.3539
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Echinococcus granulosus calpain 0.0183 0.0383 0.0359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Trypanosoma cruzi cysteine protease, putative 0.0815 0.3361 0.3278
Loa Loa (eye worm) hypothetical protein 0.1503 0.6602 0.6602
Echinococcus multilocularis tissue type plasminogen activator 0.0617 0.2427 0.2407
Plasmodium falciparum serine repeat antigen 3 0.0335 0.1098 0.1607
Plasmodium falciparum serine repeat antigen 6 0.0335 0.1098 0.1607
Onchocerca volvulus 0.0109 0.0033 0.0036
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0113 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0192 0.0425 0.0425
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0376 0.1291 0.1903
Loa Loa (eye worm) calpain family protein 1 0.0486 0.181 0.181
Loa Loa (eye worm) cysteine protease 0.1496 0.6571 0.6571
Trypanosoma brucei metacaspase MCA3 0.0236 0.0631 0.0787
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0335 0.1098 0.1512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Mycobacterium ulcerans hypothetical protein 0.0343 0.1134 0.1993
Echinococcus granulosus cathepsin b 0.2223 1 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.051 0.1923 0.2176
Brugia malayi aspartic protease BmAsp-1, identical 0.0113 0.005 0.005
Brugia malayi Cathepsin L-like precursor 0.1016 0.4308 0.4308
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0443 0.1607 0.1607
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Toxoplasma gondii hypothetical protein 0.0109 0.0033 0.0011
Echinococcus multilocularis caspase 2 0.0448 0.163 0.1609
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Brugia malayi calpain 5 0.0128 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.1496 0.6571 0.6571
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Loa Loa (eye worm) hypothetical protein 0.0104 0.0009 0.0009
Brugia malayi hypothetical protein 0.0343 0.1134 0.1134
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0109 0.0033 0.0011
Brugia malayi calpain family protein 1 0.0486 0.181 0.181
Loa Loa (eye worm) hypothetical protein 0.0175 0.0345 0.0345
Trypanosoma cruzi cruzipain precursor, putative 0.1496 0.6571 0.6528
Loa Loa (eye worm) fibroinase 0.1496 0.6571 0.6571
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0856 0.3555 0.3555
Echinococcus multilocularis Mastin 0.0343 0.1134 0.1111
Brugia malayi Calcium binding EGF domain containing protein 0.0108 0.0025 0.0025
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1496 0.6571 0.6571
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Brugia malayi calpain 7 0.0183 0.0383 0.0383
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Onchocerca volvulus Cell death protein 3 homolog 0.0448 0.163 0.2458
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1496 0.6571 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0335 0.1098 0.1607
Echinococcus multilocularis calpain 7 (C02 family) 0.0183 0.0383 0.0359
Plasmodium vivax vivapain-2 0.1496 0.6571 1
Onchocerca volvulus 0.0109 0.0033 0.0036
Echinococcus multilocularis transmembrane protease serine 3 0.0343 0.1134 0.1111
Brugia malayi cathepsin L precursor 0.0335 0.1098 0.1098
Loa Loa (eye worm) STAT protein 0.0373 0.1275 0.1275
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0352 0.1177 0.1177
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Echinococcus multilocularis calpain family protein 1, d 0.0358 0.1206 0.1183
Giardia lamblia Encystation-specific protease 0.0376 0.1291 0.0701
Echinococcus multilocularis cathepsin L cysteine protease 0.1496 0.6571 0.6562
Brugia malayi calpain family protein 1 0.0486 0.181 0.181
Echinococcus granulosus caspase 0.0531 0.2022 0.2002
Onchocerca volvulus 0.0109 0.0033 0.0036
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Plasmodium falciparum plasmepsin VI 0.0457 0.1672 0.2488
Loa Loa (eye worm) trypsin family protein 0.0343 0.1134 0.1134
Toxoplasma gondii microneme protein MIC17A 0.0109 0.0033 0.0011
Plasmodium vivax aspartyl protease, putative 0.0157 0.0257 0.0317
Loa Loa (eye worm) hypothetical protein 0.0212 0.0518 0.0518
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Brugia malayi cathepsin F-like cysteine proteinase 0.0335 0.1098 0.1098
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0335 0.1098 0.1098
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0457 0.1672 0.1672
Onchocerca volvulus 0.0113 0.005 0.0062
Echinococcus multilocularis caspase 3 0.0295 0.091 0.0887
Onchocerca volvulus 0.0109 0.0033 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1098 0.0787
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0104 0.0009 0.0009
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Plasmodium vivax aspartyl proteinase, putative 0.0457 0.1672 0.2488
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Toxoplasma gondii aspartyl protease ASP1 0.0457 0.1672 0.2516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Onchocerca volvulus 0.1016 0.4308 0.6521
Toxoplasma gondii aspartyl protease 0.0113 0.005 0.0038
Loa Loa (eye worm) hypothetical protein 0.0617 0.2427 0.2427
Schistosoma mansoni hypothetical protein 0.0343 0.1134 0.1134
Schistosoma mansoni growth factor receptor-bound protein 0.0856 0.3555 0.3555
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0113 0.005 0.005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0113 0.005 0.005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1016 0.4308 0.4237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.1098 0.0787
Echinococcus granulosus caspase 3 0.0295 0.091 0.0887
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1503 0.6602 0.6602
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Brugia malayi MH2 domain containing protein 0.012 0.0085 0.0085
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0508 0.1914 0.1893
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Onchocerca volvulus 0.1496 0.6571 0.9953
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Brugia malayi hypothetical protein 0.0113 0.005 0.005
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0192 0.0425 0.0401
Echinococcus multilocularis caspase 0.0531 0.2022 0.2002
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0531 0.2022 0.2002
Toxoplasma gondii preprocathepsin c precursor, putative 0.0443 0.1607 0.2416
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0113 0.005 0.005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1496 0.6571 0.6571
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0919 0.3851 0.5422
Schistosoma mansoni calpain-7 (C02 family) 0.0183 0.0383 0.0383
Trypanosoma cruzi cysteine proteinase, putative 0.0815 0.3361 0.3278
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1496 0.6571 1
Plasmodium falciparum metacaspase 1 0.0236 0.0631 0.089
Echinococcus granulosus glycoprotein Antigen 5 0.0343 0.1134 0.1111
Echinococcus granulosus calpain A 0.0508 0.1914 0.1893
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Onchocerca volvulus 0.0652 0.2591 0.3916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Plasmodium vivax hypothetical protein, conserved 0.0236 0.0631 0.089
Onchocerca volvulus 0.0343 0.1134 0.1706
Echinococcus multilocularis growth factor receptor bound protein 2 0.0856 0.3555 0.3539
Schistosoma mansoni cathepsin D (A01 family) 0.1386 0.6053 0.6053
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Schistosoma mansoni cathepsin S (C01 family) 0.0335 0.1098 0.1098
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Echinococcus granulosus cathepsin L 0.0815 0.3361 0.3344
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Echinococcus multilocularis calpain 0.0183 0.0383 0.0359
Trypanosoma cruzi cysteine peptidase, putative 0.048 0.1781 0.1679
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0335 0.1098 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Onchocerca volvulus 0.0109 0.0033 0.0036
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0486 0.181 0.181
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1893
Brugia malayi Trypsin-like protease protein 5 0.0343 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0431 0.155 0.155
Brugia malayi STAT protein, DNA binding domain containing protein 0.0373 0.1275 0.1275
Plasmodium falciparum serine repeat antigen 5 0.0335 0.1098 0.1607
Plasmodium falciparum serine repeat antigen 7 0.0335 0.1098 0.1607
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Plasmodium vivax aspartyl protease, putative 0.0157 0.0257 0.0317
Onchocerca volvulus Cathepsin F homolog 0.1496 0.6571 0.9953
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0343 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Entamoeba histolytica cysteine proteinase, putative 0.1496 0.6571 1
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0815 0.3361 0.3278
Echinococcus multilocularis caspase 8 0.0236 0.0631 0.0607
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Mycobacterium tuberculosis Hypothetical protein 0.031 0.098 0.1148
Loa Loa (eye worm) hypothetical protein 0.2223 1 1
Plasmodium falciparum plasmepsin I 0.0457 0.1672 0.2488
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0443 0.1607 0.2387
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0343 0.1134 0.1111
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Trichomonas vaginalis conserved hypothetical protein 0.031 0.098 0.0588
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0335 0.1098 0.1607
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0335 0.1098 0.1607
Brugia malayi cathepsin Z-like cysteine proteinase 0.051 0.1923 0.1923
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0343 0.1134 0.1134
Trypanosoma cruzi cysteine proteinase, putative 0.0815 0.3361 0.3278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) aspartyl protease 6 0.0113 0.005 0.005
Trypanosoma cruzi metacaspase 5, putative 0.0236 0.0631 0.0514
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0335 0.1098 0.1098
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.577
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Echinococcus granulosus cathepsin L cysteine protease 0.0815 0.3361 0.3344
Echinococcus multilocularis thymidylate synthase 0.0652 0.2591 0.2572
Toxoplasma gondii cathepsin B 0.0919 0.3851 0.5845
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0919 0.3851 0.5782
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Onchocerca volvulus 0.0109 0.0033 0.0036
Plasmodium vivax vivapain-3 0.0815 0.3361 0.5077
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.031 0.098 0.0868
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Entamoeba histolytica cysteine protease, putative 0.1496 0.6571 1
Brugia malayi cathepsin L-like precursor 0.1016 0.4308 0.4308
Brugia malayi Kringle domain containing protein 0.0617 0.2427 0.2427
Schistosoma mansoni calpain-7 (C02 family) 0.0183 0.0383 0.0383
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Toxoplasma gondii cathepsin CPC2 0.0376 0.1291 0.1934
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1496 0.6571 1
Toxoplasma gondii microneme protein MIC17B 0.0109 0.0033 0.0011
Onchocerca volvulus 0.0109 0.0033 0.0036
Plasmodium vivax unspecified product 0.0815 0.3361 0.5077
Plasmodium vivax metacaspase 1, putative 0.0236 0.0631 0.089
Schistosoma mansoni hypothetical protein 0.0343 0.1134 0.1134
Entamoeba histolytica cysteine proteinase, putative 0.1016 0.4308 0.6491
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Echinococcus granulosus calpain A 0.0183 0.0383 0.0359
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Entamoeba histolytica hypothetical protein 0.0335 0.1098 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Echinococcus granulosus Mastin 0.0343 0.1134 0.1111
Loa Loa (eye worm) hypothetical protein 0.0104 0.0009 0.0009
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0652 0.2591 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2223 1 1
Onchocerca volvulus Cathepsin L homolog 0.0335 0.1098 0.1652
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0343 0.1134 0.1111
Brugia malayi Papain family cysteine protease containing protein 0.0815 0.3361 0.3361
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Plasmodium falciparum cysteine repeat modular protein 1 0.0617 0.2427 0.3645
Schistosoma mansoni cathepsin C 0.0335 0.1098 0.1098
Leishmania major cysteine peptidase A (CPA) 0.1496 0.6571 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Leishmania major hypothetical protein, conserved 0.0617 0.2427 0.3573
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Echinococcus multilocularis Tolloid protein 1 0.018 0.0365 0.0341
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Trypanosoma cruzi hypothetical protein, conserved 0.0617 0.2427 0.2332
Loa Loa (eye worm) hypothetical protein 0.1503 0.6602 0.6602
Toxoplasma gondii kringle domain-containing protein 0.0617 0.2427 0.3669
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.5818
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Brugia malayi fibroinase precursor 0.0335 0.1098 0.1098
Trypanosoma brucei metacaspase 5, putative 0.0236 0.0631 0.0787
Onchocerca volvulus 0.1496 0.6571 0.9953
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0335 0.1098 0.1607
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0376 0.1291 0.0701
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0113 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Toxoplasma gondii cathepsin CPC1 0.0443 0.1607 0.2416
Echinococcus multilocularis glycoprotein Antigen 5 0.0343 0.1134 0.1111
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Brugia malayi dihydrofolate reductase family protein 0.0266 0.0771 0.0771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Echinococcus granulosus caspase 8 0.0236 0.0631 0.0607
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Onchocerca volvulus 0.1496 0.6571 0.9953
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Toxoplasma gondii PAN/Apple domain-containing protein 0.0109 0.0033 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Echinococcus multilocularis cysteine protease 0.1496 0.6571 0.6562
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0192 0.0425 0.0425
Brugia malayi Dihydrofolate reductase 0.0266 0.0771 0.0771
Schistosoma mansoni caspase-7 (C14 family) 0.0531 0.2022 0.2022
Plasmodium vivax serine-repeat antigen (SERA) 0.0335 0.1098 0.1607
Onchocerca volvulus 0.0109 0.0033 0.0036
Echinococcus granulosus cathepsin b 0.2223 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1016 0.4308 0.6191
Plasmodium falciparum plasmepsin IX 0.0157 0.0257 0.0317
Schistosoma mansoni hypothetical protein 0.0617 0.2427 0.2427
Schistosoma mansoni calpain (C02 family) 0.0183 0.0383 0.0383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0815 0.3361 0.4596
Schistosoma mansoni caspase-7 (C14 family) 0.0448 0.163 0.163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.051 0.1923 0.1923
Echinococcus granulosus thymidylate synthase 0.0652 0.2591 0.2572
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.577
Echinococcus multilocularis cathepsin b 0.2223 1 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0457 0.1672 0.2516
Plasmodium vivax unspecified product 0.048 0.1781 0.2655
Onchocerca volvulus 0.0303 0.0946 0.1421
Schistosoma mansoni growth factor receptor-bound protein 0.0856 0.3555 0.3555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.051 0.1923 0.1923
Loa Loa (eye worm) bone morphogenetic protein 1b 0.018 0.0365 0.0365
Brugia malayi Fibulin-1 precursor 0.0108 0.0025 0.0025
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0919 0.3851 0.3775
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0335 0.1098 0.1607
Schistosoma mansoni cathepsin F (C01 family) 0.1496 0.6571 0.6571
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Echinococcus multilocularis cathepsin L 0.0335 0.1098 0.1075
Echinococcus granulosus dihydrofolate reductase 0.0266 0.0771 0.0748
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0113 0.005 0.0038
Brugia malayi hypothetical protein 0.0212 0.0518 0.0518
Brugia malayi Protein kinase domain containing protein 0.0617 0.2427 0.2427
Onchocerca volvulus 0.1503 0.6602 1
Trypanosoma brucei antigen, putative 0.0183 0.0383 0.0403
Onchocerca volvulus Cathepsin L homolog 0.1496 0.6571 0.9953
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Trypanosoma brucei metacaspase MCA2 0.0236 0.0631 0.0787
Trypanosoma cruzi cruzipain precursor, putative 0.048 0.1781 0.1679
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Schistosoma mansoni calpain C (C02 family) 0.0183 0.0383 0.0383
Plasmodium vivax unspecified product 0.0335 0.1098 0.1607
Trypanosoma brucei Metacaspase-4 0.0236 0.0631 0.0787
Echinococcus granulosus cysteine protease 0.0815 0.3361 0.3344
Toxoplasma gondii aspartyl protease ASP3 0.0157 0.0257 0.0354
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0443 0.1607 0.2387
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0335 0.1098 0.1512
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0335 0.1098 0.1098
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Plasmodium falciparum serine repeat antigen 8 0.0335 0.1098 0.1607
Echinococcus granulosus cathepsin L cysteine proteinase 0.1496 0.6571 0.6562
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1512 0.6645 0.6645
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Mycobacterium ulcerans thymidylate synthase 0.0652 0.2591 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2223 1 1
Loa Loa (eye worm) calpain 5 0.0128 0.0123 0.0123
Brugia malayi Eukaryotic aspartyl protease family protein 0.0113 0.005 0.005
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0443 0.1607 0.2387
Schistosoma mansoni Mername-AA248 (C02 family) 0.0183 0.0383 0.0383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Echinococcus granulosus enteropeptidase 0.0343 0.1134 0.1111
Plasmodium vivax plasmepsin IV, putative 0.0457 0.1672 0.2488
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Loa Loa (eye worm) TK/ROR protein kinase 0.0617 0.2427 0.2427
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0192 0.0425 0.0401
Echinococcus multilocularis cathepsin b 0.2223 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0335 0.1098 0.0787
Brugia malayi Cell death protein 3 precursor 0.0448 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.0113 0.005 0.005
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0443 0.1607 0.1847
Schistosoma mansoni caspase-3 (C14 family) 0.0531 0.2022 0.2022
Entamoeba histolytica cysteine proteinase 1, putative 0.0815 0.3361 0.5021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Trypanosoma brucei cysteine peptidase C (CPC) 0.0919 0.3851 0.5782
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Echinococcus multilocularis enteropeptidase 0.0343 0.1134 0.1111
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0113 0.005 0.005
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0236 0.0631 0.0631
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Echinococcus granulosus caspase 2 0.0448 0.163 0.1609
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0486 0.181 0.181
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Onchocerca volvulus 0.1496 0.6571 0.9953
Brugia malayi hypothetical protein 0.0113 0.005 0.005
Echinococcus multilocularis cathepsin L 0.0815 0.3361 0.3344
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0918 0.3844 0.5818
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0376 0.1291 0.0701
Plasmodium falciparum plasmepsin IV 0.0457 0.1672 0.2488
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus granulosus tissue type plasminogen activator 0.0617 0.2427 0.2407
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0815 0.3361 0.5021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Onchocerca volvulus 0.0109 0.0033 0.0036
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1098 0.0987
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0335 0.1098 0.1607
Toxoplasma gondii microneme protein MIC17C 0.0109 0.0033 0.0011
Brugia malayi cathepsin F-like cysteine proteinase 0.048 0.1781 0.1781
Onchocerca volvulus 0.0617 0.2427 0.3667
Trypanosoma cruzi metacaspase 5, putative 0.0236 0.0631 0.0514
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Echinococcus granulosus cathepsin l1 0.1016 0.4308 0.4294
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Trypanosoma brucei metacaspase 0.0236 0.0631 0.0787
Plasmodium falciparum plasmepsin II 0.0457 0.1672 0.2488
Toxoplasma gondii microneme protein MIC4 0.0109 0.0033 0.0011
Loa Loa (eye worm) ctsf protein 0.1496 0.6571 0.6571
Onchocerca volvulus 0.0343 0.1134 0.1706
Brugia malayi Cathepsin L-like precursor 0.048 0.1781 0.1781
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Onchocerca volvulus 0.0109 0.0033 0.0036
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Plasmodium falciparum cysteine proteinase falcipain 3 0.1496 0.6571 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0113 0.005 0.005
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0085 0.0085
Schistosoma mansoni dihydrofolate reductase 0.0266 0.0771 0.0771
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0531 0.2022 0.2002
Echinococcus granulosus cathepsin L 0.0335 0.1098 0.1075
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Plasmodium falciparum serine repeat antigen 9 0.0335 0.1098 0.1607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Onchocerca volvulus 0.116 0.4987 0.755
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0108 0.0025 0.0025
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Toxoplasma gondii cathepsin CPL 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0457 0.1672 0.1754
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Toxoplasma gondii microneme protein, putative 0.0109 0.0033 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0104 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0376 0.1291 0.1903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Plasmodium falciparum cysteine proteinase falcipain 1 0.0815 0.3361 0.5077
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0236 0.0631 0.0631
Schistosoma mansoni cathepsin F (C01 family) 0.1496 0.6571 0.6571
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.048 0.1781 0.1781
Schistosoma mansoni cathepsin s 0.048 0.1781 0.1781
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Onchocerca volvulus 0.0212 0.0518 0.0772
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Plasmodium falciparum metacaspase-like protein 0.0236 0.0631 0.089
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus granulosus calpain 7 C02 family 0.0183 0.0383 0.0359
Loa Loa (eye worm) hypothetical protein 0.0192 0.0425 0.0425
Giardia lamblia Cathepsin B precursor 0.051 0.1923 0.2996
Schistosoma mansoni cathepsin F (C01 family) 0.1016 0.4308 0.4308
Plasmodium falciparum serine repeat antigen 1 0.0335 0.1098 0.1607
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1098 0.0787
Brugia malayi Pepsin A precursor 0.0113 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Loa Loa (eye worm) cathepsin B 0.0919 0.3851 0.3851
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0335 0.1098 0.0787
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0343 0.1134 0.1111
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Onchocerca volvulus 0.1496 0.6571 0.9953
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.018 0.0365 0.0365
Plasmodium vivax calpain, putative 0.0183 0.0383 0.0511
Echinococcus multilocularis dihydrofolate reductase 0.0266 0.0771 0.0748
Onchocerca volvulus 0.0109 0.0033 0.0036
Chlamydia trachomatis dihydrofolate reductase 0.0266 0.0771 0.5
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Loa Loa (eye worm) dihydrofolate reductase 0.0266 0.0771 0.0771
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Echinococcus multilocularis calpain 5 0.0183 0.0383 0.0359
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus multilocularis calpain A 0.0508 0.1914 0.1893
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0652 0.2591 0.2591
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Schistosoma mansoni egf-like domain protein 0.0104 0.0009 0.0009
Onchocerca volvulus 0.0335 0.1098 0.1652
Plasmodium falciparum serine repeat antigen 2 0.0335 0.1098 0.1607
Echinococcus multilocularis cathepsin L cysteine protease 0.1496 0.6571 0.6562
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Echinococcus multilocularis hypothetical protein 0.0183 0.0383 0.0359
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.5834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Loa Loa (eye worm) thymidylate synthase 0.0652 0.2591 0.2591
Brugia malayi Papain family cysteine protease containing protein 0.0815 0.3361 0.3361
Loa Loa (eye worm) hypothetical protein 0.0457 0.1672 0.1672
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0403
Brugia malayi Sex muscle abnormal protein 5 0.0856 0.3555 0.3555
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.1098 0.0787
Plasmodium falciparum plasmepsin X 0.0157 0.0257 0.0317
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1098 0.0987
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Brugia malayi Papain family cysteine protease containing protein 0.1496 0.6571 0.6571
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0402 0.1414 0.1318
Loa Loa (eye worm) hypothetical protein 0.0236 0.0631 0.0631
Entamoeba histolytica cysteine proteinase, putative 0.1496 0.6571 1
Entamoeba histolytica cysteine proteinase 2 0.0815 0.3361 0.5021
Onchocerca volvulus 0.1496 0.6571 0.9953
Loa Loa (eye worm) hypothetical protein 0.0108 0.0025 0.0025
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0183 0.0383 0.0263
Onchocerca volvulus 0.0343 0.1134 0.1706
Loa Loa (eye worm) hypothetical protein 0.0448 0.163 0.163
Plasmodium vivax vivapain-2 0.1496 0.6571 1
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Mycobacterium tuberculosis Possible exported protein 0.0386 0.1337 0.3106
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0113 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0358 0.1206 0.1206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Loa Loa (eye worm) calpain family protein 1 0.0358 0.1206 0.1206
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus granulosus cathepsin l1 0.1496 0.6571 0.6562
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0919 0.3851 0.3851
Onchocerca volvulus 0.1496 0.6571 0.9953
Echinococcus multilocularis apoptotic protease activating factor 1 0.0212 0.0518 0.0494
Toxoplasma gondii hypothetical protein 0.0109 0.0033 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Onchocerca volvulus 0.0113 0.005 0.0062
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0457 0.1672 0.1672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0815 0.3361 0.4596
Echinococcus granulosus calpain 5 0.0183 0.0383 0.0359
Toxoplasma gondii subtilisin SUB12 0.0109 0.0033 0.0011
Echinococcus multilocularis cysteine protease 0.1496 0.6571 0.6562
Brugia malayi Trypsin family protein 0.1503 0.6602 0.6602
Plasmodium vivax serine-repeat antigen (SERA) 0.0335 0.1098 0.1607
Brugia malayi Cathepsin L-like precursor 0.1016 0.4308 0.4308
Loa Loa (eye worm) calpain 0.0183 0.0383 0.0383
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0652 0.2591 1
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0113 0.005 0.005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Onchocerca volvulus Cathepsin L homolog 0.1496 0.6571 0.9953
Schistosoma mansoni hypothetical protein 0.0212 0.0518 0.0518
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0617 0.2427 0.3645
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0335 0.1098 0.0787

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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