Detailed information for compound 2076875

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 458.475 | Formula: C21H29F3N4O4
  • H donors: 3 H acceptors: 4 LogP: -0.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.CC(NC(=O)N1CCC2(CC1)N(CCNC2=O)Cc1ccccc1)C
  • InChi: 1S/C19H28N4O2.C2HF3O2/c1-15(2)21-18(25)22-11-8-19(9-12-22)17(24)20-10-13-23(19)14-16-6-4-3-5-7-16;3-2(4,5)1(6)7/h3-7,15H,8-14H2,1-2H3,(H,20,24)(H,21,25);(H,6,7)
  • InChiKey: VKYYRDUZNMPALB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1503 0.6602 0.6602
Toxoplasma gondii kringle domain-containing protein 0.0617 0.2427 0.3669
Plasmodium falciparum cysteine proteinase falcipain 3 0.1496 0.6571 1
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus granulosus calpain 0.0183 0.0383 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Brugia malayi Papain family cysteine protease containing protein 0.0815 0.3361 0.3361
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Schistosoma mansoni growth factor receptor-bound protein 0.0856 0.3555 0.3555
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Loa Loa (eye worm) hypothetical protein 0.0192 0.0425 0.0425
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1496 0.6571 0.6562
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0815 0.3361 0.4596
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Onchocerca volvulus 0.0109 0.0033 0.0036
Plasmodium falciparum serine repeat antigen 5 0.0335 0.1098 0.1572
Onchocerca volvulus Cathepsin L homolog 0.0335 0.1098 0.1652
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Loa Loa (eye worm) cysteine protease 0.1496 0.6571 0.6571
Brugia malayi calpain family protein 1 0.0486 0.181 0.181
Leishmania major metacaspase, putative 0.0236 0.0631 0.0787
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0376 0.1291 0.1869
Schistosoma mansoni caspase-7 (C14 family) 0.0448 0.163 0.163
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Loa Loa (eye worm) calpain 5 0.0128 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.1496 0.6571 0.6571
Brugia malayi cathepsin L-like precursor 0.1016 0.4308 0.4308
Brugia malayi aspartic protease BmAsp-2, identical 0.0119 0.0077 0.0077
Toxoplasma gondii hypothetical protein 0.0109 0.0033 0.0011
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0443 0.1607 0.1607
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Brugia malayi cathepsin Z-like cysteine proteinase 0.051 0.1923 0.1923
Echinococcus multilocularis enteropeptidase 0.0343 0.1134 0.1111
Onchocerca volvulus Cathepsin F homolog 0.1496 0.6571 0.9953
Echinococcus multilocularis caspase 8 0.0236 0.0631 0.0607
Echinococcus multilocularis cathepsin b 0.2223 1 1
Onchocerca volvulus 0.0343 0.1134 0.1706
Brugia malayi cathepsin L-like cysteine proteinase 0.0335 0.1098 0.1098
Echinococcus granulosus cathepsin l1 0.1016 0.4308 0.4294
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Echinococcus multilocularis calpain A 0.0508 0.1914 0.1893
Schistosoma mansoni cathepsin D (A01 family) 0.1458 0.6394 0.6394
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0343 0.1134 0.1134
Schistosoma mansoni memapsin-2 (A01 family) 0.0119 0.0077 0.0077
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0335 0.1098 0.1098
Onchocerca volvulus 0.0303 0.0946 0.1421
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0335 0.1098 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1016 0.4308 0.6191
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0481 0.1788 0.1767
Echinococcus granulosus apoptotic protease activating factor 1 0.0212 0.0518 0.0494
Echinococcus granulosus Tolloid protein 1 0.018 0.0365 0.0341
Loa Loa (eye worm) papain family cysteine protease containing protein 0.048 0.1781 0.1781
Brugia malayi hypothetical protein 0.0119 0.0077 0.0077
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.58
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0815 0.3361 0.5021
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Plasmodium vivax unspecified product 0.0335 0.1098 0.1572
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0481 0.1788 0.1788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Plasmodium falciparum plasmepsin VI 0.0481 0.1788 0.2634
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0335 0.1098 0.1512
Brugia malayi hypothetical protein 0.031 0.098 0.098
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.3365 0.3348
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Echinococcus granulosus Mastin 0.0343 0.1134 0.1111
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Loa Loa (eye worm) hypothetical protein 0.0119 0.0077 0.0077
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0335 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0443 0.1607 0.2355
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Echinococcus granulosus cathepsin L 0.0815 0.3361 0.3344
Loa Loa (eye worm) fibroinase 0.1496 0.6571 0.6571
Trypanosoma cruzi cruzipain precursor, putative 0.048 0.1781 0.1679
Echinococcus granulosus thymidylate synthase 0.0652 0.2591 0.2572
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Plasmodium falciparum serine repeat antigen 7 0.0335 0.1098 0.1572
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0481 0.1788 0.1767
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Toxoplasma gondii aspartyl protease ASP3 0.0162 0.0284 0.0395
Loa Loa (eye worm) hypothetical protein 0.0212 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0117 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Leishmania major hypothetical protein, conserved 0.0617 0.2427 0.3573
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0104 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Brugia malayi Cathepsin L-like precursor 0.048 0.1781 0.1781
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Onchocerca volvulus 0.0109 0.0033 0.0036
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Echinococcus multilocularis caspase 3 0.0295 0.091 0.0887
Onchocerca volvulus 0.0119 0.0077 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Echinococcus granulosus caspase 3 0.0295 0.091 0.0887
Loa Loa (eye worm) hypothetical protein 0.1503 0.6602 0.6602
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Echinococcus multilocularis growth factor receptor bound protein 2 0.0856 0.3555 0.3539
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.1098 0.0787
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0192 0.0425 0.0401
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0531 0.2022 0.2002
Echinococcus multilocularis caspase 0.0531 0.2022 0.2002
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Onchocerca volvulus 0.1496 0.6571 0.9953
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0085 0.0085
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1914
Brugia malayi Sex muscle abnormal protein 5 0.0856 0.3555 0.3555
Echinococcus granulosus glycoprotein Antigen 5 0.0343 0.1134 0.1111
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.0345 0.0345
Brugia malayi calpain family protein 1 0.0486 0.181 0.181
Onchocerca volvulus 0.0343 0.1134 0.1706
Loa Loa (eye worm) hypothetical protein 0.0104 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0109 0.0033 0.0011
Onchocerca volvulus 0.0343 0.1134 0.1706
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Entamoeba histolytica cysteine protease, putative 0.1496 0.6571 1
Onchocerca volvulus Cell death protein 3 homolog 0.0448 0.163 0.2458
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1098 0.0987
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0183 0.0383 0.0359
Onchocerca volvulus 0.0109 0.0033 0.0036
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Echinococcus multilocularis calpain 5 0.0183 0.0383 0.0359
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Brugia malayi Calcium binding EGF domain containing protein 0.0108 0.0025 0.0025
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1496 0.6571 0.6571
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0486 0.181 0.181
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0376 0.1291 0.0701
Echinococcus multilocularis cysteine protease 0.1496 0.6571 0.6562
Loa Loa (eye worm) STAT protein 0.0373 0.1275 0.1275
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0352 0.1177 0.1177
Echinococcus multilocularis calpain family protein 1, d 0.0358 0.1206 0.1183
Toxoplasma gondii microneme protein MIC17A 0.0109 0.0033 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.048 0.1781 0.1679
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0343 0.1134 0.1111
Echinococcus granulosus caspase 0.0531 0.2022 0.2002
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Onchocerca volvulus 0.0109 0.0033 0.0036
Loa Loa (eye worm) hypothetical protein 0.0486 0.181 0.181
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Onchocerca volvulus 0.1496 0.6571 0.9953
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0335 0.1098 0.1572
Onchocerca volvulus 0.0109 0.0033 0.0036
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0481 0.1788 0.1948
Echinococcus multilocularis hypothetical protein 0.0183 0.0383 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Plasmodium vivax aspartyl protease, putative 0.0162 0.0284 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Plasmodium vivax unspecified product 0.0815 0.3361 0.5056
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1098 0.0987
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.1098 0.0787
Brugia malayi STAT protein, DNA binding domain containing protein 0.0373 0.1275 0.1275
Loa Loa (eye worm) hypothetical protein 0.0431 0.155 0.155
Echinococcus granulosus calpain A 0.0508 0.1914 0.1893
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0343 0.1134 0.1134
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Echinococcus granulosus cathepsin l1 0.1496 0.6571 0.6562
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1893
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1496 0.6571 0.6571
Echinococcus multilocularis glycoprotein Antigen 5 0.0343 0.1134 0.1111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.051 0.1923 0.2176
Onchocerca volvulus 0.1496 0.6571 0.9953
Toxoplasma gondii preprocathepsin c precursor, putative 0.0443 0.1607 0.2416
Brugia malayi cathepsin F-like cysteine proteinase 0.048 0.1781 0.1781
Trichomonas vaginalis conserved hypothetical protein 0.031 0.098 0.0588
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2223 1 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0085 0.0085
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Schistosoma mansoni cathepsin F (C01 family) 0.1496 0.6571 0.6571
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0443 0.1607 0.2355
Entamoeba histolytica cysteine proteinase, putative 0.1496 0.6571 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0652 0.2591 1
Onchocerca volvulus 0.1496 0.6571 0.9953
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1914
Mycobacterium ulcerans hypothetical protein 0.0343 0.1134 0.1993
Plasmodium falciparum metacaspase 1 0.0236 0.0631 0.0852
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0919 0.3851 0.3775
Schistosoma mansoni calpain-7 (C02 family) 0.0183 0.0383 0.0383
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Schistosoma mansoni cathepsin D (A01 family) 0.1458 0.6394 0.6394
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Schistosoma mansoni growth factor receptor-bound protein 0.0856 0.3555 0.3555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Plasmodium vivax hypothetical protein, conserved 0.0236 0.0631 0.0852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Trypanosoma cruzi cysteine protease, putative 0.0815 0.3361 0.3278
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0335 0.1098 0.1512
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0009 0.0009
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0343 0.1134 0.1111
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0335 0.1098 0.1572
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Brugia malayi hypothetical protein 0.0343 0.1134 0.1134
Brugia malayi Cathepsin L-like cysteine proteinase 0.1016 0.4308 0.4308
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0335 0.1098 0.1098
Echinococcus granulosus calpain A 0.0183 0.0383 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1496 0.6571 0.6562
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0343 0.1134 0.1111
Echinococcus granulosus cysteine protease 0.0815 0.3361 0.3344
Echinococcus granulosus cathepsin b 0.2223 1 1
Plasmodium falciparum serine repeat antigen 9 0.0335 0.1098 0.1572
Plasmodium vivax calpain, putative 0.0183 0.0383 0.0471
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0652 0.2591 0.2591
Onchocerca volvulus 0.0617 0.2427 0.3667
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Echinococcus granulosus cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Leishmania major cysteine peptidase A (CPA) 0.1496 0.6571 1
Trypanosoma cruzi cruzipain precursor, putative 0.1496 0.6571 0.6528
Onchocerca volvulus 0.0343 0.1134 0.1706
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0335 0.1098 0.1572
Brugia malayi Protein kinase domain containing protein 0.0617 0.2427 0.2427
Trypanosoma cruzi hypothetical protein, conserved 0.0617 0.2427 0.2332
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1503 0.6602 0.6602
Plasmodium falciparum cysteine repeat modular protein 1 0.0617 0.2427 0.3618
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0919 0.3851 0.5422
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus multilocularis Tolloid protein 1 0.018 0.0365 0.0341
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Loa Loa (eye worm) trypsin family protein 0.0343 0.1134 0.1134
Giardia lamblia Cathepsin B precursor 0.051 0.1923 0.2996
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Plasmodium vivax serine-repeat antigen (SERA) 0.0335 0.1098 0.1572
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Mycobacterium tuberculosis Hypothetical protein 0.031 0.098 0.1148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.577
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0335 0.1098 0.1572
Trypanosoma brucei metacaspase 5, putative 0.0236 0.0631 0.0787
Loa Loa (eye worm) aspartyl protease 6 0.0119 0.0077 0.0077
Schistosoma mansoni cathepsin F (C01 family) 0.1496 0.6571 0.6571
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1016 0.4308 0.4237
Loa Loa (eye worm) hypothetical protein 0.0617 0.2427 0.2427
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0919 0.3851 0.5782
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0335 0.1098 0.1572
Onchocerca volvulus 0.0109 0.0033 0.0036
Toxoplasma gondii cathepsin B 0.0919 0.3851 0.5845
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.031 0.098 0.0868
Trypanosoma cruzi cysteine peptidase, putative 0.0815 0.3361 0.3278
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0815 0.3361 0.5021
Onchocerca volvulus 0.0652 0.2591 0.3916
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Plasmodium vivax metacaspase 1, putative 0.0236 0.0631 0.0852
Onchocerca volvulus 0.0109 0.0033 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Giardia lamblia Encystation-specific protease 0.0376 0.1291 0.0701
Toxoplasma gondii microneme protein MIC17B 0.0109 0.0033 0.0011
Trypanosoma cruzi cysteine proteinase, putative 0.0815 0.3361 0.3278
Schistosoma mansoni hypothetical protein 0.0343 0.1134 0.1134
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Schistosoma mansoni calpain-7 (C02 family) 0.0183 0.0383 0.0383
Echinococcus multilocularis cathepsin b 0.2223 1 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.3767
Brugia malayi thymidylate synthase 0.0652 0.2591 0.2591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0448 0.163 0.163
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.018 0.0365 0.0365
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0856 0.3555 0.3555
Brugia malayi cathepsin Z-like cysteine proteinase 0.051 0.1923 0.1923
Onchocerca volvulus 0.1496 0.6571 0.9953
Plasmodium falciparum plasmepsin II 0.0481 0.1788 0.2634
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Loa Loa (eye worm) hypothetical protein 0.0303 0.0946 0.0946
Brugia malayi cathepsin F-like cysteine proteinase 0.0335 0.1098 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0815 0.3361 0.3278
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Brugia malayi Fibulin-1 precursor 0.0108 0.0025 0.0025
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Schistosoma mansoni cathepsin B (C01 family) 0.0335 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0815 0.3361 0.4596
Onchocerca volvulus 0.1503 0.6602 1
Echinococcus granulosus tissue type plasminogen activator 0.0617 0.2427 0.2407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Trypanosoma brucei antigen, putative 0.0183 0.0383 0.0403
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0119 0.0077 0.008
Brugia malayi hypothetical protein 0.0212 0.0518 0.0518
Brugia malayi Dihydrofolate reductase 0.0266 0.0771 0.0771
Echinococcus multilocularis cathepsin L 0.0335 0.1098 0.1075
Trypanosoma brucei metacaspase 0.0236 0.0631 0.0787
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1496 0.6571 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.5834
Trypanosoma brucei cysteine peptidase C (CPC) 0.0919 0.3851 0.5782
Echinococcus granulosus dihydrofolate reductase 0.0266 0.0771 0.0748
Echinococcus multilocularis Mastin 0.0343 0.1134 0.1111
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0443 0.1607 0.2355
Toxoplasma gondii aspartyl protease 0.0119 0.0077 0.008
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1111
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0376 0.1291 0.1869
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Entamoeba histolytica hypothetical protein 0.0335 0.1098 0.1512
Schistosoma mansoni calpain C (C02 family) 0.0183 0.0383 0.0383
Echinococcus granulosus caspase 8 0.0236 0.0631 0.0607
Onchocerca volvulus 0.1496 0.6571 0.9953
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Plasmodium vivax aspartyl protease, putative 0.0162 0.0284 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1016 0.4308 0.6191
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0617 0.2427 0.3618
Schistosoma mansoni calpain (C02 family) 0.0183 0.0383 0.0383
Plasmodium falciparum serine repeat antigen 4 0.0335 0.1098 0.1572
Onchocerca volvulus 0.0109 0.0033 0.0036
Echinococcus granulosus cathepsin b 0.2223 1 1
Brugia malayi dihydrofolate reductase family protein 0.0266 0.0771 0.0771
Schistosoma mansoni caspase-7 (C14 family) 0.0531 0.2022 0.2022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Toxoplasma gondii PAN/Apple domain-containing protein 0.0109 0.0033 0.0011
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0192 0.0425 0.0425
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Entamoeba histolytica cysteine proteinase, putative 0.1496 0.6571 1
Loa Loa (eye worm) cathepsin B 0.0919 0.3851 0.3851
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0531 0.2022 0.2002
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Echinococcus granulosus caspase 2 0.0448 0.163 0.1609
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0443 0.1607 0.2355
Loa Loa (eye worm) hypothetical protein 0.0119 0.0077 0.0077
Onchocerca volvulus Cathepsin L homolog 0.1496 0.6571 0.9953
Brugia malayi hypothetical protein 0.0119 0.0077 0.0077
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Brugia malayi Cell death protein 3 precursor 0.0448 0.163 0.163
Trypanosoma brucei Metacaspase-4 0.0236 0.0631 0.0787
Loa Loa (eye worm) calpain family protein 1 0.0486 0.181 0.181
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0119 0.0077 0.0077
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0236 0.0631 0.0631
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Brugia malayi Trypsin-like protease protein 5 0.0343 0.1134 0.1134
Echinococcus granulosus transmembrane protease serine 3 0.0343 0.1134 0.1111
Onchocerca volvulus 0.0109 0.0033 0.0036
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Brugia malayi Kringle domain containing protein 0.0617 0.2427 0.2427
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0376 0.1291 0.0701
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.577
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Loa Loa (eye worm) TK/ROR protein kinase 0.0617 0.2427 0.2427
Loa Loa (eye worm) hypothetical protein 0.0236 0.0631 0.0631
Toxoplasma gondii microneme protein MIC17C 0.0109 0.0033 0.0011
Toxoplasma gondii aspartyl protease ASP1 0.0481 0.1788 0.2693
Plasmodium falciparum serine repeat antigen 8 0.0335 0.1098 0.1572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0236 0.0631 0.0631
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0481 0.1788 0.1788
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1098 0.0787
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Trypanosoma brucei metacaspase MCA2 0.0236 0.0631 0.0787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1512 0.6645 0.6645
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0335 0.1098 0.1572
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0335 0.1098 0.0787
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) ctsf protein 0.1496 0.6571 0.6571
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Brugia malayi fibroinase precursor 0.0335 0.1098 0.1098
Plasmodium falciparum cysteine proteinase falcipain 1 0.0815 0.3361 0.5056
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0443 0.1607 0.1847
Plasmodium falciparum plasmepsin IX 0.0162 0.0284 0.0318
Plasmodium vivax serine-repeat antigen (SERA) 0.0335 0.1098 0.1572
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0192 0.0425 0.0401
Schistosoma mansoni hypothetical protein 0.0617 0.2427 0.2427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Schistosoma mansoni cathepsin C 0.0335 0.1098 0.1098
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.048 0.1781 0.1781
Toxoplasma gondii cathepsin CPC1 0.0443 0.1607 0.2416
Brugia malayi Eukaryotic aspartyl protease family protein 0.0119 0.0077 0.0077
Schistosoma mansoni Mername-AA248 (C02 family) 0.0183 0.0383 0.0383
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2223 1 1
Brugia malayi calpain 5 0.0128 0.0123 0.0123
Mycobacterium ulcerans thymidylate synthase 0.0652 0.2591 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Plasmodium falciparum serine repeat antigen 1 0.0335 0.1098 0.1572
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0192 0.0425 0.0425
Echinococcus granulosus calpain 7 C02 family 0.0183 0.0383 0.0359
Plasmodium falciparum serine repeat antigen 2 0.0335 0.1098 0.1572
Brugia malayi Pepsin A precursor 0.0119 0.0077 0.0077
Brugia malayi cathepsin L precursor 0.0335 0.1098 0.1098
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.051 0.1923 0.1923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Entamoeba histolytica cysteine proteinase, putative 0.1016 0.4308 0.6491
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Plasmodium falciparum metacaspase-like protein 0.0236 0.0631 0.0852
Onchocerca volvulus 0.0212 0.0518 0.0772
Loa Loa (eye worm) hypothetical protein 0.2223 1 1
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Plasmodium vivax plasmepsin IV, putative 0.0481 0.1788 0.2634
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0481 0.1788 0.2693
Chlamydia trachomatis dihydrofolate reductase 0.0266 0.0771 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.018 0.0365 0.0365
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Plasmodium falciparum plasmepsin I 0.0481 0.1788 0.2634
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Echinococcus granulosus enteropeptidase 0.0343 0.1134 0.1111
Loa Loa (eye worm) dihydrofolate reductase 0.0266 0.0771 0.0771
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1496 0.6571 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0335 0.1098 0.1098
Onchocerca volvulus 0.0109 0.0033 0.0036
Echinococcus multilocularis dihydrofolate reductase 0.0266 0.0771 0.0748
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Loa Loa (eye worm) thymidylate synthase 0.0652 0.2591 0.2591
Onchocerca volvulus 0.0343 0.1134 0.1706
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0508 0.1914 0.1893
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Brugia malayi calpain 7 0.0183 0.0383 0.0383
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Plasmodium vivax aspartyl proteinase, putative 0.0481 0.1788 0.2634
Toxoplasma gondii microneme protein MIC4 0.0109 0.0033 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.1016 0.4308 0.4308
Trypanosoma cruzi metacaspase 5, putative 0.0236 0.0631 0.0514
Plasmodium vivax unspecified product 0.048 0.1781 0.2624
Plasmodium vivax vivapain-3 0.0815 0.3361 0.5056
Brugia malayi Cathepsin L-like precursor 0.1016 0.4308 0.4308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Echinococcus multilocularis cathepsin L 0.0815 0.3361 0.3344
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0108 0.0025 0.0025
Onchocerca volvulus 0.116 0.4987 0.755
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni caspase-3 (C14 family) 0.0531 0.2022 0.2022
Schistosoma mansoni cathepsin S (C01 family) 0.0335 0.1098 0.1098
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Brugia malayi MH2 domain containing protein 0.012 0.0085 0.0085
Schistosoma mansoni dihydrofolate reductase 0.0266 0.0771 0.0771
Onchocerca volvulus 0.0109 0.0033 0.0036
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1496 0.6571 1
Onchocerca volvulus 0.0119 0.0077 0.0104
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0104 0.0009 0.0009
Plasmodium falciparum serine repeat antigen 6 0.0335 0.1098 0.1572
Toxoplasma gondii cathepsin CPL 0.1496 0.6571 1
Toxoplasma gondii microneme protein, putative 0.0109 0.0033 0.0011
Plasmodium falciparum plasmepsin IV 0.0481 0.1788 0.2634
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Onchocerca volvulus 0.1016 0.4308 0.6521
Onchocerca volvulus 0.1496 0.6571 0.9953
Echinococcus multilocularis transmembrane protease serine 3 0.0343 0.1134 0.1111
Plasmodium vivax vivapain-2 0.1496 0.6571 1
Trypanosoma cruzi metacaspase 5, putative 0.0236 0.0631 0.0514
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Toxoplasma gondii cathepsin CPC2 0.0376 0.1291 0.1934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Plasmodium vivax vivapain-2 0.1496 0.6571 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0919 0.3851 0.3851
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Brugia malayi Papain family cysteine protease containing protein 0.0815 0.3361 0.3361
Loa Loa (eye worm) calpain family protein 1 0.0358 0.1206 0.1206
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Loa Loa (eye worm) hypothetical protein 0.0481 0.1788 0.1788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0119 0.0077 0.0077
Echinococcus multilocularis apoptotic protease activating factor 1 0.0212 0.0518 0.0494
Toxoplasma gondii hypothetical protein 0.0109 0.0033 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Loa Loa (eye worm) calpain 0.0183 0.0383 0.0383
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Plasmodium vivax vivapain-1 0.0815 0.3361 0.5056
Echinococcus granulosus calpain 5 0.0183 0.0383 0.0359
Brugia malayi Cathepsin L-like precursor 0.1016 0.4308 0.4308
Echinococcus multilocularis cysteine protease 0.1496 0.6571 0.6562
Toxoplasma gondii subtilisin SUB12 0.0109 0.0033 0.0011
Echinococcus granulosus cathepsin L 0.0335 0.1098 0.1075
Brugia malayi Trypsin family protein 0.1503 0.6602 0.6602
Echinococcus multilocularis tissue type plasminogen activator 0.0617 0.2427 0.2407
Schistosoma mansoni hypothetical protein 0.0212 0.0518 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0335 0.1098 0.0787
Onchocerca volvulus Cathepsin L homolog 0.1496 0.6571 0.9953
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Entamoeba histolytica cysteine proteinase 2 0.0815 0.3361 0.5021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0335 0.1098 0.0787
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0652 0.2591 1
Echinococcus multilocularis thymidylate synthase 0.0652 0.2591 0.2572
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Echinococcus multilocularis calpain 0.0183 0.0383 0.0359
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0918 0.3844 0.58
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Schistosoma mansoni egf-like domain protein 0.0104 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1098 0.0787
Trypanosoma cruzi cysteine proteinase, putative 0.0815 0.3361 0.3278
Brugia malayi Papain family cysteine protease containing protein 0.1496 0.6571 0.6571
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0402 0.1414 0.1318
Plasmodium falciparum plasmepsin X 0.0162 0.0284 0.0318
Onchocerca volvulus 0.0335 0.1098 0.1652
Plasmodium falciparum serine repeat antigen 3 0.0335 0.1098 0.1572
Echinococcus granulosus growth factor receptor bound protein 2 0.0856 0.3555 0.3539
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0403
Echinococcus granulosus cathepsin L cysteine protease 0.0815 0.3361 0.3344
Schistosoma mansoni cathepsin s 0.048 0.1781 0.1781
Loa Loa (eye worm) hypothetical protein 0.0108 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0183 0.0383 0.0263
Trypanosoma brucei metacaspase MCA3 0.0236 0.0631 0.0787
Entamoeba histolytica cysteine proteinase 1, putative 0.0815 0.3361 0.5021
Echinococcus granulosus cathepsin L cysteine proteinase 0.1496 0.6571 0.6562
Loa Loa (eye worm) hypothetical protein 0.0358 0.1206 0.1206
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0335 0.1098 0.1572
Mycobacterium tuberculosis Possible exported protein 0.0386 0.1337 0.3106
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0343 0.1134 0.1134
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1496 0.6571 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Echinococcus multilocularis caspase 2 0.0448 0.163 0.1609
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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