Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | calpain-like protein, putative | 0.0461 | 0.2223 | 0.8358 |
Trypanosoma cruzi | kinesin, putative | 0.0322 | 0.1267 | 0.1267 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0461 | 0.2223 | 0.2223 |
Echinococcus multilocularis | cathepsin b | 0.1587 | 1 | 1 |
Loa Loa (eye worm) | calpain | 0.0461 | 0.2223 | 0.2223 |
Loa Loa (eye worm) | hypothetical protein | 0.1221 | 0.7471 | 0.7471 |
Trypanosoma brucei | calpain-like protein, putative | 0.0461 | 0.2223 | 0.8358 |
Brugia malayi | calpain family protein 1 | 0.1221 | 0.7471 | 0.7471 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0461 | 0.2223 | 0.2223 |
Loa Loa (eye worm) | calpain 5 | 0.0322 | 0.1267 | 0.1267 |
Loa Loa (eye worm) | hypothetical protein | 0.1082 | 0.6515 | 0.6515 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0461 | 0.2223 | 0.8358 |
Loa Loa (eye worm) | hypothetical protein | 0.076 | 0.4292 | 0.4292 |
Loa Loa (eye worm) | calpain family protein 1 | 0.1221 | 0.7471 | 0.7471 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.1221 | 0.7471 | 0.7471 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0461 | 0.2223 | 0.2223 |
Brugia malayi | calpain 7 | 0.0461 | 0.2223 | 0.2223 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0524 | 0.266 | 0.266 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0461 | 0.2223 | 0.2223 |
Echinococcus granulosus | cathepsin b | 0.1587 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0461 | 0.2223 | 0.2223 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0461 | 0.2223 | 0.2223 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0524 | 0.266 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0524 | 0.266 | 0.266 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1587 | 1 | 1 |
Trypanosoma brucei | calpain-like protein, putative | 0.0461 | 0.2223 | 0.8358 |
Echinococcus multilocularis | cathepsin b | 0.1587 | 1 | 1 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0461 | 0.2223 | 0.2223 |
Trypanosoma cruzi | kinesin, putative | 0.0322 | 0.1267 | 0.1267 |
Giardia lamblia | Cathepsin B precursor | 0.0524 | 0.266 | 0.5 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0461 | 0.2223 | 0.2223 |
Schistosoma mansoni | Mername-AA248 (C02 family) | 0.0461 | 0.2223 | 0.2223 |
Giardia lamblia | Cathepsin B precursor | 0.0524 | 0.266 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0322 | 0.1267 | 1 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0461 | 0.2223 | 0.8358 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.1295 | 0.7983 | 0.7406 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0461 | 0.2223 | 0.8358 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0461 | 0.2223 | 0.2223 |
Entamoeba histolytica | calpain large subunit domain III containing protein | 0.0322 | 0.1267 | 1 |
Toxoplasma gondii | cathepsin B | 0.0524 | 0.266 | 1 |
Onchocerca volvulus | 0.076 | 0.4292 | 0.5 | |
Brugia malayi | calpain family protein 1 | 0.1221 | 0.7471 | 0.7471 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1587 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1587 | 1 | 1 |
Brugia malayi | calpain 5 | 0.0322 | 0.1267 | 0.1267 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0524 | 0.266 | 1 |
Leishmania major | kinesin, putative | 0.0322 | 0.1267 | 0.4765 |
Echinococcus granulosus | cathepsin b | 0.1587 | 1 | 1 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0461 | 0.2223 | 0.8358 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0461 | 0.2223 | 0.2223 |
Echinococcus multilocularis | calpain A | 0.1295 | 0.7984 | 0.7408 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1587 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0524 | 0.266 | 1 |
Trypanosoma brucei | kinesin, putative | 0.0322 | 0.1267 | 0.4765 |
Loa Loa (eye worm) | hypothetical protein | 0.1587 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1587 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0524 | 0.266 | 0.266 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.1295 | 0.7983 | 0.7983 |
Echinococcus granulosus | calpain A | 0.1295 | 0.7984 | 0.7408 |
Schistosoma mansoni | calpain C (C02 family) | 0.0461 | 0.2223 | 0.2223 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0461 | 0.2223 | 0.2223 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0899 | 0.5248 | 0.3889 |
Giardia lamblia | Cathepsin B precursor | 0.0524 | 0.266 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0899 | 0.5248 | 0.5248 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0461 | 0.2223 | 0.2223 |
Trypanosoma brucei | antigen, putative | 0.0461 | 0.2223 | 0.8358 |
Trypanosoma brucei | calpain-like protein, putative | 0.0461 | 0.2223 | 0.8358 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.1295 | 0.7983 | 0.7406 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.1295 | 0.7983 | 0.7983 |
Schistosoma mansoni | calpain (C02 family) | 0.0461 | 0.2223 | 0.2223 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.5248 | 0.5248 |
Plasmodium vivax | calpain, putative | 0.0461 | 0.2223 | 0.5 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0461 | 0.2223 | 0.8358 |
Plasmodium falciparum | calpain | 0.0138 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.