Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.2745 | 1 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0432 | 0.032 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1516 | 0.1516 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0144 | 0.0144 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0062 | 0.0115 | 0.0063 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.0144 | 0.0144 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase small subunit | 0.0148 | 0.0432 | 0.0381 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.2745 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0045 | 0.0053 | 0.0053 |
Plasmodium falciparum | thioredoxin reductase | 0.0062 | 0.0115 | 0.0063 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.2745 | 1 | 1 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0148 | 0.0432 | 0.0432 |
Onchocerca volvulus | 0.0045 | 0.0053 | 0.2708 | |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0045 | 0.0053 | 0.0053 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0148 | 0.0432 | 0.0363 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.005 | 0.0071 | 0.0019 |
Brugia malayi | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.004 | 0.0035 | 0.0035 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0245 | 0.0245 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0045 | 0.0053 | 0.0053 |
Onchocerca volvulus | 0.0045 | 0.0053 | 0.2708 | |
Brugia malayi | hypothetical protein | 0.0045 | 0.0053 | 0.0053 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0148 | 0.0432 | 0.0363 |
Plasmodium vivax | ribonucleotide reductase small subunit, putative | 0.005 | 0.0071 | 0.0019 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0432 | 0.032 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0045 | 0.0053 | 0.0053 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0045 | 0.0053 | 0.0053 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0733 | 0.2588 | 0.2502 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0144 | 0.5 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.0562 | 0.0562 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0432 | 0.032 |
Plasmodium falciparum | glutathione reductase | 0.0062 | 0.0115 | 0.0063 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0056 | 0.0056 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0175 | 0.0533 | 0.0533 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0355 | 0.1195 | 0.1303 |
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0355 | 0.1195 | 0.0797 |
Brugia malayi | Cell death protein 3 precursor | 0.0058 | 0.0099 | 0.0099 |
Plasmodium falciparum | plasmepsin I | 0.0082 | 0.0188 | 0.0136 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0148 | 0.0432 | 0.0369 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.0144 | 0.0144 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.239 | 0.8692 | 1 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0148 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0245 | 0.0245 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0148 | 0.0432 | 0.0369 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.2745 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0056 | 0.0056 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0255 | 0.0185 |
Loa Loa (eye worm) | glutathione reductase | 0.0062 | 0.0115 | 0.0115 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.2745 | 1 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0446 | 0.1531 | 0.1531 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0045 | 0.0053 | 0.0053 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.2745 | 1 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0058 | 0.0099 | 0.0099 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0184 | 0.0564 | 0.0564 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.239 | 0.8692 | 1 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1516 | 0.1516 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0188 | 0.0188 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0045 | 0.0053 | 0.0053 |
Plasmodium vivax | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0432 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0053 | 0.0053 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0058 | 0.0099 | 0.0099 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0082 | 0.0188 | 0.0136 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0046 | 0.0056 | 0.0056 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.0144 | 0.0144 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0045 | 0.0053 | 0.0053 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0045 | 0.0053 | 0.0053 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.2745 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0053 | 0.0053 |
Toxoplasma gondii | thioredoxin reductase | 0.0062 | 0.0115 | 0.0063 |
Brugia malayi | Thioredoxin reductase | 0.0062 | 0.0115 | 0.0115 |
Plasmodium vivax | plasmepsin IV, putative | 0.0082 | 0.0188 | 0.0136 |
Echinococcus granulosus | caspase 2 | 0.0058 | 0.0099 | 0.0099 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0053 | 0.0053 |
Brugia malayi | Kelch motif family protein | 0.0046 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.2745 | 1 | 1 |
Brugia malayi | ribonucleotide reductase 2 | 0.0148 | 0.0432 | 0.0432 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0564 | 0.0564 |
Plasmodium falciparum | plasmepsin IV | 0.0082 | 0.0188 | 0.0136 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0851 | 0.3023 | 0.3023 |
Plasmodium falciparum | plasmepsin VI | 0.0082 | 0.0188 | 0.0136 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 0.1004 | 0.1004 |
Plasmodium vivax | glutathione reductase, putative | 0.0062 | 0.0115 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0132 | 0.0132 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0082 | 0.0188 | 0.0188 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.239 | 0.8692 | 1 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0045 | 0.0053 | 0.0053 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0432 | 0.032 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0175 | 0.0533 | 0.0533 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.239 | 0.8692 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0062 | 0.0115 | 0.0115 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0082 | 0.0188 | 0.0188 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0255 | 0.0255 |
Plasmodium falciparum | plasmepsin II | 0.0082 | 0.0188 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0245 | 0.0245 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.0562 | 0.0562 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0082 | 0.0188 | 0.0136 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.0562 | 0.0562 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0432 | 0.0381 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0062 | 0.0115 | 0.0115 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0058 | 0.0099 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0045 | 0.0053 | 0.0053 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0132 | 0.0132 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0303 | 0.1004 | 0.1004 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0082 | 0.0188 | 0.0188 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2455 | 0.8934 | 0.8934 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0432 | 0.0363 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0082 | 0.0188 | 0.0136 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0045 | 0.0053 | 0.0053 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0082 | 0.0188 | 0.0188 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.2745 | 1 | 1 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.2745 | 1 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.0562 | 0.0562 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0144 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Trypanosoma brucei | trypanothione reductase | 0.0062 | 0.0115 | 0.0044 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.0714 | 0.0714 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0355 | 0.1195 | 0.1258 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.004 | 0.0035 | 0.0035 |
Brugia malayi | glutathione reductase | 0.0062 | 0.0115 | 0.0115 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0183 | 0.0562 | 0.0562 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Brugia malayi | hypothetical protein | 0.007 | 0.0144 | 0.0144 |
Brugia malayi | Pepsin A precursor | 0.0045 | 0.0053 | 0.0053 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0144 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0144 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0245 | 0.0245 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0148 | 0.0432 | 0.0363 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0859 | 0.3052 | 0.3425 |
Mycobacterium leprae | conserved hypothetical protein | 0.0355 | 0.1195 | 0.1303 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0148 | 0.0432 | 0.0432 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.2745 | 1 | 1 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.2745 | 1 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.239 | 0.8692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0099 | 0.0099 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0148 | 0.0432 | 0.0432 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0062 | 0.0115 | 0.0115 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0545 | 0.0545 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0045 | 0.0053 | 0.0053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.