Detailed information for compound 209462

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.501 | Formula: C22H33NO6
  • H donors: 2 H acceptors: 5 LogP: 2.17 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1
  • InChi: 1S/C20H31NO2.C2H2O4/c1-3-5-6-10-15-23-20(22)19-16-21(4-2)14-13-18(19)17-11-8-7-9-12-17;3-1(4)2(5)6/h7-9,11-12,18-19H,3-6,10,13-16H2,1-2H3;(H,3,4)(H,5,6)/t18-,19-;/m0./s1
  • InChiKey: SIBJNEXHOAROOS-HLRBRJAUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholinergic receptor, muscarinic 4 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 5 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 2 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 1 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0036 0.0112
Toxoplasma gondii thymidylate kinase 0.0077 0.0478 0.2639
Echinococcus multilocularis lamin dm0 0.0029 0.0119 0.0444
Schistosoma mansoni hypothetical protein 0.0351 0.2513 0.2487
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0138 0.0691
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0036 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus multilocularis thymidylate kinase 0.0077 0.0478 0.1878
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Schistosoma mansoni amine GPCR 0.0018 0.0036 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0054 0.005
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0074 0.0103
Echinococcus multilocularis somatostatin receptor 0.0018 0.0036 0.0112
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Schistosoma mansoni hypothetical protein 0.0025 0.0087 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0087 0.0052
Brugia malayi putative neuropeptide receptor 0.0018 0.0036 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0275 0.1946 0.2406
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0001
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0138 0.2335
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0036 0.0001
Brugia malayi intermediate filament protein 0.0029 0.0119 0.0637
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0036 0.0112
Trypanosoma brucei ingi protein (ORF1) 0.0275 0.1946 0.2406
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0025 0.0087 0.0315
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0054 0.0134
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0054 0.005
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0036 0.0112
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0036 0.0112
Schistosoma mansoni neuropeptide receptor 0.0018 0.0036 0.0001
Schistosoma mansoni thymidylate kinase 0.0077 0.0478 0.0445
Echinococcus granulosus allatostatin A receptor 0.0018 0.0036 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0771 0.8918
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0036 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.1872 0.4982
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0035 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0035 0.034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0861 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0119 0.0444
Echinococcus multilocularis musashi 0.0029 0.0119 0.0444
Brugia malayi larval opioid receptor 0.0018 0.0036 0.0192
Trichomonas vaginalis thymidine kinase, putative 0.0536 0.3887 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0019 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus multilocularis geminin 0.0351 0.2513 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Schistosoma mansoni myosin xvIII 0.0018 0.0036 0.0001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0036 0.0086
Brugia malayi reverse transcriptase 0.0025 0.0087 0.0464
Brugia malayi hypothetical protein 0.0025 0.0087 0.0464
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.0765 0.7488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Trypanosoma cruzi thymidine kinase, putative 0.0536 0.3887 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0138 0.0691
Loa Loa (eye worm) hypothetical protein 0.0028 0.0115 0.0297
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0036 0.0112
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0036 0.0192
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0054 0.0262
Schistosoma mansoni lamin 0.0029 0.0119 0.0085
Trypanosoma brucei thymidylate kinase, putative 0.0077 0.0478 0.0559
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0138 0.0269
Schistosoma mansoni adenoreceptor 0.0018 0.0036 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0138 0.0599
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Trypanosoma cruzi thymidylate kinase, putative 0.0077 0.0478 0.1151
Echinococcus granulosus orexin receptor type 2 0.0018 0.0036 0.0112
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0036 0.0086
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0036 0.0112
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0054 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0036 0.0086
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0138 0.022
Trichomonas vaginalis ribonuclease H1, putative 0.025 0.1763 0.4487
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0861 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0119 0.0637
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Brugia malayi G-protein coupled receptor 0.0018 0.0036 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0036 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0036 0.0112
Brugia malayi reverse transcriptase 0.0025 0.0087 0.0464
Schistosoma mansoni phosphoglucomutase 0.025 0.1763 0.1735
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0036 0.0001
Schistosoma mansoni hypothetical protein 0.0351 0.2513 0.2487
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0036 0.0112
Trypanosoma brucei thymidine kinase 0.0536 0.3887 0.485
Echinococcus granulosus ribonuclease H1 0.025 0.1763 0.7006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0036 0.0001
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0036 0.0001
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Loa Loa (eye worm) glutathione reductase 0.0051 0.0281 0.074
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus somatostatin receptor 0.0018 0.0036 0.0112
Brugia malayi thymidylate kinase 0.0077 0.0478 0.2556
Schistosoma mansoni neuropeptide receptor 0.0018 0.0036 0.0001
Brugia malayi G protein-coupled receptor 0.0018 0.0036 0.0192
Trypanosoma brucei unspecified product 0.0275 0.1946 0.2406
Echinococcus granulosus bloom syndrome protein 0.0023 0.0074 0.0265
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0036 0.0001
Schistosoma mansoni biogenic amine receptor 0.0018 0.0036 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0036 0.0001
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0074 0.0397
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus g protein coupled receptor 0.0018 0.0036 0.0112
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0001
Echinococcus granulosus KRAB A domain containing protein 0.0025 0.0087 0.0315
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.0765 0.8837
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0054 0.005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0054 0.0425
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Trichomonas vaginalis thymidine kinase, putative 0.0536 0.3887 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0019 0.0103
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0036 0.0112
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0036 0.0112
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0025 0.0087 0.0066
Entamoeba histolytica Thymidylate kinase, putative 0.0077 0.0478 0.1107
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0054 0.0289
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0138 0.0269
Mycobacterium tuberculosis Probable reductase 0.0116 0.0765 0.8837
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0771 0.1912
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0307
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0771 0.1871
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0036 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0036 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Schistosoma mansoni phosphoglucomutase 0.025 0.1763 0.1735
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0025 0.0087 0.0135
Brugia malayi RNase H family protein 0.025 0.1763 0.9422
Brugia malayi RE15519p 0.0018 0.0036 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0036 0.0112
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0771 0.7663
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0281 0.064
Schistosoma mansoni intermediate filament proteins 0.0029 0.0119 0.0085
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0077 0.0478 0.2566
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0025 0.0087 0.0315
Trichomonas vaginalis reverse transcriptases, putative 0.0025 0.0087 0.0135
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0036 0.0112
Brugia malayi hypothetical protein 0.0025 0.0087 0.0464
Giardia lamblia Reverse transcriptase/endonuclease 0.0025 0.0087 0.0135
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0861 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0036 0.0112
Mycobacterium tuberculosis Possible maturase 0.0025 0.0087 0.0631
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0771 0.1912
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0771 0.0739
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0281 0.5709
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0771 0.0739
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0036 0.0086
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Treponema pallidum ribonuclease H (rnhA) 0.025 0.1763 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.003 0.0129 0.0246
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0036 0.0112
Schistosoma mansoni hypothetical protein 0.0077 0.0478 0.0445
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0036 0.0112
Echinococcus granulosus lamin dm0 0.0029 0.0119 0.0444
Plasmodium vivax thymidylate kinase, putative 0.0077 0.0478 1
Schistosoma mansoni opsin-like receptor 0.0018 0.0036 0.0001
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0036 0.0112
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0036 0.0112
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0038 0.0004
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0138 0.2596
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0036 0.0001
Schistosoma mansoni biogenic amine receptor 0.0018 0.0036 0.0001
Echinococcus granulosus thymidylate kinase 0.0077 0.0478 0.1878
Leishmania major thymidine kinase, putative 0.0536 0.3887 1
Echinococcus granulosus fmrfamide receptor 0.0018 0.0036 0.0112
Schistosoma mansoni neuropeptide receptor 0.0018 0.0036 0.0001
Onchocerca volvulus 0.0025 0.0087 0.0295
Schistosoma mansoni amine GPCR 0.0018 0.0036 0.0001
Entamoeba histolytica thymidine kinase, putative 0.0536 0.3887 1
Echinococcus multilocularis ribonuclease H1 0.025 0.1763 0.7006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0036 0.0112
Trypanosoma brucei RNA helicase, putative 0.1086 0.7978 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.0765 0.8837
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.0765 0.8837
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0281 0.1092
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0036 0.0112
Brugia malayi Serotonin receptor 0.0018 0.0036 0.0192
Schistosoma mansoni opsin-like receptor 0.0018 0.0036 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0036 0.0112
Onchocerca volvulus 0.0025 0.0087 0.0295
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0096
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0036 0.0112
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0036 0.0112
Brugia malayi follicle stimulating hormone receptor 0.0265 0.1872 1
Trichomonas vaginalis thymidylate kinase, putative 0.0077 0.0478 0.1151
Schistosoma mansoni histamine h1 receptor 0.0018 0.0036 0.0001
Echinococcus granulosus g protein coupled receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0036 0.0112
Plasmodium falciparum glutathione reductase 0.0051 0.0281 0.5558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0074 0.0265
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0138 0.0269
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0036 0.0112
Schistosoma mansoni phosphoglucomutase 0.025 0.1763 0.1735
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0138 0.2335
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0011
Mycobacterium ulcerans thymidylate kinase 0.0077 0.0478 0.6022
Trichomonas vaginalis thymidine kinase, putative 0.0536 0.3887 1
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0025 0.0087 0.0135
Brugia malayi 6-phosphofructokinase 0.0117 0.0771 0.4121
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0054 0.0436
Trypanosoma cruzi ribonuclease H1, putative 0.025 0.1763 0.4487
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0771 1
Loa Loa (eye worm) thymidylate kinase 0.0077 0.0478 0.1266
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0138 0.2335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Trichomonas vaginalis reverse transcriptases, putative 0.0025 0.0087 0.0135
Trypanosoma brucei trypanothione reductase 0.0051 0.0281 0.031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus multilocularis serotonin receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0036 0.0112
Leishmania major hypothetical protein, conserved 0.003 0.0129 0.0246
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0036 0.0112
Echinococcus granulosus neuropeptide receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0036 0.0112
Echinococcus granulosus g protein coupled receptor 0.0018 0.0036 0.0112
Brugia malayi sulfakinin receptor protein 0.0018 0.0036 0.0192
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0036 0.0112
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0771 0.2047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0281 0.2985
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0771 0.3047
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0036 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0518 0.3753 1
Brugia malayi neuropeptide F receptor 0.0018 0.0036 0.0192
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0054 0.005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0119 0.0307
Plasmodium falciparum thymidylate kinase 0.0077 0.0478 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.0765 0.8837
Brugia malayi Dopamine receptor protein 2 0.0018 0.0036 0.0192
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0036 0.0112
Brugia malayi neuropeptide F receptor 0.0018 0.0036 0.0192
Onchocerca volvulus Ribonuclease H1 homolog 0.025 0.1763 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0036 0.0112
Echinococcus granulosus sex peptide receptor 0.0018 0.0036 0.0112
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.003 0.0129 0.0246
Brugia malayi RNase H family protein 0.025 0.1763 0.9422
Onchocerca volvulus 0.0029 0.0119 0.0482
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0036 0.0192
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0036 0.0086
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0036 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0074 0.0103
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0281 0.074
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0036 0.0112
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.025 0.1763 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0036 0.0001
Leishmania major trypanothione reductase 0.0051 0.0281 0.064
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0035 0.034
Schistosoma mansoni protein kinase 0.0025 0.0087 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0247 0.174 0.1711
Brugia malayi ORL1-like opioid receptor 0.0018 0.0036 0.0192
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0036 0.0112
Brugia malayi hypothetical protein 0.0025 0.0087 0.0464
Schistosoma mansoni hypothetical protein 0.1086 0.7978 0.7971
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0087 0.0135
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0036 0.0112
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0036 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Echinococcus granulosus hypothetical protein 0.0018 0.0036 0.0112
Schistosoma mansoni hypothetical protein 0.0025 0.0087 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0138 0.0269
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0025 0.0087 0.0135
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0001
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0036 0.0001
Trichomonas vaginalis thymidylate kinase, putative 0.0077 0.0478 0.1151
Brugia malayi Zinc knuckle family protein 0.0025 0.0087 0.0464
Onchocerca volvulus 0.0029 0.0119 0.0482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0025 0.0087 0.0135
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0036 0.0112
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0771 0.0927
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0054 0.0761
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0771 0.3047
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0036 0.0112
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0025 0.0087 0.0315
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0036 0.0086
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0771 0.2047
Trypanosoma cruzi thymidylate kinase, putative 0.0077 0.0478 0.1151
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0077 0.0478 0.5371
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0138 0.0269
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0035 0.0107
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0025 0.0087 0.0052
Brugia malayi Dopamine receptor protein 1 0.0018 0.0036 0.0192
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0036 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Chlamydia trachomatis thymidylate kinase 0.0077 0.0478 1
Giardia lamblia CDC8 0.0077 0.0478 0.1151
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0138 0.2596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Schistosoma mansoni biogenic amine receptor 0.0018 0.0036 0.0001
Trypanosoma brucei ribonuclease H1 0.025 0.1763 0.2176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0036 0.0001
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Brugia malayi RNase H family protein 0.025 0.1763 0.9422
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Schistosoma mansoni opsin-like receptor 0.0018 0.0036 0.0001
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0035 0.0097
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis lamin 0.0029 0.0119 0.0444
Schistosoma mansoni ap endonuclease 0.002 0.0054 0.0019
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0036 0.0112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0036 0.0001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0861 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Schistosoma mansoni amine GPCR 0.0018 0.0036 0.0001
Trypanosoma cruzi thymidine kinase, putative 0.0536 0.3887 1
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0025 0.0087 0.0135
Echinococcus granulosus geminin 0.0351 0.2513 1
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0036 0.0112
Giardia lamblia Thymidine kinase 0.0536 0.3887 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Brugia malayi reverse transcriptase 0.0025 0.0087 0.0464
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0054 0.0112
Brugia malayi Dopamine receptor 0.0018 0.0036 0.0192
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0036 0.0001
Toxoplasma gondii thioredoxin reductase 0.0051 0.0281 0.151
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0036 0.0001
Toxoplasma gondii ribonuclease HI protein 0.025 0.1763 1
Echinococcus multilocularis sex peptide receptor 0.0018 0.0036 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0771 0.1912
Loa Loa (eye worm) hypothetical protein 0.0518 0.3753 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0138 0.2335
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0054 0.005
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0138 0.0269
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0036 0.0112
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0036 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0771 0.1912
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Trypanosoma brucei thymidylate kinase, putative 0.0077 0.0478 0.0559
Onchocerca volvulus Putative thymidylate kinase 0.0077 0.0478 0.2561
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0025 0.0087 0.0135
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0036 0.0112
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0771 0.4262
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Trypanosoma brucei hypothetical protein, conserved 0.0275 0.1946 0.2406
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0054 0.005
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0036 0.0192
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Brugia malayi Zinc knuckle family protein 0.0025 0.0087 0.0464
Brugia malayi glutathione reductase 0.0051 0.0281 0.1503
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0036 0.0001
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0036 0.0112
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0025 0.0087 0.0315
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0138 0.0691
Brugia malayi 6-phosphofructokinase 0.0117 0.0771 0.4121
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0138 0.0269
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0771 0.1912
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0054 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Plasmodium falciparum thioredoxin reductase 0.0051 0.0281 0.5558
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.0765 0.8837
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0771 0.2047
Loa Loa (eye worm) RecQ helicase 0.0023 0.0074 0.0188
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0036 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0036 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus RNA directed DNA polymerase 0.0025 0.0087 0.0315
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0054 0.0112
Schistosoma mansoni amine GPCR 0.0018 0.0036 0.0001
Treponema pallidum thymidylate kinase (tmk) 0.0077 0.0478 0.2566
Echinococcus granulosus neuropeptide receptor 0.0018 0.0036 0.0112
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0054 0.0234
Leishmania major thymidylate kinase-like protein 0.0077 0.0478 0.1151
Brugia malayi Serotonin receptor 0.0018 0.0036 0.0192
Brugia malayi phosphofructokinase 0.0117 0.0771 0.4121
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Schistosoma mansoni thymidylate kinase 0.0077 0.0478 0.0445
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0036 0.0112
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0025 0.0087 0.0066
Brugia malayi GnHR receptor homolog 0.0018 0.0036 0.0192
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0771 0.1912
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0087 0.0315
Trypanosoma brucei ingi protein (ORF1) 0.0275 0.1946 0.2406
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0036 0.0001
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0036 0.0112
Schistosoma mansoni amine GPCR 0.0018 0.0036 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0138 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0036 0.0112
Brugia malayi AKH receptor 0.0018 0.0036 0.0192
Brugia malayi hypothetical protein 0.0025 0.0087 0.0464
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0035 0.0107
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Giardia lamblia Ribonuclease H 0.025 0.1763 0.4487
Schistosoma mansoni ap endonuclease 0.002 0.0054 0.0019
Plasmodium vivax glutathione reductase, putative 0.0051 0.0281 0.5709
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0036 0.0112
Schistosoma mansoni neuropeptide receptor 0.0018 0.0036 0.0001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0035 0.0185
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0771 0.1871
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0036 0.0192
Brugia malayi hypothetical protein 0.0018 0.0036 0.0192
Echinococcus granulosus lamin 0.0029 0.0119 0.0444
Echinococcus multilocularis serotonin receptor 0.0018 0.0036 0.0112
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0036 0.0086
Brugia malayi G-protein coupled receptor 0.0018 0.0036 0.0192
Echinococcus granulosus serotonin receptor 0.0018 0.0036 0.0112
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0036 0.0112
Brugia malayi Melatonin receptor type 1A 0.0018 0.0036 0.0192
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0025 0.0087 0.0315
Schistosoma mansoni lamin 0.0029 0.0119 0.0085
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0281 0.1092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0036 0.0086
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0025 0.0087 0.0066
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0036 0.0192
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0054 0.0184
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0036 0.0112
Trypanosoma cruzi ribonuclease H1, putative 0.025 0.1763 0.4487
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0771 0.1871
Brugia malayi Thioredoxin reductase 0.0051 0.0281 0.1503
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0036 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0036 0.0001
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0036 0.0112
Echinococcus multilocularis RNA directed DNA polymerase 0.0025 0.0087 0.0315
Toxoplasma gondii exonuclease III APE 0.002 0.0054 0.0208
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0036 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0086
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0025 0.0087 0.0295
Leishmania major ribonuclease H1, putative 0.025 0.1763 0.4487
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0036 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0119 0.0307
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0087 0.0464

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 61.4 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M1 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 61.4 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M1 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 220.3 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 220.3 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M3 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 222.1 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 222.1 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 405 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 405 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 572.7 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M4 using membranes from transfected CHO cells ChEMBL. 9986705
IC50 (binding) = 572.7 nM Displacement of [3H]-NMS binding to human Muscarinic acetylcholine receptor M4 using membranes from transfected CHO cells ChEMBL. 9986705

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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