Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | somatostatin receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 5 | 364 aa | 392 aa | 19.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Macro domain containing protein, putative | 0.003 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.003 | 0.5 | 0.5 |
Toxoplasma gondii | macro domain-containing protein | 0.003 | 0.5 | 0.5 |
Plasmodium falciparum | Appr-1-p processing domain protein | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.5 | 0.5 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.003 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.5 | 0.5 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.003 | 0.5 | 0.5 |
Giardia lamblia | Protein LRP16 | 0.003 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible lipoprotein LppD | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.003 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.003 | 0.5 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.5 | 0.5 |
Mycobacterium ulcerans | lipoprotein LppD | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.003 | 0.5 | 0.5 |
Trypanosoma brucei | Macro domain containing protein, putative | 0.003 | 0.5 | 0.5 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.003 | 0.5 | 0.5 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.003 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Tested for inhibitory activity at human recombinant sst 2 receptors expressed in CHO-K1 cells; No inhibition showed more than 50% inhibition | ChEMBL. | 9934480 | |
Activity (binding) | 0 | Tested for inhibitory activity at human recombinant sst 2 receptors expressed in CHO-K1 cells; No inhibition showed more than 50% inhibition | ChEMBL. | 9934480 |
IC50 (binding) | = -5.85 | Compound was tested for inhibition of specific [125I]-Tyr11-SRIF binding to human recombinant SST5 (somatostatin) receptor expressed in CHO-K1 cells | ChEMBL. | 9934480 |
Log IC50 (binding) | = 5.85 | Compound was tested for inhibition of specific [125I]-Tyr11-SRIF binding to human recombinant SST5 (somatostatin) receptor expressed in CHO-K1 cells | ChEMBL. | 9934480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.