Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Eukaryotic translation initiation factor 4E | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.55 uM | Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence based luciferase assay | ChEMBL. | 26264844 |
IC50 (binding) | = 3.26 uM | Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by luminescence based luciferase assay | ChEMBL. | 26264844 |
Ka (binding) | = 36.1 /uM | Binding affinity to eIF4E (unknown origin) by fluorescence quenching assay | ChEMBL. | 26264844 |
Stabilty (ADMET) | Stability of the compound assessed as human DcpS-mediated compound hydrolysis at 40 uM after 10 to 180 mins by HPLC analysis | ChEMBL. | 26264844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.