TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 560.492 | Formula: C27H27Cl2N3O4S
H donors: 2 H acceptors: 4 LogP: 4.27 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N[C@@]1(CSC2=C1C(=O)c1c(C2=O)cccc1)C(=O)NCc1ccc(cc1)Cl)CN1CCCCC1.Cl
InChi: 1S/C27H26ClN3O4S.ClH/c28-18-10-8-17(9-11-18)14-29-26(35)27(30-21(32)15-31-12-4-1-5-13-31)16-36-25-22(27)23(33)19-6-2-3-7-20(19)24(25)34;/h2-3,6-11H,1,4-5,12-16H2,(H,29,35)(H,30,32);1H/t27-;/m1./s1
InChiKey: JEUNFIVMHNCMAB-HZPIKELBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.007	1	0.5
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.007	1	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.007	1	0.5
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Brugia malayi	Dehydrogenases, short chain protein 2	0.007	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.007	1	1
Brugia malayi	Dehydrogenases, short chain protein 30	0.007	1	1
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.007	1	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.007	1	1
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Echinococcus granulosus	carbonyl reductase 1	0.007	1	1
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.007	1	1
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	1	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.007	1	0.5
Onchocerca volvulus		0.007	1	1
Echinococcus granulosus	hypothetical protein	0.007	1	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.007	1	1
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.007	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Giardia lamblia	Short-chain dehydrogenase, putative	0.007	1	0.5
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.487	0.487
Mycobacterium leprae	Probable oxidoreductase	0.007	1	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.007	1	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	1	0.5
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.007	1	1
Echinococcus multilocularis	carbonyl reductase 1	0.007	1	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.9064	0.9064
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	1	0.5
Leishmania major	hypothetical protein, conserved	0.007	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.007	1	1
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.007	1	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.007	1	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.007	1	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.007	1	1
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.007	1	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.007	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	1	0.5
Leishmania major	dehydrogenase-like protein	0.007	1	1
Onchocerca volvulus		0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Onchocerca volvulus		0.007	1	1
Brugia malayi	hypothetical protein	0.007	1	1
Echinococcus multilocularis	transient receptor potential cation channel	0.007	1	1
Onchocerca volvulus		0.007	1	1
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.007	1	1
Leishmania major	oxidoreductase-like protein	0.007	1	1
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Plasmodium vivax	hypothetical protein, conserved	0.007	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.007	1	0.5
Onchocerca volvulus		0.007	1	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.007	1	1
Mycobacterium ulcerans	carveol-like dehydrogenase	0.007	1	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.007	1	1
Brugia malayi	dehydrogenases, short chain protein 9	0.007	1	1
Trypanosoma brucei	oxidoreductase-like protein	0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.007	1	1
Brugia malayi	hypothetical protein	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	1	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.007	1	1
Echinococcus granulosus	oxidoreductase	0.007	1	1
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.007	1	0.5
Onchocerca volvulus		0.007	1	1
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Echinococcus multilocularis	retinol dehydrogenase 11	0.007	1	1
Echinococcus multilocularis	calpain A	0.0066	0.9064	0.9064
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.007	1	1
Echinococcus multilocularis	carbonyl reductase 1	0.007	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Schistosoma mansoni	retinal dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.007	1	0.5
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.007	1	1
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.007	1	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	1	0.5
Onchocerca volvulus		0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Onchocerca volvulus		0.007	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.007	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	1	0.5
Giardia lamblia	Reductase, putative	0.007	1	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.007	1	0.5
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Echinococcus granulosus	carbonyl reductase 1	0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Giardia lamblia	Hypothetical protein	0.007	1	0.5
Mycobacterium ulcerans	dehydrogenase	0.007	1	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.007	1	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.007	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.007	1	1
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Echinococcus granulosus	calpain A	0.0066	0.9064	0.9064
Leishmania major	short chain dehydrogenase, putative	0.007	1	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.007	1	1
Echinococcus multilocularis	steroid dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	1	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.007	1	0.5
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	1	0.5
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.007	1	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.007	1	1
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.007	1	1
Entamoeba histolytica	hypothetical protein	0.007	1	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.007	1	1
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Leishmania major	short chain dehydrogenase-like protein	0.007	1	1
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	1	0.5
Onchocerca volvulus		0.007	1	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.007	1	0.5
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0066	0.9064	0.9064
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.007	1	1
Onchocerca volvulus		0.007	1	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.007	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.845	0.845
Trichomonas vaginalis	steroid dehydrogenase, putative	0.007	1	0.5
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.007	1	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	1	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	1	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Toxoplasma gondii	oxidoreductase, putative	0.007	1	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.007	1	0.5
Toxoplasma gondii	carbonyl reductase 1, putative	0.007	1	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.007	1	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.007	1	1
Entamoeba histolytica	short chain dehydrogenase family protein	0.007	1	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.007	1	0.5
Leishmania major	short chain dehydrogenase, putative	0.007	1	1
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.007	1	1
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.007	1	1
Entamoeba histolytica	short chain dehydrogenase family protein	0.007	1	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.007	1	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0063	0.845	0.845
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.007	1	0.5
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.9064	0.9064
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	1	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.007	1	0.5
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Schistosoma mansoni	carbonyl reductase	0.007	1	1
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.007	1	0.5
Schistosoma mansoni	carbonyl reductase	0.007	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	1	0.5
Echinococcus granulosus	hypothetical protein	0.007	1	1
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.007	1	1
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.007	1	1
Mycobacterium ulcerans	ketoacyl reductase	0.007	1	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Echinococcus multilocularis	calpain family protein 1, d	0.0046	0.487	0.487
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.007	1	1
Plasmodium falciparum	steroid dehydrogenase, putative	0.007	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Mycobacterium ulcerans	oxidoreductase	0.007	1	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.007	1	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.007	1	1
Loa Loa (eye worm)	dehydrogenase	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.007	1	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	0.5
Onchocerca volvulus	Sepiapterin reductase homolog	0.007	1	1
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.007	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.007	1	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.007	1	0.5
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0066	0.9064	0.9064
Echinococcus multilocularis	carbonyl reductase 1	0.007	1	1
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.007	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	1	1
Leishmania major	hypothetical protein, conserved	0.007	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.007	1	1
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.007	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	1	1
Echinococcus multilocularis	oxidoreductase	0.007	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.007	1	1
Echinococcus granulosus	carbonyl reductase 1	0.007	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.007	1	1
Brugia malayi	oxidoreductase	0.007	1	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.007	1	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Echinococcus granulosus	WW domain containing oxidoreductase	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Mycobacterium ulcerans	ketoacyl reductase	0.007	1	0.5
Schistosoma mansoni	carbonyl reductase	0.007	1	1
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.007	1	0.5
Brugia malayi	Retinol dehydrogenase 12	0.007	1	1
Onchocerca volvulus		0.007	1	1
Mycobacterium ulcerans	ketoacyl reductase	0.007	1	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.007	1	1
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.007	1	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Loa Loa (eye worm)	calpain family protein 1	0.0063	0.845	0.845
Echinococcus multilocularis	retinol dehydrogenase 13	0.007	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.007	1	0.5
Toxoplasma gondii	oxidoreductase, putative	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Onchocerca volvulus		0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.007	1	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.007	1	1
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.007	1	1
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.007	1	0.5
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.007	1	1
Brugia malayi	calpain family protein 1	0.0063	0.845	0.845
Echinococcus granulosus	carbonyl reductase 1	0.007	1	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.007	1	0.5
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.007	1	0.5
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Loa Loa (eye worm)	calpain family protein 1	0.0046	0.487	0.487
Loa Loa (eye worm)	dehydrogenase	0.007	1	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.007	1	1
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.007	1	1
Leishmania major	hypothetical protein, conserved	0.007	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.007	1	0.5
Mycobacterium ulcerans	oxidoreductase	0.007	1	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Echinococcus granulosus	steroid dehydrogenase	0.007	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Loa Loa (eye worm)	oxidoreductase	0.007	1	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.007	1	1
Schistosoma mansoni	steroid dehydrogenase	0.007	1	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.6911	0.6911
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.007	1	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.007	1	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.007	1	0.5
Echinococcus multilocularis	conserved hypothetical protein	0.007	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.007	1	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.007	1	0.5
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.007	1	0.5
Leishmania major	hypothetical protein, conserved	0.007	1	1
Schistosoma mansoni	short chain dehydrogenase	0.007	1	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.007	1	1
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.007	1	0.5
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.007	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3332	0.3332
Leishmania major	pteridine reductase 1	0.007	1	1
Leishmania major	hypothetical protein, conserved	0.007	1	1
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.007	1	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	1	1
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.007	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.007	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	1	0.5
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.007	1	1
Brugia malayi	calpain family protein 1	0.0063	0.845	0.845
Onchocerca volvulus		0.007	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3622412

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2107175