Detailed information for compound 2137659

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 261.003 | Formula: C11H7N3OS2
  • H donors: 2 H acceptors: 2 LogP: 2.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 0
  • SMILES: S=C1NC(=O)/C(=C/c2ccc3c(c2)scn3)/N1
  • InChi: InChI=1S/C11H7N3OS2/c15-10-8(13-11(16)14-10)3-6-1-2-7-9(4-6)17-5-12-7/h1-5H,(H2,13,14,15,16)/b8-3-
  • InChiKey: KVKWXEDCCDYLBI-BAQGIRSFSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens CDC-like kinase 1 References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 References
Homo sapiens casein kinase 2, alpha prime polypeptide References
Homo sapiens casein kinase 2, alpha 1 polypeptide References
Homo sapiens casein kinase 2, beta polypeptide References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A References
Homo sapiens protein kinase C, beta References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Theileria parva casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum YOR039Wp-like protein, related Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni casein kinase II beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania mexicana protein kinase-like protein Get druggable targets OG5_127439 All targets in OG5_127439
Cryptosporidium parvum casein kinase II, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Giardia lamblia Casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii casein kinase ii regulatory subunit protein Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax unspecified product Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Neospora caninum hypothetical protein Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Neospora caninum hypothetical protein Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma congolense dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium falciparum casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Babesia bovis protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase II, alpha chain (CK II) Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium knowlesi casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium yoelii Protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans weaker similarity to S. cerevisiae YAK1 (YJL141C) Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus multilocularis casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii CMGC kinase, CK2 family Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Toxoplasma gondii ck2 beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium hominis protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania braziliensis protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania infantum protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania infantum casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CK2 protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC DYRK Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium yoelii protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Candida albicans weaker similarity to S. cerevisiae YAK1 (YJL141C) Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania infantum protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma congolense Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum putative protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium yoelii casein kinase ii beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania major casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum ko:K03097 casein kinase 2, alpha polypeptide, putative Get druggable targets OG5_126901 All targets in OG5_126901
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania mexicana protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium hominis protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei Casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei gambiense protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase II beta 4 subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum putative casein kinase II regulatory subunit; besthit Pf 23508244 Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Kinase, CMGC CK2 Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha prime polypeptide 350 aa 319 aa 50.2 %
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha 1 polypeptide 391 aa 316 aa 51.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Echinococcus multilocularis Protein kinase C, brain isozyme 0.007 0.2788 0.2762
Giardia lamblia Casein kinase II beta chain 0.0044 0.1527 0.2061
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.1692 0.1662
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0076 0.3077 0.3052
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7408 1
Echinococcus granulosus protein kinase c epsilon type 0.0022 0.0466 0.0431
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.1692 0.1662
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2648 0.3574
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.1527 0.1527
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.1527 0.1527
Brugia malayi Protein kinase domain containing protein 0.0014 0.0036 0.0036
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0067 0.2648 0.1323
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0014 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2648 0.3574
Entamoeba histolytica protein kinase, putative 0.0067 0.2648 0.2648
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.2648 0.2648
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2648 0.3574
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Plasmodium falciparum protein serine/threonine kinase-1 0.0076 0.3077 0.2636
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0044 0.1527 0.1496
Entamoeba histolytica protein kinase, putative 0.0014 0.0036 0.0036
Echinococcus multilocularis dual specificity 0.0067 0.2648 0.2621
Brugia malayi Csnk2b protein 0.0044 0.1527 0.1527
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Brugia malayi Casein kinase II, alpha chain 0.0165 0.7408 0.7408
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2648 0.3574
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7408 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.1527 0.5
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0218 1 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0014 0.0036 0.0036
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0076 0.3077 0.4125
Loa Loa (eye worm) AGC/PKN protein kinase 0.0014 0.0036 0.0036
Echinococcus granulosus casein kinase ii subunit beta 0.0044 0.1527 0.1496
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7408 1
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.3077 0.3052
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0014 0.0036 0.0036
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0218 1 1
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0067 0.2648 0.2648
Loa Loa (eye worm) hypothetical protein 0.0214 0.9826 0.9826
Brugia malayi protein kinase C II. 0.0022 0.0466 0.0466
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0218 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0067 0.2648 0.2648
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2648 0.3574
Brugia malayi Protein kinase domain containing protein 0.0014 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0067 0.2648 0.2621
Loa Loa (eye worm) Csnk2b protein 0.0044 0.1527 0.1527
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0165 0.7408 0.7408
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0067 0.2648 0.3542
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0014 0.0036 0.0036
Entamoeba histolytica protein kinase, putative 0.0014 0.0036 0.0036
Echinococcus multilocularis dual specificity 0.0067 0.2648 0.2621
Trypanosoma brucei Casein kinase II 0.0165 0.7408 0.7399
Toxoplasma gondii ck2 beta subunit 0.0044 0.1527 0.2022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Loa Loa (eye worm) hypothetical protein 0.0048 0.1692 0.1692
Giardia lamblia Kinase, CMGC DYRK 0.0067 0.2648 0.3574
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.1527 0.1527
Echinococcus granulosus casein kinase ii subunit alpha 0.0165 0.7408 0.7399
Giardia lamblia Kinase, CMGC CLK 0.0076 0.3077 0.4154
Brugia malayi p70 ribosomal S6 kinase beta 0.0014 0.0036 0.0036
Leishmania major protein kinase, putative 0.0076 0.3077 0.183
Echinococcus granulosus hypothetical protein 0.0072 0.2903 0.2878
Echinococcus multilocularis casein kinase ii subunit alpha 0.0165 0.7408 0.7399
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7408 1
Entamoeba histolytica protein kinase domain containing protein 0.0218 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.3077 0.183
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0076 0.3077 0.3052
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0022 0.0466 0.0466
Brugia malayi Protein kinase c protein 2 0.006 0.2295 0.2295
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2648 0.3574
Echinococcus multilocularis dual specificity 0.0218 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0218 1 1
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.1692 0.1662
Trypanosoma cruzi casein kinase II, putative 0.0165 0.7408 0.6941
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0165 0.7408 1
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7408 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.007 0.2788 0.2762
Schistosoma mansoni protein kinase 0.0165 0.7408 0.7399
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.3077 0.183
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Echinococcus multilocularis 0.0072 0.2903 0.2878
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Echinococcus granulosus dual specificity protein kinase clk2 0.0076 0.3077 0.3052
Toxoplasma gondii CMGC kinase, CK2 family 0.0165 0.7408 1
Schistosoma mansoni casein kinase II beta subunit 0.0044 0.1527 0.1496
Entamoeba histolytica protein kinase, putative 0.0014 0.0036 0.0036
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0044 0.1527 0.2022
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0218 1 1
Leishmania major protein kinase, putative 0.0076 0.3077 0.183
Echinococcus multilocularis dual specificity protein kinase clk2 0.0076 0.3077 0.3052
Echinococcus granulosus protein kinase C gamma type 0.0063 0.2432 0.2405
Entamoeba histolytica protein kinase, putative 0.0218 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.2903 0.2903
Echinococcus multilocularis protein kinase c epsilon type 0.0022 0.0466 0.0431
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.3077 0.3052
Leishmania major casein kinase II, putative 0.0165 0.7408 0.6941
Brugia malayi Protein kinase domain containing protein 0.0076 0.3077 0.3077
Schistosoma mansoni atypical protein kinase C 0.0021 0.0392 0.0357
Brugia malayi Hr1 repeat family protein 0.0014 0.0036 0.0036
Echinococcus granulosus Protein kinase C brain isozyme 0.007 0.2788 0.2762
Entamoeba histolytica protein kinase, putative 0.0014 0.0036 0.0036
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0076 0.3077 0.3077
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0014 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0218 1 1
Plasmodium vivax unspecified product 0.0165 0.7408 1
Echinococcus granulosus dual specificity 0.0067 0.2648 0.2621
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Plasmodium vivax serine/threonine kinase-1, putative 0.0076 0.3077 0.2636
Echinococcus granulosus dual specificity 0.0218 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0165 0.7408 0.7408
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0053 0.194 0.194
Echinococcus multilocularis protein kinase c iota type 0.0021 0.0392 0.0357
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.3077 0.4154
Echinococcus granulosus protein kinase c iota type 0.0021 0.0392 0.0357
Loa Loa (eye worm) AGC/NDR protein kinase 0.0014 0.0036 0.0036
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.1527 0.5
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.3077 0.183
Echinococcus multilocularis dual specificity 0.0067 0.2648 0.2621
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0218 1 1
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0067 0.2648 0.1323
Entamoeba histolytica protein kinase, putative 0.0218 1 1
Entamoeba histolytica casein kinase, putative 0.0165 0.7408 0.7408
Echinococcus multilocularis serine threonine protein kinase 0.0063 0.2432 0.2405
Echinococcus granulosus dual specificity 0.0067 0.2648 0.2621
Loa Loa (eye worm) hypothetical protein 0.0055 0.2048 0.2048
Echinococcus granulosus dual specificity 0.0067 0.2648 0.2621
Schistosoma mansoni serine/threonine protein kinase 0.007 0.2788 0.2762
Loa Loa (eye worm) hypothetical protein 0.0214 0.9826 0.9826
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.3077 0.183
Giardia lamblia Kinase, CMGC CK2 0.0165 0.7408 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0044 0.1527 0.1496
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0466 0.0431
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0036 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7408 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1527 0.2061
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7408 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0036 0.0036
Plasmodium falciparum casein kinase 2, alpha subunit 0.0165 0.7408 1
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.2648 0.2621

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.02 uM Inhibition of recombinant human GST-tagged CLK1 catalytic domain (129 to 484 residues) expressed in Escherichia coli using GRSRSRSRSRSRSRSR as substrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) = 0.7 uM Inhibition of recombinant human N-terminal His6-tagged DYRK1A catalytic domain expressed in Escherichia coli BL21(DE3) cells using KKISGRLSPIMTEQ-NH2 as substrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) = 0.9 uM Inhibition of full length recombinant human GST-tagged DYRK1B expressed in insect cells using KKISGRLSPIMTEQ-NH2 as substrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) = 1.5 uM Inhibition of recombinant human N-terminal GST-tagged DYRK2 expressed in Escherichia coli BL21(DE3) cells using KKISGRLSPIMTEQ-NH2 as substrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) = 2.4 uM Inhibition of CK2 (unknown origin) using RRRDDDSDDD-NH2 as susbtrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) > 10 uM Inhibition of PKCbeta (unknown origin) incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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