Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glutamine synthetase homolog | 0.0358 | 0.4426 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0333 | 0.4013 | 0.3164 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0691 | 1 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0111 | 0.0302 | 1 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0691 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0127 | 0.0558 | 0.0819 |
Echinococcus multilocularis | glutamine synthetase | 0.0358 | 0.4426 | 1 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0358 | 0.4426 | 0.5 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0167 | 0.1242 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0691 | 1 | 1 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0691 | 1 | 0.5 |
Loa Loa (eye worm) | Gln-2 protein | 0.0358 | 0.4426 | 1 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.05 | 0.6816 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0137 | 0.0733 | 0.1657 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0167 | 0.1242 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0137 | 0.0733 | 0.1657 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0733 | 0.1044 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0358 | 0.4426 | 0.5 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0358 | 0.4426 | 0.6493 |
Plasmodium vivax | glutamine synthetase, putative | 0.0691 | 1 | 0.5 |
Leishmania major | glutamine synthetase, putative | 0.0358 | 0.4426 | 0.5 |
Mycobacterium ulcerans | glutamine synthetase | 0.0691 | 1 | 1 |
Trichomonas vaginalis | glutamine synthetase, putative | 0.0167 | 0.1242 | 0.5 |
Echinococcus granulosus | glutamine synthetase | 0.0358 | 0.4426 | 1 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.05 | 0.6816 | 1 |
Trichomonas vaginalis | glutamine synthetase-bacteria, putative | 0.0167 | 0.1242 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.05 | 0.6816 | 0.4681 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.05 | 0.6816 | 0.5 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0358 | 0.4426 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 16.3 uM | Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay. | ChEMBL. | 11020285 |
EC50 (functional) | = 17.3 uM | Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in human prostate cancer HTB-81 cells using MTS assay. | ChEMBL. | 11020285 |
EC50 (functional) | = 18.9 uM | Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in normal human fibroblast (NHF) cells using MTS assay. | ChEMBL. | 11020285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.