Detailed information for compound 2148264

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 263.007 | Formula: C12H9NO2S2
  • H donors: 1 H acceptors: 1 LogP: 2.8 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 0
  • SMILES: S=C1NC(=O)/C(=C/c2ccc3c(c2)CCO3)/S1
  • InChi: InChI=1S/C12H9NO2S2/c14-11-10(17-12(16)13-11)6-7-1-2-9-8(5-7)3-4-15-9/h1-2,5-6H,3-4H2,(H,13,14,16)/b10-6-
  • InChiKey: DMARRXYRWLAEFB-POHAHGRESA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase C, beta References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A References
Homo sapiens epidermal growth factor receptor References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B References
Homo sapiens casein kinase 2, beta polypeptide References
Homo sapiens casein kinase 2, alpha 1 polypeptide References
Homo sapiens casein kinase 2, alpha prime polypeptide References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 References
Homo sapiens CDC-like kinase 1 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Cryptosporidium parvum putative casein kinase II regulatory subunit; besthit Pf 23508244 Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium falciparum casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Babesia bovis protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania mexicana protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans weaker similarity to S. cerevisiae YAK1 (YJL141C) Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Giardia lamblia Kinase, CMGC DYRK Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei Casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii CMGC kinase, CK2 family Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium vivax unspecified product Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium hominis protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania mexicana casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium yoelii Protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Theileria parva casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania infantum protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium berghei casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum putative protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K03097 casein kinase 2, alpha polypeptide, putative Get druggable targets OG5_126901 All targets in OG5_126901
Babesia bovis casein kinase II, alpha chain (CK II) Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma congolense Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma cruzi casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium yoelii casein kinase ii beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma brucei gambiense protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans weaker similarity to S. cerevisiae YAK1 (YJL141C) Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania mexicana protein kinase-like protein Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania braziliensis casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus multilocularis casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei gambiense protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania infantum casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase II beta 4 subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii casein kinase ii regulatory subunit protein Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni casein kinase II beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Neospora caninum casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Toxoplasma gondii ck2 beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Neospora caninum YOR039Wp-like protein, related Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) CMGC/CK2 protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania mexicana protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania donovani dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania donovani Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC CK2 Get druggable targets OG5_126901 All targets in OG5_126901
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium parvum casein kinase II, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha prime polypeptide 350 aa 319 aa 50.2 %
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha 1 polypeptide 391 aa 316 aa 51.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dual specificity protein kinase clk2 0.0076 0.3052 0.3052
Toxoplasma gondii ck2 beta subunit 0.0044 0.1496 0.2022
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0067 0.2621 0.2621
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0076 0.3052 0.3052
Schistosoma mansoni serine/threonine protein kinase 0.0218 1 1
Giardia lamblia Kinase, CMGC CLK 0.0076 0.3052 0.2636
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7399 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0076 0.3052 0.2636
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.1496 0.5
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.3052 0.3052
Entamoeba histolytica hypothetical protein 0.0218 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2621 0.3542
Echinococcus multilocularis casein kinase ii subunit alpha 0.0165 0.7399 0.7399
Entamoeba histolytica protein kinase, putative 0.0218 1 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0076 0.3052 0.3052
Echinococcus multilocularis serine threonine protein kinase 0.0063 0.2405 0.2405
Entamoeba histolytica protein kinase, putative 0.0067 0.2621 0.2621
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0076 0.3052 0.3052
Echinococcus granulosus epidermal growth factor receptor 0.018 0.8145 0.8145
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.8145 0.8145
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7399 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Entamoeba histolytica casein kinase, putative 0.0165 0.7399 0.7399
Leishmania major protein kinase, putative 0.0076 0.3052 0.183
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Toxoplasma gondii CMGC kinase, CK2 family 0.0165 0.7399 1
Entamoeba histolytica protein kinase domain containing protein 0.0165 0.7399 0.7399
Echinococcus multilocularis dual specificity 0.0067 0.2621 0.2621
Brugia malayi Casein kinase II, alpha chain 0.0165 0.7399 0.7399
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.2148 0.2148
Brugia malayi protein kinase C II. 0.0022 0.0431 0.0431
Entamoeba histolytica protein kinase domain containing protein 0.0218 1 1
Brugia malayi Protein kinase c protein 2 0.006 0.2268 0.2268
Schistosoma mansoni tyrosine kinase 0.0097 0.4067 0.4067
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7399 1
Echinococcus granulosus dual specificity 0.0067 0.2621 0.2621
Schistosoma mansoni serine/threonine protein kinase 0.007 0.2762 0.2762
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0067 0.2621 0.1323
Leishmania major protein kinase, putative 0.0076 0.3052 0.183
Echinococcus multilocularis insulin receptor 0.0058 0.2148 0.2148
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.8145 0.8145
Loa Loa (eye worm) hypothetical protein 0.0214 0.9826 0.9826
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7399 1
Schistosoma mansoni casein kinase II beta subunit 0.0044 0.1496 0.1496
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.1496 0.5
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Echinococcus multilocularis protein kinase c epsilon type 0.0022 0.0431 0.0431
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0165 0.7399 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.8145 0.8145
Leishmania major casein kinase II, putative 0.0165 0.7399 0.6941
Echinococcus granulosus Protein kinase C brain isozyme 0.007 0.2762 0.2762
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0044 0.1496 0.1496
Trypanosoma brucei Casein kinase II 0.0165 0.7399 0.7399
Echinococcus granulosus dual specificity 0.0067 0.2621 0.2621
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Schistosoma mansoni tyrosine kinase 0.0096 0.4017 0.4017
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0076 0.3052 0.4125
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7399 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.1662 0.1662
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0218 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2621 0.3542
Echinococcus multilocularis casein kinase ii subunit beta 0.0044 0.1496 0.1496
Giardia lamblia Kinase, CMGC DYRK 0.0067 0.2621 0.1906
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0218 1 1
Plasmodium vivax unspecified product 0.0165 0.7399 1
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2621 0.3542
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2621 0.3542
Loa Loa (eye worm) hypothetical protein 0.0055 0.2019 0.2019
Schistosoma mansoni serine/threonine protein kinase 0.007 0.2762 0.2762
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.1662 0.1662
Echinococcus granulosus protein kinase c epsilon type 0.0022 0.0431 0.0431
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.4067 0.4067
Echinococcus granulosus protein kinase c iota type 0.0021 0.0357 0.0357
Echinococcus granulosus dual specificity 0.0067 0.2621 0.2621
Trypanosoma cruzi casein kinase II, putative 0.0165 0.7399 0.6941
Plasmodium falciparum protein serine/threonine kinase-1 0.0076 0.3052 0.2636
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.2148 0.2148
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.1496 0.1496
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.3052 0.183
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0218 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7399 1
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.2621 0.2621
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.3052 0.4125
Echinococcus multilocularis protein kinase c iota type 0.0021 0.0357 0.0357
Echinococcus multilocularis dual specificity protein kinase clk2 0.0076 0.3052 0.3052
Echinococcus multilocularis 0.0056 0.2059 0.2059
Trichomonas vaginalis CMGC family protein kinase 0.0165 0.7399 1
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0067 0.2621 0.2621
Brugia malayi Protein kinase domain containing protein 0.0076 0.3052 0.3052
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Loa Loa (eye worm) hypothetical protein 0.0048 0.1662 0.1662
Echinococcus multilocularis dual specificity 0.0067 0.2621 0.2621
Schistosoma mansoni tyrosine kinase 0.0096 0.4017 0.4017
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0053 0.191 0.191
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.2621 0.2621
Echinococcus granulosus hypothetical protein 0.0072 0.2878 0.2878
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.1662 0.1662
Schistosoma mansoni tyrosine kinase 0.018 0.8145 0.8145
Echinococcus granulosus casein kinase ii subunit beta 0.0044 0.1496 0.1496
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Brugia malayi Csnk2b protein 0.0044 0.1496 0.1496
Echinococcus multilocularis dual specificity 0.0067 0.2621 0.2621
Schistosoma mansoni tyrosine kinase 0.0058 0.2148 0.2148
Loa Loa (eye worm) hypothetical protein 0.0072 0.2878 0.2878
Loa Loa (eye worm) Csnk2b protein 0.0044 0.1496 0.1496
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.1496 0.1496
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.2148 0.2148
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.3052 0.183
Echinococcus granulosus casein kinase ii subunit alpha 0.0165 0.7399 0.7399
Schistosoma mansoni tyrosine kinase 0.0097 0.4067 0.4067
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.3052 0.3052
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.4067 0.4067
Schistosoma mansoni protein kinase 0.0165 0.7399 0.7399
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0165 0.7399 0.7399
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Schistosoma mansoni tyrosine kinase 0.0058 0.2148 0.2148
Schistosoma mansoni tyrosine kinase 0.0096 0.4017 0.4017
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.4067 0.4067
Echinococcus multilocularis dual specificity 0.0218 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Echinococcus granulosus dual specificity 0.0218 1 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0218 1 1
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0067 0.2621 0.2621
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.3052 0.183
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Entamoeba histolytica protein kinase, putative 0.0218 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.1496 0.2022
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.1496 0.1496
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2621 0.3542
Loa Loa (eye worm) hypothetical protein 0.0214 0.9826 0.9826
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.3052 0.183
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0218 1 1
Echinococcus granulosus insulin receptor 0.0058 0.2148 0.2148
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0022 0.0431 0.0431
Schistosoma mansoni atypical protein kinase C 0.0021 0.0357 0.0357
Echinococcus multilocularis 0.0072 0.2878 0.2878
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0067 0.2621 0.1323
Giardia lamblia Kinase, CMGC CK2 0.0165 0.7399 1
Echinococcus granulosus protein kinase C gamma type 0.0063 0.2405 0.2405
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2621 0.3542
Plasmodium falciparum casein kinase 2, alpha subunit 0.0165 0.7399 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.2148 0.2148
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0044 0.1496 0.2022
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0431 0.0431
Echinococcus multilocularis Protein kinase C, brain isozyme 0.007 0.2762 0.2762
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0067 0.2621 0.3542

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.1 uM Inhibition of CK2 (unknown origin) using RRRDDDSDDD-NH2 as susbtrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) = 0.1 uM Inhibition of recombinant human N-terminal His6-tagged DYRK1A catalytic domain expressed in Escherichia coli BL21(DE3) cells using KKISGRLSPIMTEQ-NH2 as substrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) = 0.3 uM Inhibition of full length recombinant human GST-tagged DYRK1B expressed in insect cells using KKISGRLSPIMTEQ-NH2 as substrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) = 0.5 uM Inhibition of recombinant human GST-tagged CLK1 catalytic domain (129 to 484 residues) expressed in Escherichia coli using GRSRSRSRSRSRSRSR as substrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) = 1 uM Inhibition of recombinant human N-terminal GST-tagged DYRK2 expressed in Escherichia coli BL21(DE3) cells using KKISGRLSPIMTEQ-NH2 as substrate incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) > 10 uM Inhibition of EGFR (unknown origin) incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709
IC50 (binding) > 10 uM Inhibition of PKCbeta (unknown origin) incubated for 15 mins in presence of [gamma-32P]ATP ChEMBL. 26896709

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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