Detailed information for compound 21635

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 767.805 | Formula: C38H50N5O10P
  • H donors: 7 H acceptors: 8 LogP: 1.53 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 3
  • SMILES: COc1cc2cccc(c2cc1OC)CCCNC(=O)[C@@H](NC(=O)C1(CCCCC1)NC(=O)[C@H](Cc1ccc(cc1)CP(=O)(O)O)NC(=O)C)CC(=O)N
  • InChi: 1S/C38H50N5O10P/c1-24(44)41-30(19-25-12-14-26(15-13-25)23-54(49,50)51)36(47)43-38(16-5-4-6-17-38)37(48)42-31(22-34(39)45)35(46)40-18-8-11-27-9-7-10-28-20-32(52-2)33(53-3)21-29(27)28/h7,9-10,12-15,20-21,30-31H,4-6,8,11,16-19,22-23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,44)(H,42,48)(H,43,47)(H2,49,50,51)/t30-,31-/m0/s1
  • InChiKey: SLXHIXKJEPUSKD-CONSDPRKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens growth factor receptor-bound protein 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Growth factor receptor-bound protein 2, putative Get druggable targets OG5_131257 All targets in OG5_131257
Loa Loa (eye worm) sex muscle abnormal protein 5 Get druggable targets OG5_131257 All targets in OG5_131257
Schistosoma japonicum ko:K04364 growth factor receptor-binding protein 2, putative Get druggable targets OG5_131257 All targets in OG5_131257
Echinococcus multilocularis growth factor receptor bound protein 2 Get druggable targets OG5_131257 All targets in OG5_131257
Echinococcus granulosus growth factor receptor bound protein 2 Get druggable targets OG5_131257 All targets in OG5_131257
Schistosoma mansoni growth factor receptor-bound protein Get druggable targets OG5_131257 All targets in OG5_131257
Brugia malayi Sex muscle abnormal protein 5 Get druggable targets OG5_131257 All targets in OG5_131257
Schistosoma mansoni growth factor receptor-bound protein Get druggable targets OG5_131257 All targets in OG5_131257
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major hypothetical protein, conserved growth factor receptor-bound protein 2 217 aa 200 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0254 0.0973 0.3482
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0449 0.043
Echinococcus granulosus glutamate NMDA receptor subunit 0.0043 0.0072 0.0257
Echinococcus granulosus expressed protein 0.0361 0.1427 0.5062
Plasmodium vivax aspartyl proteinase, putative 0.0132 0.0449 0.1633
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.005 0.0102 0.0223
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0097 0.0013
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0049 0.0095 0.0336
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0449 0.043
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.005 0.0102 0.0362
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0048 0.0094 0.032
Loa Loa (eye worm) FAD binding domain-containing protein 0.0073 0.0201 0.0715
Brugia malayi ube2i2 protein 0.005 0.0102 0.0357
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.002 0.0053
Schistosoma mansoni glutamate receptor NMDA 0.0043 0.0072 0.0053
Schistosoma mansoni ATP-binding cassette transporter 0.0043 0.0072 0.0053
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0073 0.0201 0.0712
Brugia malayi flavodoxin family protein 0.0028 0.0007 0.0006
Brugia malayi hypothetical protein 0.0057 0.0129 0.0458
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0121 0.043
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.005 0.0102 1
Trichomonas vaginalis sulfite reductase, putative 0.0073 0.0201 0.0775
Plasmodium falciparum plasmepsin II 0.0254 0.0973 0.3568
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0073 0.0201 0.0715
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0306 0.1106
Loa Loa (eye worm) hypothetical protein 0.0132 0.0449 0.1633
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0102
Trypanosoma brucei CHAP domain containing protein, putative 0.0067 0.0175 0.0621
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0613 0.2504 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0333 0.1309 0.4644
Treponema pallidum ATP-dependent RNA helicase 0.0049 0.0095 0.0324
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0143 0.0496 0.1667
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0613 0.2504 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.002 0.007
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0662 0.2713 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0621
Schistosoma mansoni NADPH flavin oxidoreductase 0.0037 0.0045 0.0025
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0449 0.043
Leishmania major trypanothione synthetase, putative 0.0211 0.0786 0.2879
Loa Loa (eye worm) glutamate receptor 2 0.0043 0.0072 0.0242
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.005 0.0102 0.0083
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0422
Onchocerca volvulus 0.0132 0.0449 1
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.005 0.0102 0.0362
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0041 0.0061 0.0216
Plasmodium falciparum plasmepsin IX 0.0132 0.0449 0.1633
Trypanosoma brucei trypanothione synthetase 0.0211 0.0786 0.2879
Loa Loa (eye worm) hypothetical protein 0.0132 0.0449 0.1633
Echinococcus granulosus kelch ECH associated protein 1 like 0.0095 0.0292 0.1036
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.005 0.0102 0.0351
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0143 0.0496 0.1808
Plasmodium vivax aspartyl proteinase, putative 0.0254 0.0973 0.3568
Schistosoma mansoni glutamate receptor kainate 0.0043 0.0072 0.0053
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0143 0.0496 0.1808
Schistosoma mansoni hypothetical protein 0.0095 0.0293 0.0274
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0102
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0662 0.2713 0.2699
Brugia malayi hypothetical protein 0.0132 0.0449 0.1638
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0662 0.2713 0.9624
Echinococcus granulosus growth factor receptor bound protein 2 0.0157 0.0557 0.1975
Brugia malayi ribonucleotide reductase 2 0.0143 0.0496 0.1813
Plasmodium falciparum plasmepsin III 0.0132 0.0449 0.1633
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0662 0.2713 1
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0175 0.0369
Loa Loa (eye worm) hypothetical protein 0.0123 0.041 0.149
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0065 0.0165 0.0633
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0049 0.0095 0.0075
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0143 0.0496 0.1667
Brugia malayi Glutamate receptor 2 precursor 0.0043 0.0072 0.0248
Trypanosoma cruzi trypanothione synthetase 0.0211 0.0786 0.1709
Echinococcus granulosus nmda type glutamate receptor 0.0041 0.0061 0.0216
Echinococcus multilocularis kelch ECH associated protein 1 0.0095 0.0292 0.1036
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0143 0.0496 0.1808
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0049 0.0095 0.0336
Schistosoma mansoni cathepsin D (A01 family) 0.0567 0.2309 0.2294
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0073 0.0201 0.0425
Plasmodium vivax plasmepsin V, putative 0.0132 0.0449 0.1633
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0048 0.0094 0.032
Giardia lamblia Nitric oxide synthase, inducible 0.0065 0.0165 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0662 0.2713 0.5937
Echinococcus multilocularis Kelch repeat type 1 0.0095 0.0293 0.104
Toxoplasma gondii aspartyl protease ASP3 0.0132 0.0449 0.1521
Plasmodium falciparum plasmepsin V 0.0132 0.0449 0.1633
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0143 0.0496 0.0478
Trypanosoma brucei amidase, putative 0.0067 0.0175 0.0621
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0131 0.0448 0.1588
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0662 0.2713 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0089 0.0317
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.002 0.007
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0132 0.0449 0.1521
Plasmodium vivax aspartyl protease, putative 0.0132 0.0449 0.1633
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0121 0.0102
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0089 0.0317
Loa Loa (eye worm) reprolysin 0.0043 0.0072 0.0241
Leishmania major trypanothione synthetase-like protein 0.0067 0.0175 0.0621
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0089 0.0317
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0143 0.0496 0.1808
Echinococcus granulosus kelch ECH associated protein 1 0.0095 0.0292 0.1036
Schistosoma mansoni cytochrome P450 reductase 0.0073 0.0201 0.0181
Brugia malayi aspartic protease BmAsp-2, identical 0.0132 0.0449 0.1638
Leishmania major eukaryotic initiation factor 4a, putative 0.0049 0.0095 0.0324
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0049 0.0095 0.9227
Brugia malayi eukaryotic initiation factor 4A 0.0049 0.0095 0.033
Schistosoma mansoni cell polarity protein 0.0049 0.0095 0.0076
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0086 0.0254 0.0235
Mycobacterium ulcerans transcriptional regulator NrdR 0.0049 0.0097 0.0013
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0073 0.0201 0.0715
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.022 0.0828 0.3043
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.005 0.0102 0.0351
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0143 0.0496 0.1808
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0662 0.2713 1
Plasmodium falciparum nitric oxide synthase, putative 0.0073 0.0201 0.0715
Loa Loa (eye worm) hypothetical protein 0.04 0.1596 0.5871
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.04 0.1596 0.5873
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.002 0.0047
Plasmodium falciparum plasmepsin VIII, putative 0.0132 0.0449 0.1633
Brugia malayi Latrophilin receptor protein 2 0.0031 0.002 0.0053
Plasmodium falciparum plasmepsin X 0.0132 0.0449 0.1633
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0089 0.0317
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0613 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0461 0.1679
Schistosoma mansoni glutamate receptor AMPA 0.0043 0.0072 0.0053
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0049 0.0095 0.0075
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0073 0.0201 0.0712
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0072 0.0053
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0254 0.0973 0.3568
Brugia malayi flavodoxin family protein 0.0073 0.0201 0.0721
Giardia lamblia Hypothetical protein 0.0065 0.0165 1
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.1095 0.4566 1
Loa Loa (eye worm) hypothetical protein 0.0254 0.0973 0.3568
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0049 0.0095 0.0195
Schistosoma mansoni hypothetical protein 0.0067 0.0174 0.0154
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0073 0.0201 0.0712
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0121 0.043
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0049 0.0095 0.0351
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0254 0.0973 0.345
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.005 0.0102 0.0351
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0143 0.0496 0.1761
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0143 0.0496 0.1579
Toxoplasma gondii aspartyl protease 0.0132 0.0449 0.1521
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0613 0.2504 1
Echinococcus multilocularis expressed protein 0.0361 0.1427 0.5062
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0121 0.0428
Schistosoma mansoni growth factor receptor-bound protein 0.0157 0.0557 0.0538
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0132 0.0449 0.1633
Loa Loa (eye worm) hypothetical protein 0.0089 0.0268 0.0965
Loa Loa (eye worm) hypothetical protein 0.0073 0.0201 0.0715
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0049 0.0095 0.0351
Trypanosoma cruzi trypanothione synthetase 0.0211 0.0786 0.1709
Trypanosoma brucei glutathionylspermidine synthetase, putative 0.0067 0.0175 0.0621
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0449 0.043
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0662 0.2713 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0188 0.069 0.1498
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0073 0.0201 0.0444
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0687 0.2819 1
Trypanosoma cruzi trypanothione synthetase, putative 0.0067 0.0175 0.0369
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0089 0.0317
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0043 0.0072 0.0257
Loa Loa (eye worm) aspartyl protease 6 0.0132 0.0449 0.1633
Brugia malayi FAD binding domain containing protein 0.0073 0.0201 0.0721
Loa Loa (eye worm) hypothetical protein 0.0067 0.0174 0.0616
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0143 0.0496 0.1808
Leishmania major hypothetical protein, conserved 0.0067 0.0175 0.0621
Brugia malayi Pepsin A precursor 0.0132 0.0449 0.1638
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0073 0.0201 0.0712
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0621
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0254 0.0973 0.3867
Plasmodium falciparum subtilisin-like protease 1 0.0176 0.064 0.234
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0621
Loa Loa (eye worm) hypothetical protein 0.0049 0.0095 0.0324
Brugia malayi hypothetical protein 0.0132 0.0449 0.1638
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0143 0.0496 0.1808
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0174 0.0621
Chlamydia trachomatis transcriptional repressor NrdR 0.0049 0.0097 0.0061
Loa Loa (eye worm) hypothetical protein 0.0031 0.002 0.0047
Plasmodium falciparum plasmepsin IV 0.0254 0.0973 0.3568
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0073 0.0201 0.0715
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0662 0.2713 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.005 0.0102 0.0209
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0089 0.0317
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0143 0.0496 0.1699
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0089 0.0317
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0049 0.0095 0.0193
Plasmodium vivax aspartyl protease, putative 0.0132 0.0449 0.1633
Echinococcus multilocularis methionine synthase reductase 0.0045 0.0081 0.0286
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0333 0.1309 0.4644
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0143 0.0496 0.1074
Brugia malayi FAD binding domain containing protein 0.0045 0.0081 0.0278
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0254 0.0973 0.0955
Echinococcus multilocularis growth factor receptor bound protein 2 0.0157 0.0557 0.1975
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0143 0.0496 0.1808
Echinococcus granulosus adam 0.0057 0.0129 0.0459
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0143 0.0496 0.1808
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0048 0.0094 0.032
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0449 0.043
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0662 0.2713 1
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0049 0.0095 0.0336
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0089 0.0317
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0072 0.0053
Brugia malayi Glutamate receptor 1 precursor 0.0043 0.0072 0.0248
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0049 0.0095 0.0324
Schistosoma mansoni glutamate receptor AMPA 0.0043 0.0072 0.0053
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0662 0.2713 1
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0143 0.0496 0.1761
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0073 0.0201 0.0715
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0049 0.0097 0.0008
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0143 0.0496 0.1808
Echinococcus granulosus glutamate receptor 2 0.0047 0.0089 0.0317
Leishmania major trypanothione synthetase, putative 0.0067 0.0175 0.0621
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0239 0.0906 0.0888
Loa Loa (eye worm) ube2i2 protein 0.005 0.0102 0.0351
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0121 0.0422
Schistosoma mansoni diflavin oxidoreductase 0.0036 0.0043 0.0023
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0621
Trypanosoma cruzi p450 reductase, putative 0.0073 0.0201 0.0425
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.005 0.0102 1
Brugia malayi Guanylate kinase family protein 0.006 0.0141 0.0502
Plasmodium vivax flavodoxin domain containing protein 0.0065 0.0165 0.0584
Trypanosoma cruzi trypanothione synthetase, putative 0.0067 0.0175 0.0369
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0254 0.0973 0.345
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0057 0.0129 0.011
Schistosoma mansoni glutamate receptor kainate 0.0043 0.0072 0.0053
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.005 0.0102 0.0209
Echinococcus granulosus methionine synthase reductase 0.0045 0.0081 0.0286
Toxoplasma gondii aspartyl protease ASP1 0.0254 0.0973 0.3482
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0662 0.2713 1
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0613 0.2504 1
Echinococcus granulosus disks large 3 0.0049 0.0095 0.0339
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0449 0.043
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0043 0.0072 0.0257
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0073 0.0201 0.0715
Echinococcus granulosus GPCR family 2 0.0031 0.002 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0241
Trypanosoma cruzi trypanothione synthetase-like protein, putative 0.0067 0.0175 0.0369
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0369
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0049 0.0095 0.0351
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0089 0.0317
Giardia lamblia UBC3 0.005 0.0102 0.1047
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0662 0.2713 0.9624
Leishmania major cytochrome P450 reductase, putative 0.0065 0.0165 0.0584
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0049 0.0095 0.0193
Echinococcus multilocularis GPCR, family 2 0.0031 0.002 0.007
Loa Loa (eye worm) FAD binding domain-containing protein 0.0045 0.0081 0.0272
Schistosoma mansoni glutamate receptor kainate 0.0043 0.0072 0.0053
Echinococcus granulosus kelch ECH associated protein 1 like 0.0095 0.0292 0.1036
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0089 0.007
Plasmodium vivax aspartyl protease, putative 0.0132 0.0449 0.1633
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0369
Onchocerca volvulus 0.0132 0.0449 1
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.005 0.0102 0.0351
Trypanosoma brucei trypanothione synthetase, putative 0.0211 0.0786 0.2879
Plasmodium falciparum plasmepsin I 0.0254 0.0973 0.3568
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0687 0.2819 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0449 0.043
Schistosoma mansoni hypothetical protein 0.0055 0.0121 0.0102
Schistosoma mansoni growth factor receptor-bound protein 0.0157 0.0557 0.0538
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1312 0.5491 0.5482
Echinococcus multilocularis nmda type glutamate receptor 0.0041 0.0061 0.0216
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0073 0.0201 0.0715
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0132 0.0449 0.043
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0369
Schistosoma mansoni cathepsin D (A01 family) 0.0567 0.2309 0.2294
Loa Loa (eye worm) glutamate receptor 1 0.0043 0.0072 0.0242
Echinococcus multilocularis disks large 3 0.0049 0.0095 0.0339
Brugia malayi Eukaryotic aspartyl protease family protein 0.0132 0.0449 0.1638
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0369
Leishmania major p450 reductase, putative 0.0073 0.0201 0.0715
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0073 0.0201 0.0425
Brugia malayi Sex muscle abnormal protein 5 0.0157 0.0557 0.2037
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0045 0.0079 0.0264
Plasmodium falciparum eukaryotic initiation factor 4A 0.0049 0.0095 0.0324
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0306 0.1111
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0067 0.0175 0.0369
Echinococcus multilocularis kelch ECH associated protein 1 0.0095 0.0292 0.1036
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0073 0.0201 0.0425
Loa Loa (eye worm) guanylate kinase 0.0047 0.0086 0.0292
Brugia malayi aspartic protease BmAsp-1, identical 0.0132 0.0449 0.1638
Toxoplasma gondii subtilisin SUB1 0.0176 0.064 0.2238
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0043 0.0072 0.0257
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0121 0.0102
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0049 0.0095 0.2016
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0157 0.0557 0.2032
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0045 0.0081 0.0061
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0143 0.0496 0.1074
Echinococcus granulosus eukaryotic initiation factor 4A 0.0049 0.0095 0.0336
Plasmodium falciparum plasmepsin VI 0.0254 0.0973 0.3568
Plasmodium falciparum plasmepsin VII 0.0132 0.0449 0.1633
Echinococcus multilocularis adam 0.0057 0.0129 0.0459
Echinococcus multilocularis glutamate receptor 2 0.0043 0.0072 0.0257
Plasmodium vivax plasmepsin IV, putative 0.0254 0.0973 0.3568
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.005 0.0102 0.0381
Plasmodium vivax RNA helicase-1, putative 0.0049 0.0095 0.0324
Leishmania major eukaryotic initiation factor 4a, putative 0.0049 0.0095 0.0324
Plasmodium vivax subtilisin-like protease 1 0.0176 0.064 0.234

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 84.4 nM Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay ChEMBL. 11354377
IC50 (binding) = 84.4 nM Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay ChEMBL. 11354377

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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