Detailed information for compound 216641

Basic information

Technical information
  • TDR Targets ID: 216641
  • Name: benzyl (2S)-2-[[(2S)-3,4-dioxo-1-phenylbutan- 2-yl]carbamoyl]pyrrolidine-1-carboxylate
  • MW: 408.447 | Formula: C23H24N2O5
  • H donors: 1 H acceptors: 4 LogP: 2.89 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1)Cc1ccccc1
  • InChi: 1S/C23H24N2O5/c26-15-21(27)19(14-17-8-3-1-4-9-17)24-22(28)20-12-7-13-25(20)23(29)30-16-18-10-5-2-6-11-18/h1-6,8-11,15,19-20H,7,12-14,16H2,(H,24,28)/t19-,20-/m0/s1
  • InChiKey: JPYRHQYQZSTVLP-PMACEKPBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl (2S)-2-[[(1S)-1-benzyl-2,3-dioxo-propyl]carbamoyl]pyrrolidine-1-carboxylate
  • (2S)-2-[[[(1S)-1-benzyl-2,3-dioxopropyl]amino]-oxomethyl]-1-pyrrolidinecarboxylic acid benzyl ester
  • phenylmethyl (2S)-2-[[(2S)-3,4-dioxo-1-phenyl-butan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
  • (2S)-2-[[(1S)-1-benzyl-2,3-diketo-propyl]carbamoyl]pyrrolidine-1-carboxylic acid benzyl ester
  • phenylmethyl (2S)-2-[[(2S)-3,4-dioxo-1-phenylbutan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
  • phenylmethyl (2S)-2-[[(1S)-2,3-dioxo-1-(phenylmethyl)propyl]carbamoyl]pyrrolidine-1-carboxylate
  • (2S)-2-[[[(1S)-2,3-dioxo-1-(phenylmethyl)propyl]amino]-oxomethyl]-1-pyrrolidinecarboxylic acid phenylmethyl ester
  • (2S)-2-[[(1S)-1-(benzyl)-2,3-diketo-propyl]carbamoyl]pyrrolidine-1-carboxylic acid benzyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.0024 0.0147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0042
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0038 0.0091
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0096 0.0313 0.1821
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0038 0.0091
Loa Loa (eye worm) hypothetical protein 0.0096 0.0313 0.0741
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0024 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0063 0.0198 0.0293
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0018 0.0113
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0096 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0042
Onchocerca volvulus 0.0017 0.0038 0.0314
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0018 0.0113
Toxoplasma gondii heat shock protein 90, putative 0.0473 0.1615 1
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0096 0.0313 0.0489
Trypanosoma brucei heat shock protein 90, putative 0.0473 0.1615 1
Leishmania major DNA topoisomerase ii 0.0096 0.0313 0.1821
Brugia malayi kinase, mitochondrial precursor 0.0096 0.0313 0.0313
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0018 0.0113
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0042
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0096 0.0313 0.0489
Schistosoma mansoni hypothetical protein 0.0323 0.1098 0.68
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0018 0.0113
Loa Loa (eye worm) hypothetical protein 0.0096 0.0313 0.0741
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0038 0.0091
Brugia malayi MH2 domain containing protein 0.0006 0.0003 0.0002
Echinococcus multilocularis mothers against decapentaplegic 5 0.0006 0.0003 0.0017
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0038 0.0091
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0038 0.0089
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0096 0.0313 0.1821
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0096 0.0313 0.1746
Mycobacterium ulcerans heat shock protein 90 0.0377 0.1282 0.2105
Plasmodium falciparum DNA gyrase subunit B 0.0096 0.0313 0.1821
Brugia malayi glutathione reductase 0.0181 0.0607 0.0606
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0038 0.0236
Echinococcus multilocularis glutamate synthase 0.0017 0.0038 0.0236
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0198 0.1093
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0194 0.065 0.4026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0018 0.0018
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0018 0.0113
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0198 0.1282
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0017 0.0038 0.0024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0181 0.0607 0.3758
Plasmodium vivax heat shock protein, putative 0.0194 0.065 0.3937
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0018 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0018 0.0042
Mycobacterium tuberculosis Possible two component sensor kinase 0.0096 0.0313 0.0489
Plasmodium falciparum thioredoxin reductase 0.0063 0.0198 0.1093
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0038 0.0236
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0018 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0038 0.0236
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0063 0.0198 0.027
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0063 0.0198 0.1282
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0042
Giardia lamblia Grp94/Hsp90 0.0377 0.1282 0.7889
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0198 0.1093
Mycobacterium tuberculosis Probable two component sensor kinase 0.0096 0.0313 0.0489
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0038 0.0236
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0063 0.0198 0.1223
Trichomonas vaginalis heat shock protein, putative 0.029 0.0983 0.5993
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0018 0.0113
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0063 0.0198 0.027
Entamoeba histolytica heat shock protein 90, putative 0.0473 0.1615 1
Trypanosoma cruzi heat shock protein 85, putative 0.0473 0.1615 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0038 0.0236
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0018 0.0113
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0147 0.091
Schistosoma mansoni heat shock protein 0.0194 0.065 0.4026
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0004 0.0004
Trichomonas vaginalis heat shock protein, putative 0.0377 0.1282 0.7889
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0096 0.0313 0.1821
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.0091
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0096 0.0313 0.1821
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.0091
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0096 0.0313 0.2213
Brugia malayi nuclear hormone receptor 0.0011 0.0018 0.0018
Mycobacterium ulcerans arylsulfatase AtsD 0.0087 0.028 0.0409
Mycobacterium ulcerans DNA gyrase subunit B 0.0096 0.0313 0.0466
Schistosoma mansoni smad1 5 8 and 0.0006 0.0003 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0094 0.0307 0.0726
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0017 0.0038 0.0024
Giardia lamblia Pms1-like protein 0.0096 0.0313 0.1746
Plasmodium falciparum heat shock protein 90, putative 0.0194 0.065 0.3937
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0063 0.0198 0.1223
Brugia malayi MH2 domain containing protein 0.0094 0.0307 0.0306
Echinococcus granulosus thioredoxin glutathione reductase 0.0181 0.0607 0.3758
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0096 0.0313 0.0466
Brugia malayi glutamate synthase 0.0017 0.0038 0.0038
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0096 0.0313 0.1746
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0017 0.0038 0.0024
Mycobacterium ulcerans two component regulator - sensor kinase 0.0096 0.0313 0.0466
Toxoplasma gondii DNA topoisomerase 2, putative 0.0096 0.0313 0.1821
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0146
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0018 0.0018
Trypanosoma cruzi heat shock protein 90, putative 0.0377 0.1282 0.7908
Mycobacterium tuberculosis Probable reductase 0.0017 0.0038 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0005 0.003
Plasmodium falciparum heat shock protein 90 0.0473 0.1615 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0096 0.0313 0.0489
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0096 0.0313 0.3814
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0018 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0198 0.1093
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0063 0.0198 0.0293
Trypanosoma brucei heat shock protein, putative 0.0473 0.1615 1
Toxoplasma gondii heat shock protein HSP90 0.0473 0.1615 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0096 0.0313 0.0489
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0005 0.001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0017 0.0038 0.0024
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0006 0.0003 0.0017
Brugia malayi isocitrate dehydrogenase 0.0012 0.0024 0.0023
Leishmania major trypanothione reductase 0.0181 0.0607 0.3665
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0096 0.0313 0.2213
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0024 0.0147
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0377 0.1282 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0063 0.0198 0.1011
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0024 0.0023
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0146
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0038 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0018 0.0018
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0096 0.0313 0.194
Trypanosoma brucei trypanothione reductase 0.0181 0.0607 0.3665
Toxoplasma gondii Hsp90 domain-containing protein 0.0194 0.065 0.3937
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.1727 0.5949 1
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0087 0.028 0.1531
Echinococcus granulosus Smad4 0.0006 0.0003 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0018 0.0113
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0024 0.0146
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0063 0.0198 0.1093
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0194 0.065 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0198 0.1093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0117 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0038 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0018 0.0018
Mycobacterium tuberculosis Probable sulfatase 0.0087 0.028 0.0432
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0017 0.0038 0.0024
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0096 0.0313 0.1821
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0046 0.014 0.0139
Brugia malayi MH2 domain containing protein 0.0006 0.0003 0.0002
Mycobacterium ulcerans arylsulfatase AtsD 0.0087 0.028 0.0409
Plasmodium falciparum thioredoxin reductase 0.0181 0.0607 0.3665
Trypanosoma brucei heat shock protein, putative 0.0473 0.1615 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0377 0.1282 0.2124
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0096 0.0313 0.2213
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0038 0.0091
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0018 0.0113
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0146
Schistosoma mansoni glutamate synthase 0.0017 0.0038 0.0236
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0018 0.0113
Echinococcus granulosus muscleblind protein 0.0118 0.0389 0.2407
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0198 0.1282
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0096 0.0313 0.2213
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0063 0.0198 0.1093
Trypanosoma brucei Heat shock protein 83, putative 0.0473 0.1615 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0063 0.0198 0.1093
Echinococcus granulosus heat shock protein 90 0.0377 0.1282 0.7939
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0038 0.0236
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.0074 0.0073
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0087 0.028 0.4134
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0018 0.0113
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0226 0.076 0.4626
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0018 0.0018
Echinococcus granulosus dnaJ subfamily B 0.0323 0.1098 0.68
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0063 0.0198 0.0293
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0042
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0096 0.0313 0.0489
Brugia malayi Probable DNA topoisomerase II 0.0096 0.0313 0.0313
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0096 0.0313 0.0489
Schistosoma mansoni cpg binding protein 0.0024 0.0063 0.0393
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0198 0.1093
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0063 0.0198 0.1093
Loa Loa (eye worm) thioredoxin reductase 0.0181 0.0607 0.1436
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.0024 0.0147
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0038 0.0091
Echinococcus multilocularis muscleblind protein 1 0.0118 0.0389 0.2407
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0006 0.0003 0.0017
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0377 0.1282 0.7939
Loa Loa (eye worm) TOPoisomerase family member 0.0096 0.0313 0.0741
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0017 0.0038 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0024 0.0147
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0038 0.0091
Trichomonas vaginalis endoplasmin, putative 0.029 0.0983 0.5993
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0017 0.0038 0.0024
Mycobacterium ulcerans arylsulfatase, AslA 0.0087 0.028 0.0409
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0038 0.0236
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0063 0.0198 0.1093
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0063 0.0198 0.1093
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Brugia malayi steroid hormone receptor 0.0011 0.0018 0.0018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0198 0.1093
Echinococcus granulosus TGF beta signal transducer SmadC 0.0006 0.0003 0.0017
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0226 0.076 0.5802
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0096 0.0313 0.0466
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0096 0.0313 0.0466
Leishmania major developmentally regulated phosphoprotein-like protein 0.0096 0.0313 0.1821
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0024 0.0146
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0063 0.0198 0.1223
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0096 0.0313 0.1746
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0038 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0089
Schistosoma mansoni DNA topoisomerase II 0.0096 0.0313 0.194
Schistosoma mansoni smad1 5 8 and 0.0006 0.0003 0.0017
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0018 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0198 0.1093
Toxoplasma gondii selenide, water dikinase 0.0017 0.0038 0.0091
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0038 0.0236
Trichomonas vaginalis heat shock protein, putative 0.0473 0.1615 1
Leishmania major NADH dehydrogenase, putative 0.0017 0.0038 0.0091
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0226 0.076 0.1243
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0018 0.0113
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0038 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0194 0.065 0.3882
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0018 0.0018
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0018 0.0113
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0024 0.0146
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0096 0.0313 0.4669
Brugia malayi heat shock protein 90 0.0473 0.1615 0.1615
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0018 0.0113
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0275
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0181 0.0607 0.0984
Trypanosoma cruzi heat shock protein 85, putative 0.0473 0.1615 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0024 0.0055
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0096 0.0313 0.0466
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0096 0.0313 0.0489
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.0024 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0018 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0198 0.1093
Mycobacterium ulcerans sulfatase 0.0087 0.028 0.0409
Schistosoma mansoni heat shock protein 0.0473 0.1615 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0377 0.1282 0.7889
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0038 0.0091
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0096 0.0313 0.0489
Trichomonas vaginalis mercuric reductase, putative 0.0063 0.0198 0.1011
Brugia malayi MH1 domain containing protein 0.0006 0.0003 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0198 0.1093
Brugia malayi Endoplasmin precursor 0.0473 0.1615 0.1615
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0018 0.0042
Schistosoma mansoni smad 0.0006 0.0003 0.0017
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0038 0.0236
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0038 0.0091
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0063 0.0198 0.1093
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0096 0.0313 0.1746
Echinococcus multilocularis endoplasmin 0.0377 0.1282 0.7939
Schistosoma mansoni glutamate synthase 0.0017 0.0038 0.0236
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0096 0.0313 0.4669
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0096 0.0313 0.0466
Plasmodium vivax heat shock protein 90, putative 0.0194 0.065 0.3937
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0018 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0024 0.0147
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0198 0.1093
Plasmodium vivax thioredoxin reductase, putative 0.0181 0.0607 0.3665
Loa Loa (eye worm) hypothetical protein 0.0118 0.0389 0.092
Loa Loa (eye worm) MH2 domain-containing protein 0.0006 0.0003 0.0005
Entamoeba histolytica DNA topoisomerase II, putative 0.0096 0.0313 0.1746
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0096 0.0313 0.0489
Plasmodium falciparum DNA topoisomerase 2 0.0096 0.0313 0.1821
Echinococcus multilocularis heat shock protein 90 0.0473 0.1615 1
Brugia malayi nuclear receptor NHR-88 0.0011 0.0018 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0323 0.1098 0.68
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0129 0.0663
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0005 0.003
Treponema pallidum NADH oxidase 0.0063 0.0198 0.1282
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0038 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0018 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.0091
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0018 0.0018
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0096 0.0313 0.2213
Echinococcus multilocularis smad 0.0006 0.0003 0.0017
Chlamydia trachomatis DNA gyrase subunit B 0.0096 0.0313 0.3814
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0117 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0018 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0018 0.0113
Plasmodium vivax endoplasmin, putative 0.0473 0.1615 1
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0096 0.0313 0.194
Loa Loa (eye worm) heat shock protein 90 0.0473 0.1615 0.3825
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0018 0.0018
Trypanosoma brucei heat shock protein, putative 0.0473 0.1615 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0018 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0096 0.0313 0.1821
Schistosoma mansoni Smad4 0.0006 0.0003 0.0017
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0018 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Trypanosoma brucei heat shock protein 84, putative 0.0194 0.065 0.3937
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0096 0.0313 0.1821
Echinococcus granulosus GPCR family 2 0.0012 0.0024 0.0146
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0096 0.0313 0.194
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0117 0.0116
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0038 0.0091
Mycobacterium tuberculosis Possible hydrolase 0.0087 0.028 0.0432
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0198 0.1093
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.1727 0.5949 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0038 0.0091
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0038 0.0091
Trichomonas vaginalis glutathione reductase, putative 0.0063 0.0198 0.1011
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Giardia lamblia Hypothetical protein 0.0087 0.028 0.1531
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0096 0.0313 0.194
Brugia malayi Sulfatase family protein 0.0087 0.028 0.0279
Echinococcus granulosus endoplasmin 0.0377 0.1282 0.7939
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0063 0.0198 0.1093
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0096 0.0313 0.1746
Entamoeba histolytica heat shock protein 90, putative 0.0473 0.1615 1
Echinococcus multilocularis GPCR, family 2 0.0012 0.0024 0.0146
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0096 0.0313 0.1821
Mycobacterium leprae Probable two component sensor kinase MprB 0.0096 0.0313 0.2213
Plasmodium vivax heat shock protein 86, putative 0.0473 0.1615 1
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0038 0.0236
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0096 0.0313 0.1746
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0038 0.0091
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0226 0.076 0.1221
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0087 0.028 0.0432
Plasmodium falciparum glutathione reductase 0.0181 0.0607 0.3665
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Mycobacterium ulcerans putative regultory protein 0.0096 0.0313 0.0466
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0096 0.0313 0.194
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0 0.0003
Echinococcus granulosus cpg binding protein 0.0024 0.0063 0.0393
Mycobacterium tuberculosis Probable oxidoreductase 0.0063 0.0198 0.0293
Leishmania major mitochondrial DNA topoisomerase II 0.0096 0.0313 0.1821
Giardia lamblia Heat shock protein HSP 90-alpha 0.0473 0.1615 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Loa Loa (eye worm) heat shock protein 75 0.0194 0.065 0.1539
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0087 0.028 0.1531
Loa Loa (eye worm) hypothetical protein 0.0087 0.028 0.0661
Plasmodium vivax DNA gyrase subunit B, putative 0.0096 0.0313 0.1821
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0038 0.0236
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0063 0.0198 0.2209
Schistosoma mansoni cpg binding protein 0.0024 0.0063 0.0393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0198 0.1093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0018 0.0042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0038 0.0091
Trypanosoma cruzi DNA topoisomerase II, putative 0.0096 0.0313 0.1821
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0024 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0018 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0226 0.076 1
Plasmodium falciparum endoplasmin, putative 0.029 0.0983 0.6029
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0377 0.1282 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0038 0.0091
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0096 0.0313 0.1746
Echinococcus multilocularis cpg binding protein 0.0024 0.0063 0.0393
Toxoplasma gondii thioredoxin reductase 0.0181 0.0607 0.3665
Treponema pallidum heat shock protein 90 0.0377 0.1282 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0038 0.0236
Toxoplasma gondii heat shock protein 75, putative 0.0194 0.065 0.3937
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0018 0.0113
Loa Loa (eye worm) hypothetical protein 0.0096 0.0313 0.0741
Trypanosoma cruzi trypanothione reductase, putative 0.0181 0.0607 0.3665
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0 0.0003
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Trypanosoma brucei developmentally regulated phosphoprotein 0.0096 0.0313 0.1821
Mycobacterium leprae Probable two-component sensor kinase 0.0096 0.0313 0.2213
Echinococcus granulosus smad 0.0006 0.0003 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0018 0.0042
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0038 0.0091
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0038 0.0091
Schistosoma mansoni glutamate synthase 0.0017 0.0038 0.0236
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0042
Toxoplasma gondii NADPH-glutathione reductase 0.0063 0.0198 0.1093
Loa Loa (eye worm) glutathione reductase 0.0181 0.0607 0.1436
Trypanosoma cruzi Heat shock protein 83, putative 0.0473 0.1615 1
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0063 0.0198 0.1093
Mycobacterium tuberculosis Probable dehydrogenase 0.0017 0.0038 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0018 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0018 0.0042
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0096 0.0313 0.4669
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0063 0.0198 0.027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0018 0.0018
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0018 0.0113
Trypanosoma cruzi heat shock protein, putative 0.0194 0.065 0.3937
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0096 0.0313 0.2213
Echinococcus multilocularis muscleblind protein 0.0118 0.0389 0.2407
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0038 0.0091
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0146
Schistosoma mansoni heat shock protein 0.0473 0.1615 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0017 0.0038 0.0024
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0038 0.0236
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0226 0.076 0.5802
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0017 0.0038 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0018 0.0113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0 0.0003
Trypanosoma cruzi heat shock protein 90, putative 0.0279 0.0945 0.5791
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0018 0.0018
Brugia malayi CXXC zinc finger family protein 0.0023 0.0059 0.0059
Giardia lamblia Hypothetical protein 0.0087 0.028 0.1531
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Trypanosoma brucei DNA topoisomerase ii 0.0096 0.0313 0.1821
Trypanosoma cruzi heat shock protein 85, putative 0.0377 0.1282 0.7908
Echinococcus multilocularis heat shock protein 90 0.0377 0.1282 0.7939
Trichomonas vaginalis heat shock protein, putative 0.0377 0.1282 0.7889
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0096 0.0313 0.0466
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0038 0.0236
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0096 0.0313 0.1821
Brugia malayi Thioredoxin reductase 0.0181 0.0607 0.0606
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0042
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0096 0.0313 0.1821
Loa Loa (eye worm) MH1 domain-containing protein 0.0006 0.0003 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0018 0.0018
Schistosoma mansoni endoplasmin 0.0473 0.1615 1
Trypanosoma brucei heat shock protein, putative 0.0473 0.1615 1
Chlamydia trachomatis DNA gyrase subunit B 0.0096 0.0313 0.3814
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0096 0.0313 0.0489
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0018 0.0042
Plasmodium falciparum heat shock protein 90, putative 0.0194 0.065 0.3937
Trichomonas vaginalis heat shock protein, putative 0.0377 0.1282 0.7889
Loa Loa (eye worm) endoplasmin 0.0473 0.1615 0.3825
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0236
Loa Loa (eye worm) hypothetical protein 0.0118 0.0389 0.092
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0038 0.0089
Trichomonas vaginalis heat shock protein, putative 0.0194 0.065 0.3882
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0018 0.0113
Loa Loa (eye worm) transcription factor SMAD2 0.0094 0.0307 0.0726
Schistosoma mansoni pyruvate dehydrogenase 0.0096 0.0313 0.194
Brugia malayi Hsp90 protein 0.0194 0.065 0.065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0059 0.0139
Brugia malayi Isocitrate dehydrogenase 0.0012 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Plasmodium vivax glutathione reductase, putative 0.0181 0.0607 0.3665
Leishmania major heat shock protein, putative 0.0194 0.065 0.3937
Plasmodium vivax DNA topoisomerase II, putative 0.0096 0.0313 0.1821
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0096 0.0313 0.0466
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0096 0.0313 0.1821
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0018 0.0018
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0096 0.0313 0.1821
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0096 0.0313 0.1821
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0096 0.0313 0.0489
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0 0.0003
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0226 0.076 0.5802
Trypanosoma cruzi heat shock protein 85, putative 0.0473 0.1615 1
Schistosoma mansoni coup transcription factor 0.0011 0.0018 0.0113
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0046 0.014 0.0139
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0038 0.0091
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0377 0.1282 0.7908
Brugia malayi Muscleblind-like protein 0.0118 0.0389 0.0388
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.0024 0.0055
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.0024 0.0147
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0063 0.0198 0.0197
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0038 0.0236
Loa Loa (eye worm) hypothetical protein 0.0087 0.028 0.0661
Mycobacterium ulcerans arylsulfatase AtsB 0.0087 0.028 0.0409
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0198 0.1093
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0018 0.0113
Onchocerca volvulus 0.0023 0.0059 0.0644
Echinococcus granulosus mothers against decapentaplegic 5 0.0006 0.0003 0.0017
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0096 0.0313 0.0466
Trypanosoma cruzi heat shock protein 90, putative 0.0473 0.1615 1
Loa Loa (eye worm) hypothetical protein 0.1227 0.4222 1
Brugia malayi MH1 domain containing protein 0.0006 0.0003 0.0002
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0038 0.0091
Trypanosoma brucei heat shock protein 90, putative 0.0473 0.1615 1
Plasmodium falciparum glutathione reductase 0.0063 0.0198 0.1093
Trypanosoma brucei heat shock protein, putative 0.0473 0.1615 1
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.028 0.1531
Leishmania major heat shock protein 83-1 0.0473 0.1615 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0038 0.0091
Echinococcus granulosus glutamate synthase 0.0017 0.0038 0.0236
Echinococcus multilocularis heat shock protein 0.0473 0.1615 1
Schistosoma mansoni cpg binding protein 0.0023 0.0059 0.0365
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0018 0.0042
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0087 0.028 0.0432
Trypanosoma brucei heat shock protein, putative 0.0473 0.1615 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0096 0.0313 0.1746
Mycobacterium ulcerans two component sensor kinase MprB 0.0096 0.0313 0.0466
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0018 0.0113
Trypanosoma cruzi DNA topoisomerase II, putative 0.0096 0.0313 0.1821
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0096 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0027 0.0074 0.0456
Echinococcus granulosus heat shock protein 90 0.0473 0.1615 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0096 0.0313 0.2213
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0194 0.065 0.4026
Brugia malayi hypothetical protein 0.0087 0.028 0.0279
Trypanosoma brucei heat shock protein, putative 0.0473 0.1615 1
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.0091
Loa Loa (eye worm) Smad1 0.0006 0.0003 0.0005
Trypanosoma brucei heat shock protein, putative 0.0473 0.1615 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0096 0.0313 0.1746
Brugia malayi Smad1 0.0006 0.0003 0.0002
Schistosoma mansoni smad1 5 8 and 0.0006 0.0003 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0018 0.0018
Echinococcus granulosus heat shock protein 0.0473 0.1615 1
Echinococcus multilocularis Smad4 0.0006 0.0003 0.0017
Brugia malayi ecdysteroid receptor 0.0011 0.0018 0.0018
Mycobacterium tuberculosis Conserved protein 0.0096 0.0313 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0018 0.0018
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0038 0.0091
Schistosoma mansoni endoplasmin 0.0473 0.1615 1
Mycobacterium ulcerans hydrolase 0.0087 0.028 0.0409

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) 0 uM Inhibitory constant for the inactivation of the chymotrypsin like activity of proteasome from human red blood corpuscles was determined; NI means no inhibition ChEMBL. 9871688

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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